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The map label for this gene is metC [H]

Identifier: 87200567

GI number: 87200567

Start: 2756814

End: 2758046

Strand: Direct

Name: metC [H]

Synonym: Saro_2554

Alternate gene names: 87200567

Gene position: 2756814-2758046 (Clockwise)

Preceding gene: 87200566

Following gene: 87200568

Centisome position: 77.4

GC content: 69.34

Gene sequence:

>1233_bases
ATGAGCAGTTCCGACAACATGAGCGATCTGGGGCCCGGCACGCGCGGCGTGCTTGCGGGGCGGCGGGAAGAGTGGACGGG
CACGCCCGATCATCCCGGGGCCGTGGTCAATCCTGCCGTATGGCGCGCATCGACGCATCTCTACCCGGACATGGCGGCGC
TGCGGGCGCATCCGGCCAACGAGGACGGGCGGTTCTATTACGGACGGCGCGGCGCCCCGACGCAGTGGGCGCTGGCCGAG
GCGTTGACGCAGATCGAACCGGGCGCGGCAGGGACCGTGCTCTATCCATCGGGCGTCGCGGCAATCGCGGGCGTACTGCT
GACAATGCTGCGACCGGGCGACGTGCTGCTGATGACGGACAACGCCTATGAACCGAGCCGCGTGATGGCACGAGGGTTGC
TCAGGGATTTCGGCGTGGAGACGCGCTGGTTCGATCCGACGAGCATTGGCGCCTTCGAGGCCGCCTGCTGCGACAGGACG
AAGGCGGTGCTGCTGGAAAGCCCCGGCAGCCTGACCATGGAAGTGCAGGACGTGCCCGCGCTGGCGGCTGCGGCGAAGGC
GCGCGGGATCGTCAGCGTGCTGGACAACACGTGGGCATCGCCGCTGGGATTTGCGGGTCTTTCGCACGGCGTCGACATCG
TGGCGATGAGCCTGACCAAGCATGTGTCCGGCCATTCCGATTGCATGATGGGCAGCGCCAGCGCGGGACCGGACTGGTAT
CGCAAGCTGCGCCTGCGCTCGCAGGGACTGGGGCTGGTGGTTTCGCCCGACGATGCCTCGCTGATGCTGCGCGGCCTCAG
GACCATGAAGATGCGGCTTGAGGCGGAGACCGCTTCGGCGCTGGCCATCGCCGGGTGGCTGGAGGGACGGCCCGAGGTGG
CGCGGGTGCTGTGCCCGATGCTGCCGGGATCGCCCGGCCACGAGTTGTGGGCGCGCGACTTTGCCGGCGGCTGCGGGCTG
TTCAGCTTTGTCCTGAAGGGCGGCAGCAGCGCGGCGCGCGATGCGCTGATCGATGCGCTTGCGCTGTTCGGCATCGGCTA
TTCGTGGGGCGGGTTCGAGAGCCTGGCGACACCGGTCGATCCGGCATCGATCCGCACGGCGAGCGCGTGGCCGCTGGCGG
GCATGGCGATGGAGGACCGCTTCGGCGTGCGGCTTTCGATCGGGCTGGAGGACACCGCCGACCTCATCGCGGACATCGAG
CAGGCGCTTGGCGCGTGGAGGGCGGCGCTGTGA

Upstream 100 bases:

>100_bases
AACGCCCAAGGCGACTGGACCGGCGTGAGAAACTTCCCCGGGGGCTGAAGCCGCAGGGAAGCAGTCGAAACTGGTGGGCA
TTGCTGCTAACAGCGGGCCG

Downstream 100 bases:

>100_bases
TCCACAACCTGGAGAAAGTGCACCGCGAGGGGCGGAAGCTGGCCCGCGCGCTGGACAAGATCGGGTTCGACATCGGTCAC
TACCACGTGTCGGCCTGGAA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSSSDNMSDLGPGTRGVLAGRREEWTGTPDHPGAVVNPAVWRASTHLYPDMAALRAHPANEDGRFYYGRRGAPTQWALAE
ALTQIEPGAAGTVLYPSGVAAIAGVLLTMLRPGDVLLMTDNAYEPSRVMARGLLRDFGVETRWFDPTSIGAFEAACCDRT
KAVLLESPGSLTMEVQDVPALAAAAKARGIVSVLDNTWASPLGFAGLSHGVDIVAMSLTKHVSGHSDCMMGSASAGPDWY
RKLRLRSQGLGLVVSPDDASLMLRGLRTMKMRLEAETASALAIAGWLEGRPEVARVLCPMLPGSPGHELWARDFAGGCGL
FSFVLKGGSSAARDALIDALALFGIGYSWGGFESLATPVDPASIRTASAWPLAGMAMEDRFGVRLSIGLEDTADLIADIE
QALGAWRAAL

Sequences:

>Translated_410_residues
MSSSDNMSDLGPGTRGVLAGRREEWTGTPDHPGAVVNPAVWRASTHLYPDMAALRAHPANEDGRFYYGRRGAPTQWALAE
ALTQIEPGAAGTVLYPSGVAAIAGVLLTMLRPGDVLLMTDNAYEPSRVMARGLLRDFGVETRWFDPTSIGAFEAACCDRT
KAVLLESPGSLTMEVQDVPALAAAAKARGIVSVLDNTWASPLGFAGLSHGVDIVAMSLTKHVSGHSDCMMGSASAGPDWY
RKLRLRSQGLGLVVSPDDASLMLRGLRTMKMRLEAETASALAIAGWLEGRPEVARVLCPMLPGSPGHELWARDFAGGCGL
FSFVLKGGSSAARDALIDALALFGIGYSWGGFESLATPVDPASIRTASAWPLAGMAMEDRFGVRLSIGLEDTADLIADIE
QALGAWRAAL
>Mature_409_residues
SSSDNMSDLGPGTRGVLAGRREEWTGTPDHPGAVVNPAVWRASTHLYPDMAALRAHPANEDGRFYYGRRGAPTQWALAEA
LTQIEPGAAGTVLYPSGVAAIAGVLLTMLRPGDVLLMTDNAYEPSRVMARGLLRDFGVETRWFDPTSIGAFEAACCDRTK
AVLLESPGSLTMEVQDVPALAAAAKARGIVSVLDNTWASPLGFAGLSHGVDIVAMSLTKHVSGHSDCMMGSASAGPDWYR
KLRLRSQGLGLVVSPDDASLMLRGLRTMKMRLEAETASALAIAGWLEGRPEVARVLCPMLPGSPGHELWARDFAGGCGLF
SFVLKGGSSAARDALIDALALFGIGYSWGGFESLATPVDPASIRTASAWPLAGMAMEDRFGVRLSIGLEDTADLIADIEQ
ALGAWRAAL

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=352, Percent_Identity=35.7954545454545, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI299473759, Length=352, Percent_Identity=34.375, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI25453487, Length=351, Percent_Identity=31.9088319088319, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1789383, Length=401, Percent_Identity=41.3965087281795, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1790375, Length=388, Percent_Identity=34.5360824742268, Blast_Score=177, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17560056, Length=350, Percent_Identity=36.8571428571429, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17538055, Length=344, Percent_Identity=35.4651162790698, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71980708, Length=380, Percent_Identity=30.7894736842105, Blast_Score=161, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6321170, Length=352, Percent_Identity=40.625, Blast_Score=256, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6319307, Length=360, Percent_Identity=31.6666666666667, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321904, Length=347, Percent_Identity=27.6657060518732, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323333, Length=385, Percent_Identity=25.7142857142857, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321254, Length=405, Percent_Identity=26.4197530864197, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922554, Length=349, Percent_Identity=34.3839541547278, Blast_Score=188, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43282; Mature: 43151

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSDNMSDLGPGTRGVLAGRREEWTGTPDHPGAVVNPAVWRASTHLYPDMAALRAHPAN
CCCCCCCHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHCCCCC
EDGRFYYGRRGAPTQWALAEALTQIEPGAAGTVLYPSGVAAIAGVLLTMLRPGDVLLMTD
CCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEEC
NAYEPSRVMARGLLRDFGVETRWFDPTSIGAFEAACCDRTKAVLLESPGSLTMEVQDVPA
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCEEEEECCCHH
LAAAAKARGIVSVLDNTWASPLGFAGLSHGVDIVAMSLTKHVSGHSDCMMGSASAGPDWY
HHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCHHCCCCCCCCHHHH
RKLRLRSQGLGLVVSPDDASLMLRGLRTMKMRLEAETASALAIAGWLEGRPEVARVLCPM
HHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCHHHHHHHHHC
LPGSPGHELWARDFAGGCGLFSFVLKGGSSAARDALIDALALFGIGYSWGGFESLATPVD
CCCCCCHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCC
PASIRTASAWPLAGMAMEDRFGVRLSIGLEDTADLIADIEQALGAWRAAL
CHHCCCCCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSSDNMSDLGPGTRGVLAGRREEWTGTPDHPGAVVNPAVWRASTHLYPDMAALRAHPAN
CCCCCCHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHCCCCC
EDGRFYYGRRGAPTQWALAEALTQIEPGAAGTVLYPSGVAAIAGVLLTMLRPGDVLLMTD
CCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEEC
NAYEPSRVMARGLLRDFGVETRWFDPTSIGAFEAACCDRTKAVLLESPGSLTMEVQDVPA
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCEEEEECCCHH
LAAAAKARGIVSVLDNTWASPLGFAGLSHGVDIVAMSLTKHVSGHSDCMMGSASAGPDWY
HHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCHHCCCCCCCCHHHH
RKLRLRSQGLGLVVSPDDASLMLRGLRTMKMRLEAETASALAIAGWLEGRPEVARVLCPM
HHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCHHHHHHHHHC
LPGSPGHELWARDFAGGCGLFSFVLKGGSSAARDALIDALALFGIGYSWGGFESLATPVD
CCCCCCHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCC
PASIRTASAWPLAGMAMEDRFGVRLSIGLEDTADLIADIEQALGAWRAAL
CHHCCCCCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]