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The map label for this gene is icd [H]

Identifier: 87199303

GI number: 87199303

Start: 1324213

End: 1325436

Strand: Reverse

Name: icd [H]

Synonym: Saro_1282

Alternate gene names: 87199303

Gene position: 1325436-1324213 (Counterclockwise)

Preceding gene: 87199305

Following gene: 87199302

Centisome position: 37.21

GC content: 62.17

Gene sequence:

>1224_bases
ATGGCGAAGATCAAGGTGAAGAACCCGGTCGTCGAGATCGACGGCGACGAAATGACCCGGATCATCTGGGAATGGATCCG
CGAACGCCTGATCCTCCCCTACCTCGACATCGATCTCAAGTACTACGACCTCTCGGTCCAGAAGCGCGACGAGACGAACG
ACCAGATCACGATCGATTCCGCCAACGCGATCAAGCAGTATGGCGTCGGCGTGAAGTGCGCCACGATCACCCCCGACGAA
GCGCGCGTCGAGGAATTCAACCTCAAGTCGATGTGGAAGTCGCCGAACGGCACGATCCGTAACATCCTGGGCGGCGTGGT
GTTCCGCGAACCCATCGTGATCCAGAACGTGCCGCGTCTGGTCCCCGGCTGGACCGACCCCATCGTCGTCGGCCGTCACG
CTTTCGGCGACCAGTACCGCGCCACCGACTTCGTCGTGCCGGGTCCGGGCAAGCTGCGCCTCGTGTGGGAAGGCGACAAT
GGCGAAACCATCGACCGCGAGGTGTTCAACTACCCCTCGGGCGGCGTTGCCATGGCGATGTACAACCTCGACGATTCGAT
CCGCGACTTCGCCCGCGCCTCGTTCAACTATGGCCTCGGCCTGGGTTGGCCGGTGTACCTTTCGACCAAGAACACGATCC
TCAAGGCCTATGACGGCCGCTTCAAGGATCTGTTCCAGGAAGTGTTCGACACCGAAGGCTTCAAGGAAAAGTTCGCCGCC
GCCGGCATCGTCTACGAACACCGCCTGATCGACGACATGGTCGCCTCTGCGCTCAAGTGGTCGGGCAAGTTCGTCTGGGC
GTGCAAGAACTACGACGGCGACGTCCAGTCGGACACCGTCGCGCAGGGCTTCGGCTCGCTCGGCCTGATGACCTCGGTCC
TGATGACGCCGGACGGCAAGACCGTCGAGGCTGAAGCCGCGCACGGCACCGTGACCCGTCACTACCGCCAGCACCAGCAG
GGCAAGCAGACTTCGACCAACCCGATCGCGTCGATCTTCGCCTGGACCCGCGGCCTGATCTATCGCGGCAAGTTCGACGA
GACGCCGGAAGTGGTGAAGTTCGCCGAAACGCTGGAGCGCGTCTGCATCGAAACCGTCGAGAGCGGCAAGATGACCAAGG
ACCTCGCGCTGCTCATCGGGCCGGACCAGGCCTGGATGACCACCGAGAAGTTCTTCGAGGCCATCGTCGAGAACCTCGAG
ACCGAAATGAAGAACTGGGCATAA

Upstream 100 bases:

>100_bases
ACCCAAAAATTGCGCGAATCGGCGGCCTGCCTTGCACCGGGCCGCGCCTCTGCTAAGGGGAAGCGCAATTTCTCTCCCCA
GTTTGAAAGACAGGACGGAC

Downstream 100 bases:

>100_bases
GCGCCCGTTCGTTCATGGAAACAGCAAAGGGCCCCGGTTCACGCCGGGGCCCTTTTCCTTTGCAGGCGGTACATCGGGCA
ACCGGGCAGGCGTCACCCTG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MAKIKVKNPVVEIDGDEMTRIIWEWIRERLILPYLDIDLKYYDLSVQKRDETNDQITIDSANAIKQYGVGVKCATITPDE
ARVEEFNLKSMWKSPNGTIRNILGGVVFREPIVIQNVPRLVPGWTDPIVVGRHAFGDQYRATDFVVPGPGKLRLVWEGDN
GETIDREVFNYPSGGVAMAMYNLDDSIRDFARASFNYGLGLGWPVYLSTKNTILKAYDGRFKDLFQEVFDTEGFKEKFAA
AGIVYEHRLIDDMVASALKWSGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQQ
GKQTSTNPIASIFAWTRGLIYRGKFDETPEVVKFAETLERVCIETVESGKMTKDLALLIGPDQAWMTTEKFFEAIVENLE
TEMKNWA

Sequences:

>Translated_407_residues
MAKIKVKNPVVEIDGDEMTRIIWEWIRERLILPYLDIDLKYYDLSVQKRDETNDQITIDSANAIKQYGVGVKCATITPDE
ARVEEFNLKSMWKSPNGTIRNILGGVVFREPIVIQNVPRLVPGWTDPIVVGRHAFGDQYRATDFVVPGPGKLRLVWEGDN
GETIDREVFNYPSGGVAMAMYNLDDSIRDFARASFNYGLGLGWPVYLSTKNTILKAYDGRFKDLFQEVFDTEGFKEKFAA
AGIVYEHRLIDDMVASALKWSGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQQ
GKQTSTNPIASIFAWTRGLIYRGKFDETPEVVKFAETLERVCIETVESGKMTKDLALLIGPDQAWMTTEKFFEAIVENLE
TEMKNWA
>Mature_406_residues
AKIKVKNPVVEIDGDEMTRIIWEWIRERLILPYLDIDLKYYDLSVQKRDETNDQITIDSANAIKQYGVGVKCATITPDEA
RVEEFNLKSMWKSPNGTIRNILGGVVFREPIVIQNVPRLVPGWTDPIVVGRHAFGDQYRATDFVVPGPGKLRLVWEGDNG
ETIDREVFNYPSGGVAMAMYNLDDSIRDFARASFNYGLGLGWPVYLSTKNTILKAYDGRFKDLFQEVFDTEGFKEKFAAA
GIVYEHRLIDDMVASALKWSGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQQG
KQTSTNPIASIFAWTRGLIYRGKFDETPEVVKFAETLERVCIETVESGKMTKDLALLIGPDQAWMTTEKFFEAIVENLET
EMKNWA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=64.7058823529412, Blast_Score=557, Evalue=1e-159,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=63.4146341463415, Blast_Score=540, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17550822, Length=409, Percent_Identity=63.5696821515892, Blast_Score=548, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17540874, Length=408, Percent_Identity=62.7450980392157, Blast_Score=540, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6323203, Length=412, Percent_Identity=65.7766990291262, Blast_Score=562, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6324319, Length=408, Percent_Identity=63.9705882352941, Blast_Score=551, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6320137, Length=410, Percent_Identity=64.1463414634146, Blast_Score=549, Evalue=1e-157,
Organism=Drosophila melanogaster, GI21356561, Length=406, Percent_Identity=64.0394088669951, Blast_Score=553, Evalue=1e-158,
Organism=Drosophila melanogaster, GI221330987, Length=406, Percent_Identity=64.0394088669951, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI221330985, Length=406, Percent_Identity=64.0394088669951, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI28574947, Length=406, Percent_Identity=64.0394088669951, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24660849, Length=406, Percent_Identity=64.0394088669951, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24660856, Length=406, Percent_Identity=64.0394088669951, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI221330983, Length=406, Percent_Identity=64.0394088669951, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24660868, Length=406, Percent_Identity=64.0394088669951, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24660860, Length=406, Percent_Identity=64.0394088669951, Blast_Score=551, Evalue=1e-157,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45975; Mature: 45844

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVKNPVVEIDGDEMTRIIWEWIRERLILPYLDIDLKYYDLSVQKRDETNDQITIDS
CCEEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEECEEEEEEEEEECCCCCCCEEEEEC
ANAIKQYGVGVKCATITPDEARVEEFNLKSMWKSPNGTIRNILGGVVFREPIVIQNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
VPGWTDPIVVGRHAFGDQYRATDFVVPGPGKLRLVWEGDNGETIDREVFNYPSGGVAMAM
CCCCCCCEEECCHHCCCCCCCCEEEECCCCEEEEEEECCCCCCCCHHHHCCCCCCEEEEE
YNLDDSIRDFARASFNYGLGLGWPVYLSTKNTILKAYDGRFKDLFQEVFDTEGFKEKFAA
ECCCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCCHHHHHHHHHHCCCCHHHHHHH
AGIVYEHRLIDDMVASALKWSGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGK
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEECCCCC
TVEAEAAHGTVTRHYRQHQQGKQTSTNPIASIFAWTRGLIYRGKFDETPEVVKFAETLER
EEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHH
VCIETVESGKMTKDLALLIGPDQAWMTTEKFFEAIVENLETEMKNWA
HHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKIKVKNPVVEIDGDEMTRIIWEWIRERLILPYLDIDLKYYDLSVQKRDETNDQITIDS
CEEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEECEEEEEEEEEECCCCCCCEEEEEC
ANAIKQYGVGVKCATITPDEARVEEFNLKSMWKSPNGTIRNILGGVVFREPIVIQNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
VPGWTDPIVVGRHAFGDQYRATDFVVPGPGKLRLVWEGDNGETIDREVFNYPSGGVAMAM
CCCCCCCEEECCHHCCCCCCCCEEEECCCCEEEEEEECCCCCCCCHHHHCCCCCCEEEEE
YNLDDSIRDFARASFNYGLGLGWPVYLSTKNTILKAYDGRFKDLFQEVFDTEGFKEKFAA
ECCCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCCHHHHHHHHHHCCCCHHHHHHH
AGIVYEHRLIDDMVASALKWSGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGK
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEECCCCC
TVEAEAAHGTVTRHYRQHQQGKQTSTNPIASIFAWTRGLIYRGKFDETPEVVKFAETLER
EEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHH
VCIETVESGKMTKDLALLIGPDQAWMTTEKFFEAIVENLETEMKNWA
HHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]