Click here to switch to the map view.

The map label for this gene is kdpD [H]

Identifier: 87199529

GI number: 87199529

Start: 1554185

End: 1555621

Strand: Reverse

Name: kdpD [H]

Synonym: Saro_1511

Alternate gene names: 87199529

Gene position: 1555621-1554185 (Counterclockwise)

Preceding gene: 87199530

Following gene: 87199528

Centisome position: 43.68

GC content: 64.93

Gene sequence:

>1437_bases
ATGACCCGAGCCGTAGCCGCCTATCCCAAAGCATTGCTCGCGGTCGCGGCGGTCACCTGGATCACTGCGGCGCAGTTGCC
ATTGCTAGGCCTAGCCTCGTCAGCAATGCTGTTTCTGCTGCCCGTTCTAATCTCAGCCGTGCGCGGTGGAGTGGGGCCCG
GCCTAACGGCGGCGCTAACCGGTGCGGCCGCCTACAATTTCTTCCTGCTGGAGCCGCGCTACACGTTTCGCGTTCACCAG
TTGGACAATCTGGTCAGCCTTCTCGTCCTCGTTGCCGTGGCGCTAGTGACCAGCCGCCTCGCCTCTCGTCTGATGATGCG
CGAGGCGGAAGCAGTGGAACGGGCCCGACTCAGCGATGAACTGGCCGAGCTTTCAGGCCTGCTCTCCAGCCACCCCGCAC
AGCCGGCACTTGAGCGGGGTATAGCCCTGCTGGAGGCCCGCTACGGCAAGCTGGAACTGCTGCTGCCCCATGCGGGCCGG
ATTCAGGAGAACGAAGCCTTTTCCTCACTCGATGCCTCGGCGGCAGCCTGGTCCGCACACAACGGCGACATCACAGGGCA
CGGCACCGCAACGATGCCGGTCGCCGACTGGACCTTCCTGCCGCTGAGCCCGAGGAACCGCCACGATATTAGCGTCATGG
CACTGGCGCGGCCGATGGACGGTACCGTGCGCGCGGCATCCGAACTCGATCACCTGCGGCAGTTGGCCATGCTACTCGGA
CAGTGCCTGGACCGCGACGCGCTGGAGGCCGAACGACGAGAACGCGAACTGCTCGAGGAGCGGGACCGTCTGCGGCGCAC
GCTCCTCGCCTCGCTCGCCCACGATTTCCGTACGCCGCTCACGATCATCACGGGGCGGCTTGCTGAACTTGCCTCGGGCA
ATCCTGCCGCGACCGACGCGCTGGCCGCCGCGCAGCGAATGGACCGGATGATGAATGACCTGATCGGTGCGGCCCGGATC
GAGGCGGGAGCGCTGGAACCGGTGCTTGAAAGCATAGACCTCGTCGATGTCGTCGGTGCCGCGTGCGAGGGCCTGATCCA
GCCTCATGGGGTCGCGCTAAAACAGAGCATTCCCGCCGACCTCCCCTTCGTCCGCGGCGATCCCGTGTTGTTGCAACACC
TGATCGCCAACCTCATCGACAATGGCATTTGTCACGCGCGCAGTACCGTGGTCGTGAGTGCTGCAAAGCAATCGGGCCTC
GTGCTTTTGCGGGTAAGTGACGATGGCCCGGGCATCCCGGAGGGTGAACGGCAGCGCATCTTCGAGCGTTTTGCCCGGAT
CGAAGGGACCGACCGCACCCAAGGCAGCGGTCTGGGCCTTGCCATTGTAAAAGGGTTTGGCGATGTCATGGGCATGGCCG
TCACGGTTACTTCCGCGCCTTCTGGTGGGGCGCTCTTCACCGTTGCCATGCCGCGCGCCGGGCGAGCCGGAACATGA

Upstream 100 bases:

>100_bases
TGTTCCTGCATCGCAACGCCGCCGATCCTACCGCCTATTTTTCGATTCCGTCGAACCGCGTTGTCGAACTGGGCAGCCAA
ATCGAGCTATAAGGCAAATC

Downstream 100 bases:

>100_bases
GCACGGTCCTGTGCATCGACGATGAACCAGCCATTCTGCGCTTGCTGTCAGTCGTGCTCGCAGCCGATGGACATGAAGTT
ATGACGGCTACCGCTGGTCG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MTRAVAAYPKALLAVAAVTWITAAQLPLLGLASSAMLFLLPVLISAVRGGVGPGLTAALTGAAAYNFFLLEPRYTFRVHQ
LDNLVSLLVLVAVALVTSRLASRLMMREAEAVERARLSDELAELSGLLSSHPAQPALERGIALLEARYGKLELLLPHAGR
IQENEAFSSLDASAAAWSAHNGDITGHGTATMPVADWTFLPLSPRNRHDISVMALARPMDGTVRAASELDHLRQLAMLLG
QCLDRDALEAERRERELLEERDRLRRTLLASLAHDFRTPLTIITGRLAELASGNPAATDALAAAQRMDRMMNDLIGAARI
EAGALEPVLESIDLVDVVGAACEGLIQPHGVALKQSIPADLPFVRGDPVLLQHLIANLIDNGICHARSTVVVSAAKQSGL
VLLRVSDDGPGIPEGERQRIFERFARIEGTDRTQGSGLGLAIVKGFGDVMGMAVTVTSAPSGGALFTVAMPRAGRAGT

Sequences:

>Translated_478_residues
MTRAVAAYPKALLAVAAVTWITAAQLPLLGLASSAMLFLLPVLISAVRGGVGPGLTAALTGAAAYNFFLLEPRYTFRVHQ
LDNLVSLLVLVAVALVTSRLASRLMMREAEAVERARLSDELAELSGLLSSHPAQPALERGIALLEARYGKLELLLPHAGR
IQENEAFSSLDASAAAWSAHNGDITGHGTATMPVADWTFLPLSPRNRHDISVMALARPMDGTVRAASELDHLRQLAMLLG
QCLDRDALEAERRERELLEERDRLRRTLLASLAHDFRTPLTIITGRLAELASGNPAATDALAAAQRMDRMMNDLIGAARI
EAGALEPVLESIDLVDVVGAACEGLIQPHGVALKQSIPADLPFVRGDPVLLQHLIANLIDNGICHARSTVVVSAAKQSGL
VLLRVSDDGPGIPEGERQRIFERFARIEGTDRTQGSGLGLAIVKGFGDVMGMAVTVTSAPSGGALFTVAMPRAGRAGT
>Mature_477_residues
TRAVAAYPKALLAVAAVTWITAAQLPLLGLASSAMLFLLPVLISAVRGGVGPGLTAALTGAAAYNFFLLEPRYTFRVHQL
DNLVSLLVLVAVALVTSRLASRLMMREAEAVERARLSDELAELSGLLSSHPAQPALERGIALLEARYGKLELLLPHAGRI
QENEAFSSLDASAAAWSAHNGDITGHGTATMPVADWTFLPLSPRNRHDISVMALARPMDGTVRAASELDHLRQLAMLLGQ
CLDRDALEAERRERELLEERDRLRRTLLASLAHDFRTPLTIITGRLAELASGNPAATDALAAAQRMDRMMNDLIGAARIE
AGALEPVLESIDLVDVVGAACEGLIQPHGVALKQSIPADLPFVRGDPVLLQHLIANLIDNGICHARSTVVVSAAKQSGLV
LLRVSDDGPGIPEGERQRIFERFARIEGTDRTQGSGLGLAIVKGFGDVMGMAVTVTSAPSGGALFTVAMPRAGRAGT

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=487, Percent_Identity=29.1581108829569, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=30.0884955752212, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI145693157, Length=229, Percent_Identity=31.4410480349345, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789149, Length=228, Percent_Identity=29.3859649122807, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787894, Length=226, Percent_Identity=30.0884955752212, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787374, Length=273, Percent_Identity=27.4725274725275, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87081816, Length=240, Percent_Identity=28.3333333333333, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=28.4444444444444, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=248, Percent_Identity=24.1935483870968, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=28.8888888888889, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI48994928, Length=427, Percent_Identity=24.824355971897, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786783, Length=216, Percent_Identity=30.0925925925926, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790861, Length=243, Percent_Identity=27.9835390946502, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=27.1186440677966, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=213, Percent_Identity=29.1079812206573, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50745; Mature: 50614

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAVAAYPKALLAVAAVTWITAAQLPLLGLASSAMLFLLPVLISAVRGGVGPGLTAALT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
GAAAYNFFLLEPRYTFRVHQLDNLVSLLVLVAVALVTSRLASRLMMREAEAVERARLSDE
HHHHEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAELSGLLSSHPAQPALERGIALLEARYGKLELLLPHAGRIQENEAFSSLDASAAAWSAH
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHCCCHHHHCCCC
NGDITGHGTATMPVADWTFLPLSPRNRHDISVMALARPMDGTVRAASELDHLRQLAMLLG
CCCCCCCCCEECEECCEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
QCLDRDALEAERRERELLEERDRLRRTLLASLAHDFRTPLTIITGRLAELASGNPAATDA
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHH
LAAAQRMDRMMNDLIGAARIEAGALEPVLESIDLVDVVGAACEGLIQPHGVALKQSIPAD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCC
LPFVRGDPVLLQHLIANLIDNGICHARSTVVVSAAKQSGLVLLRVSDDGPGIPEGERQRI
CCCCCCCHHHHHHHHHHHHCCCCHHCCCCEEEEECCCCCEEEEEECCCCCCCCCHHHHHH
FERFARIEGTDRTQGSGLGLAIVKGFGDVMGMAVTVTSAPSGGALFTVAMPRAGRAGT
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCEEEEEEECCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
TRAVAAYPKALLAVAAVTWITAAQLPLLGLASSAMLFLLPVLISAVRGGVGPGLTAALT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
GAAAYNFFLLEPRYTFRVHQLDNLVSLLVLVAVALVTSRLASRLMMREAEAVERARLSDE
HHHHEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAELSGLLSSHPAQPALERGIALLEARYGKLELLLPHAGRIQENEAFSSLDASAAAWSAH
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHCCCHHHHCCCC
NGDITGHGTATMPVADWTFLPLSPRNRHDISVMALARPMDGTVRAASELDHLRQLAMLLG
CCCCCCCCCEECEECCEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
QCLDRDALEAERRERELLEERDRLRRTLLASLAHDFRTPLTIITGRLAELASGNPAATDA
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHH
LAAAQRMDRMMNDLIGAARIEAGALEPVLESIDLVDVVGAACEGLIQPHGVALKQSIPAD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCC
LPFVRGDPVLLQHLIANLIDNGICHARSTVVVSAAKQSGLVLLRVSDDGPGIPEGERQRI
CCCCCCCHHHHHHHHHHHHCCCCHHCCCCEEEEECCCCCEEEEEECCCCCCCCCHHHHHH
FERFARIEGTDRTQGSGLGLAIVKGFGDVMGMAVTVTSAPSGGALFTVAMPRAGRAGT
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCEEEEEEECCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1532388; 8905232; 9278503; 7499326 [H]