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The map label for this gene is ubiB [H]

Identifier: 87198618

GI number: 87198618

Start: 638968

End: 640527

Strand: Reverse

Name: ubiB [H]

Synonym: Saro_0594

Alternate gene names: 87198618

Gene position: 640527-638968 (Counterclockwise)

Preceding gene: 87198619

Following gene: 87198617

Centisome position: 17.98

GC content: 68.27

Gene sequence:

>1560_bases
TTGACCCTCCCCGCCACCCACATCCGCCGGCTGCTCGGCTGGGGCCGCACGCTCGCGCGCCATGGCGCCCTGCGCGGGAT
CGAGAACGATCCGAACACCCCGTCGCCGGTGCGCACGCTGTGCCGGATTGCGCGGCTCGGCACGATCCAGCCGCGCGATC
CCGATTATGCCGGCGCCTTCCGTGCTATCGGCCCCGCCGCGATCAAGCTCGGCCAGACCCTTGCCACCCGCCCCGACCTT
GTGGGCGAGGATGCGGCGCACAACCTCCTGGCCCTGCAGGACAACCTGCCGCCGGTCGACTACCGGCTGATCCGGGCAGA
GATCGAACGCACATTCGAAAAGCCGCTCGAAGCCCTTTTCGCGCAGTTCGATCCCGAACCGATCGGCGCGGCCTCGATCG
CGCAGGTCCACCGCGCGGTCACCACTGAAGGCCACAAGGTCGCGGTCAAGGTGCTGCGCCCGGGCGTGCGCGACAAGCTC
GCGCGCGACATCGACACCTACGAATGGGCCGCCGCCCATCTCGAAGCATTCGGCGGCGAGGCGGAGCGCCTGCGCCCGCG
TCTCGTGATCGCCAATTTCAAGCGCTGGACCGTGCGCGAGCTGGACCTGCGCCGCGAAGCCGCGTCGGCATCGGAACTGG
CCGACGTGATGAAGGCCCACGCCGGCTACCGCGTGCCCGCCATCGACTGGGACCGCACCAACGGCCGGGTGATGACGCTC
GACTGGATCGATGGCATCAAGATCAGCGACACTGCCGCGCTCGAAGCCGCCGGGCACGATCGCAAGGCGCTGGCCTCGAG
GCTCGTCCTCGCCTTCCTGACCCAGGCGATCAGCGGCGGATTCTTCCATGCCGACATGCACCAGGGCAACCTCTTCGTGC
AGCCCGACGGCACCATTGCCGCCATCGACTTCGGCATCATGGGCCGGATCGACCGCCGCGCTCGCCAGTGGCTGGCCGAA
ATTCTCTACGGCCTCACCACCGGAAACTACCGCCGCGTGGCCGAAATCCATTTCGAGGCACAATACGTGCCGAGCTACCA
CTCGGTCGACGAATTCGCGACCGCGCTGCGCGCCGTGGGCGAACCCATGCGCGGCAAGCCGGTCAGCGAGTTGTCCGTCG
GCCAGATGCTCGACGGCCTTTTCGCCATCACCCGCGATTTCGACATGCAGACCCAGCCGCACCTGCTGCTTCTGCAAAAG
ACCATGGTCATGGTCGAAGGCATCGCCACCCAGCTCGATCCGACCATCAACATGTGGGATGTCTCCGCTCCCTTCGTGCG
CAACTGGATTCGCGACGAGCTTGGTCCCGAGGCCGCGATTGCCGAGCGCATCCGCGAGGACACGCAGACCCTGCTGCGCA
TCCCCGATCTCATCCGCCGCATCGAGGACCGCTTCCCCGCCAAGGGCGGCGCGCCCGAAGCCCCGCCGCTCCCGCGCATC
GAACTGATGTGGCAGCGCAAGCGCCGCAAGCGCGGCTCCGGCTTGTCTGGCCAGTTCCTCGCCTTCCTTGCCGGCGGCGC
CCTCGTCATCGGCACCCACGCCCTCGGCTGGTGGGGCTGA

Upstream 100 bases:

>100_bases
TTCGAGCGCATGATCCGCGCCGCGGGCTTCACCCGGACGAAGGTCGAACCCATCCTCGGCGGCCTTGTCGCGATCCACTC
GGGGTGGAAGGCCTGATCGC

Downstream 100 bases:

>100_bases
AGTGCACGAAACGACGCACTCTTTGCAAAACCATCGTCACCCTGAACTCGTTTCAGGGTCCAACTCTCCCCACACACGGA
CAGCGCGGGCCGCAGAATGG

Product: 2-octaprenylphenol hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MTLPATHIRRLLGWGRTLARHGALRGIENDPNTPSPVRTLCRIARLGTIQPRDPDYAGAFRAIGPAAIKLGQTLATRPDL
VGEDAAHNLLALQDNLPPVDYRLIRAEIERTFEKPLEALFAQFDPEPIGAASIAQVHRAVTTEGHKVAVKVLRPGVRDKL
ARDIDTYEWAAAHLEAFGGEAERLRPRLVIANFKRWTVRELDLRREAASASELADVMKAHAGYRVPAIDWDRTNGRVMTL
DWIDGIKISDTAALEAAGHDRKALASRLVLAFLTQAISGGFFHADMHQGNLFVQPDGTIAAIDFGIMGRIDRRARQWLAE
ILYGLTTGNYRRVAEIHFEAQYVPSYHSVDEFATALRAVGEPMRGKPVSELSVGQMLDGLFAITRDFDMQTQPHLLLLQK
TMVMVEGIATQLDPTINMWDVSAPFVRNWIRDELGPEAAIAERIREDTQTLLRIPDLIRRIEDRFPAKGGAPEAPPLPRI
ELMWQRKRRKRGSGLSGQFLAFLAGGALVIGTHALGWWG

Sequences:

>Translated_519_residues
MTLPATHIRRLLGWGRTLARHGALRGIENDPNTPSPVRTLCRIARLGTIQPRDPDYAGAFRAIGPAAIKLGQTLATRPDL
VGEDAAHNLLALQDNLPPVDYRLIRAEIERTFEKPLEALFAQFDPEPIGAASIAQVHRAVTTEGHKVAVKVLRPGVRDKL
ARDIDTYEWAAAHLEAFGGEAERLRPRLVIANFKRWTVRELDLRREAASASELADVMKAHAGYRVPAIDWDRTNGRVMTL
DWIDGIKISDTAALEAAGHDRKALASRLVLAFLTQAISGGFFHADMHQGNLFVQPDGTIAAIDFGIMGRIDRRARQWLAE
ILYGLTTGNYRRVAEIHFEAQYVPSYHSVDEFATALRAVGEPMRGKPVSELSVGQMLDGLFAITRDFDMQTQPHLLLLQK
TMVMVEGIATQLDPTINMWDVSAPFVRNWIRDELGPEAAIAERIREDTQTLLRIPDLIRRIEDRFPAKGGAPEAPPLPRI
ELMWQRKRRKRGSGLSGQFLAFLAGGALVIGTHALGWWG
>Mature_518_residues
TLPATHIRRLLGWGRTLARHGALRGIENDPNTPSPVRTLCRIARLGTIQPRDPDYAGAFRAIGPAAIKLGQTLATRPDLV
GEDAAHNLLALQDNLPPVDYRLIRAEIERTFEKPLEALFAQFDPEPIGAASIAQVHRAVTTEGHKVAVKVLRPGVRDKLA
RDIDTYEWAAAHLEAFGGEAERLRPRLVIANFKRWTVRELDLRREAASASELADVMKAHAGYRVPAIDWDRTNGRVMTLD
WIDGIKISDTAALEAAGHDRKALASRLVLAFLTQAISGGFFHADMHQGNLFVQPDGTIAAIDFGIMGRIDRRARQWLAEI
LYGLTTGNYRRVAEIHFEAQYVPSYHSVDEFATALRAVGEPMRGKPVSELSVGQMLDGLFAITRDFDMQTQPHLLLLQKT
MVMVEGIATQLDPTINMWDVSAPFVRNWIRDELGPEAAIAERIREDTQTLLRIPDLIRRIEDRFPAKGGAPEAPPLPRIE
LMWQRKRRKRGSGLSGQFLAFLAGGALVIGTHALGWWG

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=306, Percent_Identity=30.0653594771242, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI40254938, Length=273, Percent_Identity=28.9377289377289, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI217035081, Length=222, Percent_Identity=29.2792792792793, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI34147522, Length=225, Percent_Identity=26.2222222222222, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI2367309, Length=409, Percent_Identity=36.919315403423, Blast_Score=265, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17559152, Length=266, Percent_Identity=27.8195488721804, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI32565180, Length=356, Percent_Identity=22.1910112359551, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6325148, Length=432, Percent_Identity=21.7592592592593, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323282, Length=250, Percent_Identity=23.6, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321319, Length=388, Percent_Identity=22.9381443298969, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24662575, Length=340, Percent_Identity=27.9411764705882, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI22024280, Length=256, Percent_Identity=28.125, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI18859849, Length=254, Percent_Identity=28.740157480315, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 57701; Mature: 57570

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPATHIRRLLGWGRTLARHGALRGIENDPNTPSPVRTLCRIARLGTIQPRDPDYAGAF
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHH
RAIGPAAIKLGQTLATRPDLVGEDAAHNLLALQDNLPPVDYRLIRAEIERTFEKPLEALF
HHCCHHHHHHHHHHHCCCCCCCCHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
AQFDPEPIGAASIAQVHRAVTTEGHKVAVKVLRPGVRDKLARDIDTYEWAAAHLEAFGGE
HHCCCCCCCHHHHHHHHHHHCCCCHHEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AERLRPRLVIANFKRWTVRELDLRREAASASELADVMKAHAGYRVPAIDWDRTNGRVMTL
HHHCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
DWIDGIKISDTAALEAAGHDRKALASRLVLAFLTQAISGGFFHADMHQGNLFVQPDGTIA
ECCCCEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCEE
AIDFGIMGRIDRRARQWLAEILYGLTTGNYRRVAEIHFEAQYVPSYHSVDEFATALRAVG
EEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCHHHHHHHHHHHC
EPMRGKPVSELSVGQMLDGLFAITRDFDMQTQPHLLLLQKTMVMVEGIATQLDPTINMWD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
VSAPFVRNWIRDELGPEAAIAERIREDTQTLLRIPDLIRRIEDRFPAKGGAPEAPPLPRI
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
ELMWQRKRRKRGSGLSGQFLAFLAGGALVIGTHALGWWG
HHHHHHHHHHCCCCCCHHHHHHHHCCEEEEECCCCCCCC
>Mature Secondary Structure 
TLPATHIRRLLGWGRTLARHGALRGIENDPNTPSPVRTLCRIARLGTIQPRDPDYAGAF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHH
RAIGPAAIKLGQTLATRPDLVGEDAAHNLLALQDNLPPVDYRLIRAEIERTFEKPLEALF
HHCCHHHHHHHHHHHCCCCCCCCHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
AQFDPEPIGAASIAQVHRAVTTEGHKVAVKVLRPGVRDKLARDIDTYEWAAAHLEAFGGE
HHCCCCCCCHHHHHHHHHHHCCCCHHEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AERLRPRLVIANFKRWTVRELDLRREAASASELADVMKAHAGYRVPAIDWDRTNGRVMTL
HHHCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
DWIDGIKISDTAALEAAGHDRKALASRLVLAFLTQAISGGFFHADMHQGNLFVQPDGTIA
ECCCCEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCEE
AIDFGIMGRIDRRARQWLAEILYGLTTGNYRRVAEIHFEAQYVPSYHSVDEFATALRAVG
EEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCHHHHHHHHHHHC
EPMRGKPVSELSVGQMLDGLFAITRDFDMQTQPHLLLLQKTMVMVEGIATQLDPTINMWD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
VSAPFVRNWIRDELGPEAAIAERIREDTQTLLRIPDLIRRIEDRFPAKGGAPEAPPLPRI
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
ELMWQRKRRKRGSGLSGQFLAFLAGGALVIGTHALGWWG
HHHHHHHHHHCCCCCCHHHHHHHHCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]