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The map label for this gene is 87199619

Identifier: 87199619

GI number: 87199619

Start: 1666217

End: 1667824

Strand: Direct

Name: 87199619

Synonym: Saro_1602

Alternate gene names: NA

Gene position: 1666217-1667824 (Clockwise)

Preceding gene: 87199617

Following gene: 87199620

Centisome position: 46.78

GC content: 64.37

Gene sequence:

>1608_bases
ATGACGCTAAGGCTCAACGTTCATGGTGCGGCACGGACGGTTACCGGATCGTGCTTCGAATTTGTCCTCGGGGACATGCG
CTTGCTCGTGGACTGCGGCCTGTTCCAGGGCTCCCGCTCGCTGGAAGCGCTCAACCACGAGCCGCTCGACTTTGACGTGC
ACAAGATCGACGGCGTCATCGTCACTCACGCCCATATCGATCACAGTGGCCTGCTGCCACGGCTTGCTGCCGAAGGCTAC
GAAGGGCCGATCTGGTGCACTCCGGAGACCGCAGCCCTCCTCAAGGTCATGCTGGCGGATGCCGGGCGCATCCAGGAAAG
CGAGGCCGAGCGCCGCAATCGCCGTCGCGACCGCGCGGGCGAGCCTGAATTCACGCCGATCTATACCGAGGAAGATGCGT
CCGCCGCGTGCTCGCTCACCCGGACAATCCCGCTTGGCGAGTGGTTCGATCCGGCTCCCGGATTTCGTGCGCGGTTCTGG
AACGCGGGGCATATCCTCGGTTCTGCATCGGTCGAACTGGTCGCCGATGGAACACGTGTCATGTGTTCGGGGGATGTCGG
CCCGGCCAACAAGGCGTTCCACCCAGATCCGCTGACACCTGCTGGCTTCGATCACGTCATTTGCGAATCCACGTATGGAG
ACCGCAAGCGCGAGAAGGTGACGGTCGAGGAGCGGCGCAAGCTGCTGGAGGCCGAAATCCTTGCGGCGCGGGCGCGCGGC
GGCAACCTGGTCGTTCCCTCGTTCGCGCTGGAGCGCACGCAGGAACTGCTGCTCGACATAGCGATGCTTTCCGACAGTGG
CCGCATCGGCAACGCGATGGTGTTCGTCGATTCGCCGCTGGCCAACCGCGCCACCGAAGTGTTTCAGCGCTATGTCGGAG
AACTCGAGGATACCGGCGGTCGAGACGTGTTCCGGCATCCCTCGATCCACTACGTGACCGACGTCGCCGAATCCATGCGG
CTCAACACTATATCGGGCGCGATCATCCTGGCCGCATCCGGCATGTGCGAGGCGGGACGCATCCGCCACCATCTATTCCA
CAACCTGTCACGCCGGGATTCAACGGTTCTGTTTGTCGGGTTCCAGGCCGAGGGATCGCTGGGGCGTGTCATTCTGGACG
GGGCCCAGCGGGTGCGCATATCGGGGCGCGACGTTGCCGTGCGCGCGCAGATCAGGCGGATCGACAGCTATTCCGCCCAT
GCCGATCAGGAGGAACTGCTGGGCTGGATCGCGAATTGCGGTCCCGTCGCGGGAAGCCTGATCCTCGATCATGGTGAACC
GGGCGCCATCGAAAGCCTGCGCCAGCTCGCCCAGGGGCGCGGCCTTGCGCCGACCATCATCGTACCGGAGATTGGCGAGC
AGTACGAACTTCCCGCAGGCCAGTCGGCAAGGCGTACCCGGACGGGGAGGACGGACCTTGGCCAGGCCATCGGGCGCGAC
TGGCAGAACAACTATGCGGACTTCGCAACCAACCTGAAGCGGCGTCTTGCGCAGATCGAGGATGCGCGAACCCGCCAGAA
GGCTCTCGAGGAAATGCGCGCGGTACTCGACCGCTACGCCGCTTTCCGCGAGTCCCGCAGGAAAACGTCCCACACGCGGC
ACGACTGA

Upstream 100 bases:

