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The map label for this gene is 87200476

Identifier: 87200476

GI number: 87200476

Start: 2658391

End: 2659686

Strand: Reverse

Name: 87200476

Synonym: Saro_2463

Alternate gene names: NA

Gene position: 2659686-2658391 (Counterclockwise)

Preceding gene: 87200477

Following gene: 87200474

Centisome position: 74.68

GC content: 63.66

Gene sequence:

>1296_bases
ATGAACCTGCCCTCTGTTGACAAAACGCATTCGGCTGACCTTGCAAGCTGGGTGCCTTCGGCGCTCGGCCATGCCGACTT
CCCTGTCCAGAACCTGCCGTTTGGGGTTTTCGCTCCGGCTGGGGAGCGGCCGCGGATCGGCACGGCCATCGGAGATTGCG
TTCTGGACCTCTGTGCGGTCGGAGCGCTGTTGCCGCCAGAAGTATTGCCGTTGCTGGAACTACCGGAACTCAACGCCCTT
ATGGCCGCCCCCCGGGTCGTGAAGACTGCATTGCGCCACAGGCTCTCGGAACTGCTGTCGGATGACGCTCATCGTCCCAT
GGTGGAGCCGGCTCTGCATGACGCGGCGTGCGTTGAAATGCTGCTTCCCATGCGGATCGGCGATTACACCGATTTCTACG
TCGGCATTCATCACGCAACGAATATCGGCAAGCTGTTCCGGCCCGACAACCCTCTTTTGCCCAACTACAAGCACGTGCCT
ATCGGGTATCATGGCCGTGCGTCCTCGATCAGGCAGAGCGGAGTGCCGGTGGCGCGACCGCGTGGCCAGCGCAGGGCGAA
CGATGCGGACGTTCCGGTGTTCGGGCCTTGCACGCGGCTGGACTACGAACTCGAACTCGGCGTCTGGATCAGCGAGGGCA
ACGCCTTGGGAACAACGATCCCGATTGCCGAGGCGGGCGAACACATTGCCGGGCTGTGCCTGCTAAACGACTGGTCTGCG
CGCGATATCCAGGCGTGGGAATACCAGCCGCTGGGGCCGTTCCTTGCCAAGAACTTCCACACGACGATCTCGCCCTGGGT
CGTGACTGCCGAGGCACTGGCACCTTTCCGGATCGCGCAGCCGCCTCGTCCCCTTGGGGACCCGGACCCGTTACCCTACC
TGCGCGACGAGGCGGACCGGATGGCAGGAGCCTTTGCAATCGAACTTTCCGTATGGCTGACGAGTGAACAGATGCGGGCA
GGGCGGTATCCACCTTTGCGCCTCAGCAGGGGCCCAGCGAGCAACATGTACTGGACCATTGCCCAGATGGTGACGCACCA
CGCTTCGAACGGATGCGGACTAAACTCCGGCGACCTGCTTGGCACGGGCACCATCTCCGGTACGGAGCAAGGCTCGAAGG
GCAGTCTGATCGAGATCAGCGAGGGCGGCAGGGTGCCGGTCGAACTGCCCACCGGCGAAACCCGCACCTTCCTCCTCGAT
GGCGACGAGATCAGCTTCTCGGCCACCGCGACGGCACCAGGGCGGGCCCCGATCGGCTTTGGAGAATGCCGTGCCGTGAT
CAGGCCCGCGCCATGA

Upstream 100 bases:

>100_bases
GCGCACCCGCCGCGCGCCCGAGATCGGTAAGTGGGCGCATGGCAGTGAGCTCGACGGCGCGAGCGAGTGACGCGCAAACA
ATTCTCGCGGACGATCGACG

Downstream 100 bases:

>100_bases
TCCGGCCACGGCGTATCGCCTAGACTACGGCTCCGACGAGCCGGCCGATGCCGGCCGTAAGCGCCATGGCCAATGCTCCC
CAGAAGACGACGCGAGCGAC

Product: fumarylacetoacetate hydrolase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Fumarylacetoacetate Hydrolase Family Protein; Hydroxylase; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNLPSVDKTHSADLASWVPSALGHADFPVQNLPFGVFAPAGERPRIGTAIGDCVLDLCAVGALLPPEVLPLLELPELNAL
MAAPRVVKTALRHRLSELLSDDAHRPMVEPALHDAACVEMLLPMRIGDYTDFYVGIHHATNIGKLFRPDNPLLPNYKHVP
IGYHGRASSIRQSGVPVARPRGQRRANDADVPVFGPCTRLDYELELGVWISEGNALGTTIPIAEAGEHIAGLCLLNDWSA
RDIQAWEYQPLGPFLAKNFHTTISPWVVTAEALAPFRIAQPPRPLGDPDPLPYLRDEADRMAGAFAIELSVWLTSEQMRA
GRYPPLRLSRGPASNMYWTIAQMVTHHASNGCGLNSGDLLGTGTISGTEQGSKGSLIEISEGGRVPVELPTGETRTFLLD
GDEISFSATATAPGRAPIGFGECRAVIRPAP

Sequences:

