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The map label for this gene is atpA

Identifier: 88606923

GI number: 88606923

Start: 1399721

End: 1401241

Strand: Reverse

Name: atpA

Synonym: APH_1334

Alternate gene names: 88606923

Gene position: 1401241-1399721 (Counterclockwise)

Preceding gene: 88606697

Following gene: 88607617

Centisome position: 95.24

GC content: 48.39

Gene sequence:

>1521_bases
ATGAGTGGTGTATCGTCGGGTGAGGTTCTCAAGATTCTTAGAGAGAGAATAGAGAACTTTGGTGGTCCTGTAAAAGCGGG
TAGCGTAGGGGAGGTTCTTTCTGTAAAGGATGGGATTGCTGTAGTCTACGGGTTGCATGGAGCGGGATTTGGAGAGACTG
TAGCTTTTGCTTCTGGTGTGCGCGGTGTGATATCTGGGCTGGAGAGTGATATTGCAAGCGTTGTTATCTTTGGTGAAGAC
AGAGAAGTAAAGGAAGGGGATTCTGTCGAGTGCACTGGTGAGTTGATGAAGGTGCCAGTGGGATTCTCGTTGTTGGGGCG
CGTGGTAAGTCCTTTGGGTATGCCTTTGGACGGTGAAGGTGCGATATCGGGATGTGATGGTGAGAATCCGGTAGAAGTGA
AGGCGCCGGGTATTATGGCTAGACAGCCTGTTAGTGAGCCTTTGCAGACGGGGATAAAAACGATAGATATGCTTATTCCT
ATCGGGCGTGGGCAGCGTGAGTTAATTATCGGTGATAGGAAGACGGGAAAAACTGCTATAGCGCTGGATACTATTATAAA
CCAAAAGCGGTATAATGACCGTGCGGCAAGTGAGAAGGATAAGGTATATTGCATATATGTTGCGATAGGGCAGAAGAATT
CTTCTATTGCTAGAGTGGTGAGTAAGTTGTGTGAGGCTGGTGCGGCTGATTATACGATCGTTGTTGCTACTGGTGCGTCA
GACTCTGTGCCGTTGCAGTATTTAGCTCCTTATGCTGCTTGTGCTATGGGGGAGTTTTTCCGTGATAACGGCATGCACTG
TTTGATAGTATATGATGATCTTTCTAAGCATGCGGTGGCATACAGGCAGATGTCTCTATTGTTGAGGAGGCCACCTGGTC
GGGAAGCTTATCCGGGTGATGTGTTTTATATACACTCTAGGCTTTTGGAGAGGGCGGCGAAGCTGTCGGATGCGCTTGGT
GGTGGGTCTTTGACTGCTCTGCCTATTATAGAGACGCAAGCTGGGGATGTGTCTGCGTATATTCCTACCAACGTTATCTC
CATAACTGATGGTCAGATTTTCTTGGAATCAGAGCTATTTCACAAGGGGTTTAGGCCTGCGATAAATGTAGGATTGTCGG
TATCGCGTGTGGGTTCCGCTGCGCAGGTAAAGGCTGTAAAGAAGGTTGCGGGCTCTATGAAGCTGTCTCTGGCGCAGTAC
AGGGAGTTGGAGGATTTTGCTAGGTTTGGTTCGGATCTTGATGCAAGCTCTCAGGCTATGCTTGAGAAAGGTAGGAGGAT
GATAGAGCTGTTGAAACAGGGGCAGTATTCTCCTTTATCTGTTGAGGAGCAGGTAGCGGTGATGCTTGCGGGGTCTGACA
GTTGTATTGATGCTATTCCTGTAGGTGATATGTGTCGATTTGAGAGGGGTCTGCTGGAGAAATTGCGGATTGACCATGGG
GATCTCATGGCTTGCTTGTTGGAGGATGATGTACGAAGTAAGCTGTTGGAGGTTATCAGGGGGTTTGCGGTGAGTTTTTG
A

Upstream 100 bases:

>100_bases
CACTTTTACGGTGGATGCCTCTTACGTGGGGCAGTTACGTGAGCTAACAAGGATTAGTAAGGAAGCTGTTTTTAGTATCT
AGTGATTTATTGGATGAAGC

Downstream 100 bases:

>100_bases
CAGTGAATGTTAGAGATTAGGTACTGTATGAGCGACTATGTGACTACTAGGTTTCCTATTACGAAGGGGGGCTACCAGAA
ATTGGAGTCGGAGCTGGAAG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MSGVSSGEVLKILRERIENFGGPVKAGSVGEVLSVKDGIAVVYGLHGAGFGETVAFASGVRGVISGLESDIASVVIFGED
REVKEGDSVECTGELMKVPVGFSLLGRVVSPLGMPLDGEGAISGCDGENPVEVKAPGIMARQPVSEPLQTGIKTIDMLIP
IGRGQRELIIGDRKTGKTAIALDTIINQKRYNDRAASEKDKVYCIYVAIGQKNSSIARVVSKLCEAGAADYTIVVATGAS
DSVPLQYLAPYAACAMGEFFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFYIHSRLLERAAKLSDALG
GGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLESELFHKGFRPAINVGLSVSRVGSAAQVKAVKKVAGSMKLSLAQY
RELEDFARFGSDLDASSQAMLEKGRRMIELLKQGQYSPLSVEEQVAVMLAGSDSCIDAIPVGDMCRFERGLLEKLRIDHG
DLMACLLEDDVRSKLLEVIRGFAVSF

Sequences:

>Translated_506_residues
MSGVSSGEVLKILRERIENFGGPVKAGSVGEVLSVKDGIAVVYGLHGAGFGETVAFASGVRGVISGLESDIASVVIFGED
REVKEGDSVECTGELMKVPVGFSLLGRVVSPLGMPLDGEGAISGCDGENPVEVKAPGIMARQPVSEPLQTGIKTIDMLIP
IGRGQRELIIGDRKTGKTAIALDTIINQKRYNDRAASEKDKVYCIYVAIGQKNSSIARVVSKLCEAGAADYTIVVATGAS
DSVPLQYLAPYAACAMGEFFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFYIHSRLLERAAKLSDALG
GGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLESELFHKGFRPAINVGLSVSRVGSAAQVKAVKKVAGSMKLSLAQY
RELEDFARFGSDLDASSQAMLEKGRRMIELLKQGQYSPLSVEEQVAVMLAGSDSCIDAIPVGDMCRFERGLLEKLRIDHG
DLMACLLEDDVRSKLLEVIRGFAVSF
>Mature_505_residues
SGVSSGEVLKILRERIENFGGPVKAGSVGEVLSVKDGIAVVYGLHGAGFGETVAFASGVRGVISGLESDIASVVIFGEDR
EVKEGDSVECTGELMKVPVGFSLLGRVVSPLGMPLDGEGAISGCDGENPVEVKAPGIMARQPVSEPLQTGIKTIDMLIPI
GRGQRELIIGDRKTGKTAIALDTIINQKRYNDRAASEKDKVYCIYVAIGQKNSSIARVVSKLCEAGAADYTIVVATGASD
SVPLQYLAPYAACAMGEFFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFYIHSRLLERAAKLSDALGG
GSLTALPIIETQAGDVSAYIPTNVISITDGQIFLESELFHKGFRPAINVGLSVSRVGSAAQVKAVKKVAGSMKLSLAQYR
ELEDFARFGSDLDASSQAMLEKGRRMIELLKQGQYSPLSVEEQVAVMLAGSDSCIDAIPVGDMCRFERGLLEKLRIDHGD
LMACLLEDDVRSKLLEVIRGFAVSF

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=506, Percent_Identity=61.0671936758893, Blast_Score=615, Evalue=1e-176,
Organism=Homo sapiens, GI4757810, Length=506, Percent_Identity=61.0671936758893, Blast_Score=615, Evalue=1e-176,
Organism=Homo sapiens, GI19913428, Length=307, Percent_Identity=28.0130293159609, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI19913426, Length=314, Percent_Identity=27.0700636942675, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI32189394, Length=386, Percent_Identity=24.3523316062176, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI19913424, Length=265, Percent_Identity=25.6603773584906, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1790172, Length=518, Percent_Identity=50.3861003861004, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1788251, Length=308, Percent_Identity=28.8961038961039, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790170, Length=366, Percent_Identity=23.4972677595628, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71988063, Length=511, Percent_Identity=61.252446183953, Blast_Score=624, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI71988080, Length=511, Percent_Identity=61.252446183953, Blast_Score=622, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI71988074, Length=511, Percent_Identity=57.5342465753425, Blast_Score=571, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17510931, Length=382, Percent_Identity=26.9633507853403, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17570191, Length=312, Percent_Identity=27.8846153846154, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25144756, Length=373, Percent_Identity=24.9329758713137, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17509265, Length=49, Percent_Identity=65.3061224489796, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319370, Length=500, Percent_Identity=59.6, Blast_Score=595, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319603, Length=302, Percent_Identity=29.1390728476821, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6322581, Length=385, Percent_Identity=24.6753246753247, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24658560, Length=506, Percent_Identity=60.2766798418972, Blast_Score=609, Evalue=1e-174,
Organism=Drosophila melanogaster, GI281361666, Length=302, Percent_Identity=27.1523178807947, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646341, Length=302, Percent_Identity=27.1523178807947, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136796, Length=302, Percent_Identity=27.1523178807947, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24638766, Length=386, Percent_Identity=24.3523316062176, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574560, Length=398, Percent_Identity=24.3718592964824, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_ANAPZ (Q2GIG2)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505839.1
- ProteinModelPortal:   Q2GIG2
- SMR:   Q2GIG2
- STRING:   Q2GIG2
- GeneID:   3930064
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_1334
- NMPDR:   fig|212042.5.peg.1280
- TIGR:   APH_1334
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   EFEDKML
- PhylomeDB:   Q2GIG2
- ProtClustDB:   PRK09281
- BioCyc:   APHA212042:APH_1334-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 54103; Mature: 53972

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGVSSGEVLKILRERIENFGGPVKAGSVGEVLSVKDGIAVVYGLHGAGFGETVAFASGV
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCEEEEEECCCCCCCHHHHHHHHH
RGVISGLESDIASVVIFGEDREVKEGDSVECTGELMKVPVGFSLLGRVVSPLGMPLDGEG
HHHHHHHHHCCEEEEEECCCCCCCCCCCCEECCHHHCCCCCHHHHHHHHHHCCCCCCCCC
AISGCDGENPVEVKAPGIMARQPVSEPLQTGIKTIDMLIPIGRGQRELIIGDRKTGKTAI
CEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCEEE
ALDTIINQKRYNDRAASEKDKVYCIYVAIGQKNSSIARVVSKLCEAGAADYTIVVATGAS
HHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCC
DSVPLQYLAPYAACAMGEFFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGD
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCC
VFYIHSRLLERAAKLSDALGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLESELF
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCCEEEEHHHH
HKGFRPAINVGLSVSRVGSAAQVKAVKKVAGSMKLSLAQYRELEDFARFGSDLDASSQAM
HCCCCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LEKGRRMIELLKQGQYSPLSVEEQVAVMLAGSDSCIDAIPVGDMCRFERGLLEKLRIDHG
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
DLMACLLEDDVRSKLLEVIRGFAVSF
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGVSSGEVLKILRERIENFGGPVKAGSVGEVLSVKDGIAVVYGLHGAGFGETVAFASGV
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCEEEEEECCCCCCCHHHHHHHHH
RGVISGLESDIASVVIFGEDREVKEGDSVECTGELMKVPVGFSLLGRVVSPLGMPLDGEG
HHHHHHHHHCCEEEEEECCCCCCCCCCCCEECCHHHCCCCCHHHHHHHHHHCCCCCCCCC
AISGCDGENPVEVKAPGIMARQPVSEPLQTGIKTIDMLIPIGRGQRELIIGDRKTGKTAI
CEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCEEE
ALDTIINQKRYNDRAASEKDKVYCIYVAIGQKNSSIARVVSKLCEAGAADYTIVVATGAS
HHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCC
DSVPLQYLAPYAACAMGEFFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGD
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCC
VFYIHSRLLERAAKLSDALGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLESELF
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCCEEEEHHHH
HKGFRPAINVGLSVSRVGSAAQVKAVKKVAGSMKLSLAQYRELEDFARFGSDLDASSQAM
HCCCCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LEKGRRMIELLKQGQYSPLSVEEQVAVMLAGSDSCIDAIPVGDMCRFERGLLEKLRIDHG
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
DLMACLLEDDVRSKLLEVIRGFAVSF
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA