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The map label for this gene is gcvT

Identifier: 87199867

GI number: 87199867

Start: 1949880

End: 1951046

Strand: Direct

Name: gcvT

Synonym: Saro_1850

Alternate gene names: 87199867

Gene position: 1949880-1951046 (Clockwise)

Preceding gene: 87199866

Following gene: 87199868

Centisome position: 54.75

GC content: 67.44

Gene sequence:

>1167_bases
GTGAGCGACACATACGAAAACCCAGACCTTGATCCCGACGTGCCGACCGGTCCGTTGGCCCTGCCGCTCGACCAGTGGCA
CCGCGCACGCGGCGGTCGCATGGTCGATTTCGCCGGCTACTGGATGCCGGTCCAATACAACGGAGAAGGCGGGGGCATCA
TCGCCGAGCATCTCTGGACCCGCGAGAGCGCCGGGTTTTTCGATGTTTCGCACATGGGCCAAATCTACGTTTCGGGTGAA
GGCGCTGAGGCCGCGCTCGAAGCCATCCTGCCGATCGACCTGTCCACGCTTCCGCTCGGCGGGGCGCGCTACTCGCTACT
GCTGAACGAAGACGGCGGGATACTCGATGACCTGATGGTCACGCGCTGGGGCACCGGCTTCTACCTGGTCGTCAACGGCG
CGACCAAGTGGGACGATATCGGCCACCTGCGCGAATACCTGCCGGACGAGGTGACGCTCAACCACCTCGAAGACAACGCG
CTCTTCGCGCTCCAGGGCCCGGCCGCCTGCGCGGCGCTGGAGCCCTTGGTAAAGGGCGAGCAACCGCTCTCGGCACTCAC
CTTCATGCGCGGCGCGGCATTCAGGCTGGGCGGCGTGGATGCGTGGATCAGCCGCTCGGGATACACCGGCGAGGACGGGT
TCGAAATCTCCGTCCCCTCGACCAAGGCCGCGGAACTGGCGGACCTGATCTGCGCGCAGCCGCAGGTGAAGACCATCGGC
CTTGGCGCGCGCGACAGCCTGCGCCTTGAAGCCGGCCTTCCGCTCTACGGCCACGACATGACCGACACGGTCGATCCGGT
CAGCGCGGACCTTCTGTTCGGCATCAACAAGCGCCGCCGCAACGAGGGCGGCTTCGTCGGGGCCGACAAGGTCCTGCCGT
TGATCGCCAGCGGCGCCGCCACGCGCCGCGTCGGCCTCGCCATCGAGGGCCGCATGGCCGCGCGCGAAGGTGCGACAGTG
CTTTCGAACGACGCCGAAGTCGGCACCGTCACCTCCGGCGGTTTCTCGCCCAGCCTCGAGCGGCCCATCGCCATGGCCTA
TGTGCCGGTCGATCTGGCCGCGCCGGGCACCGCCCTTTCCATCGACGTGCGCGGACGCAAGCTCGCCGCCAGCGTCGTGT
CCATGCCTTTCGTTCCCCACCGTTATCACCGCAAAGGAGCCGCCTGA

Upstream 100 bases:

>100_bases
CCATCCAAACCCGTCTGGAGAGGCGGGCGGGGGAAAGCTCTCAGGTTTCCGTGACAGAGGGGGCGCCGAATGGCGTCTGA
ACTGCACGGGAACGATATTT

Downstream 100 bases:

>100_bases
TGACCCGCTATTTCACCAAGGACCACGAATGGATCGCGGTCGAGGGCAGCGAAGCGACCGTCGGCATCACCGACTACGCA
CAGAGCCAGCTCGGTGACAT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MSDTYENPDLDPDVPTGPLALPLDQWHRARGGRMVDFAGYWMPVQYNGEGGGIIAEHLWTRESAGFFDVSHMGQIYVSGE
GAEAALEAILPIDLSTLPLGGARYSLLLNEDGGILDDLMVTRWGTGFYLVVNGATKWDDIGHLREYLPDEVTLNHLEDNA
LFALQGPAACAALEPLVKGEQPLSALTFMRGAAFRLGGVDAWISRSGYTGEDGFEISVPSTKAAELADLICAQPQVKTIG
LGARDSLRLEAGLPLYGHDMTDTVDPVSADLLFGINKRRRNEGGFVGADKVLPLIASGAATRRVGLAIEGRMAAREGATV
LSNDAEVGTVTSGGFSPSLERPIAMAYVPVDLAAPGTALSIDVRGRKLAASVVSMPFVPHRYHRKGAA

Sequences:

