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The map label for this gene is moaC

Identifier: 87200043

GI number: 87200043

Start: 2160981

End: 2161454

Strand: Direct

Name: moaC

Synonym: Saro_2027

Alternate gene names: 87200043

Gene position: 2160981-2161454 (Clockwise)

Preceding gene: 87200040

Following gene: 87200044

Centisome position: 60.67

GC content: 67.72

Gene sequence:

>474_bases
ATGAACGACCTGACCCATATCGATTCGGGCGGCACCGCCCGCATGGTGGACGTCGGCGGCAAGGCCGAAACGCACCGCGT
GGCCATCGCGCGCGGTACGATCCGGATGCGGGGGCAGACGCTCGACGCGATCCGTTCCGGCAACGCGCCCAAGGGCGACG
TCCTTGGCCCGGCGCGGATCGCGGGGATCATGGCGGCAAAGAAGACTGGCGATCTCATCCCGCTCTGCCACCCCCTCGCA
CTCGACGCCGTGAACGTCGATTTCGCCTTCGTCGCCGACGGCATCGAATGCACCGCCACCGCCTCGCTGACTGGCCGGAC
CGGGGTCGAGATGGAGGCGCTCACCGCCGTCTCGGTCGCGTTGCTGACGATCTACGACATGGCCAAGGCGCTCGACAAAG
GCATGGTGATCGAAGCGATCCGCCTCGTCGAGAAGCGCGGCGGCAAGTCGGGAACGTGGAAGGCGGCGGAGTGA

Upstream 100 bases:

>100_bases
CGCGCAAATCCGCGTCATTGGCCACGCGCGCCGGGGGCTTACACTTTCTCCTCTGGACTGTGTAAACCGTGTAAACCTGT
TCAGGAAGCAGAGGGCCGGA

Downstream 100 bases:

>100_bases
AAACGCCTCCCCTTCAGCTGGCCGAAGCGCAGGCTCGCCTGCTGGCGCTCGCGCCCAGTCTCTCGGTCGAACATCGCGCG
GTCGCGGAATGCCTCGGCCA

Product: GTP cyclohydrolase subunit MoaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MNDLTHIDSGGTARMVDVGGKAETHRVAIARGTIRMRGQTLDAIRSGNAPKGDVLGPARIAGIMAAKKTGDLIPLCHPLA
LDAVNVDFAFVADGIECTATASLTGRTGVEMEALTAVSVALLTIYDMAKALDKGMVIEAIRLVEKRGGKSGTWKAAE

Sequences:

>Translated_157_residues
MNDLTHIDSGGTARMVDVGGKAETHRVAIARGTIRMRGQTLDAIRSGNAPKGDVLGPARIAGIMAAKKTGDLIPLCHPLA
LDAVNVDFAFVADGIECTATASLTGRTGVEMEALTAVSVALLTIYDMAKALDKGMVIEAIRLVEKRGGKSGTWKAAE
>Mature_157_residues
MNDLTHIDSGGTARMVDVGGKAETHRVAIARGTIRMRGQTLDAIRSGNAPKGDVLGPARIAGIMAAKKTGDLIPLCHPLA
LDAVNVDFAFVADGIECTATASLTGRTGVEMEALTAVSVALLTIYDMAKALDKGMVIEAIRLVEKRGGKSGTWKAAE

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family

Homologues:

Organism=Escherichia coli, GI1787001, Length=156, Percent_Identity=55.7692307692308, Blast_Score=156, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI32566331, Length=149, Percent_Identity=47.6510067114094, Blast_Score=139, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28574490, Length=150, Percent_Identity=48, Blast_Score=133, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28574492, Length=137, Percent_Identity=48.1751824817518, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAC_NOVAD (Q2G6Q7)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497300.1
- ProteinModelPortal:   Q2G6Q7
- SMR:   Q2G6Q7
- STRING:   Q2G6Q7
- GeneID:   3917348
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_2027
- eggNOG:   COG0315
- HOGENOM:   HBG605231
- OMA:   PMCHPLM
- PhylomeDB:   Q2G6Q7
- ProtClustDB:   CLSK746416
- BioCyc:   NARO279238:SARO_2027-MONOMER
- HAMAP:   MF_01224_B
- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR002820
- Gene3D:   G3DSA:3.30.70.640
- TIGRFAMs:   TIGR00581

Pfam domain/function: PF01967 MoaC; SSF55040 MoaC

EC number: NA

Molecular weight: Translated: 16330; Mature: 16330

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: ACT_SITE 126-126

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLTHIDSGGTARMVDVGGKAETHRVAIARGTIRMRGQTLDAIRSGNAPKGDVLGPARI
CCCCCCCCCCCCEEEEECCCCCCCEEEEEEECEEEECCCHHHHHHCCCCCCCCCCCHHHH
AGIMAAKKTGDLIPLCHPLALDAVNVDFAFVADGIECTATASLTGRTGVEMEALTAVSVA
HHHHHHCCCCCCCCCCCCHHHEEECCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHH
LLTIYDMAKALDKGMVIEAIRLVEKRGGKSGTWKAAE
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNDLTHIDSGGTARMVDVGGKAETHRVAIARGTIRMRGQTLDAIRSGNAPKGDVLGPARI
CCCCCCCCCCCCEEEEECCCCCCCEEEEEEECEEEECCCHHHHHHCCCCCCCCCCCHHHH
AGIMAAKKTGDLIPLCHPLALDAVNVDFAFVADGIECTATASLTGRTGVEMEALTAVSVA
HHHHHHCCCCCCCCCCCCHHHEEECCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHH
LLTIYDMAKALDKGMVIEAIRLVEKRGGKSGTWKAAE
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA