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The map label for this gene is lysA [H]

Identifier: 87200688

GI number: 87200688

Start: 2913402

End: 2914661

Strand: Reverse

Name: lysA [H]

Synonym: Saro_2675

Alternate gene names: 87200688

Gene position: 2914661-2913402 (Counterclockwise)

Preceding gene: 87200689

Following gene: 87200687

Centisome position: 81.84

GC content: 66.35

Gene sequence:

>1260_bases
ATGGACCATTTTGAAGTTTCGAACGGCGTGCTCCATGCCGAAGACGTTGCCCTGCCGGTGATCGCGGCCGAAGTCGGCAC
GCCTGTCTATGTCTATTCGCGTGCCACGCTGACGCGCCACGCCCGCGTGTTCCGCGATGCACTGTCGATCCTGCCGGCGG
TGAAGATCGCCTTCGCGGTCAAGTCCAACCCCAACCTCGCCGTGCTCAAGGTGCTGGCCGCCGAAGGTTATGGTGCCGAT
GTCGTCTCGGGCGGCGAAATGGAGCGGGCGCTGGCCGCGGGCATGAAGCCTGACGGCATCGTGTTTTCCGGCGTCGGCAA
GACCGAGGCCGAGATGCGCCGGGGGATCGAGGCAGGGATCGGCCAGTTCAACCTCGAAAGCGAGGAAGAGGGGCTCGAGC
TTGCCGAGATCGCCGCGTCGATGGGCAAGGTGGCCTCTGCCGCTCTGCGCGTGAATCCGGATGTCGACGCCGGAACGCAC
GGCAAGATCTCAACGGGCAAGGCCGAGAACAAGTTCGGCGTGCCGTTCGACCGGGCGGCTGCGATCTATGCGCGGCTGGC
GGATACGCCGGGGCTGAACATGCGCGGCCTTGCGCTGCACATCGGCAGCCAGCTTTCGAAGCTCGATCCGCTGGAAGCCG
CGTTCACCAAGGTTGGCGGACTGATGCGCGCGATCCGCGAGGGTGGCCATGCGGTGACGCACATGGATCTGGGCGGCGGC
GTTGGCGTGCCCTACAAGGCGGGCGAAGTCTTCCCGCAACCTGCGGAATATGCGGCGATGGTCGCCAAGGTGACGGCGGA
CTGGGGCGTGACCCTGATGTTCGAGCCGGGCCGCGTGATCACCGGAAACACCGGCGTGCTGATGACGCAGGTGGTGCGGG
TGAAGGAAGGCGCGGGGCACCCGTGGGTCGTGGTCGACGCGGCCATGAACGATCTGGCGCGGCCGGCACTTTACGATGCC
TGGCATGATTTTGCTGCGGTGGAGCCCACCGGCGAGACCTTTGTCGCCAACATCGTCGGCCCGATCTGCGAAAGCTCGGA
CACGTTCGCCATGGCGCGGACCATCGACAAGGTCGGGCGCGGGGACCTGGCGGTTTTCCGCACCGCCGGGGCCTATGGCG
CGACGATGGCCAACACCTACAACTCGCGTCCGCTGGTGCCCGAGGTGATGGTCGATGGCGAGAAGTGGGCCGTGGTGGCC
GACCGTATCGACCCCGCCACGATCCTTGCCGCCGAGCGCGTGCCGGACTTCCTGAAGTAA

Upstream 100 bases:

>100_bases
CGCAGGCAGCCCCTGCGCGCAACGTCGAGCCGCGTCGCCGCTCGCAGGATCGCGAAGACGATCCTTTCGACCTGCCTCCC
GAAGACTGAGTTTTTTTCCG

Downstream 100 bases:

>100_bases
CGTGATGCAGTCGCTCCCTCTCTTCCACCGCATCGCGGGCCAGCCGGTCGTACTGCTGGGAGAGGGGGACGCGGCCGAGG
CGAAGCAGCGGCTGATCGAG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MDHFEVSNGVLHAEDVALPVIAAEVGTPVYVYSRATLTRHARVFRDALSILPAVKIAFAVKSNPNLAVLKVLAAEGYGAD
VVSGGEMERALAAGMKPDGIVFSGVGKTEAEMRRGIEAGIGQFNLESEEEGLELAEIAASMGKVASAALRVNPDVDAGTH
GKISTGKAENKFGVPFDRAAAIYARLADTPGLNMRGLALHIGSQLSKLDPLEAAFTKVGGLMRAIREGGHAVTHMDLGGG
VGVPYKAGEVFPQPAEYAAMVAKVTADWGVTLMFEPGRVITGNTGVLMTQVVRVKEGAGHPWVVVDAAMNDLARPALYDA
WHDFAAVEPTGETFVANIVGPICESSDTFAMARTIDKVGRGDLAVFRTAGAYGATMANTYNSRPLVPEVMVDGEKWAVVA
DRIDPATILAAERVPDFLK

Sequences:

>Translated_419_residues
MDHFEVSNGVLHAEDVALPVIAAEVGTPVYVYSRATLTRHARVFRDALSILPAVKIAFAVKSNPNLAVLKVLAAEGYGAD
VVSGGEMERALAAGMKPDGIVFSGVGKTEAEMRRGIEAGIGQFNLESEEEGLELAEIAASMGKVASAALRVNPDVDAGTH
GKISTGKAENKFGVPFDRAAAIYARLADTPGLNMRGLALHIGSQLSKLDPLEAAFTKVGGLMRAIREGGHAVTHMDLGGG
VGVPYKAGEVFPQPAEYAAMVAKVTADWGVTLMFEPGRVITGNTGVLMTQVVRVKEGAGHPWVVVDAAMNDLARPALYDA
WHDFAAVEPTGETFVANIVGPICESSDTFAMARTIDKVGRGDLAVFRTAGAYGATMANTYNSRPLVPEVMVDGEKWAVVA
DRIDPATILAAERVPDFLK
>Mature_419_residues
MDHFEVSNGVLHAEDVALPVIAAEVGTPVYVYSRATLTRHARVFRDALSILPAVKIAFAVKSNPNLAVLKVLAAEGYGAD
VVSGGEMERALAAGMKPDGIVFSGVGKTEAEMRRGIEAGIGQFNLESEEEGLELAEIAASMGKVASAALRVNPDVDAGTH
GKISTGKAENKFGVPFDRAAAIYARLADTPGLNMRGLALHIGSQLSKLDPLEAAFTKVGGLMRAIREGGHAVTHMDLGGG
VGVPYKAGEVFPQPAEYAAMVAKVTADWGVTLMFEPGRVITGNTGVLMTQVVRVKEGAGHPWVVVDAAMNDLARPALYDA
WHDFAAVEPTGETFVANIVGPICESSDTFAMARTIDKVGRGDLAVFRTAGAYGATMANTYNSRPLVPEVMVDGEKWAVVA
DRIDPATILAAERVPDFLK

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=398, Percent_Identity=24.3718592964824, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=32.8467153284672, Blast_Score=182, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17562780, Length=376, Percent_Identity=23.4042553191489, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322664, Length=373, Percent_Identity=23.0563002680965, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24586472, Length=361, Percent_Identity=24.6537396121884, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24586474, Length=361, Percent_Identity=24.0997229916898, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44111; Mature: 44111

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFEVSNGVLHAEDVALPVIAAEVGTPVYVYSRATLTRHARVFRDALSILPAVKIAFAV
CCCEECCCCEEEECCCCEEEEEHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHEEEEEE
KSNPNLAVLKVLAAEGYGADVVSGGEMERALAAGMKPDGIVFSGVGKTEAEMRRGIEAGI
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCC
GQFNLESEEEGLELAEIAASMGKVASAALRVNPDVDAGTHGKISTGKAENKFGVPFDRAA
CCCCCCCCHHCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHH
AIYARLADTPGLNMRGLALHIGSQLSKLDPLEAAFTKVGGLMRAIREGGHAVTHMDLGGG
HHHHHHCCCCCCCCCEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
VGVPYKAGEVFPQPAEYAAMVAKVTADWGVTLMFEPGRVITGNTGVLMTQVVRVKEGAGH
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHHHCCCCC
PWVVVDAAMNDLARPALYDAWHDFAAVEPTGETFVANIVGPICESSDTFAMARTIDKVGR
CEEEEEHHHHHHHCHHHHHHHHCCEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCC
GDLAVFRTAGAYGATMANTYNSRPLVPEVMVDGEKWAVVADRIDPATILAAERVPDFLK
CCEEEEEECCCCCCHHHCCCCCCCCCHHEEECCCEEEEEECCCCCHHEEEHHHCCHHCC
>Mature Secondary Structure
MDHFEVSNGVLHAEDVALPVIAAEVGTPVYVYSRATLTRHARVFRDALSILPAVKIAFAV
CCCEECCCCEEEECCCCEEEEEHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHEEEEEE
KSNPNLAVLKVLAAEGYGADVVSGGEMERALAAGMKPDGIVFSGVGKTEAEMRRGIEAGI
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCC
GQFNLESEEEGLELAEIAASMGKVASAALRVNPDVDAGTHGKISTGKAENKFGVPFDRAA
CCCCCCCCHHCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHH
AIYARLADTPGLNMRGLALHIGSQLSKLDPLEAAFTKVGGLMRAIREGGHAVTHMDLGGG
HHHHHHCCCCCCCCCEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
VGVPYKAGEVFPQPAEYAAMVAKVTADWGVTLMFEPGRVITGNTGVLMTQVVRVKEGAGH
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHHHCCCCC
PWVVVDAAMNDLARPALYDAWHDFAAVEPTGETFVANIVGPICESSDTFAMARTIDKVGR
CEEEEEHHHHHHHCHHHHHHHHCCEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCC
GDLAVFRTAGAYGATMANTYNSRPLVPEVMVDGEKWAVVADRIDPATILAAERVPDFLK
CCEEEEEECCCCCCHHHCCCCCCCCCHHEEECCCEEEEEECCCCCHHEEEHHHCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA