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The map label for this gene is ccmE

Identifier: 87199410

GI number: 87199410

Start: 1432970

End: 1433440

Strand: Direct

Name: ccmE

Synonym: Saro_1389

Alternate gene names: 87199410

Gene position: 1432970-1433440 (Clockwise)

Preceding gene: 87199409

Following gene: 87199411

Centisome position: 40.23

GC content: 64.54

Gene sequence:

>471_bases
ATGAACGCGACAAAGGCCCCGGGCGGCATAAAGCCCAAGCACCAGCGGCTTGTCCTGCTCGTCATCGCGCTTGTGGCGCT
GATTGGCGCGGGGCTTCTGGCCGCCTATGCCTTGTCCAACCAGGCGAGCTACTTCTACGTGCCCAACGACTTGGTGAAGA
ACCCGCCCGAGCAGGGCCGCGCGATCCGCTTGGGCGGCATGGTCCAGAAGGGCTCGCTCAAGACCCGGGCGGACGGCATC
ACCATCGATTTCGTCGTGGGCGACGGCAAGGCGCGCGTACCCGTGCGCTATACCGGCATTACCCCTGACCTGTTCGTCGA
AGGCTCCGGGGTGGTCGCGGAAGGGCGCATGGAGGGGCAGACTTTCGTCGCCGACAATCTCCTCGCCAAGCATGACGAAA
ACTATGTCCCCCGCCAGATGGGCGACATGACGAAAGCCCAGGCCGAGGCCGTGGTGGCGGAGACGAAATGA

Upstream 100 bases:

>100_bases
CCGCGCTGGCGATCGGTCTGGTCGGCACGCTGTTGCTGGTCGGCTGGACGCTCGCGGCGATGGTCCGCGCGGAACGGCGG
CGCGACAAGGTCAGAGGCAA

Downstream 100 bases:

>100_bases
TCGCTGAACTCGGTCTTGCCGTCCTGTGGATGGCGGCGGCGCTTGCCGCCTTGCAGCTTTTCGCCGGCGTTTCGGCCCTG
CGCCCAGGCGGCGGGGCGGC

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MNATKAPGGIKPKHQRLVLLVIALVALIGAGLLAAYALSNQASYFYVPNDLVKNPPEQGRAIRLGGMVQKGSLKTRADGI
TIDFVVGDGKARVPVRYTGITPDLFVEGSGVVAEGRMEGQTFVADNLLAKHDENYVPRQMGDMTKAQAEAVVAETK

Sequences:

>Translated_156_residues
MNATKAPGGIKPKHQRLVLLVIALVALIGAGLLAAYALSNQASYFYVPNDLVKNPPEQGRAIRLGGMVQKGSLKTRADGI
TIDFVVGDGKARVPVRYTGITPDLFVEGSGVVAEGRMEGQTFVADNLLAKHDENYVPRQMGDMTKAQAEAVVAETK
>Mature_156_residues
MNATKAPGGIKPKHQRLVLLVIALVALIGAGLLAAYALSNQASYFYVPNDLVKNPPEQGRAIRLGGMVQKGSLKTRADGI
TIDFVVGDGKARVPVRYTGITPDLFVEGSGVVAEGRMEGQTFVADNLLAKHDENYVPRQMGDMTKAQAEAVVAETK

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=128, Percent_Identity=40.625, Blast_Score=92, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_NOVAD (Q2G8J0)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496667.1
- ProteinModelPortal:   Q2G8J0
- SMR:   Q2G8J0
- STRING:   Q2G8J0
- GeneID:   3917844
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1389
- NMPDR:   fig|48935.1.peg.1245
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- PhylomeDB:   Q2G8J0
- ProtClustDB:   PRK13254
- BioCyc:   NARO279238:SARO_1389-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 16606; Mature: 16606

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: BINDING 131-131

Signals:

None

Transmembrane regions:

HASH(0x1556e3f8)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATKAPGGIKPKHQRLVLLVIALVALIGAGLLAAYALSNQASYFYVPNDLVKNPPEQGR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCC
AIRLGGMVQKGSLKTRADGITIDFVVGDGKARVPVRYTGITPDLFVEGSGVVAEGRMEGQ
EEEECCEEECCCCCCCCCCEEEEEEECCCCEECCEEECCCCCCEEECCCCEEECCCCCCC
TFVADNLLAKHDENYVPRQMGDMTKAQAEAVVAETK
EEEHHHHHHHCCCCCCCHHHHHHHHHHHHHEEECCH
>Mature Secondary Structure
MNATKAPGGIKPKHQRLVLLVIALVALIGAGLLAAYALSNQASYFYVPNDLVKNPPEQGR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCC
AIRLGGMVQKGSLKTRADGITIDFVVGDGKARVPVRYTGITPDLFVEGSGVVAEGRMEGQ
EEEECCEEECCCCCCCCCCEEEEEEECCCCEECCEEECCCCCCEEECCCCEEECCCCCCC
TFVADNLLAKHDENYVPRQMGDMTKAQAEAVVAETK
EEEHHHHHHHCCCCCCCHHHHHHHHHHHHHEEECCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA