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The map label for this gene is hmrR [H]

Identifier: 87200168

GI number: 87200168

Start: 2293603

End: 2294016

Strand: Direct

Name: hmrR [H]

Synonym: Saro_2152

Alternate gene names: 87200168

Gene position: 2293603-2294016 (Clockwise)

Preceding gene: 87200165

Following gene: 87200171

Centisome position: 64.4

GC content: 60.14

Gene sequence:

>414_bases
ATGAAAATCGGCGAGTTGTCGAAGGTGACCGGCACAAACATCGAGACCGTCCGCTATTACGAGCGGATCGGATTGCTTCC
CAAACCTGCGCGGACAGCGGGCAACTACCGCTCATATGGTGAACCGCATCGCTCGCGGCTCGCTTTCGTCAGGCATTCAC
GCGAACTCGGCTTCGCAATCGAGGAAGTCCGCTCGCTGCTCGATCTGGCCGATCATCCCGAGCGCGAGTGCTCCGAGGCC
GACCGGATCGCCACTCGGCATCTAGCGCAGGTCGAAGAGAAGATCGGCCAACTCGTTACCCTGCGCGACGAACTATCTCG
CATTATCGGTCGCTGCCGGGGCGGTCTCGCCGCCGATTGTCGTGTGATAGAAGCGCTTGGCGACCACGGAATTTGCAACG
GAGAGCATGCATGA

Upstream 100 bases:

>100_bases
CGCACGCGTTTTCGCAGCAGCTGTCGGCCAACGAATTCCTCCTCGACAATTTTCGAGTCGGCTTGCTACGTACACCCTGT
AGCAACTACAGGGTCAAGCA

Downstream 100 bases:

>100_bases
CCGATCCGACCGGAGATGCAGCAGCGATAGCTGATTGATTGGTTCGACACTGAAAATCGCGACGCAGTGACCGAACCAAC
CGCACTAGCTGTGCGTGGAA

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MKIGELSKVTGTNIETVRYYERIGLLPKPARTAGNYRSYGEPHRSRLAFVRHSRELGFAIEEVRSLLDLADHPERECSEA
DRIATRHLAQVEEKIGQLVTLRDELSRIIGRCRGGLAADCRVIEALGDHGICNGEHA

Sequences:

>Translated_137_residues
MKIGELSKVTGTNIETVRYYERIGLLPKPARTAGNYRSYGEPHRSRLAFVRHSRELGFAIEEVRSLLDLADHPERECSEA
DRIATRHLAQVEEKIGQLVTLRDELSRIIGRCRGGLAADCRVIEALGDHGICNGEHA
>Mature_137_residues
MKIGELSKVTGTNIETVRYYERIGLLPKPARTAGNYRSYGEPHRSRLAFVRHSRELGFAIEEVRSLLDLADHPERECSEA
DRIATRHLAQVEEKIGQLVTLRDELSRIIGRCRGGLAADCRVIEALGDHGICNGEHA

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=132, Percent_Identity=34.0909090909091, Blast_Score=96, Evalue=9e-22,
Organism=Escherichia coli, GI1789687, Length=138, Percent_Identity=36.231884057971, Blast_Score=90, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15335; Mature: 15335

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGELSKVTGTNIETVRYYERIGLLPKPARTAGNYRSYGEPHRSRLAFVRHSRELGFAI
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EEVRSLLDLADHPERECSEADRIATRHLAQVEEKIGQLVTLRDELSRIIGRCRGGLAADC
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RVIEALGDHGICNGEHA
HHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKIGELSKVTGTNIETVRYYERIGLLPKPARTAGNYRSYGEPHRSRLAFVRHSRELGFAI
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EEVRSLLDLADHPERECSEADRIATRHLAQVEEKIGQLVTLRDELSRIIGRCRGGLAADC
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RVIEALGDHGICNGEHA
HHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]