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The map label for this gene is nuoD

Identifier: 87200314

GI number: 87200314

Start: 2440576

End: 2441787

Strand: Reverse

Name: nuoD

Synonym: Saro_2300

Alternate gene names: 87200314

Gene position: 2441787-2440576 (Counterclockwise)

Preceding gene: 87200315

Following gene: 87200313

Centisome position: 68.56

GC content: 63.12

Gene sequence:

>1212_bases
ATGAGCCTGAGCCTCGAACAGTCGCCGACCACCGGCGACGAGGTCATCACCAACTACACGATCAACTTCGGTCCCCAGCA
CCCTGCGGCGCATGGCGTGCTGCGCATGGTGATGGAACTGGACGGCGAGATCATCGAGCGCATCGATCCGCACGTCGGCC
TGCTCCATCGCGGCACCGAGAAGCTGATCGAGCACAAGACCTACCTCCAGGCGCTGCCCTATTTCGACCGGCTCGACTAC
TGCTCGCCGCTCGGCATGGAGCACTCCTATGTGCTGGCGGTCGAAAAGCTGCTGAACATCGAGGTTCCGCTGCGCGCCCA
GTACCTTCGCGTGCTGTTCGCCGAGCTGACCCGCATCTGCAACCACATGCTCAACCTCGGGTCGCATGTCATGGACGTGG
GCGCGATGACGCCGAACCTGTGGCTGTTCGAAATCCGCGAGGACTGCCTCAACTTCTTCGAGCGCGCATCGGGCGCCCGC
ATGCACTCGGCGTGGTTCCGCCCGGGCGGCGTGCACCAGGACGTGCCGCTCAAGCTGCTGACCGACATGGCGGACTGGAT
CGACGAACGCCTGCACCCGCTGTTCGACGACGCGATGAGCCTTGTGGTCGACAACCGCATCTTCAAGCAGCGCAATGTCG
ACATCGCCGTCGTCTCCAAGGAAGACGCGCTGCGTTGGGGCTTCTCGGGACCCATGATCCGGGGTTCGGGCATTCCCTGG
GACTTGCGCAAGAGCCAGCCCTACGACGTCTATGACCGCATGGAGTTCGACATTCCCGTCGGCACCAGCGGCGACTGCTA
TGACCGCTTCATGGTCCGCGTCGAGGAAGTGCGCCAGTCGGCCCGCATAATGAAGCAGTGCATCGAACAGATGCCGGACG
GTCCGGTTGCCAGCACCGACCGCAAGGTCGTGCCGCCCAAGCGCGCCGAGATGAAGCAGTCGATGGAAGCGCTGATCCAT
CATTTCAAGCTCTACACCGAAGGCTTCCATGTGCCGGCCGGTGAGGTCTATGTCGCGACGGAAAGCCCCAAGGGCGAATT
CGGCGTCTATCTGGTCTCGGATGGTTCGAACAAGCCGTACCGCTGCAAGATCCGCCCGACCGCGTTCAGCCACCTCCAGG
CAATGGACTTCATGTGCAAGGGTCACATGCTGCCCGACGCGACCGCCATCCTCGGCGCGATCGACGTGGTGTTCGGGGAG
TGCGACCGTTGA

Upstream 100 bases:

>100_bases
TTCCGCAAGCACTGCTGCCTGTGGCGGGCACTGCGTCTGCCGCACGATGGATGCTGAAACAAGTTCAGCATGACGGTGCT
GGTTCCGAGGAGCTGTCCGC

Downstream 100 bases:

>100_bases
GCAATCTTGAAACCGCCAAGGCGATGATCGCCGCCTACAACGCGCAGGACGTGGACACCTACGTCTCGTACATGACCGAC
GACGCCTGCGAGGCGAACTA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MSLSLEQSPTTGDEVITNYTINFGPQHPAAHGVLRMVMELDGEIIERIDPHVGLLHRGTEKLIEHKTYLQALPYFDRLDY
CSPLGMEHSYVLAVEKLLNIEVPLRAQYLRVLFAELTRICNHMLNLGSHVMDVGAMTPNLWLFEIREDCLNFFERASGAR
MHSAWFRPGGVHQDVPLKLLTDMADWIDERLHPLFDDAMSLVVDNRIFKQRNVDIAVVSKEDALRWGFSGPMIRGSGIPW
DLRKSQPYDVYDRMEFDIPVGTSGDCYDRFMVRVEEVRQSARIMKQCIEQMPDGPVASTDRKVVPPKRAEMKQSMEALIH
HFKLYTEGFHVPAGEVYVATESPKGEFGVYLVSDGSNKPYRCKIRPTAFSHLQAMDFMCKGHMLPDATAILGAIDVVFGE
CDR

Sequences:

>Translated_403_residues
MSLSLEQSPTTGDEVITNYTINFGPQHPAAHGVLRMVMELDGEIIERIDPHVGLLHRGTEKLIEHKTYLQALPYFDRLDY
CSPLGMEHSYVLAVEKLLNIEVPLRAQYLRVLFAELTRICNHMLNLGSHVMDVGAMTPNLWLFEIREDCLNFFERASGAR
MHSAWFRPGGVHQDVPLKLLTDMADWIDERLHPLFDDAMSLVVDNRIFKQRNVDIAVVSKEDALRWGFSGPMIRGSGIPW
DLRKSQPYDVYDRMEFDIPVGTSGDCYDRFMVRVEEVRQSARIMKQCIEQMPDGPVASTDRKVVPPKRAEMKQSMEALIH
HFKLYTEGFHVPAGEVYVATESPKGEFGVYLVSDGSNKPYRCKIRPTAFSHLQAMDFMCKGHMLPDATAILGAIDVVFGE
CDR
>Mature_402_residues
SLSLEQSPTTGDEVITNYTINFGPQHPAAHGVLRMVMELDGEIIERIDPHVGLLHRGTEKLIEHKTYLQALPYFDRLDYC
SPLGMEHSYVLAVEKLLNIEVPLRAQYLRVLFAELTRICNHMLNLGSHVMDVGAMTPNLWLFEIREDCLNFFERASGARM
HSAWFRPGGVHQDVPLKLLTDMADWIDERLHPLFDDAMSLVVDNRIFKQRNVDIAVVSKEDALRWGFSGPMIRGSGIPWD
LRKSQPYDVYDRMEFDIPVGTSGDCYDRFMVRVEEVRQSARIMKQCIEQMPDGPVASTDRKVVPPKRAEMKQSMEALIHH
FKLYTEGFHVPAGEVYVATESPKGEFGVYLVSDGSNKPYRCKIRPTAFSHLQAMDFMCKGHMLPDATAILGAIDVVFGEC
DR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=391, Percent_Identity=62.9156010230179, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI260898743, Length=385, Percent_Identity=62.3376623376623, Blast_Score=516, Evalue=1e-146,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=41.0852713178295, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI1789076, Length=389, Percent_Identity=25.4498714652956, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1788832, Length=422, Percent_Identity=26.7772511848341, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17555284, Length=388, Percent_Identity=58.7628865979381, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17568379, Length=391, Percent_Identity=58.0562659846547, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24638644, Length=394, Percent_Identity=60.9137055837564, Blast_Score=526, Evalue=1e-149,
Organism=Drosophila melanogaster, GI221459469, Length=391, Percent_Identity=56.5217391304348, Blast_Score=491, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_NOVAD (Q2G5Y6)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497571.1
- HSSP:   Q56220
- ProteinModelPortal:   Q2G5Y6
- SMR:   Q2G5Y6
- STRING:   Q2G5Y6
- GeneID:   3916343
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_2300
- NMPDR:   fig|48935.1.peg.2907
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   IFYERAC
- PhylomeDB:   Q2G5Y6
- ProtClustDB:   PRK06075
- BioCyc:   NARO279238:SARO_2300-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 45862; Mature: 45731

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSLEQSPTTGDEVITNYTINFGPQHPAAHGVLRMVMELDGEIIERIDPHVGLLHRGTE
CCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHH
KLIEHKTYLQALPYFDRLDYCSPLGMEHSYVLAVEKLLNIEVPLRAQYLRVLFAELTRIC
HHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
NHMLNLGSHVMDVGAMTPNLWLFEIREDCLNFFERASGARMHSAWFRPGGVHQDVPLKLL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHH
TDMADWIDERLHPLFDDAMSLVVDNRIFKQRNVDIAVVSKEDALRWGFSGPMIRGSGIPW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHEECCCCCEEECCCCCC
DLRKSQPYDVYDRMEFDIPVGTSGDCYDRFMVRVEEVRQSARIMKQCIEQMPDGPVASTD
CCCCCCCCCHHHCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RKVVPPKRAEMKQSMEALIHHFKLYTEGFHVPAGEVYVATESPKGEFGVYLVSDGSNKPY
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCE
RCKIRPTAFSHLQAMDFMCKGHMLPDATAILGAIDVVFGECDR
EEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLSLEQSPTTGDEVITNYTINFGPQHPAAHGVLRMVMELDGEIIERIDPHVGLLHRGTE
CCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHH
KLIEHKTYLQALPYFDRLDYCSPLGMEHSYVLAVEKLLNIEVPLRAQYLRVLFAELTRIC
HHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
NHMLNLGSHVMDVGAMTPNLWLFEIREDCLNFFERASGARMHSAWFRPGGVHQDVPLKLL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHH
TDMADWIDERLHPLFDDAMSLVVDNRIFKQRNVDIAVVSKEDALRWGFSGPMIRGSGIPW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHEECCCCCEEECCCCCC
DLRKSQPYDVYDRMEFDIPVGTSGDCYDRFMVRVEEVRQSARIMKQCIEQMPDGPVASTD
CCCCCCCCCHHHCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RKVVPPKRAEMKQSMEALIHHFKLYTEGFHVPAGEVYVATESPKGEFGVYLVSDGSNKPY
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCE
RCKIRPTAFSHLQAMDFMCKGHMLPDATAILGAIDVVFGECDR
EEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA