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The map label for this gene is glcD [H]

Identifier: 87198838

GI number: 87198838

Start: 869612

End: 871045

Strand: Reverse

Name: glcD [H]

Synonym: Saro_0816

Alternate gene names: 87198838

Gene position: 871045-869612 (Counterclockwise)

Preceding gene: 87198840

Following gene: 87198836

Centisome position: 24.46

GC content: 68.69

Gene sequence:

>1434_bases
ATGCCGCCGCCGCCGCGCTACAATCGTGCGATGGACAGCCTGCCCGATCTTCGCCGCCACCCACTTCCCGCCGGCTTCAT
CGAACGCCTGCGCCAGCGCTTCGCCGATGCCTGCCAGACCGCAGAGGCCATCCGCGCCCAGCACGGCGGCAGCGAATCGC
ACTTCCCCACCGTCCTTCCCGATGCCGTCGTCTTCGTCCGTGACACGAAGGATGTGGTCGACTGCGTGGACCTCTGCCGC
GAGGGCGGCGTCGCGCTCGTGCCCTTCGGAGCCGGCACTTCGCTCGAAGGCCACACACTCCCGCTGGCCGGCGGGATCAG
CCTCGACCTGTCGCGCATGGACACGGTCCTTGCCGTGAACGAGGCGGACTTCGACTGCACCGTCCAGCCCGGCATCCGCC
GCGAAGCGCTCAATGCGCACTTGCGCGACACGGGCCTGTTCTTTCCCATCGACCCGGGCGCGAACGCCACCATCGGCGGC
ATGGCGGCGACCCGCGCCTCGGGCACCAACGCCGTGCGCTATGGCACGATGCGCGAGGCGGTTCTCGGGCTCGAGGTCGT
GACGCCGCAGGGCAAGGTGGTCACCACCGGCCGCCGCGCCCGCAAGTCCGCCGCCGGGTACGATCTGACCCGTCTCTACA
TCGGCTCGGAAGGCACGCTCGGGATCATCACCGCCATCACCCTGCGCCTCCACCCCGTCCCCGAAGCGGTCATGGCCGCC
ACGTGCCCGTTCGCCACACTGGAAGGCGCGGTCGACACGGTCGTGCAGGCCTTTCATGCCGGGGTGCCGATGGCGCGGAT
CGAACTGCTCGACGCGATGCAGGTCCACGCCGTGAACCTTCGCGCAGGGCTGGGCCTGCCCGAAGCGCCCACACTGTTCT
TCGAATTTCACGGCAGCGAGACAGGCGTTGCCGAACAGGTGGAAATGGTCCGCACGCTTGCGGGGGCCAATGGCGGCGGC
GACTTCCACTGGGCGACCCGGACCGAGGACCGCACCCGCCTCTGGCGCGCACGGCACGAGGCCTACTACGCCGCCGTCGG
ACTGCGCCCCAACGCCATAGGCTGGACCAGCGACGTCTGCGTCCCGATGAGCCGCCTTGCGCAGTGCATCCTCGAAACGC
GCGAGGACCTCGACCGGGCGAGCGTTCCGGCAACCATCGTCGGCCATGTCGGCGACGGCAATTTCCACGCGATCTTCTCG
ATCGATCCCGCTGCTCCGCACGAACTCGACGAAGTGGCAGAGATCAACCGCCGCATGGTTGCGCGCGCACTGGCCATGGG
CGGCACCTGCACCGGCGAACACGGCATCGGCATCGGCAAGCAGGACATGCTCGTCGACGAACTCGGCGAGGACGCGGTCG
ACGTTATGCGCGCCCTGAAGCGTGCCCTCGATCCGCAGAACCTGTTCAACCCGGGCAAGATCTTCCGGCTATAG

Upstream 100 bases:

>100_bases
CGGACCACGTCACGCATGGTCTTTCCTGCGCGCTGTATCGCGGCTGAACGGTGATGCGCCATAGCAGAAAACCTGATCGA
CGAAAAAAGGTGCGTTCGCC

Downstream 100 bases:

>100_bases
CAGGTTCTCCCGGCCAGCGCCGTTGCGAGGCGGCAAAGCCCGCTCGCAACGGCGAATGGCCGGAAGCCTTACTCCATCTC
GAGAATGATGGCGTCCACTG

Product: D-lactate dehydrogenase (cytochrome)

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MPPPPRYNRAMDSLPDLRRHPLPAGFIERLRQRFADACQTAEAIRAQHGGSESHFPTVLPDAVVFVRDTKDVVDCVDLCR
EGGVALVPFGAGTSLEGHTLPLAGGISLDLSRMDTVLAVNEADFDCTVQPGIRREALNAHLRDTGLFFPIDPGANATIGG
MAATRASGTNAVRYGTMREAVLGLEVVTPQGKVVTTGRRARKSAAGYDLTRLYIGSEGTLGIITAITLRLHPVPEAVMAA
TCPFATLEGAVDTVVQAFHAGVPMARIELLDAMQVHAVNLRAGLGLPEAPTLFFEFHGSETGVAEQVEMVRTLAGANGGG
DFHWATRTEDRTRLWRARHEAYYAAVGLRPNAIGWTSDVCVPMSRLAQCILETREDLDRASVPATIVGHVGDGNFHAIFS
IDPAAPHELDEVAEINRRMVARALAMGGTCTGEHGIGIGKQDMLVDELGEDAVDVMRALKRALDPQNLFNPGKIFRL

Sequences:

>Translated_477_residues
MPPPPRYNRAMDSLPDLRRHPLPAGFIERLRQRFADACQTAEAIRAQHGGSESHFPTVLPDAVVFVRDTKDVVDCVDLCR
EGGVALVPFGAGTSLEGHTLPLAGGISLDLSRMDTVLAVNEADFDCTVQPGIRREALNAHLRDTGLFFPIDPGANATIGG
MAATRASGTNAVRYGTMREAVLGLEVVTPQGKVVTTGRRARKSAAGYDLTRLYIGSEGTLGIITAITLRLHPVPEAVMAA
TCPFATLEGAVDTVVQAFHAGVPMARIELLDAMQVHAVNLRAGLGLPEAPTLFFEFHGSETGVAEQVEMVRTLAGANGGG
DFHWATRTEDRTRLWRARHEAYYAAVGLRPNAIGWTSDVCVPMSRLAQCILETREDLDRASVPATIVGHVGDGNFHAIFS
IDPAAPHELDEVAEINRRMVARALAMGGTCTGEHGIGIGKQDMLVDELGEDAVDVMRALKRALDPQNLFNPGKIFRL
>Mature_476_residues
PPPPRYNRAMDSLPDLRRHPLPAGFIERLRQRFADACQTAEAIRAQHGGSESHFPTVLPDAVVFVRDTKDVVDCVDLCRE
GGVALVPFGAGTSLEGHTLPLAGGISLDLSRMDTVLAVNEADFDCTVQPGIRREALNAHLRDTGLFFPIDPGANATIGGM
AATRASGTNAVRYGTMREAVLGLEVVTPQGKVVTTGRRARKSAAGYDLTRLYIGSEGTLGIITAITLRLHPVPEAVMAAT
CPFATLEGAVDTVVQAFHAGVPMARIELLDAMQVHAVNLRAGLGLPEAPTLFFEFHGSETGVAEQVEMVRTLAGANGGGD
FHWATRTEDRTRLWRARHEAYYAAVGLRPNAIGWTSDVCVPMSRLAQCILETREDLDRASVPATIVGHVGDGNFHAIFSI
DPAAPHELDEVAEINRRMVARALAMGGTCTGEHGIGIGKQDMLVDELGEDAVDVMRALKRALDPQNLFNPGKIFRL

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=454, Percent_Identity=51.1013215859031, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI37595754, Length=477, Percent_Identity=48.4276729559748, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI119964728, Length=427, Percent_Identity=30.4449648711944, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI4501993, Length=458, Percent_Identity=25.3275109170306, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789351, Length=423, Percent_Identity=30.2600472813239, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1787977, Length=547, Percent_Identity=27.0566727605119, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI48994907, Length=451, Percent_Identity=22.6164079822616, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI48994914, Length=138, Percent_Identity=32.6086956521739, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71992373, Length=443, Percent_Identity=46.9525959367946, Blast_Score=415, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71992381, Length=443, Percent_Identity=45.5981941309255, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71992392, Length=376, Percent_Identity=49.468085106383, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17534361, Length=425, Percent_Identity=25.1764705882353, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17556096, Length=457, Percent_Identity=24.0700218818381, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320027, Length=486, Percent_Identity=38.0658436213992, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6320023, Length=497, Percent_Identity=26.3581488933602, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320764, Length=439, Percent_Identity=26.6514806378132, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI18921117, Length=421, Percent_Identity=28.978622327791, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24639277, Length=421, Percent_Identity=28.978622327791, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24639275, Length=421, Percent_Identity=28.978622327791, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24653753, Length=465, Percent_Identity=26.8817204301075, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 51216; Mature: 51085

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPPPRYNRAMDSLPDLRRHPLPAGFIERLRQRFADACQTAEAIRAQHGGSESHFPTVLP
CCCCCCCHHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DAVVFVRDTKDVVDCVDLCREGGVALVPFGAGTSLEGHTLPLAGGISLDLSRMDTVLAVN
CCEEEEECCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCEEEHHHCCEEEEEE
EADFDCTVQPGIRREALNAHLRDTGLFFPIDPGANATIGGMAATRASGTNAVRYGTMREA
CCCCCEEECCCHHHHHHHHHHHHCCCEEEECCCCCCEECCCHHCCCCCCCCEEECHHHHH
VLGLEVVTPQGKVVTTGRRARKSAAGYDLTRLYIGSEGTLGIITAITLRLHPVPEAVMAA
HHCEEEECCCCCEEECCHHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEECCCCHHHHHH
TCPFATLEGAVDTVVQAFHAGVPMARIELLDAMQVHAVNLRAGLGLPEAPTLFFEFHGSE
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCEEEEEECCCC
TGVAEQVEMVRTLAGANGGGDFHWATRTEDRTRLWRARHEAYYAAVGLRPNAIGWTSDVC
CCHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCHH
VPMSRLAQCILETREDLDRASVPATIVGHVGDGNFHAIFSIDPAAPHELDEVAEINRRMV
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHH
ARALAMGGTCTGEHGIGIGKQDMLVDELGEDAVDVMRALKRALDPQNLFNPGKIFRL
HHHHHCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCHHHCCCCCCEECC
>Mature Secondary Structure 
PPPPRYNRAMDSLPDLRRHPLPAGFIERLRQRFADACQTAEAIRAQHGGSESHFPTVLP
CCCCCCHHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DAVVFVRDTKDVVDCVDLCREGGVALVPFGAGTSLEGHTLPLAGGISLDLSRMDTVLAVN
CCEEEEECCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCEEEHHHCCEEEEEE
EADFDCTVQPGIRREALNAHLRDTGLFFPIDPGANATIGGMAATRASGTNAVRYGTMREA
CCCCCEEECCCHHHHHHHHHHHHCCCEEEECCCCCCEECCCHHCCCCCCCCEEECHHHHH
VLGLEVVTPQGKVVTTGRRARKSAAGYDLTRLYIGSEGTLGIITAITLRLHPVPEAVMAA
HHCEEEECCCCCEEECCHHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEECCCCHHHHHH
TCPFATLEGAVDTVVQAFHAGVPMARIELLDAMQVHAVNLRAGLGLPEAPTLFFEFHGSE
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCEEEEEECCCC
TGVAEQVEMVRTLAGANGGGDFHWATRTEDRTRLWRARHEAYYAAVGLRPNAIGWTSDVC
CCHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCHH
VPMSRLAQCILETREDLDRASVPATIVGHVGDGNFHAIFSIDPAAPHELDEVAEINRRMV
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHH
ARALAMGGTCTGEHGIGIGKQDMLVDELGEDAVDVMRALKRALDPQNLFNPGKIFRL
HHHHHCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]