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The map label for this gene is pcaK [H]

Identifier: 87199605

GI number: 87199605

Start: 1646637

End: 1647869

Strand: Direct

Name: pcaK [H]

Synonym: Saro_1588

Alternate gene names: 87199605

Gene position: 1646637-1647869 (Clockwise)

Preceding gene: 87199604

Following gene: 87199606

Centisome position: 46.23

GC content: 68.37

Gene sequence:

>1233_bases
ATGGCTATCCCACCCACTGCGCCTGCCGGCGAAGGGCCGGCAAGCTGGACCCGCAAGGGCCTTGCCATCGTGGCGCTGTG
CTTTGCGATCAACATGGCGGACGGGGTCGACGTGACGATCCTGTCCTTCATCGCACCGCGTCTCCAGGCGGAGTGGGGCA
TCGGGTCCGACACGATGGGCAGCCTGTTCAGCGCGGGGCTGATCGGCATGGCGATAGGTGGCATGTTCATCGCCCCGCTG
GCCGATCGGCTGGGCCGGCGCGCTGTGATCCTGGCGGCGCTCGCGCTGATGTCGCTCGGCATGCTGGCGAGCAGCTTCGC
GGGCAGCGTCTCGTTCCTGTTCGCGATGCGCGTTCTGGTCGGTTCCGGCATCGGCACGGTGCTGGCGGCAATGGCGGCGC
TTGCGGCCGAGAGTGCGCCGCCGGATCGGCGCAACCTGGCGGTTGGCGTAGTCCAGGCGGGTTATCCTTTCGCGGCGGTG
TTCACCGGCCTGATCGTGGCGAAGCTGCTGCCGGTACATGGCTGGCAGGCGATGCTGCTGGGCGCGGCGGTGTTGACGGT
CGTGCTTTTCCCCGCGGCGTGGTTCGTACTGCCGCGAGGCCGTCCGGTTGCGTCGGGCGCCGCGGCCGGCGGCAAAGCAC
CGGACGCGGGGAGGGTGTCCCACCTGTTCTCCCCCGAGCTGCGCGCGCGCACCATCGCGCTGTGGAGCGCGGTCTTTTTC
GGCCTGATGGTGCTCTACTTCATCGTCAGCTGGATACCGAAGCTGTCCATCGCCGCCGGTCTGTCGGAGACGAACGGCAT
CTATGCCGGCGCGCTCTACAACCTGGGCGCGTTCGTCGGCACGATGGCGATGAGCTTTCTCGCGCTGCGGGTTCCGCTGG
GCAGGCTGGTGCCGACGATGCTTGTCCTTGCCGGGGCGGCGATGATCCTGTTCGGGTCGGTCGCCATGCCGGTCTGGCTC
ACACTGGTCGTTGCGTTTGCCATCGGTGTGCTGCTGCAAGGGGGCTACAACGGGGTCTGGCCCATCGCTGCGGGTGCCTA
TCCCGACGCGCTGCGCGCAACGGGCGTGGGCTGGGCGATCGGCGTTGGCCGGGGCGGCGCGGTGATCGGCCCGATGCTGG
GTGGATACCTCATGGCCGCGAGCGCGCCGCTGCCCATTCTCTTTGCCGCCTATTGCGTCCCGCTGGTCATCTGCGCCGGT
GCTGCGTTCCTCGTCGAGCGCTACAAAATGTAA

Upstream 100 bases:

>100_bases
GACTGACCGCGCGGCGGTGCGGGCAGGGCGCCGGATCGCCCTGCCGGCAACCACATGCGGATCGGCCACTCGTCCCCCGG
ACCAGTCAAGGAGAGGACGA

Downstream 100 bases:

>100_bases
CCAACCAGTCACAGTTTATTTGACAGGGACTAGTTCGTAACATAAATGCGACCTCGTGAAGGGCTACGACTCAAGTGGCC
CGTGGAGGAGGATGACATGC

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MAIPPTAPAGEGPASWTRKGLAIVALCFAINMADGVDVTILSFIAPRLQAEWGIGSDTMGSLFSAGLIGMAIGGMFIAPL
ADRLGRRAVILAALALMSLGMLASSFAGSVSFLFAMRVLVGSGIGTVLAAMAALAAESAPPDRRNLAVGVVQAGYPFAAV
FTGLIVAKLLPVHGWQAMLLGAAVLTVVLFPAAWFVLPRGRPVASGAAAGGKAPDAGRVSHLFSPELRARTIALWSAVFF
GLMVLYFIVSWIPKLSIAAGLSETNGIYAGALYNLGAFVGTMAMSFLALRVPLGRLVPTMLVLAGAAMILFGSVAMPVWL
TLVVAFAIGVLLQGGYNGVWPIAAGAYPDALRATGVGWAIGVGRGGAVIGPMLGGYLMAASAPLPILFAAYCVPLVICAG
AAFLVERYKM

Sequences:

>Translated_410_residues
MAIPPTAPAGEGPASWTRKGLAIVALCFAINMADGVDVTILSFIAPRLQAEWGIGSDTMGSLFSAGLIGMAIGGMFIAPL
ADRLGRRAVILAALALMSLGMLASSFAGSVSFLFAMRVLVGSGIGTVLAAMAALAAESAPPDRRNLAVGVVQAGYPFAAV
FTGLIVAKLLPVHGWQAMLLGAAVLTVVLFPAAWFVLPRGRPVASGAAAGGKAPDAGRVSHLFSPELRARTIALWSAVFF
GLMVLYFIVSWIPKLSIAAGLSETNGIYAGALYNLGAFVGTMAMSFLALRVPLGRLVPTMLVLAGAAMILFGSVAMPVWL
TLVVAFAIGVLLQGGYNGVWPIAAGAYPDALRATGVGWAIGVGRGGAVIGPMLGGYLMAASAPLPILFAAYCVPLVICAG
AAFLVERYKM
>Mature_409_residues
AIPPTAPAGEGPASWTRKGLAIVALCFAINMADGVDVTILSFIAPRLQAEWGIGSDTMGSLFSAGLIGMAIGGMFIAPLA
DRLGRRAVILAALALMSLGMLASSFAGSVSFLFAMRVLVGSGIGTVLAAMAALAAESAPPDRRNLAVGVVQAGYPFAAVF
TGLIVAKLLPVHGWQAMLLGAAVLTVVLFPAAWFVLPRGRPVASGAAAGGKAPDAGRVSHLFSPELRARTIALWSAVFFG
LMVLYFIVSWIPKLSIAAGLSETNGIYAGALYNLGAFVGTMAMSFLALRVPLGRLVPTMLVLAGAAMILFGSVAMPVWLT
LVVAFAIGVLLQGGYNGVWPIAAGAYPDALRATGVGWAIGVGRGGAVIGPMLGGYLMAASAPLPILFAAYCVPLVICAGA
AFLVERYKM

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=415, Percent_Identity=26.0240963855422, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI87081723, Length=377, Percent_Identity=30.7692307692308, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082231, Length=203, Percent_Identity=29.5566502463054, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082159, Length=389, Percent_Identity=22.879177377892, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=408, Percent_Identity=25.4901960784314, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922874, Length=392, Percent_Identity=24.7448979591837, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24640198, Length=139, Percent_Identity=28.0575539568345, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24640196, Length=139, Percent_Identity=28.0575539568345, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24640200, Length=139, Percent_Identity=28.0575539568345, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41924; Mature: 41793

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPPTAPAGEGPASWTRKGLAIVALCFAINMADGVDVTILSFIAPRLQAEWGIGSDTMG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
SLFSAGLIGMAIGGMFIAPLADRLGRRAVILAALALMSLGMLASSFAGSVSFLFAMRVLV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSGIGTVLAAMAALAAESAPPDRRNLAVGVVQAGYPFAAVFTGLIVAKLLPVHGWQAMLL
CCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHH
GAAVLTVVLFPAAWFVLPRGRPVASGAAAGGKAPDAGRVSHLFSPELRARTIALWSAVFF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHH
GLMVLYFIVSWIPKLSIAAGLSETNGIYAGALYNLGAFVGTMAMSFLALRVPLGRLVPTM
HHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LVLAGAAMILFGSVAMPVWLTLVVAFAIGVLLQGGYNGVWPIAAGAYPDALRATGVGWAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEE
GVGRGGAVIGPMLGGYLMAASAPLPILFAAYCVPLVICAGAAFLVERYKM
ECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIPPTAPAGEGPASWTRKGLAIVALCFAINMADGVDVTILSFIAPRLQAEWGIGSDTMG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
SLFSAGLIGMAIGGMFIAPLADRLGRRAVILAALALMSLGMLASSFAGSVSFLFAMRVLV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSGIGTVLAAMAALAAESAPPDRRNLAVGVVQAGYPFAAVFTGLIVAKLLPVHGWQAMLL
CCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHH
GAAVLTVVLFPAAWFVLPRGRPVASGAAAGGKAPDAGRVSHLFSPELRARTIALWSAVFF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHH
GLMVLYFIVSWIPKLSIAAGLSETNGIYAGALYNLGAFVGTMAMSFLALRVPLGRLVPTM
HHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LVLAGAAMILFGSVAMPVWLTLVVAFAIGVLLQGGYNGVWPIAAGAYPDALRATGVGWAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEE
GVGRGGAVIGPMLGGYLMAASAPLPILFAAYCVPLVICAGAAFLVERYKM
ECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]