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The map label for this gene is frmA [H]

Identifier: 87199017

GI number: 87199017

Start: 1037964

End: 1039052

Strand: Reverse

Name: frmA [H]

Synonym: Saro_0995

Alternate gene names: 87199017

Gene position: 1039052-1037964 (Counterclockwise)

Preceding gene: 87199018

Following gene: 87199016

Centisome position: 29.17

GC content: 66.94

Gene sequence:

>1089_bases
ATGAAAGCCGCCGTACTCGTCGAACCGGGCAAGCCGCTGGATATTCAGCATCTCAGCGTGTCCAAGCCCGGCCCGCATGA
AGTCCTTATCCGCACCGCAGCCTGCGGGCTGTGCCATTCGGACTTGCACTTCATCGAAGGTGCCTATCCCCATCCGCTGC
CCGCGGTGCCGGGGCACGAGGCGGCGGGGATCGTCGAGGCGGTCGGCTCGGAAGTGCGCACGGTCAAGGTGGGTGACGCG
GTCGTCACCTGCCTGTCCGCGTTCTGCGGTCATTGCGAGTTCTGCGTGACCGGCCGGATGTCGCTGTGCCTTGGCGGCGA
CACCCGGCGCGGCGCGGGCGAGGCACCTCGCCTTACCCGCACCGACGACGGCAGCGCCGTGAACCAGATGCTCAACCTCT
CGGCCTTTGCCGAACAGATGCTGGTGCACGAACATGCCTGCGTGGCGATCAATCCCGAGATGCCGCTCGACCGCGCGGCG
GTGATCGGCTGCGCGGTCACCACTGGCGCGGGTGCGGTGTTCAACGCGGCGAAGCTGACCCCGGGCGAGACGGTCTGCGT
GGTCGGCTGTGGCGGCGTCGGCCTTGCCACGGTCAACGCCGCGAAGATCGCCGGCGCAGGCCGGATCATCGCGGTGGACC
CGATGCCGGAAAAGCGCGAACTGGCCATGAAGCTGGGCGCGACCGATGTGATGGACGCGGGACCCGATGCGGCGGCACAG
ATCGTCGAGATGACGAAAGGCGGCGTCCACCATGCGATCGAGGCCGTGGGGCGTCCGGCATCGGGCGACCTTGCGGTCGC
GACGCTGCGCCGCGGCGGCACCGCCACGATCCTTGGCATGATGCCGCTGGCACACAAGGTCGGACTTTCCGCGATGGACC
TGCTGTCGGACAAGAAGCTGCAGGGCGCCATCATGGGCCGCAACCACTTCCCGGTGGACCTGCCGCGCCTGGTCGACTTC
TACATGCGCGGCTTGCTCGATCTCGACACGATCATTGCCGAACGCATCCCGCTCGAAGGGATCAACGATGGCTTCGAGAA
GATGAAGCAGGGCCATTCCGCCCGCTCTGTCATCGTGTTCGACCAATGA

Upstream 100 bases:

>100_bases
CGCATCGAGTTTGCCCGCCATGCCGACATGCCGCAGGCCGACCGGGGCTTCAGCTCCGGCGACCTCGGCGTGGCACGTTG
ACGTTCAGGAGTAATCGCAG

Downstream 100 bases:

>100_bases
CGCAGGCTCCCATGGACGCGCAGACCGCCTTCACCGGCACGGTTGCACCCGAAGGCGCCGACAGGCTGGACGAAGCCAGT
CTGACCCGCTGGTTCGAGAC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKAAVLVEPGKPLDIQHLSVSKPGPHEVLIRTAACGLCHSDLHFIEGAYPHPLPAVPGHEAAGIVEAVGSEVRTVKVGDA
VVTCLSAFCGHCEFCVTGRMSLCLGGDTRRGAGEAPRLTRTDDGSAVNQMLNLSAFAEQMLVHEHACVAINPEMPLDRAA
VIGCAVTTGAGAVFNAAKLTPGETVCVVGCGGVGLATVNAAKIAGAGRIIAVDPMPEKRELAMKLGATDVMDAGPDAAAQ
IVEMTKGGVHHAIEAVGRPASGDLAVATLRRGGTATILGMMPLAHKVGLSAMDLLSDKKLQGAIMGRNHFPVDLPRLVDF
YMRGLLDLDTIIAERIPLEGINDGFEKMKQGHSARSVIVFDQ

Sequences:

>Translated_362_residues
MKAAVLVEPGKPLDIQHLSVSKPGPHEVLIRTAACGLCHSDLHFIEGAYPHPLPAVPGHEAAGIVEAVGSEVRTVKVGDA
VVTCLSAFCGHCEFCVTGRMSLCLGGDTRRGAGEAPRLTRTDDGSAVNQMLNLSAFAEQMLVHEHACVAINPEMPLDRAA
VIGCAVTTGAGAVFNAAKLTPGETVCVVGCGGVGLATVNAAKIAGAGRIIAVDPMPEKRELAMKLGATDVMDAGPDAAAQ
IVEMTKGGVHHAIEAVGRPASGDLAVATLRRGGTATILGMMPLAHKVGLSAMDLLSDKKLQGAIMGRNHFPVDLPRLVDF
YMRGLLDLDTIIAERIPLEGINDGFEKMKQGHSARSVIVFDQ
>Mature_362_residues
MKAAVLVEPGKPLDIQHLSVSKPGPHEVLIRTAACGLCHSDLHFIEGAYPHPLPAVPGHEAAGIVEAVGSEVRTVKVGDA
VVTCLSAFCGHCEFCVTGRMSLCLGGDTRRGAGEAPRLTRTDDGSAVNQMLNLSAFAEQMLVHEHACVAINPEMPLDRAA
VIGCAVTTGAGAVFNAAKLTPGETVCVVGCGGVGLATVNAAKIAGAGRIIAVDPMPEKRELAMKLGATDVMDAGPDAAAQ
IVEMTKGGVHHAIEAVGRPASGDLAVATLRRGGTATILGMMPLAHKVGLSAMDLLSDKKLQGAIMGRNHFPVDLPRLVDF
YMRGLLDLDTIIAERIPLEGINDGFEKMKQGHSARSVIVFDQ

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=368, Percent_Identity=38.5869565217391, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=38.5869565217391, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI4501929, Length=368, Percent_Identity=37.7717391304348, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI71743840, Length=364, Percent_Identity=34.6153846153846, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI262073058, Length=364, Percent_Identity=34.6153846153846, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI71565154, Length=364, Percent_Identity=34.3406593406593, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI156523966, Length=365, Percent_Identity=33.6986301369863, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI71565152, Length=370, Percent_Identity=33.5135135135135, Blast_Score=201, Evalue=6e-52,
Organism=Homo sapiens, GI4501939, Length=357, Percent_Identity=34.1736694677871, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI156627571, Length=357, Percent_Identity=26.6106442577031, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=36.3387978142077, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI87081918, Length=362, Percent_Identity=29.5580110497238, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788073, Length=357, Percent_Identity=27.4509803921569, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1790045, Length=371, Percent_Identity=26.4150943396226, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786825, Length=386, Percent_Identity=27.979274611399, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87082125, Length=376, Percent_Identity=28.7234042553192, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786518, Length=351, Percent_Identity=28.4900284900285, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788407, Length=245, Percent_Identity=29.7959183673469, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788075, Length=363, Percent_Identity=25.6198347107438, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI226510992, Length=354, Percent_Identity=24.5762711864407, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787863, Length=369, Percent_Identity=24.9322493224932, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082401, Length=368, Percent_Identity=23.6413043478261, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=372, Percent_Identity=32.7956989247312, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71997431, Length=374, Percent_Identity=32.620320855615, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17565904, Length=335, Percent_Identity=31.6417910447761, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17562584, Length=364, Percent_Identity=28.021978021978, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71988145, Length=362, Percent_Identity=25.414364640884, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17562876, Length=369, Percent_Identity=26.0162601626016, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562582, Length=370, Percent_Identity=27.2972972972973, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=361, Percent_Identity=26.3157894736842, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=33.9622641509434, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6319621, Length=360, Percent_Identity=30.2777777777778, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323729, Length=355, Percent_Identity=30.4225352112676, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323961, Length=366, Percent_Identity=29.2349726775956, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324486, Length=358, Percent_Identity=27.9329608938547, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=360, Percent_Identity=29.1666666666667, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319258, Length=330, Percent_Identity=27.8787878787879, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=272, Percent_Identity=30.5147058823529, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=272, Percent_Identity=30.1470588235294, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=337, Percent_Identity=27.0029673590504, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=35.5978260869565, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI17137530, Length=256, Percent_Identity=28.90625, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17737897, Length=270, Percent_Identity=27.4074074074074, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 37634; Mature: 37634

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVLVEPGKPLDIQHLSVSKPGPHEVLIRTAACGLCHSDLHFIEGAYPHPLPAVPGHE
CCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AAGIVEAVGSEVRTVKVGDAVVTCLSAFCGHCEFCVTGRMSLCLGGDTRRGAGEAPRLTR
HHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCCCCCCEE
TDDGSAVNQMLNLSAFAEQMLVHEHACVAINPEMPLDRAAVIGCAVTTGAGAVFNAAKLT
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHEEEEEECCCCHHEECCCCC
PGETVCVVGCGGVGLATVNAAKIAGAGRIIAVDPMPEKRELAMKLGATDVMDAGPDAAAQ
CCCEEEEEECCCCCEEEECHHHCCCCCCEEEECCCCCHHHHHHHCCCCHHCCCCCHHHHH
IVEMTKGGVHHAIEAVGRPASGDLAVATLRRGGTATILGMMPLAHKVGLSAMDLLSDKKL
HHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHCCHHHHHHHCCCH
QGAIMGRNHFPVDLPRLVDFYMRGLLDLDTIIAERIPLEGINDGFEKMKQGHSARSVIVF
HHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEE
DQ
CC
>Mature Secondary Structure
MKAAVLVEPGKPLDIQHLSVSKPGPHEVLIRTAACGLCHSDLHFIEGAYPHPLPAVPGHE
CCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AAGIVEAVGSEVRTVKVGDAVVTCLSAFCGHCEFCVTGRMSLCLGGDTRRGAGEAPRLTR
HHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCCCCCCEE
TDDGSAVNQMLNLSAFAEQMLVHEHACVAINPEMPLDRAAVIGCAVTTGAGAVFNAAKLT
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHEEEEEECCCCHHEECCCCC
PGETVCVVGCGGVGLATVNAAKIAGAGRIIAVDPMPEKRELAMKLGATDVMDAGPDAAAQ
CCCEEEEEECCCCCEEEECHHHCCCCCCEEEECCCCCHHHHHHHCCCCHHCCCCCHHHHH
IVEMTKGGVHHAIEAVGRPASGDLAVATLRRGGTATILGMMPLAHKVGLSAMDLLSDKKL
HHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHCCHHHHHHHCCCH
QGAIMGRNHFPVDLPRLVDFYMRGLLDLDTIIAERIPLEGINDGFEKMKQGHSARSVIVF
HHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEE
DQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]