>100_bases
CCCCGGAGCGCCCGTTTAGACAGGAAACCGTTGCACGTTCAAGTGCCGTTCCGGCAAACCCCTGCTTGCCAGTGGCGTTG
GGGCGGATCATGCTGGATCC

Downstream 100 bases:

>100_bases
CGTCCGATTCAAAGGGTTCAAAGCCCATTCGCTTGACTGCGTGAACGTTCTCATATAGGTGAACGTTCACAACAGGCGCT
CGGCGTCGAATCCGTGTGAT

Product: beta-lactamase-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTLRLNVHGAARTVTGSCFEFVLGDMRLLVDCGLFQGSRSLEALNHEPLDFDVHKIDGVIVTHAHIDHSGLLPRLAAEGY
EGPIWCTPETAALLKVMLADAGRIQESEAERRNRRRDRAGEPEFTPIYTEEDASAACSLTRTIPLGEWFDPAPGFRARFW
NAGHILGSASVELVADGTRVMCSGDVGPANKAFHPDPLTPAGFDHVICESTYGDRKREKVTVEERRKLLEAEILAARARG
GNLVVPSFALERTQELLLDIAMLSDSGRIGNAMVFVDSPLANRATEVFQRYVGELEDTGGRDVFRHPSIHYVTDVAESMR
LNTISGAIILAASGMCEAGRIRHHLFHNLSRRDSTVLFVGFQAEGSLGRVILDGAQRVRISGRDVAVRAQIRRIDSYSAH
ADQEELLGWIANCGPVAGSLILDHGEPGAIESLRQLAQGRGLAPTIIVPEIGEQYELPAGQSARRTRTGRTDLGQAIGRD
WQNNYADFATNLKRRLAQIEDARTRQKALEEMRAVLDRYAAFRESRRKTSHTRHD

Sequences:

>Translated_535_residues
MTLRLNVHGAARTVTGSCFEFVLGDMRLLVDCGLFQGSRSLEALNHEPLDFDVHKIDGVIVTHAHIDHSGLLPRLAAEGY
EGPIWCTPETAALLKVMLADAGRIQESEAERRNRRRDRAGEPEFTPIYTEEDASAACSLTRTIPLGEWFDPAPGFRARFW
NAGHILGSASVELVADGTRVMCSGDVGPANKAFHPDPLTPAGFDHVICESTYGDRKREKVTVEERRKLLEAEILAARARG
GNLVVPSFALERTQELLLDIAMLSDSGRIGNAMVFVDSPLANRATEVFQRYVGELEDTGGRDVFRHPSIHYVTDVAESMR
LNTISGAIILAASGMCEAGRIRHHLFHNLSRRDSTVLFVGFQAEGSLGRVILDGAQRVRISGRDVAVRAQIRRIDSYSAH
ADQEELLGWIANCGPVAGSLILDHGEPGAIESLRQLAQGRGLAPTIIVPEIGEQYELPAGQSARRTRTGRTDLGQAIGRD
WQNNYADFATNLKRRLAQIEDARTRQKALEEMRAVLDRYAAFRESRRKTSHTRHD
>Mature_534_residues
TLRLNVHGAARTVTGSCFEFVLGDMRLLVDCGLFQGSRSLEALNHEPLDFDVHKIDGVIVTHAHIDHSGLLPRLAAEGYE
GPIWCTPETAALLKVMLADAGRIQESEAERRNRRRDRAGEPEFTPIYTEEDASAACSLTRTIPLGEWFDPAPGFRARFWN
AGHILGSASVELVADGTRVMCSGDVGPANKAFHPDPLTPAGFDHVICESTYGDRKREKVTVEERRKLLEAEILAARARGG
NLVVPSFALERTQELLLDIAMLSDSGRIGNAMVFVDSPLANRATEVFQRYVGELEDTGGRDVFRHPSIHYVTDVAESMRL
NTISGAIILAASGMCEAGRIRHHLFHNLSRRDSTVLFVGFQAEGSLGRVILDGAQRVRISGRDVAVRAQIRRIDSYSAHA
DQEELLGWIANCGPVAGSLILDHGEPGAIESLRQLAQGRGLAPTIIVPEIGEQYELPAGQSARRTRTGRTDLGQAIGRDW
QNNYADFATNLKRRLAQIEDARTRQKALEEMRAVLDRYAAFRESRRKTSHTRHD

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=432, Percent_Identity=25.462962962963, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI33300633, Length=478, Percent_Identity=24.8953974895398, Blast_Score=124, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32566029, Length=436, Percent_Identity=26.8348623853211, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32564696, Length=443, Percent_Identity=25.0564334085779, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6323307, Length=452, Percent_Identity=25.4424778761062, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24648013, Length=447, Percent_Identity=26.3982102908277, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI21358523, Length=448, Percent_Identity=25.6696428571429, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 59037; Mature: 58906

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRLNVHGAARTVTGSCFEFVLGDMRLLVDCGLFQGSRSLEALNHEPLDFDVHKIDGVI
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEECCEE
VTHAHIDHSGLLPRLAAEGYEGPIWCTPETAALLKVMLADAGRIQESEAERRNRRRDRAG
EEEEECCCCCCCHHHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
EPEFTPIYTEEDASAACSLTRTIPLGEWFDPAPGFRARFWNAGHILGSASVELVADGTRV
CCCCCCEEECCCCHHHHEEEEECCCCCCCCCCCCCHHEEECCCEEECCCCEEEEECCCEE
MCSGDVGPANKAFHPDPLTPAGFDHVICESTYGDRKREKVTVEERRKLLEAEILAARARG
EEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCC
GNLVVPSFALERTQELLLDIAMLSDSGRIGNAMVFVDSPLANRATEVFQRYVGELEDTGG
CCEEECHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCC
RDVFRHPSIHYVTDVAESMRLNTISGAIILAASGMCEAGRIRHHLFHNLSRRDSTVLFVG
CCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEE
FQAEGSLGRVILDGAQRVRISGRDVAVRAQIRRIDSYSAHADQEELLGWIANCGPVAGSL
EECCCCCCCEEECCCCEEEECCCCEEEHHHHHHHHCCCCCCCHHHHHHHHHCCCHHCCCE
ILDHGEPGAIESLRQLAQGRGLAPTIIVPEIGEQYELPAGQSARRTRTGRTDLGQAIGRD
EEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHCCCCCHHHHHHHCCC
WQNNYADFATNLKRRLAQIEDARTRQKALEEMRAVLDRYAAFRESRRKTSHTRHD
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLRLNVHGAARTVTGSCFEFVLGDMRLLVDCGLFQGSRSLEALNHEPLDFDVHKIDGVI
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEECCEE
VTHAHIDHSGLLPRLAAEGYEGPIWCTPETAALLKVMLADAGRIQESEAERRNRRRDRAG
EEEEECCCCCCCHHHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
EPEFTPIYTEEDASAACSLTRTIPLGEWFDPAPGFRARFWNAGHILGSASVELVADGTRV
CCCCCCEEECCCCHHHHEEEEECCCCCCCCCCCCCHHEEECCCEEECCCCEEEEECCCEE
MCSGDVGPANKAFHPDPLTPAGFDHVICESTYGDRKREKVTVEERRKLLEAEILAARARG
EEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCC
GNLVVPSFALERTQELLLDIAMLSDSGRIGNAMVFVDSPLANRATEVFQRYVGELEDTGG
CCEEECHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCC
RDVFRHPSIHYVTDVAESMRLNTISGAIILAASGMCEAGRIRHHLFHNLSRRDSTVLFVG
CCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEE
FQAEGSLGRVILDGAQRVRISGRDVAVRAQIRRIDSYSAHADQEELLGWIANCGPVAGSL
EECCCCCCCEEECCCCEEEECCCCEEEHHHHHHHHCCCCCCCHHHHHHHHHCCCHHCCCE
ILDHGEPGAIESLRQLAQGRGLAPTIIVPEIGEQYELPAGQSARRTRTGRTDLGQAIGRD
EEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHCCCCCHHHHHHHCCC
WQNNYADFATNLKRRLAQIEDARTRQKALEEMRAVLDRYAAFRESRRKTSHTRHD
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA