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The map label for this gene is folP [H]

Identifier: 87199858

GI number: 87199858

Start: 1940747

End: 1941853

Strand: Direct

Name: folP [H]

Synonym: Saro_1841

Alternate gene names: 87199858

Gene position: 1940747-1941853 (Clockwise)

Preceding gene: 87199857

Following gene: 87199860

Centisome position: 54.49

GC content: 67.84

Gene sequence:

>1107_bases
ATGCTGAAAGTCTACATTCGTCCGATCGCGCTGGCCGACAGCCCCCAGTCGGAGGAAGGCGAGGCCATCCGTCTAGGGGG
CGGGCTGGTCTATGCAAGCCGCTTCGCGCTGATCGTCCGCGACGGCGCGCGGGTCGTGTCGCGCCGCCGATTTTCGGTGC
CCGAAGTTTCGAGAGCTTTTGGCGCCCTGCCGGATGGCCTTGCCGCAGAAGCTGCGGCCCAGTGGGACAACCTGCGCCGC
GTCCATCAGCCGATTGGCTGTGGCCAGCGCATGCTGCGGCTCGACCAGCCGCAGGTCATGGGCATTCTCAACGTAACGCC
CGACAGCTTCTCCGACGGGGGCAAGTTCCTCGACAGGCCCGAGACTGCGCTCGAACACGCTCACGCGATGCTTGCGGCGG
GCGCGGCGCTGATCGACGTCGGCGGGGAATCGACCCGCCCCGGCGCCGCCGCCGTCTGGGAAGGCGACGAGGCGAAGCGC
GTGGTCCCGGTCATCGAGGCCCTGGCCGCTTCCGGCGCCGCGATCTCGATAGACAGTCGCCGATCTACGGTGATCGAGGC
GGCGCTTGCCGCAGGCGCACACATCGTCAACGACGTTTCGGCAATGCGCCACGATCCGCGCACGGCGGAAATCGTGGCCG
CCAGCGGTGCGCCGGTCGTGCTGATGCATGCGCCAGGAAGCGACGGCGACCTCCATGCCGATGGCGAATATGCGGATGTG
GTGCTCGACGTCTTCGATGCCTTGCGCGAACGGCGCGACGCGGCGCTAGCCGGCGGGATCGCTCCCGAGAAGATCCTTCT
CGATCCGGGCATCGGCTTCGGCAAGTCGCTCGCGGAGAATCTGGCGCTGGTGAACGCCCTGCCGATGTTCCACGCGCTGG
GCCACCCGATCCTTTTCGGGGCGAGCCGCAAGCGCATGATCGGCGCGCTATCCAACGAGGCGCCGGCGCACCAGCGCATG
GCTGGTTCGGTTATGCTGGCGCTGAAGGCGATGGACGCCGGATGCCAGATGGTCCGCGTTCACGATGTGGCCGAGACGGT
TCAGGCCCTGCATGTCTGGCGCGGGCTGCGCGACGCGGCGTTGACGGATTTCAGCCAACTGGCCTGA

Upstream 100 bases:

>100_bases
CAGCTCTACCTGCTCGCCGTGGAAGATTGATCCTCTTGCCAGCGTACTGCGCCCCCGCCTAGGCGGGGGCAGGGGCAAAG
GGCCCTGGCGGGGACTGGAA

Downstream 100 bases:

>100_bases
CGTCAGGCCGCGTTGTCGATCCCGAGCTCGGACAGCTTGCGGTAGAGCGTCGAGCGCCCGATGCCGAGCCTTCTGGCGAC
CTCGGTCATGCGGCCGCGAT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MLKVYIRPIALADSPQSEEGEAIRLGGGLVYASRFALIVRDGARVVSRRRFSVPEVSRAFGALPDGLAAEAAAQWDNLRR
VHQPIGCGQRMLRLDQPQVMGILNVTPDSFSDGGKFLDRPETALEHAHAMLAAGAALIDVGGESTRPGAAAVWEGDEAKR
VVPVIEALAASGAAISIDSRRSTVIEAALAAGAHIVNDVSAMRHDPRTAEIVAASGAPVVLMHAPGSDGDLHADGEYADV
VLDVFDALRERRDAALAGGIAPEKILLDPGIGFGKSLAENLALVNALPMFHALGHPILFGASRKRMIGALSNEAPAHQRM
AGSVMLALKAMDAGCQMVRVHDVAETVQALHVWRGLRDAALTDFSQLA

Sequences:

>Translated_368_residues
MLKVYIRPIALADSPQSEEGEAIRLGGGLVYASRFALIVRDGARVVSRRRFSVPEVSRAFGALPDGLAAEAAAQWDNLRR
VHQPIGCGQRMLRLDQPQVMGILNVTPDSFSDGGKFLDRPETALEHAHAMLAAGAALIDVGGESTRPGAAAVWEGDEAKR
VVPVIEALAASGAAISIDSRRSTVIEAALAAGAHIVNDVSAMRHDPRTAEIVAASGAPVVLMHAPGSDGDLHADGEYADV
VLDVFDALRERRDAALAGGIAPEKILLDPGIGFGKSLAENLALVNALPMFHALGHPILFGASRKRMIGALSNEAPAHQRM
AGSVMLALKAMDAGCQMVRVHDVAETVQALHVWRGLRDAALTDFSQLA
>Mature_368_residues
MLKVYIRPIALADSPQSEEGEAIRLGGGLVYASRFALIVRDGARVVSRRRFSVPEVSRAFGALPDGLAAEAAAQWDNLRR
VHQPIGCGQRMLRLDQPQVMGILNVTPDSFSDGGKFLDRPETALEHAHAMLAAGAALIDVGGESTRPGAAAVWEGDEAKR
VVPVIEALAASGAAISIDSRRSTVIEAALAAGAHIVNDVSAMRHDPRTAEIVAASGAPVVLMHAPGSDGDLHADGEYADV
VLDVFDALRERRDAALAGGIAPEKILLDPGIGFGKSLAENLALVNALPMFHALGHPILFGASRKRMIGALSNEAPAHQRM
AGSVMLALKAMDAGCQMVRVHDVAETVQALHVWRGLRDAALTDFSQLA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=262, Percent_Identity=46.5648854961832, Blast_Score=214, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=27.9874213836478, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 38758; Mature: 38758

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVYIRPIALADSPQSEEGEAIRLGGGLVYASRFALIVRDGARVVSRRRFSVPEVSRAF
CEEEEEEEEEECCCCCCCCCCEEEECCCEEEHHHEEEEEECCHHHHHHHCCCCCHHHHHH
GALPDGLAAEAAAQWDNLRRVHQPIGCGQRMLRLDQPQVMGILNVTPDSFSDGGKFLDRP
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCH
ETALEHAHAMLAAGAALIDVGGESTRPGAAAVWEGDEAKRVVPVIEALAASGAAISIDSR
HHHHHHHHHHHHCCCCEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEECCH
RSTVIEAALAAGAHIVNDVSAMRHDPRTAEIVAASGAPVVLMHAPGSDGDLHADGEYADV
HHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHH
VLDVFDALRERRDAALAGGIAPEKILLDPGIGFGKSLAENLALVNALPMFHALGHPILFG
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEC
ASRKRMIGALSNEAPAHQRMAGSVMLALKAMDAGCQMVRVHDVAETVQALHVWRGLRDAA
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
LTDFSQLA
HHHHHHCC
>Mature Secondary Structure
MLKVYIRPIALADSPQSEEGEAIRLGGGLVYASRFALIVRDGARVVSRRRFSVPEVSRAF
CEEEEEEEEEECCCCCCCCCCEEEECCCEEEHHHEEEEEECCHHHHHHHCCCCCHHHHHH
GALPDGLAAEAAAQWDNLRRVHQPIGCGQRMLRLDQPQVMGILNVTPDSFSDGGKFLDRP
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCH
ETALEHAHAMLAAGAALIDVGGESTRPGAAAVWEGDEAKRVVPVIEALAASGAAISIDSR
HHHHHHHHHHHHCCCCEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEECCH
RSTVIEAALAAGAHIVNDVSAMRHDPRTAEIVAASGAPVVLMHAPGSDGDLHADGEYADV
HHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHH
VLDVFDALRERRDAALAGGIAPEKILLDPGIGFGKSLAENLALVNALPMFHALGHPILFG
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEC
ASRKRMIGALSNEAPAHQRMAGSVMLALKAMDAGCQMVRVHDVAETVQALHVWRGLRDAA
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
LTDFSQLA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]