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The map label for this gene is folE [H]

Identifier: 87200023

GI number: 87200023

Start: 2140974

End: 2141588

Strand: Reverse

Name: folE [H]

Synonym: Saro_2007

Alternate gene names: 87200023

Gene position: 2141588-2140974 (Counterclockwise)

Preceding gene: 87200024

Following gene: 87200022

Centisome position: 60.13

GC content: 65.85

Gene sequence:

>615_bases
ATGAGCAGTCTGGTTGGGCCCGACGAGGACGATGATCTGGCCCGGGGCAAGGTGCCCGTGCCCCAGGACGTGCAGGACGC
GATCCGCACGCTGATCCGCTGGTCCGGCGACGATCCGGAGCGTGAAGGCCTGCTCGACACGCCCAAGCGCGTGGCGCGGG
CGTGGAAGGAATACTGCCAGGGCTATGGCGAGGACCCGGCGGTCCATCTTTCGCGCCAGTTCGAGGAAGTGGGCGGCTAC
GACGAGATCGTGCTGCTGAAGGACATTCCGTTCCAGTCGCACTGCGAACACCACATGGCGCCGATCATCGGCAAGGCGGC
GATTGCCTATCTGCCGCGCGACAAGGTGGTCGGCATCTCGAAGCTGGCGCGGGTGCTGCATGGCTTTGCGCGTCGCCTGC
AGATTCAGGAACGGCTTACGGCAGAGGTCGCCCAGTGCATCTGGGACAACCTGCGGCCGCATGGCGTTGCGGTGGTAATC
GAGGCACAGCACGCGTGCATGACCGCGCGCGGTGTGCGGACGCCCGGCGTCGGCATGGTGACGAGCCGCCTGATGGGCAC
GTTCCTCGACGACAACCGCAGCCGCAAGGAAGTGCTGAGCTTGATGGGCTATTGA

Upstream 100 bases:

>100_bases
GATCCCGAGCGGCCGGAGGAGATGCTGTCCTTCTACCGCCGGGGCCTGTTCAAGAGCCGCATCCTGCGGCGGCCGATGCG
CTGAAGGACGAAGGAAAGCG

Downstream 100 bases:

>100_bases
TGGGCCGTTGCCGGGTCTCGGAAAACAAACGTTACAATTCCGCATCTTGGCGGGACAATTGGGGTGCTTAGGTGAGTAGT
GTCACCAGCCGAAAAAGGCT

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MSSLVGPDEDDDLARGKVPVPQDVQDAIRTLIRWSGDDPEREGLLDTPKRVARAWKEYCQGYGEDPAVHLSRQFEEVGGY
DEIVLLKDIPFQSHCEHHMAPIIGKAAIAYLPRDKVVGISKLARVLHGFARRLQIQERLTAEVAQCIWDNLRPHGVAVVI
EAQHACMTARGVRTPGVGMVTSRLMGTFLDDNRSRKEVLSLMGY

Sequences:

>Translated_204_residues
MSSLVGPDEDDDLARGKVPVPQDVQDAIRTLIRWSGDDPEREGLLDTPKRVARAWKEYCQGYGEDPAVHLSRQFEEVGGY
DEIVLLKDIPFQSHCEHHMAPIIGKAAIAYLPRDKVVGISKLARVLHGFARRLQIQERLTAEVAQCIWDNLRPHGVAVVI
EAQHACMTARGVRTPGVGMVTSRLMGTFLDDNRSRKEVLSLMGY
>Mature_203_residues
SSLVGPDEDDDLARGKVPVPQDVQDAIRTLIRWSGDDPEREGLLDTPKRVARAWKEYCQGYGEDPAVHLSRQFEEVGGYD
EIVLLKDIPFQSHCEHHMAPIIGKAAIAYLPRDKVVGISKLARVLHGFARRLQIQERLTAEVAQCIWDNLRPHGVAVVIE
AQHACMTARGVRTPGVGMVTSRLMGTFLDDNRSRKEVLSLMGY

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=196, Percent_Identity=42.3469387755102, Blast_Score=157, Evalue=6e-39,
Organism=Homo sapiens, GI4503949, Length=196, Percent_Identity=42.3469387755102, Blast_Score=157, Evalue=6e-39,
Organism=Homo sapiens, GI66932970, Length=166, Percent_Identity=40.9638554216867, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI66932972, Length=159, Percent_Identity=42.7672955974843, Blast_Score=123, Evalue=1e-28,
Organism=Escherichia coli, GI1788476, Length=161, Percent_Identity=38.5093167701863, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560486, Length=179, Percent_Identity=44.1340782122905, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6321706, Length=184, Percent_Identity=45.1086956521739, Blast_Score=164, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24656782, Length=182, Percent_Identity=42.8571428571429, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24656796, Length=182, Percent_Identity=42.8571428571429, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24656791, Length=182, Percent_Identity=42.8571428571429, Blast_Score=144, Evalue=6e-35,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 22782; Mature: 22651

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLVGPDEDDDLARGKVPVPQDVQDAIRTLIRWSGDDPEREGLLDTPKRVARAWKEYCQ
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
GYGEDPAVHLSRQFEEVGGYDEIVLLKDIPFQSHCEHHMAPIIGKAAIAYLPRDKVVGIS
CCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCHH
KLARVLHGFARRLQIQERLTAEVAQCIWDNLRPHGVAVVIEAQHACMTARGVRTPGVGMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHCCCCCCCHHHH
TSRLMGTFLDDNRSRKEVLSLMGY
HHHHHHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SSLVGPDEDDDLARGKVPVPQDVQDAIRTLIRWSGDDPEREGLLDTPKRVARAWKEYCQ
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
GYGEDPAVHLSRQFEEVGGYDEIVLLKDIPFQSHCEHHMAPIIGKAAIAYLPRDKVVGIS
CCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCHH
KLARVLHGFARRLQIQERLTAEVAQCIWDNLRPHGVAVVIEAQHACMTARGVRTPGVGMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHCCCCCCCHHHH
TSRLMGTFLDDNRSRKEVLSLMGY
HHHHHHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]