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The map label for this gene is ppi [H]

Identifier: 87200265

GI number: 87200265

Start: 2391325

End: 2392023

Strand: Reverse

Name: ppi [H]

Synonym: Saro_2251

Alternate gene names: 87200265

Gene position: 2392023-2391325 (Counterclockwise)

Preceding gene: 87200266

Following gene: 87200264

Centisome position: 67.16

GC content: 63.81

Gene sequence:

>699_bases
ATGGTTTCGCGCTTTCTTTCCGCACTTGCGCTTGGCGCTGCCCTGATCGCGTCGCCGGTGGCGGCGCAGGACAAGCCGGC
AGACGCTGCCAAGGATGCACCCGCCGCGGCCACCGTCCAGAAGGCGATCCCTTATTCCGTGAACAGCGACCAGTCGGTCG
ATCGCGAGAACATCCTCTATCTCGACCTGTCGAACGGCGGGCGTGTCGCTATCCGGCTGATGCCGGAATGGGCGCCGAAC
CACGTGGAGCGGATCAAGACGCTGGCGCGCCAGGGCTTCTACAACGGGATCGCGTTCCATCGCGTCATTGACGGCTTCAT
GGCGCAGACCGGCGACCCGACCGGAACCGGGCAGGGCGGTTCACAGCTTCCTGACCTGACCGCGGAATTCAATTCGATCC
CGCACGTGCGCGGTTCGGTCTCGATGGCCCGCACGAACGAGCCGAACACCGCGAACAGCCAGTTCTTCATCGTGTTCTAT
CCACGCTTCGCGCTTGACCACAAGTACACCAACTTCGGTCGCGTGATTGCCGGCATGGATTATGTCGATGCCATCGCACG
GGGCGAACCGCCGGCAAGCCCGACCAAGATCGTCCAGGCATCGATCGCGGCAGACGACAAGCCCGTTCCCGCACCGGCAG
CGCCGGCGGCACCGGCTGCGATCACTGCCGACATGCTGAGCAATTCGAAGTCGAACTGA

Upstream 100 bases:

>100_bases
GACGCAGGAGGGCGGGCCTCTCGCCCGCGGCACTCGTTCATTGCAGTGACAGCGCGTCCGGCCTATTGGCGGCGCAACCT
ATCCGGAGTTCCACCTTATC

Downstream 100 bases:

>100_bases
GCCAGGTTTGGCGCTAGGGCGCGCCCATGCGCGTTGATCTCTTCGACTTCGAACTGCCGTCCGAAAACATCGCCCTGCGT
CCGGCACGGCCTCGCGATTC

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MVSRFLSALALGAALIASPVAAQDKPADAAKDAPAAATVQKAIPYSVNSDQSVDRENILYLDLSNGGRVAIRLMPEWAPN
HVERIKTLARQGFYNGIAFHRVIDGFMAQTGDPTGTGQGGSQLPDLTAEFNSIPHVRGSVSMARTNEPNTANSQFFIVFY
PRFALDHKYTNFGRVIAGMDYVDAIARGEPPASPTKIVQASIAADDKPVPAPAAPAAPAAITADMLSNSKSN

Sequences:

>Translated_232_residues
MVSRFLSALALGAALIASPVAAQDKPADAAKDAPAAATVQKAIPYSVNSDQSVDRENILYLDLSNGGRVAIRLMPEWAPN
HVERIKTLARQGFYNGIAFHRVIDGFMAQTGDPTGTGQGGSQLPDLTAEFNSIPHVRGSVSMARTNEPNTANSQFFIVFY
PRFALDHKYTNFGRVIAGMDYVDAIARGEPPASPTKIVQASIAADDKPVPAPAAPAAPAAITADMLSNSKSN
>Mature_232_residues
MVSRFLSALALGAALIASPVAAQDKPADAAKDAPAAATVQKAIPYSVNSDQSVDRENILYLDLSNGGRVAIRLMPEWAPN
HVERIKTLARQGFYNGIAFHRVIDGFMAQTGDPTGTGQGGSQLPDLTAEFNSIPHVRGSVSMARTNEPNTANSQFFIVFY
PRFALDHKYTNFGRVIAGMDYVDAIARGEPPASPTKIVQASIAADDKPVPAPAAPAAPAAITADMLSNSKSN

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=127, Percent_Identity=44.8818897637795, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI24308049, Length=124, Percent_Identity=45.9677419354839, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI7706339, Length=151, Percent_Identity=37.7483443708609, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI5031987, Length=142, Percent_Identity=42.2535211267606, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI10863927, Length=128, Percent_Identity=39.0625, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI64276486, Length=147, Percent_Identity=34.0136054421769, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4505991, Length=128, Percent_Identity=41.40625, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1789763, Length=133, Percent_Identity=36.8421052631579, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1786736, Length=132, Percent_Identity=36.3636363636364, Blast_Score=79, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=142, Percent_Identity=42.2535211267606, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17532641, Length=185, Percent_Identity=35.1351351351351, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17539496, Length=125, Percent_Identity=42.4, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71980594, Length=143, Percent_Identity=39.8601398601399, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=123, Percent_Identity=43.9024390243902, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17539498, Length=168, Percent_Identity=34.5238095238095, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=139, Percent_Identity=38.8489208633094, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=141, Percent_Identity=37.5886524822695, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17986117, Length=147, Percent_Identity=39.4557823129252, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24652460, Length=125, Percent_Identity=42.4, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19922376, Length=130, Percent_Identity=35.3846153846154, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922912, Length=150, Percent_Identity=42.6666666666667, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24664125, Length=141, Percent_Identity=36.8794326241135, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357783, Length=141, Percent_Identity=36.8794326241135, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 24522; Mature: 24522

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSRFLSALALGAALIASPVAAQDKPADAAKDAPAAATVQKAIPYSVNSDQSVDRENILY
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEE
LDLSNGGRVAIRLMPEWAPNHVERIKTLARQGFYNGIAFHRVIDGFMAQTGDPTGTGQGG
EEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
SQLPDLTAEFNSIPHVRGSVSMARTNEPNTANSQFFIVFYPRFALDHKYTNFGRVIAGMD
CCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCHHHCCCCCHHHHHHHHHH
YVDAIARGEPPASPTKIVQASIAADDKPVPAPAAPAAPAAITADMLSNSKSN
HHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MVSRFLSALALGAALIASPVAAQDKPADAAKDAPAAATVQKAIPYSVNSDQSVDRENILY
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEE
LDLSNGGRVAIRLMPEWAPNHVERIKTLARQGFYNGIAFHRVIDGFMAQTGDPTGTGQGG
EEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
SQLPDLTAEFNSIPHVRGSVSMARTNEPNTANSQFFIVFYPRFALDHKYTNFGRVIAGMD
CCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCHHHCCCCCHHHHHHHHHH
YVDAIARGEPPASPTKIVQASIAADDKPVPAPAAPAAPAAITADMLSNSKSN
HHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA