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The map label for this gene is lysC [H]

Identifier: 87201316

GI number: 87201316

Start: 3522575

End: 3523831

Strand: Direct

Name: lysC [H]

Synonym: Saro_3304

Alternate gene names: 87201316

Gene position: 3522575-3523831 (Clockwise)

Preceding gene: 87201313

Following gene: 87201318

Centisome position: 98.9

GC content: 66.19

Gene sequence:

>1257_bases
TTGGCCCGCATCGTGATGAAATTCGGCGGCACTTCGATGGCCGGCACCGAGCGCATCCGCCGCGTGGCGCGCATCGTGCA
GCGCCAGCAGGCGGCAGGGCACGAGGTGGCGGTGGTCGTCTCTGCCATGGCGGGCGAGACCGACCGCCTCGTCAACTTCT
GCCGCGAGGCGAACCCGCTCTACGATCCGGCCGAATACGACGTGGTCGTGGCCAGCGGCGAGCAAGTGACGTCGGGTCTC
CTGGCGATGCATCTCCAGGCGCTGGGCTGCAAGGCGCGCTCGTGGCTGGGATGGCAGCTGCCGATCCACACCGACGACGC
GCATTCGAAGGCGCGCATCGAAGGCATCGATTCGGAAGCGCTGCTTGCCAGCATGGGCGCGGGCGAGATCGCGGTGATCC
CGGGATTCCAGGGCCTTACCGCCGACAACCGCGTGACCACCCTGGGCCGTGGCGGTTCCGACACTTCGGCCGTGGCAGTG
GCGGCGGCGGTCAAGGCCGACCGTTGCGACATCTACACCGACGTGGACGGGGTCTACACCACCGATCCGCGCATCGTGGC
CAAGGCCCGCAAGCTCAAGAACGTGACCTACGAGGAAATGCTCGAACTGGCCTCGGTCGGCTCGAAGGTCCTGCAGACCC
GCTCGGTCAGCCTTGCCATGAAGGAAGGCGTGCGCGTGCAGGTGCTTTCCTCATTCATCGACGACGACGCCCCGGCGGCG
GACACGATCCCCGGCACGATGATCGTTTCCGACGAGGAACTTGAAGGATTGGATATGGAACGCCAGCTGATCACCGGCAT
CGCCGCCGACAAGAACGAGGCGAAAGTTACCCTGACCCGCATCGCGGACCGCCCCGGCGCGGTCGCGGCGATCTTCGGCC
CGCTGGCCGCGGCGAACATCAACGTCGACATGATCATCCAGAACATCGCCAAGGACAAGGGCGAGACCGACGTCACCTTC
ACGGTTCCGATCTCGGACCTCGCCCGTACCCAGGCGCTGCTTGAAGAGCGCAAGGACACGATCGGCTACTACCGCATGCT
GGCCAACAGCAAGGTCGCCAAGATCAGCGTCGTCGGCGTCGGCATGCGCAGCCACGCCGGCGTCGCCAGCACCATGTTCC
GCGCCCTGGCCGACCGCGGCATCAATATCCAGGCGATCACCACCAGCGAGATCAAGGTCTCGGTGCTGATCGACGAGGAC
GAGACCGAACTCGCGGTGCGCGTGCTGCACACCGCCTACGGCCTCGACGGCGAGTAA

Upstream 100 bases:

>100_bases
GGTTGCATTGCTCATATGACGTCCCTAAAGCGCGCGCGCCGCAGGGTCCATGGCCCATGCGGGAAAGATTCTTTCGTTCG
TACAACCTGGGAGCAAGCCC

Downstream 100 bases:

>100_bases
GACGTCTTTCCGGGGGCGGACCACGGTTCGCCCCCGTCCGCCTTTCAGCGGATCAGCAGGCCCCATCCCGACAGCAGTTG
CTCGGCCTGTTCGCGCGAGA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MARIVMKFGGTSMAGTERIRRVARIVQRQQAAGHEVAVVVSAMAGETDRLVNFCREANPLYDPAEYDVVVASGEQVTSGL
LAMHLQALGCKARSWLGWQLPIHTDDAHSKARIEGIDSEALLASMGAGEIAVIPGFQGLTADNRVTTLGRGGSDTSAVAV
AAAVKADRCDIYTDVDGVYTTDPRIVAKARKLKNVTYEEMLELASVGSKVLQTRSVSLAMKEGVRVQVLSSFIDDDAPAA
DTIPGTMIVSDEELEGLDMERQLITGIAADKNEAKVTLTRIADRPGAVAAIFGPLAAANINVDMIIQNIAKDKGETDVTF
TVPISDLARTQALLEERKDTIGYYRMLANSKVAKISVVGVGMRSHAGVASTMFRALADRGINIQAITTSEIKVSVLIDED
ETELAVRVLHTAYGLDGE

Sequences:

>Translated_418_residues
MARIVMKFGGTSMAGTERIRRVARIVQRQQAAGHEVAVVVSAMAGETDRLVNFCREANPLYDPAEYDVVVASGEQVTSGL
LAMHLQALGCKARSWLGWQLPIHTDDAHSKARIEGIDSEALLASMGAGEIAVIPGFQGLTADNRVTTLGRGGSDTSAVAV
AAAVKADRCDIYTDVDGVYTTDPRIVAKARKLKNVTYEEMLELASVGSKVLQTRSVSLAMKEGVRVQVLSSFIDDDAPAA
DTIPGTMIVSDEELEGLDMERQLITGIAADKNEAKVTLTRIADRPGAVAAIFGPLAAANINVDMIIQNIAKDKGETDVTF
TVPISDLARTQALLEERKDTIGYYRMLANSKVAKISVVGVGMRSHAGVASTMFRALADRGINIQAITTSEIKVSVLIDED
ETELAVRVLHTAYGLDGE
>Mature_417_residues
ARIVMKFGGTSMAGTERIRRVARIVQRQQAAGHEVAVVVSAMAGETDRLVNFCREANPLYDPAEYDVVVASGEQVTSGLL
AMHLQALGCKARSWLGWQLPIHTDDAHSKARIEGIDSEALLASMGAGEIAVIPGFQGLTADNRVTTLGRGGSDTSAVAVA
AAVKADRCDIYTDVDGVYTTDPRIVAKARKLKNVTYEEMLELASVGSKVLQTRSVSLAMKEGVRVQVLSSFIDDDAPAAD
TIPGTMIVSDEELEGLDMERQLITGIAADKNEAKVTLTRIADRPGAVAAIFGPLAAANINVDMIIQNIAKDKGETDVTFT
VPISDLARTQALLEERKDTIGYYRMLANSKVAKISVVGVGMRSHAGVASTMFRALADRGINIQAITTSEIKVSVLIDEDE
TELAVRVLHTAYGLDGE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=478, Percent_Identity=29.2887029288703, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1790455, Length=468, Percent_Identity=27.3504273504274, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790376, Length=284, Percent_Identity=26.056338028169, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=383, Percent_Identity=27.4151436031332, Blast_Score=113, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44631; Mature: 44499

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIVMKFGGTSMAGTERIRRVARIVQRQQAAGHEVAVVVSAMAGETDRLVNFCREANPL
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHCCCHHHHHHHHHHCCCC
YDPAEYDVVVASGEQVTSGLLAMHLQALGCKARSWLGWQLPIHTDDAHSKARIEGIDSEA
CCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEECCCCHHH
LLASMGAGEIAVIPGFQGLTADNRVTTLGRGGSDTSAVAVAAAVKADRCDIYTDVDGVYT
HHHHCCCCCEEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEECCCCEEE
TDPRIVAKARKLKNVTYEEMLELASVGSKVLQTRSVSLAMKEGVRVQVLSSFIDDDAPAA
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC
DTIPGTMIVSDEELEGLDMERQLITGIAADKNEAKVTLTRIADRPGAVAAIFGPLAAANI
CCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEHHCHHHCCC
NVDMIIQNIAKDKGETDVTFTVPISDLARTQALLEERKDTIGYYRMLANSKVAKISVVGV
CHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEE
GMRSHAGVASTMFRALADRGINIQAITTSEIKVSVLIDEDETELAVRVLHTAYGLDGE
CCCCCCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEECCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ARIVMKFGGTSMAGTERIRRVARIVQRQQAAGHEVAVVVSAMAGETDRLVNFCREANPL
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHCCCHHHHHHHHHHCCCC
YDPAEYDVVVASGEQVTSGLLAMHLQALGCKARSWLGWQLPIHTDDAHSKARIEGIDSEA
CCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEECCCCHHH
LLASMGAGEIAVIPGFQGLTADNRVTTLGRGGSDTSAVAVAAAVKADRCDIYTDVDGVYT
HHHHCCCCCEEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEECCCCEEE
TDPRIVAKARKLKNVTYEEMLELASVGSKVLQTRSVSLAMKEGVRVQVLSSFIDDDAPAA
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC
DTIPGTMIVSDEELEGLDMERQLITGIAADKNEAKVTLTRIADRPGAVAAIFGPLAAANI
CCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEHHCHHHCCC
NVDMIIQNIAKDKGETDVTFTVPISDLARTQALLEERKDTIGYYRMLANSKVAKISVVGV
CHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEE
GMRSHAGVASTMFRALADRGINIQAITTSEIKVSVLIDEDETELAVRVLHTAYGLDGE
CCCCCCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEECCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]