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The map label for this gene is pntAA [H]

Identifier: 87199860

GI number: 87199860

Start: 1943572

End: 1944699

Strand: Direct

Name: pntAA [H]

Synonym: Saro_1843

Alternate gene names: 87199860

Gene position: 1943572-1944699 (Clockwise)

Preceding gene: 87199858

Following gene: 87199861

Centisome position: 54.57

GC content: 65.07

Gene sequence:

>1128_bases
ATGGCGGGGGCAATGAAGATCGCCGTCCTCAGGGAACGCGCGACGGGGGAGACCAGGGTTTCGGCAACGCCGGAAACCGT
GAAGAAGTTCATTGCCCTTGGGGCAACAGTTGCAATTGAAGAAGGTGCAGGCATTACCGCCTCGATTTCCGACGAGGATT
ATCGCGCGGTGGGCGCCGAAGTCGTGTCCAGTCCGGCAAACGGGGCGGACATCGTGCTTGGCGTCCAGGGCCCCGAGCCC
GAACTGCTGGCGGGCGTGAAGCCCGGTGCCTGGATCGTGGCCGGGCTTGATCCATTCGTGAAGCGCGCCCGCGTGGACGC
TTATGCGGCCGCCGGCCTTGAAGCGCTGGCGATGGAGTTCATGCCGCGCATTACACGTGCACAGTCGATGGACATCCTGT
CGTCGCAGTCGAACCTTGCCGGCTACAAGGCCGTGCTGGTGGCCGCCAACCTTTATGGTCGCGCGTTCCCGATGATGATG
ACGGCGGCGGGCACCGTCTCTGCCGCCAAGGCTTTTGTCATGGGCGTCGGCGTTGCCGGCCTCCAGGCCATCGCCACCGC
TCGCCGTCTCGGCGCGCAGGTTTCGGCGACCGACGTCCGTTCGGCAACGAAGGAGCAGATCCAGTCGCTCGGTGCCAAGC
CGATCTTCGTGGAAAGCGTTGCGGGCATCGAAGGCGAGGGCGCCGGCGGCTATGCCACGGAAATGTCCGAGGAATACCAG
AAGGCCCAGGCCGAGCTGGTGAGCGCGCATATCGCCAAGCAGGACATCGTCATCACCACGGCGCTGATCCCGGGCCGCGC
CGCGCCGCGCCTGATTTCCGATGCGCAGATTGCCACGATGAAGCCCGGTTCGGTCATCTTCGACCTTGCCGTGGCCCAGG
GCGGCAACGTCGAGGGTTCGGTGCCCGACCAGGTTGTCGAGAAGCACGGCGTGAAGATCGTCGGCTACTCGAACACGCCC
GCGCACCTGCCGGCCGACGCTTCGGCGCTGTTCAGCCGCAACCTCTACAACTTCCTCTCGGCCTTCTGGGACAAGGAACA
GGGCAAGCCCGTTCTGGACGAGGAAATCGGCAACGCCATCCGCCTGACGCAGGGCGGCAAGGTGGTCAACGAACGTCTGC
TCGGCTGA

Upstream 100 bases:

>100_bases
CAGGCCACCTATTCCGGTTTCGTCAATATGTTGAAGTGGTCGACGCCGGCAATCTGCCTCATCGTCTTCCTGATCATCCT
GGCGATCCAGTAAGCCACGC

Downstream 100 bases:

>100_bases
GGGGGCCTGACATGGACTTCATATCGATCCTGAGCATTTTCGTGCTCGCCTGCTTTGTCGGGTACTACGTCGTCTGGTCG
GTCACGCCGGCCCTTCACAC

Product: alanine dehydrogenase/PNT-like

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MAGAMKIAVLRERATGETRVSATPETVKKFIALGATVAIEEGAGITASISDEDYRAVGAEVVSSPANGADIVLGVQGPEP
ELLAGVKPGAWIVAGLDPFVKRARVDAYAAAGLEALAMEFMPRITRAQSMDILSSQSNLAGYKAVLVAANLYGRAFPMMM
TAAGTVSAAKAFVMGVGVAGLQAIATARRLGAQVSATDVRSATKEQIQSLGAKPIFVESVAGIEGEGAGGYATEMSEEYQ
KAQAELVSAHIAKQDIVITTALIPGRAAPRLISDAQIATMKPGSVIFDLAVAQGGNVEGSVPDQVVEKHGVKIVGYSNTP
AHLPADASALFSRNLYNFLSAFWDKEQGKPVLDEEIGNAIRLTQGGKVVNERLLG

Sequences:

>Translated_375_residues
MAGAMKIAVLRERATGETRVSATPETVKKFIALGATVAIEEGAGITASISDEDYRAVGAEVVSSPANGADIVLGVQGPEP
ELLAGVKPGAWIVAGLDPFVKRARVDAYAAAGLEALAMEFMPRITRAQSMDILSSQSNLAGYKAVLVAANLYGRAFPMMM
TAAGTVSAAKAFVMGVGVAGLQAIATARRLGAQVSATDVRSATKEQIQSLGAKPIFVESVAGIEGEGAGGYATEMSEEYQ
KAQAELVSAHIAKQDIVITTALIPGRAAPRLISDAQIATMKPGSVIFDLAVAQGGNVEGSVPDQVVEKHGVKIVGYSNTP
AHLPADASALFSRNLYNFLSAFWDKEQGKPVLDEEIGNAIRLTQGGKVVNERLLG
>Mature_374_residues
AGAMKIAVLRERATGETRVSATPETVKKFIALGATVAIEEGAGITASISDEDYRAVGAEVVSSPANGADIVLGVQGPEPE
LLAGVKPGAWIVAGLDPFVKRARVDAYAAAGLEALAMEFMPRITRAQSMDILSSQSNLAGYKAVLVAANLYGRAFPMMMT
AAGTVSAAKAFVMGVGVAGLQAIATARRLGAQVSATDVRSATKEQIQSLGAKPIFVESVAGIEGEGAGGYATEMSEEYQK
AQAELVSAHIAKQDIVITTALIPGRAAPRLISDAQIATMKPGSVIFDLAVAQGGNVEGSVPDQVVEKHGVKIVGYSNTPA
HLPADASALFSRNLYNFLSAFWDKEQGKPVLDEEIGNAIRLTQGGKVVNERLLG

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=351, Percent_Identity=37.6068376068376, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI122939153, Length=351, Percent_Identity=37.6068376068376, Blast_Score=218, Evalue=1e-56,
Organism=Escherichia coli, GI1787887, Length=351, Percent_Identity=43.3048433048433, Blast_Score=268, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17550456, Length=336, Percent_Identity=43.452380952381, Blast_Score=261, Evalue=5e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 38894; Mature: 38763

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGAMKIAVLRERATGETRVSATPETVKKFIALGATVAIEEGAGITASISDEDYRAVGAE
CCCCEEEEEEHHCCCCCCEECCCHHHHHHHHHHCCEEEEECCCCEEEECCCCHHHHHHHH
VVSSPANGADIVLGVQGPEPELLAGVKPGAWIVAGLDPFVKRARVDAYAAAGLEALAMEF
HHCCCCCCCEEEEECCCCCCHHEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
MPRITRAQSMDILSSQSNLAGYKAVLVAANLYGRAFPMMMTAAGTVSAAKAFVMGVGVAG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHH
LQAIATARRLGAQVSATDVRSATKEQIQSLGAKPIFVESVAGIEGEGAGGYATEMSEEYQ
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHCCCCCCCCCCHHHHHHHHHH
KAQAELVSAHIAKQDIVITTALIPGRAAPRLISDAQIATMKPGSVIFDLAVAQGGNVEGS
HHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHCCCEEEEECCCCEEEEEEECCCCCCCCC
VPDQVVEKHGVKIVGYSNTPAHLPADASALFSRNLYNFLSAFWDKEQGKPVLDEEIGNAI
CHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCEE
RLTQGGKVVNERLLG
EEECCCHHHHHHCCC
>Mature Secondary Structure 
AGAMKIAVLRERATGETRVSATPETVKKFIALGATVAIEEGAGITASISDEDYRAVGAE
CCCEEEEEEHHCCCCCCEECCCHHHHHHHHHHCCEEEEECCCCEEEECCCCHHHHHHHH
VVSSPANGADIVLGVQGPEPELLAGVKPGAWIVAGLDPFVKRARVDAYAAAGLEALAMEF
HHCCCCCCCEEEEECCCCCCHHEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
MPRITRAQSMDILSSQSNLAGYKAVLVAANLYGRAFPMMMTAAGTVSAAKAFVMGVGVAG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHH
LQAIATARRLGAQVSATDVRSATKEQIQSLGAKPIFVESVAGIEGEGAGGYATEMSEEYQ
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHCCCCCCCCCCHHHHHHHHHH
KAQAELVSAHIAKQDIVITTALIPGRAAPRLISDAQIATMKPGSVIFDLAVAQGGNVEGS
HHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHCCCEEEEECCCCEEEEEEECCCCCCCCC
VPDQVVEKHGVKIVGYSNTPAHLPADASALFSRNLYNFLSAFWDKEQGKPVLDEEIGNAI
CHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCEE
RLTQGGKVVNERLLG
EEECCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]