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The map label for this gene is guaB [H]

Identifier: 87199769

GI number: 87199769

Start: 1846624

End: 1848126

Strand: Direct

Name: guaB [H]

Synonym: Saro_1752

Alternate gene names: 87199769

Gene position: 1846624-1848126 (Clockwise)

Preceding gene: 87199768

Following gene: 87199770

Centisome position: 51.85

GC content: 66.2

Gene sequence:

>1503_bases
ATGGGCCGCCACGAATCTCCCCGGACACAGGAAGTGGCGCCCATCATGGATATCCCTCTCGGCCTTACCTTCGACGACGT
GCTTCTGCGTCCTGCCGAGTCGGACATCGTGCCATCCCAGGCCGACACCCGCACCCGCCTGACCAAGGGCATCGGCCTCA
ACATCCCAATCCTGTCCTCTGCCATGGACACCGTGACCGAGGCCGACATGGCCATCGTCATGGCGCAGCTTGGCGGGATC
GGCGTACTCCACCGCAACCTTTCGATCGAAGAGCAGTGCGCCGCGGTCCGGGCGGTAAAGCGCTTCGAGAGCGGGATGGT
CGTCAACCCCATCACCATTTCCCCCGATGCCCCGCTGGGCGAGGCGCAGGCGCTGATGCGCCAGCACAAGATCAGCGGCA
TTCCGGTGGTCGAGGCGTCCGGCAAGCTCGTCGGCATTCTCACCAACCGCGACGTGCGCTTTGCCGACAACCCGCAGCAG
CCCGTGCGCGAACTCATGACGCACGAGAACCTGGCGACCGTGAAGCTCGGTTCGAGTGGCGACGAGGCGCGCCGCCTGCT
GCATCAGCGCCGGATCGAGAAGCTGCTGGTGGTGGACGATGCCTTCCACTGCATTGGCCTCATCACGGTGAAGGACATCG
AGAAGGCGGTCACTTTCCCCAACGCCACCAAGGATGCGGCCGGACGCCTGCGCGTTGCCGCCGCCACGACGGTCGGCGAA
AAAGGCCTCCTGCGCACCCAGGCGCTGGTCGAGGCGGAATGCGACGTGGTGATCATCGACACCGCCCACGGGCACAACCG
TGACGTTGCCCGCGCCGTCGAGGCAGCGAAGAAGCTGTCGAATTCGGTCCAGGTGATCGCCGGCAACGTCGCCACGGCCG
AGGCGACGCGTTCGCTGATCGATGCGGGCGCGGACGGCGTGAAGATCGGCATCGGCCCCGGATCGATCTGCACCACCCGC
ATCGTCGCGGGCGTTGGCGTGCCCCAGCTGACCGCCGTGATGGAATGCGCCGCCGAAGCGGAAAAGTCGGGCGTGCCGGT
CATTGCCGACGGCGGCCTGCGGACTTCGGGCGACGCTGCAAAGGCGCTGGCCGCCGGTGCAAGCTCGGTCATGATCGGGT
CGATGCTTGCCGGCACCGAGGAAGCGCCGGGCGAGACGTTCCTCTACCAGGGACGCGCCTACAAGTCGTATCGCGGCATG
GGTTCGGTGGGTGCGATGGCGCGCGGCAGCGCGGATCGCTATTTCCAGCAGGACATCAAGGACCAAATGAAGCTGGTGCC
TGAAGGCATTGAAGGCCAGGTGCCCTACAAGGGACCGGCCAAGGATGTGGTCCACCAGCTCGTCGGCGGCATCAAGGCCG
CGATGGGCTATACCGGCAGCCCCACGATCGACGATCTGCGCAAGCGCGCGCAGTTCGTGCGCATCACCAATGCGGGCCTG
CGCGAAAGTCACGTCCACGACGTGACGATCACGCGCGAGGCGCCGAACTACAAGGTGGGCTGA

Upstream 100 bases:

>100_bases
AGGCGGAACTGGTCCGCGCATTCGCCGATCCGAAGCGCTATCCGGGGGCCGGATCGAAGCGGGCCCAAACCCCCTAGCGG
AACCCGATCTTCCTGTTTAC

Downstream 100 bases:

>100_bases
GAGCCACCCGATGACCCCTTCCGCCCGCGTACAGGCGGCGATCGATCTGCTTGACGCGGTGATCGCGGCGGCGAAGGCGC
AAGGGGCATCTGCCGATCGG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MGRHESPRTQEVAPIMDIPLGLTFDDVLLRPAESDIVPSQADTRTRLTKGIGLNIPILSSAMDTVTEADMAIVMAQLGGI
GVLHRNLSIEEQCAAVRAVKRFESGMVVNPITISPDAPLGEAQALMRQHKISGIPVVEASGKLVGILTNRDVRFADNPQQ
PVRELMTHENLATVKLGSSGDEARRLLHQRRIEKLLVVDDAFHCIGLITVKDIEKAVTFPNATKDAAGRLRVAAATTVGE
KGLLRTQALVEAECDVVIIDTAHGHNRDVARAVEAAKKLSNSVQVIAGNVATAEATRSLIDAGADGVKIGIGPGSICTTR
IVAGVGVPQLTAVMECAAEAEKSGVPVIADGGLRTSGDAAKALAAGASSVMIGSMLAGTEEAPGETFLYQGRAYKSYRGM
GSVGAMARGSADRYFQQDIKDQMKLVPEGIEGQVPYKGPAKDVVHQLVGGIKAAMGYTGSPTIDDLRKRAQFVRITNAGL
RESHVHDVTITREAPNYKVG

Sequences:

>Translated_500_residues
MGRHESPRTQEVAPIMDIPLGLTFDDVLLRPAESDIVPSQADTRTRLTKGIGLNIPILSSAMDTVTEADMAIVMAQLGGI
GVLHRNLSIEEQCAAVRAVKRFESGMVVNPITISPDAPLGEAQALMRQHKISGIPVVEASGKLVGILTNRDVRFADNPQQ
PVRELMTHENLATVKLGSSGDEARRLLHQRRIEKLLVVDDAFHCIGLITVKDIEKAVTFPNATKDAAGRLRVAAATTVGE
KGLLRTQALVEAECDVVIIDTAHGHNRDVARAVEAAKKLSNSVQVIAGNVATAEATRSLIDAGADGVKIGIGPGSICTTR
IVAGVGVPQLTAVMECAAEAEKSGVPVIADGGLRTSGDAAKALAAGASSVMIGSMLAGTEEAPGETFLYQGRAYKSYRGM
GSVGAMARGSADRYFQQDIKDQMKLVPEGIEGQVPYKGPAKDVVHQLVGGIKAAMGYTGSPTIDDLRKRAQFVRITNAGL
RESHVHDVTITREAPNYKVG
>Mature_499_residues
GRHESPRTQEVAPIMDIPLGLTFDDVLLRPAESDIVPSQADTRTRLTKGIGLNIPILSSAMDTVTEADMAIVMAQLGGIG
VLHRNLSIEEQCAAVRAVKRFESGMVVNPITISPDAPLGEAQALMRQHKISGIPVVEASGKLVGILTNRDVRFADNPQQP
VRELMTHENLATVKLGSSGDEARRLLHQRRIEKLLVVDDAFHCIGLITVKDIEKAVTFPNATKDAAGRLRVAAATTVGEK
GLLRTQALVEAECDVVIIDTAHGHNRDVARAVEAAKKLSNSVQVIAGNVATAEATRSLIDAGADGVKIGIGPGSICTTRI
VAGVGVPQLTAVMECAAEAEKSGVPVIADGGLRTSGDAAKALAAGASSVMIGSMLAGTEEAPGETFLYQGRAYKSYRGMG
SVGAMARGSADRYFQQDIKDQMKLVPEGIEGQVPYKGPAKDVVHQLVGGIKAAMGYTGSPTIDDLRKRAQFVRITNAGLR
ESHVHDVTITREAPNYKVG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=455, Percent_Identity=40, Blast_Score=312, Evalue=5e-85,
Organism=Homo sapiens, GI34328928, Length=455, Percent_Identity=40, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI156616279, Length=455, Percent_Identity=40, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI34328930, Length=455, Percent_Identity=40, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI217035152, Length=476, Percent_Identity=38.4453781512605, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI66933016, Length=481, Percent_Identity=38.045738045738, Blast_Score=301, Evalue=9e-82,
Organism=Homo sapiens, GI217035148, Length=455, Percent_Identity=39.3406593406593, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI217035150, Length=455, Percent_Identity=37.3626373626374, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI50541954, Length=251, Percent_Identity=37.0517928286853, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI50541952, Length=251, Percent_Identity=37.0517928286853, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI50541948, Length=251, Percent_Identity=37.0517928286853, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI50541956, Length=251, Percent_Identity=37.0517928286853, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI156104880, Length=250, Percent_Identity=36.4, Blast_Score=162, Evalue=1e-39,
Organism=Escherichia coli, GI1788855, Length=480, Percent_Identity=57.5, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1786293, Length=223, Percent_Identity=39.4618834080717, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=509, Percent_Identity=34.5776031434185, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI71994389, Length=431, Percent_Identity=36.8909512761021, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17560440, Length=277, Percent_Identity=34.6570397111913, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323585, Length=483, Percent_Identity=40.3726708074534, Blast_Score=326, Evalue=6e-90,
Organism=Saccharomyces cerevisiae, GI6322012, Length=477, Percent_Identity=38.7840670859539, Blast_Score=312, Evalue=9e-86,
Organism=Saccharomyces cerevisiae, GI6323464, Length=461, Percent_Identity=40.3470715835141, Blast_Score=307, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6319352, Length=354, Percent_Identity=37.8531073446328, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6319353, Length=117, Percent_Identity=38.4615384615385, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641071, Length=480, Percent_Identity=38.3333333333333, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24641073, Length=480, Percent_Identity=38.3333333333333, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=38.496583143508, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52848; Mature: 52717

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRHESPRTQEVAPIMDIPLGLTFDDVLLRPAESDIVPSQADTRTRLTKGIGLNIPILSS
CCCCCCCCCCCCCCHHCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHH
AMDTVTEADMAIVMAQLGGIGVLHRNLSIEEQCAAVRAVKRFESGMVVNPITISPDAPLG
HHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCEECCEEECCCCCCH
EAQALMRQHKISGIPVVEASGKLVGILTNRDVRFADNPQQPVRELMTHENLATVKLGSSG
HHHHHHHHHCCCCCEEEECCCCEEEEEECCCEEECCCCHHHHHHHHHCCCEEEEEECCCC
DEARRLLHQRRIEKLLVVDDAFHCIGLITVKDIEKAVTFPNATKDAAGRLRVAAATTVGE
HHHHHHHHHHHHHHEEHCCCCHHHHEEEEHHHHHHHHCCCCCCCHHCCCEEEEEEHHCCC
KGLLRTQALVEAECDVVIIDTAHGHNRDVARAVEAAKKLSNSVQVIAGNVATAEATRSLI
CCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHH
DAGADGVKIGIGPGSICTTRIVAGVGVPQLTAVMECAAEAEKSGVPVIADGGLRTSGDAA
HCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHH
KALAAGASSVMIGSMLAGTEEAPGETFLYQGRAYKSYRGMGSVGAMARGSADRYFQQDIK
HHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHCCCCCCCHHHCCCHHHHHHHHHH
DQMKLVPEGIEGQVPYKGPAKDVVHQLVGGIKAAMGYTGSPTIDDLRKRAQFVRITNAGL
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEECCCC
RESHVHDVTITREAPNYKVG
CCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
GRHESPRTQEVAPIMDIPLGLTFDDVLLRPAESDIVPSQADTRTRLTKGIGLNIPILSS
CCCCCCCCCCCCCHHCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHH
AMDTVTEADMAIVMAQLGGIGVLHRNLSIEEQCAAVRAVKRFESGMVVNPITISPDAPLG
HHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCEECCEEECCCCCCH
EAQALMRQHKISGIPVVEASGKLVGILTNRDVRFADNPQQPVRELMTHENLATVKLGSSG
HHHHHHHHHCCCCCEEEECCCCEEEEEECCCEEECCCCHHHHHHHHHCCCEEEEEECCCC
DEARRLLHQRRIEKLLVVDDAFHCIGLITVKDIEKAVTFPNATKDAAGRLRVAAATTVGE
HHHHHHHHHHHHHHEEHCCCCHHHHEEEEHHHHHHHHCCCCCCCHHCCCEEEEEEHHCCC
KGLLRTQALVEAECDVVIIDTAHGHNRDVARAVEAAKKLSNSVQVIAGNVATAEATRSLI
CCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHH
DAGADGVKIGIGPGSICTTRIVAGVGVPQLTAVMECAAEAEKSGVPVIADGGLRTSGDAA
HCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHH
KALAAGASSVMIGSMLAGTEEAPGETFLYQGRAYKSYRGMGSVGAMARGSADRYFQQDIK
HHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHCCCCCCCHHHCCCHHHHHHHHHH
DQMKLVPEGIEGQVPYKGPAKDVVHQLVGGIKAAMGYTGSPTIDDLRKRAQFVRITNAGL
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEECCCC
RESHVHDVTITREAPNYKVG
CCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA