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The map label for this gene is moeA [H]

Identifier: 87200044

GI number: 87200044

Start: 2161451

End: 2162656

Strand: Direct

Name: moeA [H]

Synonym: Saro_2028

Alternate gene names: 87200044

Gene position: 2161451-2162656 (Clockwise)

Preceding gene: 87200043

Following gene: 87200045

Centisome position: 60.69

GC content: 70.4

Gene sequence:

>1206_bases
GTGAAAACGCCTCCCCTTCAGCTGGCCGAAGCGCAGGCTCGCCTGCTGGCGCTCGCGCCCAGTCTCTCGGTCGAACATCG
CGCGGTCGCGGAATGCCTCGGCCACTACATCGCCACCCCGCTTCACGCCCGCCGAACCCAACCCGCCGCGCCCCTTTCGG
CGATGGATGGCCATGCCATGCGCGCCGCCGATCTTCCGGGCCCCTGGCGTGTCATTGGCGAGAGCGCGGCCGGCCATCCG
TTCGGCGGCACCGTCGGTCGCGGCGAAGCGGTCAGGATCAGCACGGGCGCGATGCTGCCGGCGGGCGCCGACATGGTCCT
CCTCCAGGAAGACAGCGCACGCGACGGCGAAACGTTGACCCTGACTGGCGAGCCGCCCGCGCCTCCGGGCCGCCATATCC
GCCCCGCCGGCATGGACTTCACCGCCGACACCACGCTGATCGAAGCCGGCACCCGCATCGGGCCCGCGCAGATCGCGCTG
GCGATCGCGGCAGGGCACAGCCACCTCGCGGTGCGCCGCCCGTTGCGCCTCACGGTCATCGACAGCGGAGACGAACTGGT
CCGGCCCGGCAACACGACGCGTCTGCACCAGCTTCCCGCCAGCAATGGCCCCATGCTCTGCGCCATGGCTTCGGCGCTGC
CCTGCGACATCAGCCACATCGGCCCGATCGCGGACCGGATCGAAGATCTCGCCGCCGCGCTCGATGGCGCGCATGAGGCC
GATGTCGTCGTGACCAGCGGCGGGGCTTCGGTCGGTGACCACGACCTCGTCCGTCCCGCACTCGAGGCGGTGGGCGCGAA
GATCGATTTCTGGCGCGTGGGCATCAAGCCGGGCAAGCCGCTGCTCGTCGCGACAAGAGGCAACCAGGTCATCATCGGCC
TGCCCGGCAACCCAGCCTCGGCCTTCGTCACCGCGTTCCTGTTCCTCTTGCCTCTGCTGCGCGCCAGCCTCGGCGCGGCG
AGCCCGCTCCCCCGCACCATCCCGGCGAGGCTGGCTGGCCCGATGGGGCCGGGCGGCAGCCGCATGGAATTCCTCAGGGC
CCACTGGGATGGCAACGGCGTCACACTTGATGAACTCCAGGATTCCGGGGCGCTCTCGCCGCTCGCCCGGGCGAACGCGC
TTGTCGTGCGCGAGGCGGGAAGCGAGCGGAAGGAGGGCGGAACGGATGTTCCGATCTACCTGCTCGAAAATGGCGGAATT
GCTTGA

Upstream 100 bases:

>100_bases
TCTACGACATGGCCAAGGCGCTCGACAAAGGCATGGTGATCGAAGCGATCCGCCTCGTCGAGAAGCGCGGCGGCAAGTCG
GGAACGTGGAAGGCGGCGGA

Downstream 100 bases:

>100_bases
CGAGTCGCAATTGGTTGCTTATCCGTTCCACATTCGTTCACCGGAACATGCACCCCGTTCCGGTCTATGGAAGACCCGTG
GTTTCGCCATGAAACCACCA

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKTPPLQLAEAQARLLALAPSLSVEHRAVAECLGHYIATPLHARRTQPAAPLSAMDGHAMRAADLPGPWRVIGESAAGHP
FGGTVGRGEAVRISTGAMLPAGADMVLLQEDSARDGETLTLTGEPPAPPGRHIRPAGMDFTADTTLIEAGTRIGPAQIAL
AIAAGHSHLAVRRPLRLTVIDSGDELVRPGNTTRLHQLPASNGPMLCAMASALPCDISHIGPIADRIEDLAAALDGAHEA
DVVVTSGGASVGDHDLVRPALEAVGAKIDFWRVGIKPGKPLLVATRGNQVIIGLPGNPASAFVTAFLFLLPLLRASLGAA
SPLPRTIPARLAGPMGPGGSRMEFLRAHWDGNGVTLDELQDSGALSPLARANALVVREAGSERKEGGTDVPIYLLENGGI
A

Sequences:

>Translated_401_residues
MKTPPLQLAEAQARLLALAPSLSVEHRAVAECLGHYIATPLHARRTQPAAPLSAMDGHAMRAADLPGPWRVIGESAAGHP
FGGTVGRGEAVRISTGAMLPAGADMVLLQEDSARDGETLTLTGEPPAPPGRHIRPAGMDFTADTTLIEAGTRIGPAQIAL
AIAAGHSHLAVRRPLRLTVIDSGDELVRPGNTTRLHQLPASNGPMLCAMASALPCDISHIGPIADRIEDLAAALDGAHEA
DVVVTSGGASVGDHDLVRPALEAVGAKIDFWRVGIKPGKPLLVATRGNQVIIGLPGNPASAFVTAFLFLLPLLRASLGAA
SPLPRTIPARLAGPMGPGGSRMEFLRAHWDGNGVTLDELQDSGALSPLARANALVVREAGSERKEGGTDVPIYLLENGGI
A
>Mature_401_residues
MKTPPLQLAEAQARLLALAPSLSVEHRAVAECLGHYIATPLHARRTQPAAPLSAMDGHAMRAADLPGPWRVIGESAAGHP
FGGTVGRGEAVRISTGAMLPAGADMVLLQEDSARDGETLTLTGEPPAPPGRHIRPAGMDFTADTTLIEAGTRIGPAQIAL
AIAAGHSHLAVRRPLRLTVIDSGDELVRPGNTTRLHQLPASNGPMLCAMASALPCDISHIGPIADRIEDLAAALDGAHEA
DVVVTSGGASVGDHDLVRPALEAVGAKIDFWRVGIKPGKPLLVATRGNQVIIGLPGNPASAFVTAFLFLLPLLRASLGAA
SPLPRTIPARLAGPMGPGGSRMEFLRAHWDGNGVTLDELQDSGALSPLARANALVVREAGSERKEGGTDVPIYLLENGGI
A

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=341, Percent_Identity=35.4838709677419, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI10880983, Length=341, Percent_Identity=35.4838709677419, Blast_Score=173, Evalue=3e-43,
Organism=Escherichia coli, GI1787049, Length=370, Percent_Identity=33.2432432432432, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI25147659, Length=334, Percent_Identity=33.8323353293413, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17562606, Length=322, Percent_Identity=26.0869565217391, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17136978, Length=275, Percent_Identity=33.4545454545455, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24638841, Length=275, Percent_Identity=33.4545454545455, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41415; Mature: 41415

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTPPLQLAEAQARLLALAPSLSVEHRAVAECLGHYIATPLHARRTQPAAPLSAMDGHAM
CCCCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHCCCCCE
RAADLPGPWRVIGESAAGHPFGGTVGRGEAVRISTGAMLPAGADMVLLQEDSARDGETLT
EECCCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEEE
LTGEPPAPPGRHIRPAGMDFTADTTLIEAGTRIGPAQIALAIAAGHSHLAVRRPLRLTVI
EECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHEEEEEECCCCCEEEECCEEEEEE
DSGDELVRPGNTTRLHQLPASNGPMLCAMASALPCDISHIGPIADRIEDLAAALDGAHEA
CCCCCEECCCCCCEEEECCCCCCCEEEEECCCCCCCHHHCCHHHHHHHHHHHHHCCCCCC
DVVVTSGGASVGDHDLVRPALEAVGAKIDFWRVGIKPGKPLLVATRGNQVIIGLPGNPAS
CEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCEEEEECCCCCHH
AFVTAFLFLLPLLRASLGAASPLPRTIPARLAGPMGPGGSRMEFLRAHWDGNGVTLDELQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCHHHEEEEEECCCCEEHHHHC
DSGALSPLARANALVVREAGSERKEGGTDVPIYLLENGGIA
CCCCCCHHHHCCEEEEECCCCCHHCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MKTPPLQLAEAQARLLALAPSLSVEHRAVAECLGHYIATPLHARRTQPAAPLSAMDGHAM
CCCCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHCCCCCE
RAADLPGPWRVIGESAAGHPFGGTVGRGEAVRISTGAMLPAGADMVLLQEDSARDGETLT
EECCCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEEE
LTGEPPAPPGRHIRPAGMDFTADTTLIEAGTRIGPAQIALAIAAGHSHLAVRRPLRLTVI
EECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHEEEEEECCCCCEEEECCEEEEEE
DSGDELVRPGNTTRLHQLPASNGPMLCAMASALPCDISHIGPIADRIEDLAAALDGAHEA
CCCCCEECCCCCCEEEECCCCCCCEEEEECCCCCCCHHHCCHHHHHHHHHHHHHCCCCCC
DVVVTSGGASVGDHDLVRPALEAVGAKIDFWRVGIKPGKPLLVATRGNQVIIGLPGNPAS
CEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCEEEEECCCCCHH
AFVTAFLFLLPLLRASLGAASPLPRTIPARLAGPMGPGGSRMEFLRAHWDGNGVTLDELQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCHHHEEEEEECCCCEEHHHHC
DSGALSPLARANALVVREAGSERKEGGTDVPIYLLENGGIA
CCCCCCHHHHCCEEEEECCCCCHHCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]