>Translated_388_residues
MSDTYENPDLDPDVPTGPLALPLDQWHRARGGRMVDFAGYWMPVQYNGEGGGIIAEHLWTRESAGFFDVSHMGQIYVSGE
GAEAALEAILPIDLSTLPLGGARYSLLLNEDGGILDDLMVTRWGTGFYLVVNGATKWDDIGHLREYLPDEVTLNHLEDNA
LFALQGPAACAALEPLVKGEQPLSALTFMRGAAFRLGGVDAWISRSGYTGEDGFEISVPSTKAAELADLICAQPQVKTIG
LGARDSLRLEAGLPLYGHDMTDTVDPVSADLLFGINKRRRNEGGFVGADKVLPLIASGAATRRVGLAIEGRMAAREGATV
LSNDAEVGTVTSGGFSPSLERPIAMAYVPVDLAAPGTALSIDVRGRKLAASVVSMPFVPHRYHRKGAA
>Mature_387_residues
SDTYENPDLDPDVPTGPLALPLDQWHRARGGRMVDFAGYWMPVQYNGEGGGIIAEHLWTRESAGFFDVSHMGQIYVSGEG
AEAALEAILPIDLSTLPLGGARYSLLLNEDGGILDDLMVTRWGTGFYLVVNGATKWDDIGHLREYLPDEVTLNHLEDNAL
FALQGPAACAALEPLVKGEQPLSALTFMRGAAFRLGGVDAWISRSGYTGEDGFEISVPSTKAAELADLICAQPQVKTIGL
GARDSLRLEAGLPLYGHDMTDTVDPVSADLLFGINKRRRNEGGFVGADKVLPLIASGAATRRVGLAIEGRMAAREGATVL
SNDAEVGTVTSGGFSPSLERPIAMAYVPVDLAAPGTALSIDVRGRKLAASVVSMPFVPHRYHRKGAA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=371, Percent_Identity=42.3180592991914, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI257796258, Length=350, Percent_Identity=41.4285714285714, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI257796254, Length=364, Percent_Identity=38.7362637362637, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI257796256, Length=319, Percent_Identity=41.3793103448276, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI197927446, Length=317, Percent_Identity=25.8675078864353, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI21361378, Length=317, Percent_Identity=25.8675078864353, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI24797151, Length=347, Percent_Identity=23.0547550432277, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1789272, Length=364, Percent_Identity=35.4395604395604, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17560118, Length=373, Percent_Identity=36.9973190348526, Blast_Score=217, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6320222, Length=382, Percent_Identity=40.0523560209424, Blast_Score=236, Evalue=6e-63,
Organism=Drosophila melanogaster, GI20129441, Length=375, Percent_Identity=41.6, Blast_Score=262, Evalue=3e-70,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41301; Mature: 41170

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTYENPDLDPDVPTGPLALPLDQWHRARGGRMVDFAGYWMPVQYNGEGGGIIAEHLWT
CCCCCCCCCCCCCCCCCCEECCHHHHHHHCCCEEEEECCEEEEEEECCCCCCEEHHHHHC
RESAGFFDVSHMGQIYVSGEGAEAALEAILPIDLSTLPLGGARYSLLLNEDGGILDDLMV
CCCCCEEECCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
TRWGTGFYLVVNGATKWDDIGHLREYLPDEVTLNHLEDNALFALQGPAACAALEPLVKGE
HCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCEEEEECCCHHHHHHHHHHCCC
QPLSALTFMRGAAFRLGGVDAWISRSGYTGEDGFEISVPSTKAAELADLICAQPQVKTIG
CCHHHHHHHHCCCEEECCCHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEE
LGARDSLRLEAGLPLYGHDMTDTVDPVSADLLFGINKRRRNEGGFVGADKVLPLIASGAA
CCCCCCEEEECCCCEECCCCCCCCCCCCHHHEECCCHHCCCCCCEEEHHHHHHHHHCCCC
TRRVGLAIEGRMAAREGATVLSNDAEVGTVTSGGFSPSLERPIAMAYVPVDLAAPGTALS
CEEEEEEEECCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCEEEEEEEEEECCCCCEEE
IDVRGRKLAASVVSMPFVPHRYHRKGAA
EEECCCHHHHHHHHCCCCCCHHHCCCCC
>Mature Secondary Structure 
SDTYENPDLDPDVPTGPLALPLDQWHRARGGRMVDFAGYWMPVQYNGEGGGIIAEHLWT
CCCCCCCCCCCCCCCCCEECCHHHHHHHCCCEEEEECCEEEEEEECCCCCCEEHHHHHC
RESAGFFDVSHMGQIYVSGEGAEAALEAILPIDLSTLPLGGARYSLLLNEDGGILDDLMV
CCCCCEEECCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
TRWGTGFYLVVNGATKWDDIGHLREYLPDEVTLNHLEDNALFALQGPAACAALEPLVKGE
HCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCEEEEECCCHHHHHHHHHHCCC
QPLSALTFMRGAAFRLGGVDAWISRSGYTGEDGFEISVPSTKAAELADLICAQPQVKTIG
CCHHHHHHHHCCCEEECCCHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEE
LGARDSLRLEAGLPLYGHDMTDTVDPVSADLLFGINKRRRNEGGFVGADKVLPLIASGAA
CCCCCCEEEECCCCEECCCCCCCCCCCCHHHEECCCHHCCCCCCEEEHHHHHHHHHCCCC
TRRVGLAIEGRMAAREGATVLSNDAEVGTVTSGGFSPSLERPIAMAYVPVDLAAPGTALS
CEEEEEEEECCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCEEEEEEEEEECCCCCEEE
IDVRGRKLAASVVSMPFVPHRYHRKGAA
EEECCCHHHHHHHHCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA