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The map label for this gene is lig [H]

Identifier: 87198094

GI number: 87198094

Start: 69911

End: 71506

Strand: Direct

Name: lig [H]

Synonym: Saro_0068

Alternate gene names: 87198094

Gene position: 69911-71506 (Clockwise)

Preceding gene: 87198093

Following gene: 87198095

Centisome position: 1.96

GC content: 67.17

Gene sequence:

>1596_bases
ATGAACCGCTTTGCCGCCCTGCTCGACGCGCTCGTGCTCACCCCGTCGCGCAACGCGAAGCTTTTGCTGCTGGCCGACTA
CCTGCGCGAGACGCCCGATCCCGACCGTGGGTGGGCGCTTGCCGCGCTGACCGACGGGCTGGACTTCCCGGCGGTGAAGG
CAAGCACCATCCGCGCGCTCATGGCGGAGCGCATCGATCCGGTGCTGTGGACGCTGAGCCGCGACTATGTCGGCGACACG
GCCGAAACCGCCAGCCTGCTCTGGCCGGAACCCATCGGCGACCGCCTGCCCGCGCCCTCCGTCGCCGAAGTGGTAGACAC
GCTCCATGCGGCCACGCGCGGCACCGCACCGGGCATCCTGGCCGAGCTTCTGGACCGCCTTGACGTCAATGGTCGCTATG
CTTTGCTGAAGCTTGCGACCGGCGCCATGCGCATCGGCATCTCGGCGCGGCTTGCCAAGGTCGCCTTCGCCCAAGCCTTC
GACGTGCGGGTCGATGACGTCGAGGAGTACTGGCACGGGCAGGCGCCGCCCTATCTGCCCTTGTTCGACTGGGCGGCGAA
CGGAGCGCCACCGCCGCGAACGGACCTGCTGCCGCTGTTCCGTCCGTTCATGCTCGCCCATCCGCTCGAAGCGGAACGCC
TCGATCTTGCCGAATTCGCCGCCGAATGGAAATGGGACGGCATCCGGGTGCAGATCGTCCATGTCGCAGGCGAGACGCGG
GTCTATTCGCGCAGTGGCGACGACATTTCGGCCACCTTCCCCGAAATCGCGGACGCGCTTGACCGGCCCTGCGTTCTCGA
CGGCGAACTGCTGGTGCGCGGCGCGCATCAGGGCGGCGAGACCGGCGGCGCGGCAAGCTTCAACGCGCTCCAGCAGCGTC
TCGGCCGCAAGACCGTGTCGAAGGCCATGCTGCGCGACTACCCGGCTTTCGTCCGGCTCTACGATGTCCTTATCGAAGGG
GCCGAGGACTTGCGCGAATGGGCCTGGGAGCAGCGCCGTGCCCGGCTCGAGACGCTGGCCCCGCAGCTCCATCCCGAACG
CTTCGATCTTTCGCAGGTGATCCCGGCCGGAAGCTTCGACGAACTTGCCGAGATCCGCGGTCGTTCGCGCGACGAGGCCA
TCGAGGGCGTGATGCTGAAGCGGCGCGACAGCCCATATGTCGCCGGTCGCCGCACCGGCCTGTGGTACAAATGGAAGCGC
GATCCGCTGCTGATCGACTGCGTGCTGATGTATGCCCAGCGTGGAAGCGGGAAGCGATCCTCGTTCTATTCGGATTACAC
CTTCGGCTGCTGGAACGGCGATCCCGATGCGGGGGCCGAGCTCCTGCCGGTCGGCAAGGCCTATTTCGGCTTCACCGACG
AGGAACTGAAGTGGCTCGACCGCCATGTCCGCCAGCACACCGTGGCAAAGTTCGGCCCGGTGCGTGAAACCGACAAGTCG
CTGGTGTTCGAAGTCGCCTTCGATAGCGTCCACGCCAGCAAGCGGCACAAGTCCGGCGTCGCCATGCGCTTCCCCCGCAT
CAGCCGCATCCGGACGGACAAGCCCGCCCACGAGGCCGACCGGCTGGAGACGCTGAAGGCCTTGATCGCCGACTAG

Upstream 100 bases:

>100_bases
GGCACTGGCGCTTGCAGGATACGAGGACGAGGATGATTGAGGCTGGCCCGTTCCAGCCCGGCTCGGGATGGTCACTCTCC
GCGTGGCGGAGAAGGCCTGC

Downstream 100 bases:

>100_bases
GGAACCGGCGACGGGACGCGCTCGTTCGACGACAGATTGTTGGGAGATAACGATAATGATGAACCTGCTCCTCGCCGCTC
CGGCCGCGCTGCTGGGCAAG

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MNRFAALLDALVLTPSRNAKLLLLADYLRETPDPDRGWALAALTDGLDFPAVKASTIRALMAERIDPVLWTLSRDYVGDT
AETASLLWPEPIGDRLPAPSVAEVVDTLHAATRGTAPGILAELLDRLDVNGRYALLKLATGAMRIGISARLAKVAFAQAF
DVRVDDVEEYWHGQAPPYLPLFDWAANGAPPPRTDLLPLFRPFMLAHPLEAERLDLAEFAAEWKWDGIRVQIVHVAGETR
VYSRSGDDISATFPEIADALDRPCVLDGELLVRGAHQGGETGGAASFNALQQRLGRKTVSKAMLRDYPAFVRLYDVLIEG
AEDLREWAWEQRRARLETLAPQLHPERFDLSQVIPAGSFDELAEIRGRSRDEAIEGVMLKRRDSPYVAGRRTGLWYKWKR
DPLLIDCVLMYAQRGSGKRSSFYSDYTFGCWNGDPDAGAELLPVGKAYFGFTDEELKWLDRHVRQHTVAKFGPVRETDKS
LVFEVAFDSVHASKRHKSGVAMRFPRISRIRTDKPAHEADRLETLKALIAD

Sequences:

>Translated_531_residues
MNRFAALLDALVLTPSRNAKLLLLADYLRETPDPDRGWALAALTDGLDFPAVKASTIRALMAERIDPVLWTLSRDYVGDT
AETASLLWPEPIGDRLPAPSVAEVVDTLHAATRGTAPGILAELLDRLDVNGRYALLKLATGAMRIGISARLAKVAFAQAF
DVRVDDVEEYWHGQAPPYLPLFDWAANGAPPPRTDLLPLFRPFMLAHPLEAERLDLAEFAAEWKWDGIRVQIVHVAGETR
VYSRSGDDISATFPEIADALDRPCVLDGELLVRGAHQGGETGGAASFNALQQRLGRKTVSKAMLRDYPAFVRLYDVLIEG
AEDLREWAWEQRRARLETLAPQLHPERFDLSQVIPAGSFDELAEIRGRSRDEAIEGVMLKRRDSPYVAGRRTGLWYKWKR
DPLLIDCVLMYAQRGSGKRSSFYSDYTFGCWNGDPDAGAELLPVGKAYFGFTDEELKWLDRHVRQHTVAKFGPVRETDKS
LVFEVAFDSVHASKRHKSGVAMRFPRISRIRTDKPAHEADRLETLKALIAD
>Mature_531_residues
MNRFAALLDALVLTPSRNAKLLLLADYLRETPDPDRGWALAALTDGLDFPAVKASTIRALMAERIDPVLWTLSRDYVGDT
AETASLLWPEPIGDRLPAPSVAEVVDTLHAATRGTAPGILAELLDRLDVNGRYALLKLATGAMRIGISARLAKVAFAQAF
DVRVDDVEEYWHGQAPPYLPLFDWAANGAPPPRTDLLPLFRPFMLAHPLEAERLDLAEFAAEWKWDGIRVQIVHVAGETR
VYSRSGDDISATFPEIADALDRPCVLDGELLVRGAHQGGETGGAASFNALQQRLGRKTVSKAMLRDYPAFVRLYDVLIEG
AEDLREWAWEQRRARLETLAPQLHPERFDLSQVIPAGSFDELAEIRGRSRDEAIEGVMLKRRDSPYVAGRRTGLWYKWKR
DPLLIDCVLMYAQRGSGKRSSFYSDYTFGCWNGDPDAGAELLPVGKAYFGFTDEELKWLDRHVRQHTVAKFGPVRETDKS
LVFEVAFDSVHASKRHKSGVAMRFPRISRIRTDKPAHEADRLETLKALIAD

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=351, Percent_Identity=25.6410256410256, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71985269, Length=474, Percent_Identity=25.3164556962025, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320038, Length=359, Percent_Identity=30.08356545961, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24762424, Length=363, Percent_Identity=26.4462809917355, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 59336; Mature: 59336

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFAALLDALVLTPSRNAKLLLLADYLRETPDPDRGWALAALTDGLDFPAVKASTIRAL
CCHHHHHHHHHHCCCCCCCEEEEEEHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHH
MAERIDPVLWTLSRDYVGDTAETASLLWPEPIGDRLPAPSVAEVVDTLHAATRGTAPGIL
HHHHCCHHHEEHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHH
AELLDRLDVNGRYALLKLATGAMRIGISARLAKVAFAQAFDVRVDDVEEYWHGQAPPYLP
HHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
LFDWAANGAPPPRTDLLPLFRPFMLAHPLEAERLDLAEFAAEWKWDGIRVQIVHVAGETR
HHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCE
VYSRSGDDISATFPEIADALDRPCVLDGELLVRGAHQGGETGGAASFNALQQRLGRKTVS
EEECCCCCCCCHHHHHHHHHCCCEEECCHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
KAMLRDYPAFVRLYDVLIEGAEDLREWAWEQRRARLETLAPQLHPERFDLSQVIPAGSFD
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHCCCCCCCHHHHCCCCCHH
ELAEIRGRSRDEAIEGVMLKRRDSPYVAGRRTGLWYKWKRDPLLIDCVLMYAQRGSGKRS
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCC
SFYSDYTFGCWNGDPDAGAELLPVGKAYFGFTDEELKWLDRHVRQHTVAKFGPVRETDKS
CCCCCCEEECCCCCCCCCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LVFEVAFDSVHASKRHKSGVAMRFPRISRIRTDKPAHEADRLETLKALIAD
HEEHHHHHHHHHHHHHCCCCEEECCCHHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNRFAALLDALVLTPSRNAKLLLLADYLRETPDPDRGWALAALTDGLDFPAVKASTIRAL
CCHHHHHHHHHHCCCCCCCEEEEEEHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHH
MAERIDPVLWTLSRDYVGDTAETASLLWPEPIGDRLPAPSVAEVVDTLHAATRGTAPGIL
HHHHCCHHHEEHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHH
AELLDRLDVNGRYALLKLATGAMRIGISARLAKVAFAQAFDVRVDDVEEYWHGQAPPYLP
HHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
LFDWAANGAPPPRTDLLPLFRPFMLAHPLEAERLDLAEFAAEWKWDGIRVQIVHVAGETR
HHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCE
VYSRSGDDISATFPEIADALDRPCVLDGELLVRGAHQGGETGGAASFNALQQRLGRKTVS
EEECCCCCCCCHHHHHHHHHCCCEEECCHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
KAMLRDYPAFVRLYDVLIEGAEDLREWAWEQRRARLETLAPQLHPERFDLSQVIPAGSFD
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHCCCCCCCHHHHCCCCCHH
ELAEIRGRSRDEAIEGVMLKRRDSPYVAGRRTGLWYKWKRDPLLIDCVLMYAQRGSGKRS
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCC
SFYSDYTFGCWNGDPDAGAELLPVGKAYFGFTDEELKWLDRHVRQHTVAKFGPVRETDKS
CCCCCCEEECCCCCCCCCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LVFEVAFDSVHASKRHKSGVAMRFPRISRIRTDKPAHEADRLETLKALIAD
HEEHHHHHHHHHHHHHCCCCEEECCCHHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA