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The map label for this gene is clpA [C]

Identifier: 87198092

GI number: 87198092

Start: 66339

End: 68717

Strand: Direct

Name: clpA [C]

Synonym: Saro_0066

Alternate gene names: 87198092

Gene position: 66339-68717 (Clockwise)

Preceding gene: 87198089

Following gene: 87198093

Centisome position: 1.86

GC content: 65.24

Gene sequence:

>2379_bases
ATGCCCAGTTTCGCCCAGAGCCTCGAGAAGACGCTGCACACCGCGCTCGCCAACGCGTCCGAGCGCAGCCACGAGTACGC
GACTCTCGAGCACCTCCTGCTGGCCCTGATCGACGATCCGGATGCGGCGCAGGTCATGCAGGCCTGCGGCGTCGACCTCG
GCGATCTCGGCGATGTCGTGCGCCAGTACCTCGACCAGGAATACCAGTCGCTCAAGACGCAGGAGAAGGCCGACCCGCAG
CCGACAGCCGGCTTCCAGCGGGTGATCCAGCGCGCCATCCTGCACGTCCAGTCCAGCGGCAAGGACACCGTCACCGGCGC
CAACGTGCTGGTCGCGCTGTTCTCCGAACGCGACAGCTATGCGGTCTATTTCCTGCAGCAGCAGGACATGAGCCGCCTCG
ACGCGGTCAGCTTCATCAGCCACGGCATCGGCAAGGGTGGACGCCAGGTCGATGGCCGCACGCCCAAGGGCGCCGAGGAG
GATGTACCCAAGCAGCAGGAAGAAAAGGCCGACGCCAAGGGGCAGAAGAAGGAAACCGCTCTCGACCAGTTCTGCGTCAA
CCTCAACGAGAAGGCGCTGGCGGGCAAGGTCGATCCGCTGATCGGGCGCGGGCCGGAAGTGGATCGCACGATCCAGATCC
TGTGCCGCCGCAGCAAGAACAACCCGCTCTACGTGGGCGATCCCGGCGTGGGCAAGACCGCCATCGCCGAGGGCCTCGCG
CGCAAGATCGTCGAGGGCGAAGTGCCCGAGGTCCTCTCCGAGGCGGTGATCTATTCGCTCGACATGGGCAGCCTGCTCGC
CGGCACCCGCTATCGCGGCGACTTCGAGGAACGCCTCAAGCAGGTCGTCTCCGAGCTCGAGAAGATGCCGCACGCGATCC
TGTTCATCGACGAGATCCATACCGTGATCGGCGCCGGCGCGACCAGCGGCGGGGCGATGGACGCTTCGAACCTGCTCAAG
CCCGCGCTTTCGGGCGGGACCATCCGCTGCATCGGCTCGACCACCTACAAGGAGTTCCGCAACCACTTCGAAAAGGACCG
CGCCCTGCTGCGCCGGTTCCAGAAGATCGACGTGAACGAACCCACAGTCGAGGACACGATCAAGATCCTCAAGGGCCTGC
GCACGGCGTTCGAGGAACACCACAAGGTCAAGTACACGCCCGACGCGATCAAGACCGCGGTCGAGCTTTCCGCGCGCTAC
ATCAACGACCGCAAGCTGCCCGACAAGGCGATCGACGTGATCGACGAAGTGGGCGCGATGCAGATGCTGGTGCCGCCCTC
GAAGCGCAAGAAGACCATCACCGCGCGCGAGATCGAGCAGGTCATCGCGACCATGGCCCGCATCCCGCCCAAGTCGGTGT
CGAGCGACGACAAGAAGGTCCTCGAACACCTCGAACGCGACCTGAAGCGCCTCGTGTTCGGGCAGGACAAGGCGATCGAG
GTGCTGTCCTCGGCGATGAAGCTCAGCCGCGCGGGCCTGCGCGATCCGGACAAGCCGATCGGCTCGTTCCTTTTCTCGGG
CCCGACCGGCGTCGGCAAGACCGAGGTTGCCCGCAGCCTTGCCCAGATCATGGGCATTCCGCTGCAGCGCTTCGACATGT
CCGAATACATGGAGCGCCACTCGGTCTCGCGCCTGATCGGCGCACCTCCGGGCTATGTCGGCTTCGACCAGGGCGGTCTT
CTCACTGATGCCATCGACCAGCAGCCGCACTGCGTCCTGCTGCTCGACGAGATCGAGAAGGCGCACCCCGACCTGTTCAA
CATCCTGCTCCAGGTGATGGACAACGGCCGCCTGACCGACCACCACGGCAAGACCGTCGACTTCCGCAACGTGGTCCTGA
TCATGACCACCAATGCGGGCGCTTCGGACATGGCGCGCCAGGGCATCGGCTTCGGCGACGTGTCGAAGGCGGACGCGGGC
GACGAGGCGGTGAAGAAGATGTTCACCCCCGAGTTCCGCAACCGCCTCGATGCCATCGTGCCCTTCGCGTACCTGCCGCC
CGAAGTCGTCAGCCGCGTCGTCGACAAGTTCGTGCTCCAGCTCGAACTCCAGCTTGCCGACCAGAACGTGCACATCCAGT
TCGATGCCGATGCGCGCGCCTGGCTGGCGAAGAAGGGCTATGACCGCCTCTATGGCGCGCGGCCGATGGCCCGCGTGATC
CAGGAAAAGGTCAAGAAGCCGCTGGCCGAGGAATTGCTGTTCGGCAAGCTCGCCAATGGCGGCGAGGTCCATGTCAGCCT
CAAGCAGGAGGAGGGCCAGGAAGGCGCCCTCTCGTTCGAGCTGACCCCGGCCGCGCCGAAGCTGGTCAACAAGAAGAAGG
GCAAGAAGAGCAAGGCGGGCGATACCACCGCCGAGGAACCCAACGCCGACGAGGCCTGA

Upstream 100 bases:

>100_bases
GGTTTAGCCGCGGTTAATAACGCGTGTGCACTCTCTCGGTCCGGGCCCTCGCAAGCCCTGACGGGGAACCCACCGGCGCA
AGCCAGAAAGTAGCCGTACC

Downstream 100 bases:

>100_bases
TTCTCCGCTCGAGACCTGACAGAAGAAGGCCTGCCTTTCGGGGCGGGCCTTTTTTCTGCATGCGCCAGGGCCACCCGGCA
CCAAGGGCACTGGAACCCGA

Product: ATP dependent Clp protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 792; Mature: 791

Protein sequence:

>792_residues
MPSFAQSLEKTLHTALANASERSHEYATLEHLLLALIDDPDAAQVMQACGVDLGDLGDVVRQYLDQEYQSLKTQEKADPQ
PTAGFQRVIQRAILHVQSSGKDTVTGANVLVALFSERDSYAVYFLQQQDMSRLDAVSFISHGIGKGGRQVDGRTPKGAEE
DVPKQQEEKADAKGQKKETALDQFCVNLNEKALAGKVDPLIGRGPEVDRTIQILCRRSKNNPLYVGDPGVGKTAIAEGLA
RKIVEGEVPEVLSEAVIYSLDMGSLLAGTRYRGDFEERLKQVVSELEKMPHAILFIDEIHTVIGAGATSGGAMDASNLLK
PALSGGTIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVNEPTVEDTIKILKGLRTAFEEHHKVKYTPDAIKTAVELSARY
INDRKLPDKAIDVIDEVGAMQMLVPPSKRKKTITAREIEQVIATMARIPPKSVSSDDKKVLEHLERDLKRLVFGQDKAIE
VLSSAMKLSRAGLRDPDKPIGSFLFSGPTGVGKTEVARSLAQIMGIPLQRFDMSEYMERHSVSRLIGAPPGYVGFDQGGL
LTDAIDQQPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTDHHGKTVDFRNVVLIMTTNAGASDMARQGIGFGDVSKADAG
DEAVKKMFTPEFRNRLDAIVPFAYLPPEVVSRVVDKFVLQLELQLADQNVHIQFDADARAWLAKKGYDRLYGARPMARVI
QEKVKKPLAEELLFGKLANGGEVHVSLKQEEGQEGALSFELTPAAPKLVNKKKGKKSKAGDTTAEEPNADEA

Sequences:

>Translated_792_residues
MPSFAQSLEKTLHTALANASERSHEYATLEHLLLALIDDPDAAQVMQACGVDLGDLGDVVRQYLDQEYQSLKTQEKADPQ
PTAGFQRVIQRAILHVQSSGKDTVTGANVLVALFSERDSYAVYFLQQQDMSRLDAVSFISHGIGKGGRQVDGRTPKGAEE
DVPKQQEEKADAKGQKKETALDQFCVNLNEKALAGKVDPLIGRGPEVDRTIQILCRRSKNNPLYVGDPGVGKTAIAEGLA
RKIVEGEVPEVLSEAVIYSLDMGSLLAGTRYRGDFEERLKQVVSELEKMPHAILFIDEIHTVIGAGATSGGAMDASNLLK
PALSGGTIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVNEPTVEDTIKILKGLRTAFEEHHKVKYTPDAIKTAVELSARY
INDRKLPDKAIDVIDEVGAMQMLVPPSKRKKTITAREIEQVIATMARIPPKSVSSDDKKVLEHLERDLKRLVFGQDKAIE
VLSSAMKLSRAGLRDPDKPIGSFLFSGPTGVGKTEVARSLAQIMGIPLQRFDMSEYMERHSVSRLIGAPPGYVGFDQGGL
LTDAIDQQPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTDHHGKTVDFRNVVLIMTTNAGASDMARQGIGFGDVSKADAG
DEAVKKMFTPEFRNRLDAIVPFAYLPPEVVSRVVDKFVLQLELQLADQNVHIQFDADARAWLAKKGYDRLYGARPMARVI
QEKVKKPLAEELLFGKLANGGEVHVSLKQEEGQEGALSFELTPAAPKLVNKKKGKKSKAGDTTAEEPNADEA
>Mature_791_residues
PSFAQSLEKTLHTALANASERSHEYATLEHLLLALIDDPDAAQVMQACGVDLGDLGDVVRQYLDQEYQSLKTQEKADPQP
TAGFQRVIQRAILHVQSSGKDTVTGANVLVALFSERDSYAVYFLQQQDMSRLDAVSFISHGIGKGGRQVDGRTPKGAEED
VPKQQEEKADAKGQKKETALDQFCVNLNEKALAGKVDPLIGRGPEVDRTIQILCRRSKNNPLYVGDPGVGKTAIAEGLAR
KIVEGEVPEVLSEAVIYSLDMGSLLAGTRYRGDFEERLKQVVSELEKMPHAILFIDEIHTVIGAGATSGGAMDASNLLKP
ALSGGTIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVNEPTVEDTIKILKGLRTAFEEHHKVKYTPDAIKTAVELSARYI
NDRKLPDKAIDVIDEVGAMQMLVPPSKRKKTITAREIEQVIATMARIPPKSVSSDDKKVLEHLERDLKRLVFGQDKAIEV
LSSAMKLSRAGLRDPDKPIGSFLFSGPTGVGKTEVARSLAQIMGIPLQRFDMSEYMERHSVSRLIGAPPGYVGFDQGGLL
TDAIDQQPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTDHHGKTVDFRNVVLIMTTNAGASDMARQGIGFGDVSKADAGD
EAVKKMFTPEFRNRLDAIVPFAYLPPEVVSRVVDKFVLQLELQLADQNVHIQFDADARAWLAKKGYDRLYGARPMARVIQ
EKVKKPLAEELLFGKLANGGEVHVSLKQEEGQEGALSFELTPAAPKLVNKKKGKKSKAGDTTAEEPNADEA

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=323, Percent_Identity=31.2693498452012, Blast_Score=165, Evalue=2e-40,
Organism=Escherichia coli, GI1787109, Length=749, Percent_Identity=58.7449933244326, Blast_Score=900, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=419, Percent_Identity=41.7661097852029, Blast_Score=292, Evalue=6e-80,
Organism=Saccharomyces cerevisiae, GI6320464, Length=325, Percent_Identity=44.3076923076923, Blast_Score=282, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=410, Percent_Identity=36.0975609756098, Blast_Score=244, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: 3.4.21.92

Molecular weight: Translated: 87083; Mature: 86951

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSFAQSLEKTLHTALANASERSHEYATLEHLLLALIDDPDAAQVMQACGVDLGDLGDVV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHH
RQYLDQEYQSLKTQEKADPQPTAGFQRVIQRAILHVQSSGKDTVTGANVLVALFSERDSY
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCE
AVYFLQQQDMSRLDAVSFISHGIGKGGRQVDGRTPKGAEEDVPKQQEEKADAKGQKKETA
EEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHH
LDQFCVNLNEKALAGKVDPLIGRGPEVDRTIQILCRRSKNNPLYVGDPGVGKTAIAEGLA
HHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHH
RKIVEGEVPEVLSEAVIYSLDMGSLLAGTRYRGDFEERLKQVVSELEKMPHAILFIDEIH
HHHHCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHEEHHHHHH
TVIGAGATSGGAMDASNLLKPALSGGTIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVNE
HHHHCCCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTVEDTIKILKGLRTAFEEHHKVKYTPDAIKTAVELSARYINDRKLPDKAIDVIDEVGAM
CCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
QMLVPPSKRKKTITAREIEQVIATMARIPPKSVSSDDKKVLEHLERDLKRLVFGQDKAIE
EEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
VLSSAMKLSRAGLRDPDKPIGSFLFSGPTGVGKTEVARSLAQIMGIPLQRFDMSEYMERH
HHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHH
SVSRLIGAPPGYVGFDQGGLLTDAIDQQPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTD
HHHHHHCCCCCCCCCCCCCCCHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCEEC
HHGKTVDFRNVVLIMTTNAGASDMARQGIGFGDVSKADAGDEAVKKMFTPEFRNRLDAIV
CCCCEEEECCEEEEEECCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHC
PFAYLPPEVVSRVVDKFVLQLELQLADQNVHIQFDADARAWLAKKGYDRLYGARPMARVI
CHHCCCHHHHHHHHHHHHHHHHHEECCCCEEEEECCCHHHHHHHCCHHHHHCCCHHHHHH
QEKVKKPLAEELLFGKLANGGEVHVSLKQEEGQEGALSFELTPAAPKLVNKKKGKKSKAG
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEECCCCHHHHHHHCCCCCCCC
DTTAEEPNADEA
CCCCCCCCCCCC
>Mature Secondary Structure 
PSFAQSLEKTLHTALANASERSHEYATLEHLLLALIDDPDAAQVMQACGVDLGDLGDVV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHH
RQYLDQEYQSLKTQEKADPQPTAGFQRVIQRAILHVQSSGKDTVTGANVLVALFSERDSY
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCE
AVYFLQQQDMSRLDAVSFISHGIGKGGRQVDGRTPKGAEEDVPKQQEEKADAKGQKKETA
EEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHH
LDQFCVNLNEKALAGKVDPLIGRGPEVDRTIQILCRRSKNNPLYVGDPGVGKTAIAEGLA
HHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHH
RKIVEGEVPEVLSEAVIYSLDMGSLLAGTRYRGDFEERLKQVVSELEKMPHAILFIDEIH
HHHHCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHEEHHHHHH
TVIGAGATSGGAMDASNLLKPALSGGTIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVNE
HHHHCCCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTVEDTIKILKGLRTAFEEHHKVKYTPDAIKTAVELSARYINDRKLPDKAIDVIDEVGAM
CCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
QMLVPPSKRKKTITAREIEQVIATMARIPPKSVSSDDKKVLEHLERDLKRLVFGQDKAIE
EEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
VLSSAMKLSRAGLRDPDKPIGSFLFSGPTGVGKTEVARSLAQIMGIPLQRFDMSEYMERH
HHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHH
SVSRLIGAPPGYVGFDQGGLLTDAIDQQPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTD
HHHHHHCCCCCCCCCCCCCCCHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCEEC
HHGKTVDFRNVVLIMTTNAGASDMARQGIGFGDVSKADAGDEAVKKMFTPEFRNRLDAIV
CCCCEEEECCEEEEEECCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHC
PFAYLPPEVVSRVVDKFVLQLELQLADQNVHIQFDADARAWLAKKGYDRLYGARPMARVI
CHHCCCHHHHHHHHHHHHHHHHHEECCCCEEEEECCCHHHHHHHCCHHHHHCCCHHHHHH
QEKVKKPLAEELLFGKLANGGEVHVSLKQEEGQEGALSFELTPAAPKLVNKKKGKKSKAG
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEECCCCHHHHHHHCCCCCCCC
DTTAEEPNADEA
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]