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The map label for this gene is phhA

Identifier: 87201199

GI number: 87201199

Start: 3407491

End: 3408429

Strand: Reverse

Name: phhA

Synonym: Saro_3187

Alternate gene names: 87201199

Gene position: 3408429-3407491 (Counterclockwise)

Preceding gene: 87201204

Following gene: 87201194

Centisome position: 95.7

GC content: 66.03

Gene sequence:

>939_bases
ATGTTGACAACGACCGCACCCGCTTTCGACTATGCCTGCCTACCGGAAATGCCGGAGGGCGTGTTCACCGCGCCCTTGCG
CCGCCCGGACCGCGTGGGCGAGGACTGGCTCGAGCCTGCGCAACACCGCTACACCGCGCAGGAGCACGCGATCTGGGATG
AGCTTTACGCCCGCCAGATGGAACTTCTGCCCGGCAGGGCCTGCAGCGCCTTCCTGCAGGGCCTGGAGCGGCTCGACCTC
GGGCGCGGAGGCGTGCCCGACTTCGCACGGCTTTCGTCCGAGCTTGGCGCGCTGACTGGCTGGAGCGTCGTGCCCGTGCC
GATGCTGATCCCCGATCACGTGTTCTTCTGGCACCTGGCGAACCGCCGCTTTCCCGCAGGCAACTTCATCCGCACGCGCG
AGACGTTCGATTACATCCAGGAGCCCGACGTCTTCCACGATGTCTTCGGCCACGTACCGATGCTGACCGACCCGACTTAT
GCCGACTACATGCAGGAGTATGGCCGCGCCGGGTGGAAGGCGATGCGTTACAACCGGCTCAAGGCGCTGGGCGCGCTCTA
CTGGTACACGGTGGAGTTCGGGCTGGTGATCGAGGACGGCGCGCCCAAGGTCTATGGTGCGGGGATCCTCTCCGGCCCGC
GCGAGGCGGTGTTCGCGCTGGAGGGGCAGTCGCCCAACCGCATCATGCTCAACGTCGACCGGGTCATGCGCACGGATTAC
GTGATCGACGATCTCCAGCCGACCTATTTCGTGATCGAGAGCTTCGCGGACCTCTATCACCAGACGGTCGAGCGCGATTT
CGACCGGCTCTACCGCGCGCTCGGCGCCGGGTTCACTTATGCCAACACTGCGGTGATCGACGTGGACGACGTGCTGCACC
GGGGCACGCTGGAATACCACCTGCGGGGCGGGCGCGGATCGGGCGCAATTCCGGTCTGA

Upstream 100 bases:

>100_bases
CGGGCCGTTGCGGTAGAATCAGGACAAAGTCAAGCACGGAGAGACCGACGGAGGCATTTGCCCGAACCTCGATTGCGTGC
TATTGGTTGCATTGGAAACC

Downstream 100 bases:

>100_bases
TTTCCGGTCCCGGCTGCGACAAGCAAGCAAAAACCCGGCGTAGCCGAGGCTCCGCCGGGTTTTCGGTTCCGTGACCGGAT
GGCTGCCAGCCGGTACGGGA

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MLTTTAPAFDYACLPEMPEGVFTAPLRRPDRVGEDWLEPAQHRYTAQEHAIWDELYARQMELLPGRACSAFLQGLERLDL
GRGGVPDFARLSSELGALTGWSVVPVPMLIPDHVFFWHLANRRFPAGNFIRTRETFDYIQEPDVFHDVFGHVPMLTDPTY
ADYMQEYGRAGWKAMRYNRLKALGALYWYTVEFGLVIEDGAPKVYGAGILSGPREAVFALEGQSPNRIMLNVDRVMRTDY
VIDDLQPTYFVIESFADLYHQTVERDFDRLYRALGAGFTYANTAVIDVDDVLHRGTLEYHLRGGRGSGAIPV

Sequences:

