| Definition | Novosphingobium aromaticivorans DSM 12444 chromosome, complete genome. |
|---|---|
| Accession | NC_007794 |
| Length | 3,561,584 |
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The map label for this gene is fabG [H]
Identifier: 87199020
GI number: 87199020
Start: 1041882
End: 1042730
Strand: Reverse
Name: fabG [H]
Synonym: Saro_0998
Alternate gene names: 87199020
Gene position: 1042730-1041882 (Counterclockwise)
Preceding gene: 87199025
Following gene: 87199019
Centisome position: 29.28
GC content: 66.67
Gene sequence:
>849_bases ATGCGATTCGACGGAAAGACCGTGGTGGTAACGGGCGCCGCGTCGGGCATCGGGCGGGCGGCGGCGCTGGCCTTCGCTGC GGAAGGCGCGAAAGTCTATGCGGCGGACATCGACGAGGCGGGGCTGGCAGAGACGGCTGCGCAATCGAACGGCGCGATCC GGACCGCGCGCTGCGACGTTACCCGCTGCGAGGACATCAAGGCCCTGATGGATCGCGCAGGCACCGAGACGGGCGGCATC GACACCGTGTTCAACAATGCCGGCGCAGGCGGTGACCGCGCGCCCATCGACGAGATCGAGCCCGAAGGCTGGGACCGGAC GATGGACCTGCTGCTGCGGTCGGTCGCTTTCGGCATTCGCTATGCCGTGCCGCACATGAAGGGCCGCCATGGCGCATCGT TCGTGAACACGTCCAGCGTAGCGGCGGTCGGCCCCGGTTATTCGCCCACGGCCTATGCAGTTGCAAAGGCGGGCGTGCTT CACCTGACGAAGGTCGCTGCGGCGGACCTTGCGAAGCACCAGATCCGCGTGAACGCGGTGCAGCCCGGCTTCATCAACAC CAACATCTTCACCAGCTCGCTCGAAATGCCGGAGGAACTGGAAGCACAGGCCAAGGGCGCGATCGCGGCGATGTCGCAAC AGGCCCAGCCGGTAGCGCGGGGCGGACAGCCAGAGGATATCGCGCAAGCCGTGCTTTTCCTCGCGAGCGAGGCGGCGGGC TTCGTGACGGGGACTTCGCTCATCGTCGATGGCGGCATCACCGTGGGCCCGCGCCATAGCTGGGACCCGAACATGCCCGG CCTGTTCGATGCGCTGCAGCAGATGAAGGAAAGCGGCAAGGTTTCATGA
Upstream 100 bases:
>100_bases CCTGCATGCCGTAGCGTCAACCGGCAAAGCATTGACGCGAGGTCTTTCCCCCCTAAGCTGACGTAAACGTAAAACGGCAC GAAACGCCGGGGAGAGGGCA
Downstream 100 bases:
>100_bases TCCCGATACAGGGCAAGGTTCCCACCCGCCTCGCCCTGTTCAACGGGCTTGGCAGCGTGGCCTACGGCATCAAGGACAAT GGCTTCGCCACGTTCCTGCT
Product: short-chain dehydrogenase/reductase SDR
Products: NA
Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]
Number of amino acids: Translated: 282; Mature: 282
Protein sequence:
>282_residues MRFDGKTVVVTGAASGIGRAAALAFAAEGAKVYAADIDEAGLAETAAQSNGAIRTARCDVTRCEDIKALMDRAGTETGGI DTVFNNAGAGGDRAPIDEIEPEGWDRTMDLLLRSVAFGIRYAVPHMKGRHGASFVNTSSVAAVGPGYSPTAYAVAKAGVL HLTKVAAADLAKHQIRVNAVQPGFINTNIFTSSLEMPEELEAQAKGAIAAMSQQAQPVARGGQPEDIAQAVLFLASEAAG FVTGTSLIVDGGITVGPRHSWDPNMPGLFDALQQMKESGKVS
Sequences:
>Translated_282_residues MRFDGKTVVVTGAASGIGRAAALAFAAEGAKVYAADIDEAGLAETAAQSNGAIRTARCDVTRCEDIKALMDRAGTETGGI DTVFNNAGAGGDRAPIDEIEPEGWDRTMDLLLRSVAFGIRYAVPHMKGRHGASFVNTSSVAAVGPGYSPTAYAVAKAGVL HLTKVAAADLAKHQIRVNAVQPGFINTNIFTSSLEMPEELEAQAKGAIAAMSQQAQPVARGGQPEDIAQAVLFLASEAAG FVTGTSLIVDGGITVGPRHSWDPNMPGLFDALQQMKESGKVS >Mature_282_residues MRFDGKTVVVTGAASGIGRAAALAFAAEGAKVYAADIDEAGLAETAAQSNGAIRTARCDVTRCEDIKALMDRAGTETGGI DTVFNNAGAGGDRAPIDEIEPEGWDRTMDLLLRSVAFGIRYAVPHMKGRHGASFVNTSSVAAVGPGYSPTAYAVAKAGVL HLTKVAAADLAKHQIRVNAVQPGFINTNIFTSSLEMPEELEAQAKGAIAAMSQQAQPVARGGQPEDIAQAVLFLASEAAG FVTGTSLIVDGGITVGPRHSWDPNMPGLFDALQQMKESGKVS
Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=35.3174603174603, Blast_Score=129, Evalue=2e-30, Organism=Homo sapiens, GI66933014, Length=255, Percent_Identity=36.8627450980392, Blast_Score=124, Evalue=8e-29, Organism=Homo sapiens, GI126723750, Length=258, Percent_Identity=32.1705426356589, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI15277342, Length=274, Percent_Identity=32.8467153284672, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI59889578, Length=235, Percent_Identity=32.7659574468085, Blast_Score=103, Evalue=1e-22, Organism=Homo sapiens, GI5031737, Length=249, Percent_Identity=30.9236947791165, Blast_Score=101, Evalue=9e-22, Organism=Homo sapiens, GI19923817, Length=296, Percent_Identity=28.0405405405405, Blast_Score=95, Evalue=7e-20, Organism=Homo sapiens, GI31542939, Length=210, Percent_Identity=31.9047619047619, Blast_Score=93, Evalue=3e-19, Organism=Homo sapiens, GI7705925, Length=250, Percent_Identity=31.6, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI4504505, Length=248, Percent_Identity=30.241935483871, Blast_Score=89, Evalue=6e-18, Organism=Homo sapiens, GI33667109, Length=186, Percent_Identity=31.7204301075269, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI4503301, Length=256, Percent_Identity=28.125, Blast_Score=84, Evalue=2e-16, Organism=Homo sapiens, GI126723191, Length=184, Percent_Identity=31.5217391304348, Blast_Score=83, Evalue=4e-16, Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=26.8, Blast_Score=82, Evalue=4e-16, Organism=Homo sapiens, GI40548397, Length=190, Percent_Identity=30, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI214010158, Length=190, Percent_Identity=30, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI214010156, Length=190, Percent_Identity=30, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI22758144, Length=190, Percent_Identity=30, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI224922801, Length=175, Percent_Identity=30.2857142857143, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI109715829, Length=255, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=9e-13, Organism=Homo sapiens, GI302344755, Length=106, Percent_Identity=36.7924528301887, Blast_Score=68, Evalue=8e-12, Organism=Homo sapiens, GI4758504, Length=265, Percent_Identity=27.1698113207547, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI40254986, Length=207, Percent_Identity=29.951690821256, Blast_Score=65, Evalue=9e-11, Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=35.6862745098039, Blast_Score=127, Evalue=1e-30, Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=33.8582677165354, Blast_Score=124, Evalue=6e-30, Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=35.2941176470588, Blast_Score=114, Evalue=9e-27, Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=30.7086614173228, Blast_Score=105, Evalue=4e-24, Organism=Escherichia coli, GI87082100, Length=264, Percent_Identity=31.8181818181818, Blast_Score=100, Evalue=7e-23, Organism=Escherichia coli, GI1786812, Length=256, Percent_Identity=29.6875, Blast_Score=99, Evalue=4e-22, Organism=Escherichia coli, GI1789378, Length=264, Percent_Identity=30.6818181818182, Blast_Score=89, Evalue=3e-19, Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=30.5555555555556, Blast_Score=89, Evalue=3e-19, Organism=Escherichia coli, GI1788459, Length=255, Percent_Identity=29.0196078431373, Blast_Score=87, Evalue=2e-18, Organism=Escherichia coli, GI87082160, Length=259, Percent_Identity=29.3436293436293, Blast_Score=85, Evalue=4e-18, Organism=Escherichia coli, GI1787526, Length=212, Percent_Identity=28.7735849056604, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1787820, Length=229, Percent_Identity=24.4541484716157, Blast_Score=69, Evalue=3e-13, Organism=Escherichia coli, GI2367365, Length=258, Percent_Identity=29.4573643410853, Blast_Score=65, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=35.3383458646617, Blast_Score=129, Evalue=2e-30, Organism=Caenorhabditis elegans, GI17562904, Length=270, Percent_Identity=32.962962962963, Blast_Score=125, Evalue=3e-29, Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=7e-28, Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=33.8345864661654, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=35.1351351351351, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17555706, Length=258, Percent_Identity=34.4961240310078, Blast_Score=114, Evalue=5e-26, Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=32.5842696629214, Blast_Score=113, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17538480, Length=266, Percent_Identity=33.0827067669173, Blast_Score=112, Evalue=3e-25, Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=34.9206349206349, Blast_Score=111, Evalue=4e-25, Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=32.5757575757576, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI71994600, Length=252, Percent_Identity=34.5238095238095, Blast_Score=110, Evalue=9e-25, Organism=Caenorhabditis elegans, GI17551412, Length=268, Percent_Identity=33.955223880597, Blast_Score=109, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17563726, Length=278, Percent_Identity=30.9352517985612, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI72000259, Length=266, Percent_Identity=30.8270676691729, Blast_Score=107, Evalue=7e-24, Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=31.203007518797, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=32.1969696969697, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17560332, Length=274, Percent_Identity=32.8467153284672, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17565030, Length=273, Percent_Identity=32.6007326007326, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI17544670, Length=268, Percent_Identity=28.7313432835821, Blast_Score=104, Evalue=6e-23, Organism=Caenorhabditis elegans, GI17531453, Length=280, Percent_Identity=31.0714285714286, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI193204405, Length=264, Percent_Identity=32.5757575757576, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17562908, Length=283, Percent_Identity=30.3886925795053, Blast_Score=101, Evalue=5e-22, Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=29.8039215686275, Blast_Score=97, Evalue=7e-21, Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=28.125, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI115534694, Length=253, Percent_Identity=29.2490118577075, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17536025, Length=287, Percent_Identity=26.4808362369338, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17536651, Length=278, Percent_Identity=27.3381294964029, Blast_Score=79, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17568967, Length=191, Percent_Identity=28.2722513089005, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17564282, Length=193, Percent_Identity=27.979274611399, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17561272, Length=277, Percent_Identity=27.7978339350181, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17538182, Length=261, Percent_Identity=26.0536398467433, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI17555612, Length=257, Percent_Identity=27.6264591439689, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI193207185, Length=148, Percent_Identity=35.1351351351351, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=25.6410256410256, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI193203115, Length=191, Percent_Identity=26.1780104712042, Blast_Score=64, Evalue=6e-11, Organism=Caenorhabditis elegans, GI32563809, Length=211, Percent_Identity=27.9620853080569, Blast_Score=64, Evalue=7e-11, Organism=Caenorhabditis elegans, GI17507613, Length=211, Percent_Identity=27.9620853080569, Blast_Score=64, Evalue=7e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=29.5336787564767, Blast_Score=72, Evalue=1e-13, Organism=Saccharomyces cerevisiae, GI6324126, Length=259, Percent_Identity=26.6409266409266, Blast_Score=70, Evalue=5e-13, Organism=Saccharomyces cerevisiae, GI6323882, Length=273, Percent_Identity=26.007326007326, Blast_Score=68, Evalue=2e-12, Organism=Drosophila melanogaster, GI23397609, Length=264, Percent_Identity=34.8484848484849, Blast_Score=125, Evalue=2e-29, Organism=Drosophila melanogaster, GI21355319, Length=258, Percent_Identity=32.9457364341085, Blast_Score=115, Evalue=4e-26, Organism=Drosophila melanogaster, GI24644339, Length=267, Percent_Identity=31.8352059925094, Blast_Score=112, Evalue=2e-25, Organism=Drosophila melanogaster, GI28571526, Length=265, Percent_Identity=33.5849056603774, Blast_Score=105, Evalue=2e-23, Organism=Drosophila melanogaster, GI21357041, Length=266, Percent_Identity=31.5789473684211, Blast_Score=101, Evalue=5e-22, Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=31.8897637795276, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI24643142, Length=251, Percent_Identity=27.8884462151394, Blast_Score=85, Evalue=4e-17, Organism=Drosophila melanogaster, GI24644337, Length=273, Percent_Identity=32.967032967033, Blast_Score=85, Evalue=5e-17, Organism=Drosophila melanogaster, GI161076933, Length=196, Percent_Identity=30.6122448979592, Blast_Score=79, Evalue=4e-15, Organism=Drosophila melanogaster, GI24584748, Length=196, Percent_Identity=30.6122448979592, Blast_Score=79, Evalue=5e-15, Organism=Drosophila melanogaster, GI18859837, Length=191, Percent_Identity=28.7958115183246, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI281364892, Length=193, Percent_Identity=27.979274611399, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI281364494, Length=249, Percent_Identity=28.9156626506024, Blast_Score=71, Evalue=8e-13, Organism=Drosophila melanogaster, GI24649181, Length=191, Percent_Identity=29.3193717277487, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24665243, Length=203, Percent_Identity=29.064039408867, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI221331218, Length=231, Percent_Identity=28.1385281385281, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI24665247, Length=204, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI221331216, Length=232, Percent_Identity=28.448275862069, Blast_Score=65, Evalue=5e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011284 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.100 [H]
Molecular weight: Translated: 29156; Mature: 29156
Theoretical pI: Translated: 5.13; Mature: 5.13
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRFDGKTVVVTGAASGIGRAAALAFAAEGAKVYAADIDEAGLAETAAQSNGAIRTARCDV CCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHCCCCEEEEECCC TRCEDIKALMDRAGTETGGIDTVFNNAGAGGDRAPIDEIEPEGWDRTMDLLLRSVAFGIR HHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH YAVPHMKGRHGASFVNTSSVAAVGPGYSPTAYAVAKAGVLHLTKVAAADLAKHQIRVNAV HHCCCCCCCCCCCEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE QPGFINTNIFTSSLEMPEELEAQAKGAIAAMSQQAQPVARGGQPEDIAQAVLFLASEAAG CCCEEECCEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHCC FVTGTSLIVDGGITVGPRHSWDPNMPGLFDALQQMKESGKVS CEECCEEEEECCEEECCCCCCCCCCCHHHHHHHHHHHCCCCC >Mature Secondary Structure MRFDGKTVVVTGAASGIGRAAALAFAAEGAKVYAADIDEAGLAETAAQSNGAIRTARCDV CCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHCCCCEEEEECCC TRCEDIKALMDRAGTETGGIDTVFNNAGAGGDRAPIDEIEPEGWDRTMDLLLRSVAFGIR HHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH YAVPHMKGRHGASFVNTSSVAAVGPGYSPTAYAVAKAGVLHLTKVAAADLAKHQIRVNAV HHCCCCCCCCCCCEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE QPGFINTNIFTSSLEMPEELEAQAKGAIAAMSQQAQPVARGGQPEDIAQAVLFLASEAAG CCCEEECCEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHCC FVTGTSLIVDGGITVGPRHSWDPNMPGLFDALQQMKESGKVS CEECCEEEEECCEEECCCCCCCCCCCHHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 10360571 [H]