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The map label for this gene is fabG [C]

Identifier: 87200686

GI number: 87200686

Start: 2911534

End: 2912442

Strand: Direct

Name: fabG [C]

Synonym: Saro_2673

Alternate gene names: 87200686

Gene position: 2911534-2912442 (Clockwise)

Preceding gene: 87200684

Following gene: 87200691

Centisome position: 81.75

GC content: 65.24

Gene sequence:

>909_bases
ATGAGCATTTCCTTCGAAGGCCGCGTAGCGATCGTCACCGGAGCGGGCGGTGGCCTTGGCCGCGCTTACGCGCTCGAACT
GGCCCGTCGCGGCGCGAAGGTCGTCGTGAACGATCTGGGCGGGTCGCGCGATGGCACCGGCCATTCCGACGCCGCGCTGA
AGGTGGTCGAGGAAATCGAGGCCATGGGCGGCGAAGCCATGTCGAACGGCGGTTCGGTCAGCGAATACGAACAGATGGTC
GAGATGGTCGCCAAGACGAAGGAGCGCTGGGGCGGCGTCCACGTCCTGATCAACAACGCGGGCATCCTGCGCGACAAGAG
CTTCACCAAGATGGACCCGGCCGACTTCGAGATGGTCGTGCGCGTCCACCTTATCGGCTCGGCCTTCGCCACCAAGGCCT
GCTGGGATCTGATGCGCGAACAAAACTACGGCCGCATCCTGATGACCGCCTCGTCCACCGGCCTGTTCGGCAACTTCGGC
CAGGCCAACTATGGCGCGGCCAAGCTCGGCCTCGCGGGCCTCACCAAGACCCTCTACCTCGAAGGCGCGAAGAACAACAT
CAAGGTCAACACGCTGGCCCCCGTGGCCGCCACGCGCATGACCGAGGACATCTTCCCCGAGGAAGCGTTCAAGCTGTTCG
GTCCCGAAAACGTCGTTCCCGCCGCGCTCTTCCTGGTCTCGGATGATGCCCCGACGAACGCCATCGTCGGCGCAGGCGGC
GGTGCATACCACGGCGCGTGGGTGACGATGAACAAGGGCGTCCTCCTGCCCCCCGCCGAACGCACGGTCGAAGGATTCGC
CGCCAACTGGGAAAAGATCAACGACCGCACCGGCGACTTCGCCCCGCAATCGGGCGCGGAACAGAGCCAGGTGATCATCG
GCCAGTTGCAGGCGGCGATGAAGGGCTAA

Upstream 100 bases:

>100_bases
TTTATGGCGAAGCGTGCTGGCGGTTGCCTAAGCGCCGCCTACGTGGCATCGCTCCCCACATGTTAACCGCGCGATTAGGC
GCGAGTGGAGTGAAGGCGAG

Downstream 100 bases:

>100_bases
GCCCAGTCGTTCACCACTGCCCGCCCAACTCAGAACTCACCGTCGCCCCGGACTTGATCCGGGGCCCCGCTGCCGTTTGC
GACATCGGCGGCCCGCGCAG

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSISFEGRVAIVTGAGGGLGRAYALELARRGAKVVVNDLGGSRDGTGHSDAALKVVEEIEAMGGEAMSNGGSVSEYEQMV
EMVAKTKERWGGVHVLINNAGILRDKSFTKMDPADFEMVVRVHLIGSAFATKACWDLMREQNYGRILMTASSTGLFGNFG
QANYGAAKLGLAGLTKTLYLEGAKNNIKVNTLAPVAATRMTEDIFPEEAFKLFGPENVVPAALFLVSDDAPTNAIVGAGG
GAYHGAWVTMNKGVLLPPAERTVEGFAANWEKINDRTGDFAPQSGAEQSQVIIGQLQAAMKG

Sequences:

>Translated_302_residues
MSISFEGRVAIVTGAGGGLGRAYALELARRGAKVVVNDLGGSRDGTGHSDAALKVVEEIEAMGGEAMSNGGSVSEYEQMV
EMVAKTKERWGGVHVLINNAGILRDKSFTKMDPADFEMVVRVHLIGSAFATKACWDLMREQNYGRILMTASSTGLFGNFG
QANYGAAKLGLAGLTKTLYLEGAKNNIKVNTLAPVAATRMTEDIFPEEAFKLFGPENVVPAALFLVSDDAPTNAIVGAGG
GAYHGAWVTMNKGVLLPPAERTVEGFAANWEKINDRTGDFAPQSGAEQSQVIIGQLQAAMKG
>Mature_301_residues
SISFEGRVAIVTGAGGGLGRAYALELARRGAKVVVNDLGGSRDGTGHSDAALKVVEEIEAMGGEAMSNGGSVSEYEQMVE
MVAKTKERWGGVHVLINNAGILRDKSFTKMDPADFEMVVRVHLIGSAFATKACWDLMREQNYGRILMTASSTGLFGNFGQ
ANYGAAKLGLAGLTKTLYLEGAKNNIKVNTLAPVAATRMTEDIFPEEAFKLFGPENVVPAALFLVSDDAPTNAIVGAGGG
AYHGAWVTMNKGVLLPPAERTVEGFAANWEKINDRTGDFAPQSGAEQSQVIIGQLQAAMKG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=295, Percent_Identity=47.1186440677966, Blast_Score=243, Evalue=1e-64,
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=30.0411522633745, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI15277342, Length=247, Percent_Identity=31.1740890688259, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI4503817, Length=197, Percent_Identity=25.8883248730964, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI25282469, Length=255, Percent_Identity=27.4509803921569, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=30.7086614173228, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40807363, Length=191, Percent_Identity=29.3193717277487, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI142976729, Length=195, Percent_Identity=29.2307692307692, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40254986, Length=200, Percent_Identity=27, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI31542939, Length=253, Percent_Identity=27.6679841897233, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI109715829, Length=251, Percent_Identity=26.6932270916335, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI210032110, Length=195, Percent_Identity=27.1794871794872, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=34.6456692913386, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082100, Length=245, Percent_Identity=28.9795918367347, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790717, Length=236, Percent_Identity=27.1186440677966, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787905, Length=237, Percent_Identity=27.8481012658228, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789208, Length=210, Percent_Identity=27.6190476190476, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789057, Length=217, Percent_Identity=32.258064516129, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082160, Length=194, Percent_Identity=31.4432989690722, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786812, Length=246, Percent_Identity=26.0162601626016, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=299, Percent_Identity=44.4816053511706, Blast_Score=241, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI25147288, Length=209, Percent_Identity=33.4928229665072, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17555706, Length=246, Percent_Identity=32.520325203252, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=30.2564102564103, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193203115, Length=235, Percent_Identity=30.2127659574468, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17564282, Length=178, Percent_Identity=30.3370786516854, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17567345, Length=197, Percent_Identity=28.9340101522843, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=29.4573643410853, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=28.1746031746032, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=204, Percent_Identity=28.921568627451, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=203, Percent_Identity=31.5270935960591, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71982365, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17555612, Length=221, Percent_Identity=30.316742081448, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=279, Percent_Identity=49.4623655913978, Blast_Score=243, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6324126, Length=191, Percent_Identity=29.3193717277487, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18859837, Length=278, Percent_Identity=44.2446043165468, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24649181, Length=225, Percent_Identity=33.7777777777778, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24640492, Length=192, Percent_Identity=27.0833333333333, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24639444, Length=190, Percent_Identity=34.2105263157895, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI281364892, Length=193, Percent_Identity=26.9430051813472, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581726, Length=195, Percent_Identity=28.2051282051282, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356301, Length=194, Percent_Identity=26.8041237113402, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21355631, Length=175, Percent_Identity=29.7142857142857, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357673, Length=197, Percent_Identity=27.9187817258883, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI23397609, Length=193, Percent_Identity=30.0518134715026, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21355319, Length=258, Percent_Identity=28.2945736434109, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 31848; Mature: 31716

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISFEGRVAIVTGAGGGLGRAYALELARRGAKVVVNDLGGSRDGTGHSDAALKVVEEIE
CCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
AMGGEAMSNGGSVSEYEQMVEMVAKTKERWGGVHVLINNAGILRDKSFTKMDPADFEMVV
HCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEEE
RVHLIGSAFATKACWDLMREQNYGRILMTASSTGLFGNFGQANYGAAKLGLAGLTKTLYL
EEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCEEEEE
EGAKNNIKVNTLAPVAATRMTEDIFPEEAFKLFGPENVVPAALFLVSDDAPTNAIVGAGG
ECCCCCEEEEEECCHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEEECCCCCCEEEECCC
GAYHGAWVTMNKGVLLPPAERTVEGFAANWEKINDRTGDFAPQSGAEQSQVIIGQLQAAM
CCCCCEEEEECCCEECCCHHHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
KG
CC
>Mature Secondary Structure 
SISFEGRVAIVTGAGGGLGRAYALELARRGAKVVVNDLGGSRDGTGHSDAALKVVEEIE
CCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
AMGGEAMSNGGSVSEYEQMVEMVAKTKERWGGVHVLINNAGILRDKSFTKMDPADFEMVV
HCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEEE
RVHLIGSAFATKACWDLMREQNYGRILMTASSTGLFGNFGQANYGAAKLGLAGLTKTLYL
EEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCEEEEE
EGAKNNIKVNTLAPVAATRMTEDIFPEEAFKLFGPENVVPAALFLVSDDAPTNAIVGAGG
ECCCCCEEEEEECCHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEEECCCCCCEEEECCC
GAYHGAWVTMNKGVLLPPAERTVEGFAANWEKINDRTGDFAPQSGAEQSQVIIGQLQAAM
CCCCCEEEEECCCEECCCHHHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
KG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]