>Translated_312_residues
MLTTTAPAFDYACLPEMPEGVFTAPLRRPDRVGEDWLEPAQHRYTAQEHAIWDELYARQMELLPGRACSAFLQGLERLDL
GRGGVPDFARLSSELGALTGWSVVPVPMLIPDHVFFWHLANRRFPAGNFIRTRETFDYIQEPDVFHDVFGHVPMLTDPTY
ADYMQEYGRAGWKAMRYNRLKALGALYWYTVEFGLVIEDGAPKVYGAGILSGPREAVFALEGQSPNRIMLNVDRVMRTDY
VIDDLQPTYFVIESFADLYHQTVERDFDRLYRALGAGFTYANTAVIDVDDVLHRGTLEYHLRGGRGSGAIPV
>Mature_312_residues
MLTTTAPAFDYACLPEMPEGVFTAPLRRPDRVGEDWLEPAQHRYTAQEHAIWDELYARQMELLPGRACSAFLQGLERLDL
GRGGVPDFARLSSELGALTGWSVVPVPMLIPDHVFFWHLANRRFPAGNFIRTRETFDYIQEPDVFHDVFGHVPMLTDPTY
ADYMQEYGRAGWKAMRYNRLKALGALYWYTVEFGLVIEDGAPKVYGAGILSGPREAVFALEGQSPNRIMLNVDRVMRTDY
VIDDLQPTYFVIESFADLYHQTVERDFDRLYRALGAGFTYANTAVIDVDDVLHRGTLEYHLRGGRGSGAIPV

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=218, Percent_Identity=34.8623853211009, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI88900505, Length=218, Percent_Identity=34.8623853211009, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI88900501, Length=218, Percent_Identity=34.8623853211009, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI4759248, Length=234, Percent_Identity=31.6239316239316, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4557819, Length=218, Percent_Identity=31.1926605504587, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI31795563, Length=230, Percent_Identity=31.304347826087, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17531391, Length=242, Percent_Identity=33.4710743801653, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI115532103, Length=231, Percent_Identity=32.9004329004329, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI115533973, Length=231, Percent_Identity=32.9004329004329, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71980736, Length=238, Percent_Identity=31.0924369747899, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71980731, Length=149, Percent_Identity=28.8590604026846, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17136776, Length=218, Percent_Identity=31.1926605504587, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17136774, Length=218, Percent_Identity=31.1926605504587, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI62472054, Length=232, Percent_Identity=30.6034482758621, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24660393, Length=232, Percent_Identity=30.6034482758621, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24654994, Length=225, Percent_Identity=29.3333333333333, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 35409; Mature: 35409

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTTTAPAFDYACLPEMPEGVFTAPLRRPDRVGEDWLEPAQHRYTAQEHAIWDELYARQM
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLPGRACSAFLQGLERLDLGRGGVPDFARLSSELGALTGWSVVPVPMLIPDHVFFWHLA
HHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCHHHEEHHH
NRRFPAGNFIRTRETFDYIQEPDVFHDVFGHVPMLTDPTYADYMQEYGRAGWKAMRYNRL
CCCCCCCCCEEHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KALGALYWYTVEFGLVIEDGAPKVYGAGILSGPREAVFALEGQSPNRIMLNVDRVMRTDY
HHHHHHHEEEEEEEEEEECCCCCEEECCCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHH
VIDDLQPTYFVIESFADLYHQTVERDFDRLYRALGAGFTYANTAVIDVDDVLHRGTLEYH
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEEEHHHHHHCCCEEEE
LRGGRGSGAIPV
EECCCCCCCCCC
>Mature Secondary Structure
MLTTTAPAFDYACLPEMPEGVFTAPLRRPDRVGEDWLEPAQHRYTAQEHAIWDELYARQM
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLPGRACSAFLQGLERLDLGRGGVPDFARLSSELGALTGWSVVPVPMLIPDHVFFWHLA
HHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCHHHEEHHH
NRRFPAGNFIRTRETFDYIQEPDVFHDVFGHVPMLTDPTYADYMQEYGRAGWKAMRYNRL
CCCCCCCCCEEHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KALGALYWYTVEFGLVIEDGAPKVYGAGILSGPREAVFALEGQSPNRIMLNVDRVMRTDY
HHHHHHHEEEEEEEEEEECCCCCEEECCCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHH
VIDDLQPTYFVIESFADLYHQTVERDFDRLYRALGAGFTYANTAVIDVDDVLHRGTLEYH
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEEEHHHHHHCCCEEEE
LRGGRGSGAIPV
EECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]