Click here to switch to the map view.

The map label for this gene is ghrA [H]

Identifier: 87200960

GI number: 87200960

Start: 3165997

End: 3166926

Strand: Reverse

Name: ghrA [H]

Synonym: Saro_2948

Alternate gene names: 87200960

Gene position: 3166926-3165997 (Counterclockwise)

Preceding gene: 87200961

Following gene: 87200959

Centisome position: 88.92

GC content: 67.42

Gene sequence:

>930_bases
ATGACCATGCTCTATCACGGCCCCGAAGCGCGCGGCGCGATCTGGGCCGATATCTTTGCCCGCAGGCTGCCGGACGTCCC
GTTCCGCCGCTGGAGCGAGGATGCCATCGACGCGCCAGCCGTGCGTTTCCTTGCGGCGTGGAATCCGGCGCCCGAATTCG
TCGCGCAGTTCCCGAACCTCGAAGTCCTGTTCTGCGTCGGGGCAGGCGTCGACCAGTTGCCGCTTGCGGATCTGCCTCCA
AAGGTTCGCGTCGTTCGCATGATCGAGCCGGGCATTTCGGTGGCCATGGCAGAGTATGTCGCGACCGCCTGCCTTGCGCT
GCATCGCGACCTGCCGCACTTCGTTGCCGAGCAGCGCGCCGATCGCTGGAGCTACGCCGCTCCCCGTCTCGCCACAGAGC
GGCGCGTGGGGGTGATGGGGCTGGGTGAACTCGGCCAGGCCTCGCTCCGGTTGCTGCGGCCACTCGGCTTCCGACTCTCC
GGCTGGAGCCGCAGCGCCCATGCTATCGACGGCGTTGAGTGCTTTGCCGGGGCCGAAGCGCTCGACGCATTCCTCGCCCA
GGCCGATATCCTGGTCTGTCTCCTGCCGCTGACGTCGGCAACGCGCGGCATTCTCTGCCGCCAGACATTCGAAAAGATGC
CTCGTGGTGCCGCGCTGGTGAATGCGGGCCGCGGTGCGCACCTCGTTGCGGAGGATCTCCTCGCCGCCCTGGAATCCGGG
CAATTGCGCGCCGCGATGCTCGACGTGACCGATCCGGAGCCGCTGCCGCAAGGCCACGCATTCTATAGTCATCCGGCGAT
TTTCCTTACGCCCCATGTCGCTGCCGAAACGCGGCCGGAAACCGCGGGCGAGGTGCTTGCCGACAATGTCGCGCGCATCC
TGGCGGGCCAGGTGCCGGTCGGCGAAGTGGACCGAGCGAGGGGTTACTGA

Upstream 100 bases:

>100_bases
GTCCGCTGGGGCGCTGGTTCGTCCTTGTCGAGGCGCTCGTGCTGGCGGTTCTTTCCATCACCGGCCCCGTCATGTGGTGG
CAGGCAAGAAGGCTGCGCAA

Downstream 100 bases:

>100_bases
ATGCGCGGCACGTCGTGCCGTGAAATGTCTGCAAAAAGTGCCGGGAGCCGGATCGGGCAACTGCGAACGGATGCAAGTTC
CGGCCCGGCGGTGGTGCTAT

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTMLYHGPEARGAIWADIFARRLPDVPFRRWSEDAIDAPAVRFLAAWNPAPEFVAQFPNLEVLFCVGAGVDQLPLADLPP
KVRVVRMIEPGISVAMAEYVATACLALHRDLPHFVAEQRADRWSYAAPRLATERRVGVMGLGELGQASLRLLRPLGFRLS
GWSRSAHAIDGVECFAGAEALDAFLAQADILVCLLPLTSATRGILCRQTFEKMPRGAALVNAGRGAHLVAEDLLAALESG
QLRAAMLDVTDPEPLPQGHAFYSHPAIFLTPHVAAETRPETAGEVLADNVARILAGQVPVGEVDRARGY

Sequences:

>Translated_309_residues
MTMLYHGPEARGAIWADIFARRLPDVPFRRWSEDAIDAPAVRFLAAWNPAPEFVAQFPNLEVLFCVGAGVDQLPLADLPP
KVRVVRMIEPGISVAMAEYVATACLALHRDLPHFVAEQRADRWSYAAPRLATERRVGVMGLGELGQASLRLLRPLGFRLS
GWSRSAHAIDGVECFAGAEALDAFLAQADILVCLLPLTSATRGILCRQTFEKMPRGAALVNAGRGAHLVAEDLLAALESG
QLRAAMLDVTDPEPLPQGHAFYSHPAIFLTPHVAAETRPETAGEVLADNVARILAGQVPVGEVDRARGY
>Mature_308_residues
TMLYHGPEARGAIWADIFARRLPDVPFRRWSEDAIDAPAVRFLAAWNPAPEFVAQFPNLEVLFCVGAGVDQLPLADLPPK
VRVVRMIEPGISVAMAEYVATACLALHRDLPHFVAEQRADRWSYAAPRLATERRVGVMGLGELGQASLRLLRPLGFRLSG
WSRSAHAIDGVECFAGAEALDAFLAQADILVCLLPLTSATRGILCRQTFEKMPRGAALVNAGRGAHLVAEDLLAALESGQ
LRAAMLDVTDPEPLPQGHAFYSHPAIFLTPHVAAETRPETAGEVLADNVARILAGQVPVGEVDRARGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=245, Percent_Identity=31.8367346938775, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI23308577, Length=255, Percent_Identity=27.843137254902, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI87081824, Length=316, Percent_Identity=35.7594936708861, Blast_Score=194, Evalue=5e-51,
Organism=Escherichia coli, GI87082289, Length=272, Percent_Identity=26.1029411764706, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=243, Percent_Identity=27.1604938271605, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324055, Length=260, Percent_Identity=26.9230769230769, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322116, Length=320, Percent_Identity=24.6875, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320925, Length=312, Percent_Identity=24.3589743589744, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28574286, Length=251, Percent_Identity=29.0836653386454, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI45551003, Length=261, Percent_Identity=29.1187739463602, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24585514, Length=261, Percent_Identity=29.1187739463602, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28574282, Length=261, Percent_Identity=29.1187739463602, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28574284, Length=261, Percent_Identity=29.1187739463602, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI45552429, Length=261, Percent_Identity=29.1187739463602, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28571528, Length=174, Percent_Identity=31.0344827586207, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921140, Length=225, Percent_Identity=28.4444444444444, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585516, Length=172, Percent_Identity=30.8139534883721, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646446, Length=271, Percent_Identity=25.830258302583, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24646448, Length=271, Percent_Identity=25.830258302583, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24646452, Length=271, Percent_Identity=25.830258302583, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24646450, Length=271, Percent_Identity=25.830258302583, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33437; Mature: 33306

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMLYHGPEARGAIWADIFARRLPDVPFRRWSEDAIDAPAVRFLAAWNPAPEFVAQFPNL
CCEEEECCCCCCHHHHHHHHHHCCCCCCHHCCCHHCCHHHHHHHHHCCCCHHHHHHCCCC
EVLFCVGAGVDQLPLADLPPKVRVVRMIEPGISVAMAEYVATACLALHRDLPHFVAEQRA
EEEEEECCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DRWSYAAPRLATERRVGVMGLGELGQASLRLLRPLGFRLSGWSRSAHAIDGVECFAGAEA
HHHCCCCCCHHHHHCCCEEECCHHHHHHHHHHHHCCCEECCCCCCCCCCCCHHHHHHHHH
LDAFLAQADILVCLLPLTSATRGILCRQTFEKMPRGAALVNAGRGAHLVAEDLLAALESG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCC
QLRAAMLDVTDPEPLPQGHAFYSHPAIFLTPHVAAETRPETAGEVLADNVARILAGQVPV
CEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GEVDRARGY
CCCHHCCCC
>Mature Secondary Structure 
TMLYHGPEARGAIWADIFARRLPDVPFRRWSEDAIDAPAVRFLAAWNPAPEFVAQFPNL
CEEEECCCCCCHHHHHHHHHHCCCCCCHHCCCHHCCHHHHHHHHHCCCCHHHHHHCCCC
EVLFCVGAGVDQLPLADLPPKVRVVRMIEPGISVAMAEYVATACLALHRDLPHFVAEQRA
EEEEEECCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DRWSYAAPRLATERRVGVMGLGELGQASLRLLRPLGFRLSGWSRSAHAIDGVECFAGAEA
HHHCCCCCCHHHHHCCCEEECCHHHHHHHHHHHHCCCEECCCCCCCCCCCCHHHHHHHHH
LDAFLAQADILVCLLPLTSATRGILCRQTFEKMPRGAALVNAGRGAHLVAEDLLAALESG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCC
QLRAAMLDVTDPEPLPQGHAFYSHPAIFLTPHVAAETRPETAGEVLADNVARILAGQVPV
CEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GEVDRARGY
CCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA