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The map label for this gene is fghA [H]

Identifier: 87200934

GI number: 87200934

Start: 3139911

End: 3140768

Strand: Reverse

Name: fghA [H]

Synonym: Saro_2922

Alternate gene names: 87200934

Gene position: 3140768-3139911 (Counterclockwise)

Preceding gene: 87200935

Following gene: 87200930

Centisome position: 88.18

GC content: 67.72

Gene sequence:

>858_bases
ATGAGCATCGAGACCGTATCGACAAGCAAGGCGCACGGCGGAACGCTGGGCGTCTACAAGCACGATTCGGCCTCCACGGG
GACGGGAATGACCTTTTCGGTCTTCCTGCCCCCACAGGCGGCCGCCGGCGCAAAGCTGCCGGTGCTGGTCTACCTTTCGG
GGCTTACCTGCACGCACGCCAACGTCACCGACAAGGGCGAGTACCGCAAGGCTTGCGCGGAGCACGGCCTGGTCTTCGTC
GCCCCGGATACGAGCCCGCGCGGCGAGGGCGTGGCTGACGATCCTGACGCGGCCTACGACTTCGGACTGGGCGCGGGGTT
CTACGTGAACGCAACGCAGCAGCCGTTCGCGCGGCACTACCGCATGTGGGACTATATCGCCGAGGAACTGCCCGCCCTGC
TGGCGGCGAACTTCCCGGTCGACCTTGGCCGCATGGGCATTACCGGGCACTCGATGGGCGGGCACGGCGCGCTGACGCTG
GGGCTGACCCATCCCGAGAAGTTCCGTTCGCTTTCGGCCTTCGCGCCGATCGTCGCGCCGGGGCAGGTGCCGTGGGGCCA
CAAGGCGCTGGGCGGCTATCTGGGCGACGACCGCGCAGCGTGGCGCAAGCACGACGCGGTGGCGCTGATCGAGGACGGCC
GGCGGCCGGGGGGCGACATTCTGGTCGACCAGGGCGATGCGGACGGTTTTCTTGTCGAACAGCTTCGGCCGGAACTGCTC
GATGCGGCCTGCAAGGCGGCGGGCGTCGACCTGACGCTGCGGATGCAGCCGGGCTACGACCACAGCTACAACTTCATTTC
GACCTTCATGGACGACCATGTGCGCTGGCATGCGGAGCGTTTGAAGGTCCGGCCCTGA

Upstream 100 bases:

>100_bases
GCGAGGACCCGCCGGGACCGCGCGAGGGTTCGCCCTACTATCTCGCCTATCTGCGCGATCCTTCCGGCAACAAGCTCTGC
GCGCTGGACATCATCGCCTG

Downstream 100 bases:

>100_bases
TCCATCCCTTGCCCTCGGGTGGAGTCCTGGGGGCGGGACGAAGCCTTGGCCCGGATCAAGCCCGGGCCGACGAAGGTGCG
GGGCGGCAGGGTTTTGGGGT

Product: carboxylesterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSIETVSTSKAHGGTLGVYKHDSASTGTGMTFSVFLPPQAAAGAKLPVLVYLSGLTCTHANVTDKGEYRKACAEHGLVFV
APDTSPRGEGVADDPDAAYDFGLGAGFYVNATQQPFARHYRMWDYIAEELPALLAANFPVDLGRMGITGHSMGGHGALTL
GLTHPEKFRSLSAFAPIVAPGQVPWGHKALGGYLGDDRAAWRKHDAVALIEDGRRPGGDILVDQGDADGFLVEQLRPELL
DAACKAAGVDLTLRMQPGYDHSYNFISTFMDDHVRWHAERLKVRP

Sequences:

>Translated_285_residues
MSIETVSTSKAHGGTLGVYKHDSASTGTGMTFSVFLPPQAAAGAKLPVLVYLSGLTCTHANVTDKGEYRKACAEHGLVFV
APDTSPRGEGVADDPDAAYDFGLGAGFYVNATQQPFARHYRMWDYIAEELPALLAANFPVDLGRMGITGHSMGGHGALTL
GLTHPEKFRSLSAFAPIVAPGQVPWGHKALGGYLGDDRAAWRKHDAVALIEDGRRPGGDILVDQGDADGFLVEQLRPELL
DAACKAAGVDLTLRMQPGYDHSYNFISTFMDDHVRWHAERLKVRP
>Mature_284_residues
SIETVSTSKAHGGTLGVYKHDSASTGTGMTFSVFLPPQAAAGAKLPVLVYLSGLTCTHANVTDKGEYRKACAEHGLVFVA
PDTSPRGEGVADDPDAAYDFGLGAGFYVNATQQPFARHYRMWDYIAEELPALLAANFPVDLGRMGITGHSMGGHGALTLG
LTHPEKFRSLSAFAPIVAPGQVPWGHKALGGYLGDDRAAWRKHDAVALIEDGRRPGGDILVDQGDADGFLVEQLRPELLD
AACKAAGVDLTLRMQPGYDHSYNFISTFMDDHVRWHAERLKVRP

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=283, Percent_Identity=50.1766784452297, Blast_Score=296, Evalue=2e-80,
Organism=Escherichia coli, GI1786551, Length=282, Percent_Identity=46.8085106382979, Blast_Score=270, Evalue=8e-74,
Organism=Escherichia coli, GI1788477, Length=280, Percent_Identity=49.6428571428571, Blast_Score=267, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI17510185, Length=284, Percent_Identity=50, Blast_Score=270, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=43.9189189189189, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI45551932, Length=283, Percent_Identity=46.643109540636, Blast_Score=258, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24648347, Length=283, Percent_Identity=46.643109540636, Blast_Score=258, Evalue=4e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30604; Mature: 30473

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIETVSTSKAHGGTLGVYKHDSASTGTGMTFSVFLPPQAAAGAKLPVLVYLSGLTCTHA
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCEEECC
NVTDKGEYRKACAEHGLVFVAPDTSPRGEGVADDPDAAYDFGLGAGFYVNATQQPFARHY
CCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCHHHCCCCCCEEECCCCCHHHHHH
RMWDYIAEELPALLAANFPVDLGRMGITGHSMGGHGALTLGLTHPEKFRSLSAFAPIVAP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCEECC
GQVPWGHKALGGYLGDDRAAWRKHDAVALIEDGRRPGGDILVDQGDADGFLVEQLRPELL
CCCCCCHHHHCCCCCCCHHHHHCCCCEEEEECCCCCCCCEEEECCCCCCHHHHHHCHHHH
DAACKAAGVDLTLRMQPGYDHSYNFISTFMDDHVRWHAERLKVRP
HHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SIETVSTSKAHGGTLGVYKHDSASTGTGMTFSVFLPPQAAAGAKLPVLVYLSGLTCTHA
CCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCEEECC
NVTDKGEYRKACAEHGLVFVAPDTSPRGEGVADDPDAAYDFGLGAGFYVNATQQPFARHY
CCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCHHHCCCCCCEEECCCCCHHHHHH
RMWDYIAEELPALLAANFPVDLGRMGITGHSMGGHGALTLGLTHPEKFRSLSAFAPIVAP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCEECC
GQVPWGHKALGGYLGDDRAAWRKHDAVALIEDGRRPGGDILVDQGDADGFLVEQLRPELL
CCCCCCHHHHCCCCCCCHHHHHCCCCEEEEECCCCCCCCEEEECCCCCCHHHHHHCHHHH
DAACKAAGVDLTLRMQPGYDHSYNFISTFMDDHVRWHAERLKVRP
HHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]