>Translated_431_residues
MNLPSVDKTHSADLASWVPSALGHADFPVQNLPFGVFAPAGERPRIGTAIGDCVLDLCAVGALLPPEVLPLLELPELNAL
MAAPRVVKTALRHRLSELLSDDAHRPMVEPALHDAACVEMLLPMRIGDYTDFYVGIHHATNIGKLFRPDNPLLPNYKHVP
IGYHGRASSIRQSGVPVARPRGQRRANDADVPVFGPCTRLDYELELGVWISEGNALGTTIPIAEAGEHIAGLCLLNDWSA
RDIQAWEYQPLGPFLAKNFHTTISPWVVTAEALAPFRIAQPPRPLGDPDPLPYLRDEADRMAGAFAIELSVWLTSEQMRA
GRYPPLRLSRGPASNMYWTIAQMVTHHASNGCGLNSGDLLGTGTISGTEQGSKGSLIEISEGGRVPVELPTGETRTFLLD
GDEISFSATATAPGRAPIGFGECRAVIRPAP
>Mature_431_residues
MNLPSVDKTHSADLASWVPSALGHADFPVQNLPFGVFAPAGERPRIGTAIGDCVLDLCAVGALLPPEVLPLLELPELNAL
MAAPRVVKTALRHRLSELLSDDAHRPMVEPALHDAACVEMLLPMRIGDYTDFYVGIHHATNIGKLFRPDNPLLPNYKHVP
IGYHGRASSIRQSGVPVARPRGQRRANDADVPVFGPCTRLDYELELGVWISEGNALGTTIPIAEAGEHIAGLCLLNDWSA
RDIQAWEYQPLGPFLAKNFHTTISPWVVTAEALAPFRIAQPPRPLGDPDPLPYLRDEADRMAGAFAIELSVWLTSEQMRA
GRYPPLRLSRGPASNMYWTIAQMVTHHASNGCGLNSGDLLGTGTISGTEQGSKGSLIEISEGGRVPVELPTGETRTFLLD
GDEISFSATATAPGRAPIGFGECRAVIRPAP

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=427, Percent_Identity=46.6042154566745, Blast_Score=352, Evalue=5e-97,
Organism=Caenorhabditis elegans, GI17568863, Length=420, Percent_Identity=45.7142857142857, Blast_Score=333, Evalue=7e-92,
Organism=Drosophila melanogaster, GI24657182, Length=415, Percent_Identity=44.3373493975904, Blast_Score=324, Evalue=8e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 46429; Mature: 46429

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLPSVDKTHSADLASWVPSALGHADFPVQNLPFGVFAPAGERPRIGTAIGDCVLDLCAV
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHH
GALLPPEVLPLLELPELNALMAAPRVVKTALRHRLSELLSDDAHRPMVEPALHDAACVEM
CCCCCHHHHCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LLPMRIGDYTDFYVGIHHATNIGKLFRPDNPLLPNYKHVPIGYHGRASSIRQSGVPVARP
HHHHHCCCCCEEEEEEECCCCCHHHCCCCCCCCCCCEECCCCCCCCHHHHHHCCCCCCCC
RGQRRANDADVPVFGPCTRLDYELELGVWISEGNALGTTIPIAEAGEHIAGLCLLNDWSA
CCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCEECHHHCCCCEEEEEEECCCCC
RDIQAWEYQPLGPFLAKNFHTTISPWVVTAEALAPFRIAQPPRPLGDPDPLPYLRDEADR
CCCCCCCCCCCCHHHHCCCCCCCCCCEEEHHHHCCEEECCCCCCCCCCCCCCHHHHHHHH
MAGAFAIELSVWLTSEQMRAGRYPPLRLSRGPASNMYWTIAQMVTHHASNGCGLNSGDLL
HHCEEEEEEEEEEEHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEE
GTGTISGTEQGSKGSLIEISEGGRVPVELPTGETRTFLLDGDEISFSATATAPGRAPIGF
EECCCCCCCCCCCCCEEEECCCCEEEEEECCCCCEEEEEECCCEEEEEEECCCCCCCCCH
GECRAVIRPAP
HHHHEEECCCC
>Mature Secondary Structure
MNLPSVDKTHSADLASWVPSALGHADFPVQNLPFGVFAPAGERPRIGTAIGDCVLDLCAV
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHH
GALLPPEVLPLLELPELNALMAAPRVVKTALRHRLSELLSDDAHRPMVEPALHDAACVEM
CCCCCHHHHCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LLPMRIGDYTDFYVGIHHATNIGKLFRPDNPLLPNYKHVPIGYHGRASSIRQSGVPVARP
HHHHHCCCCCEEEEEEECCCCCHHHCCCCCCCCCCCEECCCCCCCCHHHHHHCCCCCCCC
RGQRRANDADVPVFGPCTRLDYELELGVWISEGNALGTTIPIAEAGEHIAGLCLLNDWSA
CCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCEECHHHCCCCEEEEEEECCCCC
RDIQAWEYQPLGPFLAKNFHTTISPWVVTAEALAPFRIAQPPRPLGDPDPLPYLRDEADR
CCCCCCCCCCCCHHHHCCCCCCCCCCEEEHHHHCCEEECCCCCCCCCCCCCCHHHHHHHH
MAGAFAIELSVWLTSEQMRAGRYPPLRLSRGPASNMYWTIAQMVTHHASNGCGLNSGDLL
HHCEEEEEEEEEEEHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEE
GTGTISGTEQGSKGSLIEISEGGRVPVELPTGETRTFLLDGDEISFSATATAPGRAPIGF
EECCCCCCCCCCCCCEEEECCCCEEEEEECCCCCEEEEEECCCEEEEEEECCCCCCCCCH
GECRAVIRPAP
HHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA