| Definition | Novosphingobium aromaticivorans DSM 12444 chromosome, complete genome. |
|---|---|
| Accession | NC_007794 |
| Length | 3,561,584 |
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The map label for this gene is yxbG [H]
Identifier: 87199890
GI number: 87199890
Start: 1974514
End: 1975353
Strand: Direct
Name: yxbG [H]
Synonym: Saro_1873
Alternate gene names: 87199890
Gene position: 1974514-1975353 (Clockwise)
Preceding gene: 87199889
Following gene: 87199891
Centisome position: 55.44
GC content: 65.24
Gene sequence:
>840_bases ATGGGAACTCTCGACAGGTTCGATATCAAGGGGCGCAGTGCGCTCGTCACAGGCGCGGCTTCGGGCATCGGACTGGCCTA TGCCGAGGCGATGGCCGAGGCGGGGGCGGCAGTGACGCTGACCGACATCGACGCGGAAGGCGCGGAGCGCGAGGCTGCTC GTCTTCGTGCCGAAGGGTACGAAGTCCGTGCCGAGAAGCTGGACGTTTCCGACTGGGACAACGTCGCGGCCGCCTTCGAC GCGCACGACAAGGCCTATGGCGGGCTGGACATCTGCTTTGCCAATGCCGGTATCGACACCGGTGCGGGATTCTGGAACCC TGCGGGGCACCGGAACCCCGAGGGCCAGGTCGATACCTACGACCACAAGCGCTGGGACAGGTCGATCCAGATCAACCTCA ACGGGGTTTTCTATACCGTGAGCAACGCGGTGCGGATCATGAAGAAGGAAGGCCGCGCCAATGGCCGCACCGGCGGGTCG ATCGTTACGACCGCATCGAACGCCGGCCTCGTGACCGAGCCGATCGTCGGCCTGCCCTATATGCCCGCAAAGGCCGGCGT CCTGCACATGGTGCGCGCGCTGGGACTGGAGCTGGCCGAATTCGGCATCCGCATCAACGCGATCGCGCCGGGGCCGTTCG TGACCAACATCGGTGGTGGCTGGCTCAAGAAGGACCCGGTCGCGCGGGCTGCGTGGGATGCCATCGTGCCGCTTGGATCG GTTGCGGAGACCGATCAGATCAAGCCGCTGGCGCTGCTGCTGGCGTCGGACGCTTCGGACTACATGACCGGCAGCCACGT GGTGATCGATGGCGGCATGATGCTCGGCAAGTACAAGTAA
Upstream 100 bases:
>100_bases GTGGCGGGGTGCGGGCCCGGAGAATGCTGCAACGGCTGATCGAGCGCGAGAGACAGCAGGACGCTGCCTGAAGCACACGC AAGACAACAAGAGGATGCCA
Downstream 100 bases:
>100_bases GGAAACCCCATGCGCGCCGCCGTGATGCAGGGCCTGCACAAGCCGCTGGCCATCGATACGATCCCCGATCCGACGCCGGG CGAGGGTGATGTCGTGGTCA
Product: short-chain dehydrogenase/reductase SDR
Products: D-Gluconate; Nicotinamide adenine dinucleotide phosphate [C]
Alternate protein names: NA
Number of amino acids: Translated: 279; Mature: 278
Protein sequence:
>279_residues MGTLDRFDIKGRSALVTGAASGIGLAYAEAMAEAGAAVTLTDIDAEGAEREAARLRAEGYEVRAEKLDVSDWDNVAAAFD AHDKAYGGLDICFANAGIDTGAGFWNPAGHRNPEGQVDTYDHKRWDRSIQINLNGVFYTVSNAVRIMKKEGRANGRTGGS IVTTASNAGLVTEPIVGLPYMPAKAGVLHMVRALGLELAEFGIRINAIAPGPFVTNIGGGWLKKDPVARAAWDAIVPLGS VAETDQIKPLALLLASDASDYMTGSHVVIDGGMMLGKYK
Sequences:
>Translated_279_residues MGTLDRFDIKGRSALVTGAASGIGLAYAEAMAEAGAAVTLTDIDAEGAEREAARLRAEGYEVRAEKLDVSDWDNVAAAFD AHDKAYGGLDICFANAGIDTGAGFWNPAGHRNPEGQVDTYDHKRWDRSIQINLNGVFYTVSNAVRIMKKEGRANGRTGGS IVTTASNAGLVTEPIVGLPYMPAKAGVLHMVRALGLELAEFGIRINAIAPGPFVTNIGGGWLKKDPVARAAWDAIVPLGS VAETDQIKPLALLLASDASDYMTGSHVVIDGGMMLGKYK >Mature_278_residues GTLDRFDIKGRSALVTGAASGIGLAYAEAMAEAGAAVTLTDIDAEGAEREAARLRAEGYEVRAEKLDVSDWDNVAAAFDA HDKAYGGLDICFANAGIDTGAGFWNPAGHRNPEGQVDTYDHKRWDRSIQINLNGVFYTVSNAVRIMKKEGRANGRTGGSI VTTASNAGLVTEPIVGLPYMPAKAGVLHMVRALGLELAEFGIRINAIAPGPFVTNIGGGWLKKDPVARAAWDAIVPLGSV AETDQIKPLALLLASDASDYMTGSHVVIDGGMMLGKYK
Specific function: Catalyzes A Reversible Reduction Of 5-Ketoglutanate To Form D-Gluconate. Dependent On Nadp, Almost Inactive With NAD. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=272, Percent_Identity=26.4705882352941, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI31542939, Length=208, Percent_Identity=33.1730769230769, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI4758504, Length=215, Percent_Identity=32.093023255814, Blast_Score=78, Evalue=8e-15, Organism=Homo sapiens, GI126723750, Length=285, Percent_Identity=27.719298245614, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI19923817, Length=287, Percent_Identity=25.4355400696864, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI224922801, Length=188, Percent_Identity=31.3829787234043, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI40254992, Length=260, Percent_Identity=29.2307692307692, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI15277342, Length=266, Percent_Identity=27.0676691729323, Blast_Score=72, Evalue=8e-13, Organism=Homo sapiens, GI7705925, Length=271, Percent_Identity=27.6752767527675, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI5031737, Length=267, Percent_Identity=25.0936329588015, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI59889578, Length=253, Percent_Identity=24.5059288537549, Blast_Score=69, Evalue=7e-12, Organism=Homo sapiens, GI33667109, Length=206, Percent_Identity=28.1553398058252, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI126723191, Length=203, Percent_Identity=26.6009852216749, Blast_Score=66, Evalue=4e-11, Organism=Homo sapiens, GI4503301, Length=268, Percent_Identity=24.2537313432836, Blast_Score=65, Evalue=7e-11, Organism=Homo sapiens, GI83715985, Length=201, Percent_Identity=30.3482587064677, Blast_Score=65, Evalue=8e-11, Organism=Escherichia coli, GI1790717, Length=272, Percent_Identity=27.9411764705882, Blast_Score=108, Evalue=3e-25, Organism=Escherichia coli, GI87082100, Length=276, Percent_Identity=34.4202898550725, Blast_Score=103, Evalue=1e-23, Organism=Escherichia coli, GI1787335, Length=269, Percent_Identity=30.8550185873606, Blast_Score=95, Evalue=4e-21, Organism=Escherichia coli, GI1786812, Length=278, Percent_Identity=29.136690647482, Blast_Score=91, Evalue=7e-20, Organism=Escherichia coli, GI1788459, Length=265, Percent_Identity=27.9245283018868, Blast_Score=89, Evalue=5e-19, Organism=Escherichia coli, GI87082160, Length=277, Percent_Identity=26.7148014440433, Blast_Score=87, Evalue=1e-18, Organism=Escherichia coli, GI1789378, Length=272, Percent_Identity=29.7794117647059, Blast_Score=86, Evalue=3e-18, Organism=Escherichia coli, GI1789208, Length=273, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=4e-17, Organism=Escherichia coli, GI2367175, Length=263, Percent_Identity=27.7566539923954, Blast_Score=81, Evalue=7e-17, Organism=Escherichia coli, GI1787905, Length=272, Percent_Identity=27.5735294117647, Blast_Score=77, Evalue=2e-15, Organism=Escherichia coli, GI1789057, Length=277, Percent_Identity=25.2707581227437, Blast_Score=68, Evalue=7e-13, Organism=Caenorhabditis elegans, GI25147288, Length=265, Percent_Identity=30.188679245283, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17560676, Length=263, Percent_Identity=26.615969581749, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17562910, Length=275, Percent_Identity=28.3636363636364, Blast_Score=84, Evalue=5e-17, Organism=Caenorhabditis elegans, GI17555706, Length=265, Percent_Identity=28.3018867924528, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI193204405, Length=283, Percent_Identity=28.2685512367491, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17562908, Length=283, Percent_Identity=28.2685512367491, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI72000259, Length=286, Percent_Identity=25.8741258741259, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17561402, Length=271, Percent_Identity=27.6752767527675, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17562904, Length=283, Percent_Identity=27.208480565371, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17562906, Length=283, Percent_Identity=27.208480565371, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17563726, Length=282, Percent_Identity=28.3687943262411, Blast_Score=77, Evalue=7e-15, Organism=Caenorhabditis elegans, GI17536651, Length=267, Percent_Identity=27.3408239700375, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17536025, Length=272, Percent_Identity=28.3088235294118, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI193203115, Length=241, Percent_Identity=27.8008298755187, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17531453, Length=282, Percent_Identity=26.5957446808511, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17564282, Length=246, Percent_Identity=26.0162601626016, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17560220, Length=290, Percent_Identity=28.2758620689655, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17561272, Length=251, Percent_Identity=31.4741035856574, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17560150, Length=287, Percent_Identity=25.4355400696864, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17559104, Length=276, Percent_Identity=28.6231884057971, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17560332, Length=288, Percent_Identity=28.8194444444444, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17562990, Length=286, Percent_Identity=26.5734265734266, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI193203117, Length=235, Percent_Identity=26.3829787234043, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI71994600, Length=274, Percent_Identity=25.5474452554745, Blast_Score=68, Evalue=7e-12, Organism=Caenorhabditis elegans, GI17565030, Length=275, Percent_Identity=28.3636363636364, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17538182, Length=209, Percent_Identity=30.1435406698565, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=284, Percent_Identity=27.112676056338, Blast_Score=72, Evalue=1e-13, Organism=Drosophila melanogaster, GI21355319, Length=272, Percent_Identity=27.9411764705882, Blast_Score=100, Evalue=2e-21, Organism=Drosophila melanogaster, GI24644339, Length=277, Percent_Identity=27.7978339350181, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI24665243, Length=224, Percent_Identity=29.0178571428571, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI221331218, Length=220, Percent_Identity=29.5454545454545, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI24639444, Length=272, Percent_Identity=29.0441176470588, Blast_Score=78, Evalue=7e-15, Organism=Drosophila melanogaster, GI24665247, Length=224, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=9e-15, Organism=Drosophila melanogaster, GI23397609, Length=271, Percent_Identity=28.7822878228782, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI221331216, Length=220, Percent_Identity=29.0909090909091, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI17737361, Length=208, Percent_Identity=33.1730769230769, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI21357041, Length=272, Percent_Identity=27.9411764705882, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI28571526, Length=268, Percent_Identity=27.2388059701493, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI24643142, Length=267, Percent_Identity=25.4681647940075, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24644337, Length=275, Percent_Identity=26.9090909090909, Blast_Score=64, Evalue=8e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.69 [C]
Molecular weight: Translated: 29377; Mature: 29245
Theoretical pI: Translated: 5.15; Mature: 5.15
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGTLDRFDIKGRSALVTGAASGIGLAYAEAMAEAGAAVTLTDIDAEGAEREAARLRAEGY CCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCC EVRAEKLDVSDWDNVAAAFDAHDKAYGGLDICFANAGIDTGAGFWNPAGHRNPEGQVDTY EEEEEEECCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC DHKRWDRSIQINLNGVFYTVSNAVRIMKKEGRANGRTGGSIVTTASNAGLVTEPIVGLPY CCCCCCCEEEEEEEEEEEEEHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEECCCCCCCC MPAKAGVLHMVRALGLELAEFGIRINAIAPGPFVTNIGGGWLKKDPVARAAWDAIVPLGS CCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEECCCCCCCCCCCCHHHHHHHHCCCCC VAETDQIKPLALLLASDASDYMTGSHVVIDGGMMLGKYK CCCCCCCCCEEEEEECCCCHHCCCCEEEEECCEEEECCC >Mature Secondary Structure GTLDRFDIKGRSALVTGAASGIGLAYAEAMAEAGAAVTLTDIDAEGAEREAARLRAEGY CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCC EVRAEKLDVSDWDNVAAAFDAHDKAYGGLDICFANAGIDTGAGFWNPAGHRNPEGQVDTY EEEEEEECCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC DHKRWDRSIQINLNGVFYTVSNAVRIMKKEGRANGRTGGSIVTTASNAGLVTEPIVGLPY CCCCCCCEEEEEEEEEEEEEHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEECCCCCCCC MPAKAGVLHMVRALGLELAEFGIRINAIAPGPFVTNIGGGWLKKDPVARAAWDAIVPLGS CCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEECCCCCCCCCCCCHHHHHHHHCCCCC VAETDQIKPLALLLASDASDYMTGSHVVIDGGMMLGKYK CCCCCCCCCEEEEEECCCCHHCCCCEEEEECCEEEECCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NAD+; NADH; NADP+; NADPH [C]
Metal ions: Mn2+ [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 0.02 {NADP+}} 20 {D-gluconate}} 0.006 {NADPH}} 0.9 {5-keto-D-gluconate}} [C]
Substrates: 5-Dehydro-D-gluconate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]
Specific reaction: 5-Dehydro-D-gluconate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced <==> D-Gluconate + Nicotinamide adenine dinucleotide phosphate [C]
General reaction: Redox reaction [C]
Inhibitor: Cd2+; Cs2+; Cu2+; Divalent metal ions; Hg2+; Ni2+; p-Chloromercuribenzoate; Sn2+; Sulfhydryl reagents [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7584049; 9384377 [H]