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The map label for this gene is atoC [H]

Identifier: 87200063

GI number: 87200063

Start: 2185739

End: 2187115

Strand: Reverse

Name: atoC [H]

Synonym: Saro_2047

Alternate gene names: 87200063

Gene position: 2187115-2185739 (Counterclockwise)

Preceding gene: 87200064

Following gene: 87200062

Centisome position: 61.41

GC content: 64.2

Gene sequence:

>1377_bases
ATGAGCGAAGCGAAGCCCGGACAGCGACCGGCACTGCTGATCGTCGAGGACGATCCCGGTCTGCAGGCGCAGTTGAAATG
GGCGTACGAGGATTTCGACGTCTTCATCGCGGGCGACAGGGTAAGCGCGCTGACCCTGCTACGTTCGGTGGAACCGGCGG
TCGTGACCCTCGACCTCGGGTTGCCGCCCGATCCTGACGGAACCACCGAGGGCTTTGCCGTGCTCGACGAGATCATGGCC
CTGCGCCCCGACACCAAGGTGATCGTCGCAAGCGGCCACGGTGCCCGCGAAAGCGCGCTCAAGGCCATCGAGAAGGGGGC
GTACGACTTCTACCAGAAGCCGGTGGACATCGATGCGTTGGGCCTGATCGTTCGCCGTGCGCTGCACCTTTCGCGGATCG
AGTCCGAAAATCGCCATCTCGCGACCCGTGCAAGCACCGACAACAGGGTGCTGGGGCGCATGATCACCGCGGCACCCGAG
ATGATCAAGGTGGCCCGCACAATCGAGCGCGTCGCCAATACCAGCGTCTCGGTGATGCTGCTGGGCGCGAGCGGCACCGG
CAAGGAACTGTTGGCGCGCGGCCTGCATGATGCGTCCGGACGCGCACGCGGATCGTTTGTCGCGATCAACTGCGCGGCCA
TTCCGGAGAATCTGCTCGAAAGCGAACTGTTCGGGCACGAGAAGGGAGCGTTTACCGGAGCGGTCAAGACGACCGAGGGC
AAGATCGAACAGGCCAGCGGCGGCACGCTGTTCCTCGACGAAGTGGGCGACATTCCGCTCCAGCTTCAGGTCAAGCTGCT
GCGCTTCCTGCAGGAACGGACGATCGAGCGCATCGGCGGGCGAAAGTCGATCGAGGTCGATACACGCATCGTCTGCGCCA
CGCACCAGAACCTCGAGGCCATGATTGCCGATGGGCGGTTCCGCGAGGACCTTTACTATCGCCTCGCGGAAATCGTTGTG
CGCATTCCCAGCCTGGCGGAGCGCCCCGGCGATGCGACGCTTCTCGCCAAGACCTTTCTCATGCGCTTTGCCAAGGAGAT
GAACCCGCAGGTCAAGGGCTTCGCGCCGGATGCGCTGGCGGCGATCGACAGCTGGAACTGGCCCGGAAACGTCCGCGAGC
TGGAGAACCGCGTCAAGCGTGCGGTCATCATGGCCGACGGCAGGCTGGTTACCGCAACCGATCTCGACCTGCCGGGAAAT
GCGGACGAGGAATCATCGCCGCTCAACCTGAAGACCGCGCGCGAAGCGACTGACCGCAAGGTCATCCGCCACGCGCTCGC
CCGCAGCGAAGGCAACATCTCCAGCACCGCGCGCCTGCTCGGCATCAGCAGGCCGACGCTTTATGATCTGCTCAAGCAGT
ACGACCTCCAGAACTAG

Upstream 100 bases:

>100_bases
TCGGTAGCCGCTTCACGGTGCGGCTGCCGCTGGCGGCGGCAAAGCCGTTGATGGATTCGATTGGCGGCAGCACAGGCTCC
GCCGACAAGAAGGTGGCATG

Downstream 100 bases:

>100_bases
GCGGCTGGCCGCCGGCCTGCTGCTTGTCGCGCTGGCGGTCGGGCCGGCGCGTGGAGGTACGTCCGTTGGCGATGCCCTCG
CCAAGGCAAGGACCGCCCTG

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSEAKPGQRPALLIVEDDPGLQAQLKWAYEDFDVFIAGDRVSALTLLRSVEPAVVTLDLGLPPDPDGTTEGFAVLDEIMA
LRPDTKVIVASGHGARESALKAIEKGAYDFYQKPVDIDALGLIVRRALHLSRIESENRHLATRASTDNRVLGRMITAAPE
MIKVARTIERVANTSVSVMLLGASGTGKELLARGLHDASGRARGSFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEG
KIEQASGGTLFLDEVGDIPLQLQVKLLRFLQERTIERIGGRKSIEVDTRIVCATHQNLEAMIADGRFREDLYYRLAEIVV
RIPSLAERPGDATLLAKTFLMRFAKEMNPQVKGFAPDALAAIDSWNWPGNVRELENRVKRAVIMADGRLVTATDLDLPGN
ADEESSPLNLKTAREATDRKVIRHALARSEGNISSTARLLGISRPTLYDLLKQYDLQN

Sequences:

>Translated_458_residues
MSEAKPGQRPALLIVEDDPGLQAQLKWAYEDFDVFIAGDRVSALTLLRSVEPAVVTLDLGLPPDPDGTTEGFAVLDEIMA
LRPDTKVIVASGHGARESALKAIEKGAYDFYQKPVDIDALGLIVRRALHLSRIESENRHLATRASTDNRVLGRMITAAPE
MIKVARTIERVANTSVSVMLLGASGTGKELLARGLHDASGRARGSFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEG
KIEQASGGTLFLDEVGDIPLQLQVKLLRFLQERTIERIGGRKSIEVDTRIVCATHQNLEAMIADGRFREDLYYRLAEIVV
RIPSLAERPGDATLLAKTFLMRFAKEMNPQVKGFAPDALAAIDSWNWPGNVRELENRVKRAVIMADGRLVTATDLDLPGN
ADEESSPLNLKTAREATDRKVIRHALARSEGNISSTARLLGISRPTLYDLLKQYDLQN
>Mature_457_residues
SEAKPGQRPALLIVEDDPGLQAQLKWAYEDFDVFIAGDRVSALTLLRSVEPAVVTLDLGLPPDPDGTTEGFAVLDEIMAL
RPDTKVIVASGHGARESALKAIEKGAYDFYQKPVDIDALGLIVRRALHLSRIESENRHLATRASTDNRVLGRMITAAPEM
IKVARTIERVANTSVSVMLLGASGTGKELLARGLHDASGRARGSFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEGK
IEQASGGTLFLDEVGDIPLQLQVKLLRFLQERTIERIGGRKSIEVDTRIVCATHQNLEAMIADGRFREDLYYRLAEIVVR
IPSLAERPGDATLLAKTFLMRFAKEMNPQVKGFAPDALAAIDSWNWPGNVRELENRVKRAVIMADGRLVTATDLDLPGNA
DEESSPLNLKTAREATDRKVIRHALARSEGNISSTARLLGISRPTLYDLLKQYDLQN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=454, Percent_Identity=41.8502202643172, Blast_Score=351, Evalue=5e-98,
Organism=Escherichia coli, GI1790437, Length=447, Percent_Identity=41.1633109619687, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI1788905, Length=453, Percent_Identity=38.1898454746137, Blast_Score=295, Evalue=6e-81,
Organism=Escherichia coli, GI1790299, Length=487, Percent_Identity=37.3716632443532, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI87082117, Length=255, Percent_Identity=47.843137254902, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1789087, Length=328, Percent_Identity=41.1585365853659, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1789233, Length=358, Percent_Identity=41.6201117318436, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI87082152, Length=319, Percent_Identity=39.4984326018809, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=38.0503144654088, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1786524, Length=343, Percent_Identity=39.3586005830904, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI1787583, Length=327, Percent_Identity=35.474006116208, Blast_Score=205, Evalue=6e-54,
Organism=Escherichia coli, GI1789828, Length=354, Percent_Identity=31.3559322033898, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI87081858, Length=337, Percent_Identity=27.893175074184, Blast_Score=131, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50077; Mature: 49946

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAKPGQRPALLIVEDDPGLQAQLKWAYEDFDVFIAGDRVSALTLLRSVEPAVVTLDLG
CCCCCCCCCCEEEEEECCCCCEEEEEEEEECEEEEEECCHHHHHHHHHCCCCEEEEEECC
LPPDPDGTTEGFAVLDEIMALRPDTKVIVASGHGARESALKAIEKGAYDFYQKPVDIDAL
CCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHCCCCCHHHH
GLIVRRALHLSRIESENRHLATRASTDNRVLGRMITAAPEMIKVARTIERVANTSVSVML
HHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
LGASGTGKELLARGLHDASGRARGSFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEG
EECCCCCHHHHHHCCCCCCCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCCEECEEECCCC
KIEQASGGTLFLDEVGDIPLQLQVKLLRFLQERTIERIGGRKSIEVDTRIVCATHQNLEA
CEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEEECCCCHH
MIADGRFREDLYYRLAEIVVRIPSLAERPGDATLLAKTFLMRFAKEMNPQVKGFAPDALA
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
AIDSWNWPGNVRELENRVKRAVIMADGRLVTATDLDLPGNADEESSPLNLKTAREATDRK
HHHCCCCCCCHHHHHHHHHHEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
VIRHALARSEGNISSTARLLGISRPTLYDLLKQYDLQN
HHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEAKPGQRPALLIVEDDPGLQAQLKWAYEDFDVFIAGDRVSALTLLRSVEPAVVTLDLG
CCCCCCCCCEEEEEECCCCCEEEEEEEEECEEEEEECCHHHHHHHHHCCCCEEEEEECC
LPPDPDGTTEGFAVLDEIMALRPDTKVIVASGHGARESALKAIEKGAYDFYQKPVDIDAL
CCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHCCCCCHHHH
GLIVRRALHLSRIESENRHLATRASTDNRVLGRMITAAPEMIKVARTIERVANTSVSVML
HHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
LGASGTGKELLARGLHDASGRARGSFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEG
EECCCCCHHHHHHCCCCCCCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCCEECEEECCCC
KIEQASGGTLFLDEVGDIPLQLQVKLLRFLQERTIERIGGRKSIEVDTRIVCATHQNLEA
CEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEEECCCCHH
MIADGRFREDLYYRLAEIVVRIPSLAERPGDATLLAKTFLMRFAKEMNPQVKGFAPDALA
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
AIDSWNWPGNVRELENRVKRAVIMADGRLVTATDLDLPGNADEESSPLNLKTAREATDRK
HHHCCCCCCCHHHHHHHHHHEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
VIRHALARSEGNISSTARLLGISRPTLYDLLKQYDLQN
HHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]