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The map label for this gene is 87200606

Identifier: 87200606

GI number: 87200606

Start: 2800825

End: 2802342

Strand: Direct

Name: 87200606

Synonym: Saro_2593

Alternate gene names: NA

Gene position: 2800825-2802342 (Clockwise)

Preceding gene: 87200605

Following gene: 87200608

Centisome position: 78.64

GC content: 68.71

Gene sequence:

>1518_bases
TTGACCTGGGAACCCGAAATCGAGGAACTGCGCCGCCGCGAGGCCATGGCGGAGCAGATGGGCGGTGCCGAAAAGGTCGC
GCGCCAGCACGCGCGCGGCAAGCTTGACGCCCGTGCCCGCATTGCCGGGGTCGTCGATGCCGGCAGCTTCCGCGAGATCG
GCAAGATCGCCGGCAAGGGCCGTTACGGCCCCGACGGCGAACTGCTCGACCTTGCCCCCTCCAACCTCATCTTCGGCCGC
GCCAACGTCGAAGGCCGGCCGGTCGTCGCCTCGGCCGACGACTTCACCGTGCGCGGCGGCGCGGCCGATGCCGCCATTGC
CCGCAAGTTCATCCAGTGCGAACAGATGGCGCACACCCTGAAGATCCCGCTCATCCGGATGATCGACGGGACCGGCGGCG
GCGGCTCGGTGCGGACGCTCGAGGATATCGGGGCCACCTATGTTCCCGCAACGCCAGGCTGGGGCGATGTCGTCAGGAAC
CTCGACACCGTCCCAGTTGTCGCCCTGTCGCTCGGCCCCACCGCCGGGCTCGGCGCGGCGCGCGTCGTCGCCAGCCACTA
TTCGATCATGGTCAAGGGCCTCTCGCAGCTCTTCGCCGCAGGCCCCGCCGTCGTCGCCGCCATTGGCGAGGACCGCGACA
AGGAAGGGCTCGGCGGCAGCGCCATCCACACCCGCAACGGCGTGGTCGACGAGGAAGTCGCCAACGAGGCCGAAGCCTTC
GCCCGCGCCCGGCGCTTCCTCTCCTATCTGCCAAGCCACGTGGGCGGCGCGGCGCCACGCACTGTCGCAGCAGACCCGAC
GGACCGCCGCGAGGACTTCCTGATCGACCTCGTCCCGCGCGAAGCCAAGCAGGTCTATTCGATGCGCCGCCTGCTCGACG
CGGTGGTCGACAAGGGCAGCCTGTTCGAGATGGGCCGGCTCTGGGGCCGCGCCGTCATCACCGCATTTGCGCGGCTGGAC
GGCTGGCCCGTTGCCGTCCTCGCCAGCGACCCCAGCTACCTCGGTGGCTCATGGGATGCGCGCAGCAGCGAAAAGGCGGA
GCGCTTCGTCAAGCTGGCCGACCAGTTCCGCCTGCCGCTGGTCCACATGGTCGACAACCCGGGCTTCATGATCGGCCACA
CCGCCGAAAGCACAGGCACGATCCGCTATGGCGTGCAGGCGATGAACGCAATCTACAAGGCCACCGTGCCGCTTTGCTCG
GTGATCGTTCGCCGCGCCTATGGCATTGCCGGCAGCGCGATGAGCAATGCAGAGGCATTCCAGTACCGCTTTGCCTGGCC
ATCCGGCGACTGGGGAAGCCTGCCCATCGAAGGCGGCATCGAGGTCGCCTACAAGTCCGAGATCGAGGCTGCCGAAGACC
CCGCCGCCCATCTCGGGGCTATCCGCGACCGGCTCAACCGCGTCCGCTCCCCCTTCCGCACGGCAGAGCGTTTCGGCGTG
GAAGACATCGTCGATCCCCGCGACACCCGCCCACTGCTGTGCGAATTCGCCAATCTCGCCTGGCGCACGCTACCCTGA

Upstream 100 bases:

>100_bases
GGCGGCGGAGTAGCGCCTGCCGGCAAGTGTCAAGCAATCCGCATTGCGCTCCCCACCCAAATCGAGTGAACTGCCTACCG
ATAAACGGAGAGGCACAAGC

Downstream 100 bases:

>100_bases
GGCACCGACGTCACCCCGCCGACAGCAGTTCAGCCGCCGCCGGCGCTTCCTCCAGAAGCTCGATCAGCCCGCGTTCATGG
CGTGAAAGCCAGCGCGTCGC

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MTWEPEIEELRRREAMAEQMGGAEKVARQHARGKLDARARIAGVVDAGSFREIGKIAGKGRYGPDGELLDLAPSNLIFGR
ANVEGRPVVASADDFTVRGGAADAAIARKFIQCEQMAHTLKIPLIRMIDGTGGGGSVRTLEDIGATYVPATPGWGDVVRN
LDTVPVVALSLGPTAGLGAARVVASHYSIMVKGLSQLFAAGPAVVAAIGEDRDKEGLGGSAIHTRNGVVDEEVANEAEAF
ARARRFLSYLPSHVGGAAPRTVAADPTDRREDFLIDLVPREAKQVYSMRRLLDAVVDKGSLFEMGRLWGRAVITAFARLD
GWPVAVLASDPSYLGGSWDARSSEKAERFVKLADQFRLPLVHMVDNPGFMIGHTAESTGTIRYGVQAMNAIYKATVPLCS
VIVRRAYGIAGSAMSNAEAFQYRFAWPSGDWGSLPIEGGIEVAYKSEIEAAEDPAAHLGAIRDRLNRVRSPFRTAERFGV
EDIVDPRDTRPLLCEFANLAWRTLP

Sequences:

>Translated_505_residues
MTWEPEIEELRRREAMAEQMGGAEKVARQHARGKLDARARIAGVVDAGSFREIGKIAGKGRYGPDGELLDLAPSNLIFGR
ANVEGRPVVASADDFTVRGGAADAAIARKFIQCEQMAHTLKIPLIRMIDGTGGGGSVRTLEDIGATYVPATPGWGDVVRN
LDTVPVVALSLGPTAGLGAARVVASHYSIMVKGLSQLFAAGPAVVAAIGEDRDKEGLGGSAIHTRNGVVDEEVANEAEAF
ARARRFLSYLPSHVGGAAPRTVAADPTDRREDFLIDLVPREAKQVYSMRRLLDAVVDKGSLFEMGRLWGRAVITAFARLD
GWPVAVLASDPSYLGGSWDARSSEKAERFVKLADQFRLPLVHMVDNPGFMIGHTAESTGTIRYGVQAMNAIYKATVPLCS
VIVRRAYGIAGSAMSNAEAFQYRFAWPSGDWGSLPIEGGIEVAYKSEIEAAEDPAAHLGAIRDRLNRVRSPFRTAERFGV
EDIVDPRDTRPLLCEFANLAWRTLP
>Mature_504_residues
TWEPEIEELRRREAMAEQMGGAEKVARQHARGKLDARARIAGVVDAGSFREIGKIAGKGRYGPDGELLDLAPSNLIFGRA
NVEGRPVVASADDFTVRGGAADAAIARKFIQCEQMAHTLKIPLIRMIDGTGGGGSVRTLEDIGATYVPATPGWGDVVRNL
DTVPVVALSLGPTAGLGAARVVASHYSIMVKGLSQLFAAGPAVVAAIGEDRDKEGLGGSAIHTRNGVVDEEVANEAEAFA
RARRFLSYLPSHVGGAAPRTVAADPTDRREDFLIDLVPREAKQVYSMRRLLDAVVDKGSLFEMGRLWGRAVITAFARLDG
WPVAVLASDPSYLGGSWDARSSEKAERFVKLADQFRLPLVHMVDNPGFMIGHTAESTGTIRYGVQAMNAIYKATVPLCSV
IVRRAYGIAGSAMSNAEAFQYRFAWPSGDWGSLPIEGGIEVAYKSEIEAAEDPAAHLGAIRDRLNRVRSPFRTAERFGVE
DIVDPRDTRPLLCEFANLAWRTLP

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=506, Percent_Identity=32.8063241106719, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI295821216, Length=526, Percent_Identity=32.1292775665399, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI11545863, Length=499, Percent_Identity=26.25250501002, Blast_Score=144, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25147362, Length=503, Percent_Identity=31.4115308151093, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI25147359, Length=503, Percent_Identity=31.4115308151093, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17552936, Length=505, Percent_Identity=28.3168316831683, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323863, Length=264, Percent_Identity=25.3787878787879, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24586065, Length=524, Percent_Identity=26.5267175572519, Blast_Score=162, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 54422; Mature: 54290

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWEPEIEELRRREAMAEQMGGAEKVARQHARGKLDARARIAGVVDAGSFREIGKIAGKG
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHEEEEECCCCHHHHHHHHCCC
RYGPDGELLDLAPSNLIFGRANVEGRPVVASADDFTVRGGAADAAIARKFIQCEQMAHTL
CCCCCCCEEECCCCCEEEEECCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHH
KIPLIRMIDGTGGGGSVRTLEDIGATYVPATPGWGDVVRNLDTVPVVALSLGPTAGLGAA
HCCEEEEEECCCCCCCCCCHHHCCCEECCCCCCHHHHHHCCCCCCEEEEECCCCCCCHHH
RVVASHYSIMVKGLSQLFAAGPAVVAAIGEDRDKEGLGGSAIHTRNGVVDEEVANEAEAF
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHH
ARARRFLSYLPSHVGGAAPRTVAADPTDRREDFLIDLVPREAKQVYSMRRLLDAVVDKGS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCC
LFEMGRLWGRAVITAFARLDGWPVAVLASDPSYLGGSWDARSSEKAERFVKLADQFRLPL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCE
VHMVDNPGFMIGHTAESTGTIRYGVQAMNAIYKATVPLCSVIVRRAYGIAGSAMSNAEAF
EEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCE
QYRFAWPSGDWGSLPIEGGIEVAYKSEIEAAEDPAAHLGAIRDRLNRVRSPFRTAERFGV
EEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
EDIVDPRDTRPLLCEFANLAWRTLP
HHCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TWEPEIEELRRREAMAEQMGGAEKVARQHARGKLDARARIAGVVDAGSFREIGKIAGKG
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHEEEEECCCCHHHHHHHHCCC
RYGPDGELLDLAPSNLIFGRANVEGRPVVASADDFTVRGGAADAAIARKFIQCEQMAHTL
CCCCCCCEEECCCCCEEEEECCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHH
KIPLIRMIDGTGGGGSVRTLEDIGATYVPATPGWGDVVRNLDTVPVVALSLGPTAGLGAA
HCCEEEEEECCCCCCCCCCHHHCCCEECCCCCCHHHHHHCCCCCCEEEEECCCCCCCHHH
RVVASHYSIMVKGLSQLFAAGPAVVAAIGEDRDKEGLGGSAIHTRNGVVDEEVANEAEAF
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHH
ARARRFLSYLPSHVGGAAPRTVAADPTDRREDFLIDLVPREAKQVYSMRRLLDAVVDKGS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCC
LFEMGRLWGRAVITAFARLDGWPVAVLASDPSYLGGSWDARSSEKAERFVKLADQFRLPL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCE
VHMVDNPGFMIGHTAESTGTIRYGVQAMNAIYKATVPLCSVIVRRAYGIAGSAMSNAEAF
EEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCE
QYRFAWPSGDWGSLPIEGGIEVAYKSEIEAAEDPAAHLGAIRDRLNRVRSPFRTAERFGV
EEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
EDIVDPRDTRPLLCEFANLAWRTLP
HHCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]