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The map label for this gene is trxA [C]

Identifier: 87200012

GI number: 87200012

Start: 2125964

End: 2126284

Strand: Reverse

Name: trxA [C]

Synonym: Saro_1996

Alternate gene names: 87200012

Gene position: 2126284-2125964 (Counterclockwise)

Preceding gene: 87200013

Following gene: 87200008

Centisome position: 59.7

GC content: 63.86

Gene sequence:

>321_bases
ATGCCGACCAAAGCCGTCACCGACGCCAGCTTCGCCAGCGATGTCCTGGGCAGCAGCAAGCCCGTGCTCGTCGATTTCTG
GGCGGACTGGTGCGGCCCCTGCAAGATGATCGCCCCGGCGCTCGAGGAGATCGCCGAGGAGCTTGGCGACAAGGTCGAGA
TCGCCAAGGTCGACATCATGGAAAACACGGACACCGCCAGCAAGTTCGGCGTCCAGTCGATCCCGCTGCTGATCCTCTTC
AAGGACGGTCAGCCCGTGGCGCAGAAGCTTGGCGCAGCGCCGAAGAGCCAGCTCAAGGGCTGGCTGGAAAGCGTTCTCTG
A

Upstream 100 bases:

>100_bases
GCTGCGCCTTGCCGGACAGCAGGAATCCTTTTCCGCATGATCGGTTGCGCGCTGCAACCGACGGCCTAAATTGGCCGCAA
AGACAACAGGAGTTCAACGA

Downstream 100 bases:

>100_bases
GCCCATGCCGCAGTGCCCTCGCCATGGCGGGGGCCTCGGTCGGGCGACGGGCGACCTCAGCCGATCAGTGACATCCGCTC
GGCCAGCGCGTCGAACAGCG

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MPTKAVTDASFASDVLGSSKPVLVDFWADWCGPCKMIAPALEEIAEELGDKVEIAKVDIMENTDTASKFGVQSIPLLILF
KDGQPVAQKLGAAPKSQLKGWLESVL

Sequences:

>Translated_106_residues
MPTKAVTDASFASDVLGSSKPVLVDFWADWCGPCKMIAPALEEIAEELGDKVEIAKVDIMENTDTASKFGVQSIPLLILF
KDGQPVAQKLGAAPKSQLKGWLESVL
>Mature_105_residues
PTKAVTDASFASDVLGSSKPVLVDFWADWCGPCKMIAPALEEIAEELGDKVEIAKVDIMENTDTASKFGVQSIPLLILFK
DGQPVAQKLGAAPKSQLKGWLESVL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=38.5416666666667, Blast_Score=79, Evalue=6e-16,
Organism=Homo sapiens, GI21361657, Length=81, Percent_Identity=44.4444444444444, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI4758304, Length=86, Percent_Identity=38.3720930232558, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI20070125, Length=80, Percent_Identity=36.25, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI5031973, Length=97, Percent_Identity=34.020618556701, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=53.4653465346535, Blast_Score=114, Evalue=1e-27,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=42.3913043478261, Blast_Score=90, Evalue=2e-20,
Organism=Escherichia coli, GI87081747, Length=88, Percent_Identity=32.9545454545455, Blast_Score=60, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=35.4166666666667, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17554386, Length=101, Percent_Identity=36.6336633663366, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=76, Percent_Identity=43.421052631579, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=82, Percent_Identity=35.3658536585366, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=81, Percent_Identity=43.2098765432099, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=74, Percent_Identity=39.1891891891892, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=74, Percent_Identity=37.8378378378378, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=94, Percent_Identity=42.5531914893617, Blast_Score=78, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=94, Percent_Identity=43.6170212765958, Blast_Score=77, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319925, Length=95, Percent_Identity=33.6842105263158, Blast_Score=68, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=38.1443298969072, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24639826, Length=70, Percent_Identity=44.2857142857143, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17648013, Length=80, Percent_Identity=41.25, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583090, Length=80, Percent_Identity=41.25, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664269, Length=76, Percent_Identity=39.4736842105263, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21358065, Length=92, Percent_Identity=34.7826086956522, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=29.0322580645161, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11347; Mature: 11216

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTKAVTDASFASDVLGSSKPVLVDFWADWCGPCKMIAPALEEIAEELGDKVEIAKVDIM
CCCCCCCCHHHHHHHHCCCCCEEEEECHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEEC
ENTDTASKFGVQSIPLLILFKDGQPVAQKLGAAPKSQLKGWLESVL
CCCCCHHHCCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PTKAVTDASFASDVLGSSKPVLVDFWADWCGPCKMIAPALEEIAEELGDKVEIAKVDIM
CCCCCCCHHHHHHHHCCCCCEEEEECHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEEC
ENTDTASKFGVQSIPLLILFKDGQPVAQKLGAAPKSQLKGWLESVL
CCCCCHHHCCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]