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The map label for this gene is rcsC [H]

Identifier: 87200064

GI number: 87200064

Start: 2187115

End: 2189250

Strand: Reverse

Name: rcsC [H]

Synonym: Saro_2048

Alternate gene names: 87200064

Gene position: 2189250-2187115 (Counterclockwise)

Preceding gene: 87200065

Following gene: 87200063

Centisome position: 61.47

GC content: 65.54

Gene sequence:

>2136_bases
ATGCTCAATCCACTGACCTGGGAAGGCTTCGGCGAGTGGGCGTTCATCGCCTCGGCATTCGCGTTCCTGATGCTGGCCGC
GTGGCGCTGGGAACGCCGCCGCCGCGACGGGGGAGCATCCGGTCGCGCCGATGTGATGGTCTACGGGGTGACCGCCGCCT
GGGCGCTGGTCATCGCGGGAATGGGGCCGCTGACCTTCGTGGCGCAGCTTTTCGAGACGCTGCGGAGCCTCGGCTGGCTG
AGCCTTGCGCTTGTCCTTTTCACGCGCGACGGACGCCACGCCAGCGTCGGGCCGGTCCGACCGGTCTTCGCTTCGCTGGT
CTTTGTGGAATTGCTTCAGCCGCTACTGCTGCTGATGAACCTGCGGTCCGGGCACGTTCCGGCCGCGCAGGCGATGATTT
TCCAGATATCGGTGCTCTTCCGACTGCTGGTGGCCACTGGCGCGCTGGTGCTGGTCCATAACCTCTATGCCGGTGCGATG
GCGCAACAGCGGACGGCGCTGCGCTGGACCTGTGCTGCCCTGGCGATGATCTGGGGCTACGATCTCAATCTCTACACGAT
CGCCTATCTGGCCAAGTCGGTCCCGGCCGAACTGGTCGCCCTGCGCGGTGTTGCGCAGTTGGGCGCTGCCGCATTGCTGG
TGGTCGGCGCCGTGCGCGGTCGCTCGGCGCTGCGTTTTTCGCCGTCGCGAGCGGTGGCATTCCAGTCGCTCTCGTTGCTG
GTGATCGGCGTCTACATGATCGTGATGGTCGGCGCGGCGCAGTCGCTGGCCTGGATGGGCGGGAATGCCAGCCAACTCGT
GCAATTGGGCTTCGTCTTCGTGACCAGCGTGCTGGTCGTGGCGATCATGCCGTCCGGTCGCGTGCGCGGCTGGCTCAAGG
TCATGGTGGCCAAGCATTTCTTCCAGCACCGCTATGACTACCGAGCCGAATGGCTCCGCTTTACCCGCACGATAGGACGC
GCGGGCGCACATGCTCCGCCATTGCATGAGCGCGTGGTGCAGGCAGTGGCCGACATCACCGACAGTTCGTCGGGCCTGTT
GCTGGTGCCGGCGGAAGGCGGCGAGCTTGTGCTTGCGGCCCGCTGGCAGTGGCCGACTGCGGAAGTTCCGGCAGAGGCTG
TCCCGGCAGGCGCCGTGCCATTCTTCGAAAAGCGGGGCTTCATCGTCGATCTGGATGAATTGCGCGCCGGCGTCGACTTG
CAGGGCGAGAAGGCGGTCGTACCGGGCTGGCTGGTCGATGAGCAGGCGGCGTGGGCCCTGGTGCCGCTGCTTCATTTCGA
CCGGCTTGTCGGCCTGGTGATCCTTGGGCGCCCGCCAGTGGCGCGCAAGTTCGACTGGGAAGATTTCGATCTGCTGCGGG
TCGTGGGAATGCAGCTCGCAAGTTATCTGGCCGAGCACGCAGGCCAATCGGCCTTGCTCGAGGCCAGCCGCTTCGACGAG
TTCAACCGCCGCATGGCCTTCGTCATGCACGATATCAAGAACCTCGCGAGCCAGCTCAGCCTGCTGTCGCGCAACGCCGA
AAAGCACGCGGAGAATCCCGAGTTCCGTGCGGACATGCTGATCACGCTGCGCAACTCGGCGGACAAGCTGAACGCACTGC
TGGCCCGGCTGTCCCGATATGGTGGCAGCGGCAGCGAGAAGGTCGAGGAAGTCGACGTCGGCGAGATCCTGCGAGCGGTC
GCCGAGCGTTACAATGCGCCGGGCCTTGCACGGGTTCATCTGACGCACGTCTCGCCGTGCCCGGTCCTGGCCAATCGCGA
AGGGCTCGAGCAGGTCGTCCTTCATCTGGTGCAGAACGCGCTCGATGCCAGCCCGGATGGCATGGCCGTGTTCCTGCAGC
TTCACGCCGACGGCCTCTATTGCACCATCGAGGTTATCGACACCGGCTGCGGCATGAGCGCGGAATTCATCCGCAACCGT
CTGTTCAAGCCGTTCGTGTCGACCAAGCAGGGTGGCTTCGGCATCGGCGCGTTCGAGGCGCGCGAACTGGTCAAGGCGAT
GCGAGGCAAGCTCGAGGTCGAGAGCCGCGAGGGGCTCGGTAGCCGCTTCACGGTGCGGCTGCCGCTGGCGGCGGCAAAGC
CGTTGATGGATTCGATTGGCGGCAGCACAGGCTCCGCCGACAAGAAGGTGGCATGA

Upstream 100 bases:

>100_bases
TACTACGCCAAGAACTACACCCCCTTTCTCGATCTCCTGATCCTGCTCCAGACCTTGCGCGTCGTGCTGTGGCACGAAGG
CGCGCGGTGAAAGGCGTGCC

Downstream 100 bases:

>100_bases
TGAGCGAAGCGAAGCCCGGACAGCGACCGGCACTGCTGATCGTCGAGGACGATCCCGGTCTGCAGGCGCAGTTGAAATGG
GCGTACGAGGATTTCGACGT

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Capsular synthesis regulator component C [H]

Number of amino acids: Translated: 711; Mature: 711

Protein sequence:

>711_residues
MLNPLTWEGFGEWAFIASAFAFLMLAAWRWERRRRDGGASGRADVMVYGVTAAWALVIAGMGPLTFVAQLFETLRSLGWL
SLALVLFTRDGRHASVGPVRPVFASLVFVELLQPLLLLMNLRSGHVPAAQAMIFQISVLFRLLVATGALVLVHNLYAGAM
AQQRTALRWTCAALAMIWGYDLNLYTIAYLAKSVPAELVALRGVAQLGAAALLVVGAVRGRSALRFSPSRAVAFQSLSLL
VIGVYMIVMVGAAQSLAWMGGNASQLVQLGFVFVTSVLVVAIMPSGRVRGWLKVMVAKHFFQHRYDYRAEWLRFTRTIGR
AGAHAPPLHERVVQAVADITDSSSGLLLVPAEGGELVLAARWQWPTAEVPAEAVPAGAVPFFEKRGFIVDLDELRAGVDL
QGEKAVVPGWLVDEQAAWALVPLLHFDRLVGLVILGRPPVARKFDWEDFDLLRVVGMQLASYLAEHAGQSALLEASRFDE
FNRRMAFVMHDIKNLASQLSLLSRNAEKHAENPEFRADMLITLRNSADKLNALLARLSRYGGSGSEKVEEVDVGEILRAV
AERYNAPGLARVHLTHVSPCPVLANREGLEQVVLHLVQNALDASPDGMAVFLQLHADGLYCTIEVIDTGCGMSAEFIRNR
LFKPFVSTKQGGFGIGAFEARELVKAMRGKLEVESREGLGSRFTVRLPLAAAKPLMDSIGGSTGSADKKVA

Sequences:

>Translated_711_residues
MLNPLTWEGFGEWAFIASAFAFLMLAAWRWERRRRDGGASGRADVMVYGVTAAWALVIAGMGPLTFVAQLFETLRSLGWL
SLALVLFTRDGRHASVGPVRPVFASLVFVELLQPLLLLMNLRSGHVPAAQAMIFQISVLFRLLVATGALVLVHNLYAGAM
AQQRTALRWTCAALAMIWGYDLNLYTIAYLAKSVPAELVALRGVAQLGAAALLVVGAVRGRSALRFSPSRAVAFQSLSLL
VIGVYMIVMVGAAQSLAWMGGNASQLVQLGFVFVTSVLVVAIMPSGRVRGWLKVMVAKHFFQHRYDYRAEWLRFTRTIGR
AGAHAPPLHERVVQAVADITDSSSGLLLVPAEGGELVLAARWQWPTAEVPAEAVPAGAVPFFEKRGFIVDLDELRAGVDL
QGEKAVVPGWLVDEQAAWALVPLLHFDRLVGLVILGRPPVARKFDWEDFDLLRVVGMQLASYLAEHAGQSALLEASRFDE
FNRRMAFVMHDIKNLASQLSLLSRNAEKHAENPEFRADMLITLRNSADKLNALLARLSRYGGSGSEKVEEVDVGEILRAV
AERYNAPGLARVHLTHVSPCPVLANREGLEQVVLHLVQNALDASPDGMAVFLQLHADGLYCTIEVIDTGCGMSAEFIRNR
LFKPFVSTKQGGFGIGAFEARELVKAMRGKLEVESREGLGSRFTVRLPLAAAKPLMDSIGGSTGSADKKVA
>Mature_711_residues
MLNPLTWEGFGEWAFIASAFAFLMLAAWRWERRRRDGGASGRADVMVYGVTAAWALVIAGMGPLTFVAQLFETLRSLGWL
SLALVLFTRDGRHASVGPVRPVFASLVFVELLQPLLLLMNLRSGHVPAAQAMIFQISVLFRLLVATGALVLVHNLYAGAM
AQQRTALRWTCAALAMIWGYDLNLYTIAYLAKSVPAELVALRGVAQLGAAALLVVGAVRGRSALRFSPSRAVAFQSLSLL
VIGVYMIVMVGAAQSLAWMGGNASQLVQLGFVFVTSVLVVAIMPSGRVRGWLKVMVAKHFFQHRYDYRAEWLRFTRTIGR
AGAHAPPLHERVVQAVADITDSSSGLLLVPAEGGELVLAARWQWPTAEVPAEAVPAGAVPFFEKRGFIVDLDELRAGVDL
QGEKAVVPGWLVDEQAAWALVPLLHFDRLVGLVILGRPPVARKFDWEDFDLLRVVGMQLASYLAEHAGQSALLEASRFDE
FNRRMAFVMHDIKNLASQLSLLSRNAEKHAENPEFRADMLITLRNSADKLNALLARLSRYGGSGSEKVEEVDVGEILRAV
AERYNAPGLARVHLTHVSPCPVLANREGLEQVVLHLVQNALDASPDGMAVFLQLHADGLYCTIEVIDTGCGMSAEFIRNR
LFKPFVSTKQGGFGIGAFEARELVKAMRGKLEVESREGLGSRFTVRLPLAAAKPLMDSIGGSTGSADKKVA

Specific function: Member of the two-component regulatory system RcsC/RcsB involved in the regulation of the expression of genes involved in colanic acid capsule synthesis. Together with RcsF, RcsC probably functions as a membrane-associated protein kinase that phosphorylat

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=206, Percent_Identity=31.0679611650485, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI87081816, Length=116, Percent_Identity=36.2068965517241, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1788549, Length=232, Percent_Identity=23.7068965517241, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790436, Length=209, Percent_Identity=26.3157894736842, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR019017
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09456 RcsC; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 77450; Mature: 77450

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS50109 HIS_KIN ; PS00214 FABP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNPLTWEGFGEWAFIASAFAFLMLAAWRWERRRRDGGASGRADVMVYGVTAAWALVIAG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHC
MGPLTFVAQLFETLRSLGWLSLALVLFTRDGRHASVGPVRPVFASLVFVELLQPLLLLMN
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LRSGHVPAAQAMIFQISVLFRLLVATGALVLVHNLYAGAMAQQRTALRWTCAALAMIWGY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLNLYTIAYLAKSVPAELVALRGVAQLGAAALLVVGAVRGRSALRFSPSRAVAFQSLSLL
CCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHH
VIGVYMIVMVGAAQSLAWMGGNASQLVQLGFVFVTSVLVVAIMPSGRVRGWLKVMVAKHF
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
FQHRYDYRAEWLRFTRTIGRAGAHAPPLHERVVQAVADITDSSSGLLLVPAEGGELVLAA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEE
RWQWPTAEVPAEAVPAGAVPFFEKRGFIVDLDELRAGVDLQGEKAVVPGWLVDEQAAWAL
ECCCCCCCCCHHHCCCCCCCHHHCCCCEEEHHHHHCCCCCCCCCEECCCEEECCCHHHHH
VPLLHFDRLVGLVILGRPPVARKFDWEDFDLLRVVGMQLASYLAEHAGQSALLEASRFDE
HHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
FNRRMAFVMHDIKNLASQLSLLSRNAEKHAENPEFRADMLITLRNSADKLNALLARLSRY
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHC
GGSGSEKVEEVDVGEILRAVAERYNAPGLARVHLTHVSPCPVLANREGLEQVVLHLVQNA
CCCCCCHHHHCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
LDASPDGMAVFLQLHADGLYCTIEVIDTGCGMSAEFIRNRLFKPFVSTKQGGFGIGAFEA
HCCCCCCEEEEEEEECCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHH
RELVKAMRGKLEVESREGLGSRFTVRLPLAAAKPLMDSIGGSTGSADKKVA
HHHHHHHHCCEEEECCCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MLNPLTWEGFGEWAFIASAFAFLMLAAWRWERRRRDGGASGRADVMVYGVTAAWALVIAG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHC
MGPLTFVAQLFETLRSLGWLSLALVLFTRDGRHASVGPVRPVFASLVFVELLQPLLLLMN
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LRSGHVPAAQAMIFQISVLFRLLVATGALVLVHNLYAGAMAQQRTALRWTCAALAMIWGY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLNLYTIAYLAKSVPAELVALRGVAQLGAAALLVVGAVRGRSALRFSPSRAVAFQSLSLL
CCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHH
VIGVYMIVMVGAAQSLAWMGGNASQLVQLGFVFVTSVLVVAIMPSGRVRGWLKVMVAKHF
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
FQHRYDYRAEWLRFTRTIGRAGAHAPPLHERVVQAVADITDSSSGLLLVPAEGGELVLAA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEE
RWQWPTAEVPAEAVPAGAVPFFEKRGFIVDLDELRAGVDLQGEKAVVPGWLVDEQAAWAL
ECCCCCCCCCHHHCCCCCCCHHHCCCCEEEHHHHHCCCCCCCCCEECCCEEECCCHHHHH
VPLLHFDRLVGLVILGRPPVARKFDWEDFDLLRVVGMQLASYLAEHAGQSALLEASRFDE
HHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
FNRRMAFVMHDIKNLASQLSLLSRNAEKHAENPEFRADMLITLRNSADKLNALLARLSRY
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHC
GGSGSEKVEEVDVGEILRAVAERYNAPGLARVHLTHVSPCPVLANREGLEQVVLHLVQNA
CCCCCCHHHHCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
LDASPDGMAVFLQLHADGLYCTIEVIDTGCGMSAEFIRNRLFKPFVSTKQGGFGIGAFEA
HCCCCCCEEEEEEEECCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHH
RELVKAMRGKLEVESREGLGSRFTVRLPLAAAKPLMDSIGGSTGSADKKVA
HHHHHHHHCCEEEECCCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2404948; 8366025; 9097040; 9278503; 11758943; 11309126; 13129944 [H]