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The map label for this gene is moeB [H]

Identifier: 87198028

GI number: 87198028

Start: 1629

End: 2423

Strand: Direct

Name: moeB [H]

Synonym: Saro_0002

Alternate gene names: 87198028

Gene position: 1629-2423 (Clockwise)

Preceding gene: 87198027

Following gene: 87198030

Centisome position: 0.05

GC content: 66.54

Gene sequence:

>795_bases
ATGACGACGCCTGCCCTCTCCCCGGCTCTCACGCCGGACCGTCTTGACCGCTTCGCCCGCCATATCGTCCTGCCCGAAGT
GGGCGCGATCGGGCAGGCTCGGCTGGCCGCGAGCCATGTCGTGCTGGTCGGCATGGGCGGCATCGGATCGCCGGCGCTCC
AGTATCTTGCGGGCGCGGGCGTCGGCAGGCTCACGCTGATCGACGACGACGTGGTCGAAGCATCGAACCTCCAGCGCCAG
ACGATCTATACCGAAGAAGACCTCGGCAAGCCCAAAGCGCAAGCGGCGGCAGCATGGGTCGCGCGGTTCGATCCGGCGCT
CGAGGTCGTACATCACGTCACCCGCATCGGGCGGGAGAATGCCGCGGACCTAATCGCCGGAGCCGACGTCGTGCTCGACG
GTTCGGACAACTTCGCCACGCGCCTGTCGGTTTCGGACGCCTGCGTTTCGGTAGGGGTAGCGCTCTCCAGTGTCGCTTTA
GGTCGCTTTCAGGGACAGGTGGCGAATTTCGCCGGGCACCGTCCGGGTGAGGCCTGCTACCGCTGTTTCGTGGGCGATGC
CTTCGATGCCGAGGACTGCGACACATGCGCCGACCTTGGGGTGCTGGGCGCGATGGTCGGCATGATCGGCGCATTCGGAG
CGATGGCGGCGATGCGGGTACTGCTGGAAGGCGTCAGCACGCTGGGCGACCCGCAATGGGGCCAACTCCACGTATTCGAC
GGCCTCAAACCCAGCCTGAGAACCATGCGCATCGCCCGCGATCCCGAATGTCGGGGCTGCACTTCAGGCCAGTAG

Upstream 100 bases:

>100_bases
TCCCTGGCCGGTCCATCGGTTTTCCCGGGGTTTTGCACAGACATGGCCCGGAGGCGCGCAATGCTCGCCTTCGGGCCGTT
TTGCATCTAGATGCGCTCCC

Downstream 100 bases:

>100_bases
CTCGTCGACCCAGGCGGTCACCGTCTCGGTCGCCGGACCAAGCCGCGTCTCGTGGAACCAGGCCGACCCCTGAGAGCGTT
CCAGATTGAGTTCGAGTGTC

Product: UBA/THIF-type NAD/FAD binding domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MTTPALSPALTPDRLDRFARHIVLPEVGAIGQARLAASHVVLVGMGGIGSPALQYLAGAGVGRLTLIDDDVVEASNLQRQ
TIYTEEDLGKPKAQAAAAWVARFDPALEVVHHVTRIGRENAADLIAGADVVLDGSDNFATRLSVSDACVSVGVALSSVAL
GRFQGQVANFAGHRPGEACYRCFVGDAFDAEDCDTCADLGVLGAMVGMIGAFGAMAAMRVLLEGVSTLGDPQWGQLHVFD
GLKPSLRTMRIARDPECRGCTSGQ

Sequences:

>Translated_264_residues
MTTPALSPALTPDRLDRFARHIVLPEVGAIGQARLAASHVVLVGMGGIGSPALQYLAGAGVGRLTLIDDDVVEASNLQRQ
TIYTEEDLGKPKAQAAAAWVARFDPALEVVHHVTRIGRENAADLIAGADVVLDGSDNFATRLSVSDACVSVGVALSSVAL
GRFQGQVANFAGHRPGEACYRCFVGDAFDAEDCDTCADLGVLGAMVGMIGAFGAMAAMRVLLEGVSTLGDPQWGQLHVFD
GLKPSLRTMRIARDPECRGCTSGQ
>Mature_263_residues
TTPALSPALTPDRLDRFARHIVLPEVGAIGQARLAASHVVLVGMGGIGSPALQYLAGAGVGRLTLIDDDVVEASNLQRQT
IYTEEDLGKPKAQAAAAWVARFDPALEVVHHVTRIGRENAADLIAGADVVLDGSDNFATRLSVSDACVSVGVALSSVALG
RFQGQVANFAGHRPGEACYRCFVGDAFDAEDCDTCADLGVLGAMVGMIGAFGAMAAMRVLLEGVSTLGDPQWGQLHVFDG
LKPSLRTMRIARDPECRGCTSGQ

Specific function: Involved In The Biosynthesis Of A Demolybdo Cofactor (Molybdopterin), Necessary For Molybdoenzymes. Plays A Role In The Activation Of The Small Subunit Of The Molybdopterin Converting Factor (Moad). [C]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=235, Percent_Identity=43.4042553191489, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI4885649, Length=149, Percent_Identity=30.2013422818792, Blast_Score=71, Evalue=9e-13,
Organism=Escherichia coli, GI1787048, Length=251, Percent_Identity=36.6533864541833, Blast_Score=162, Evalue=1e-41,
Organism=Escherichia coli, GI87082356, Length=246, Percent_Identity=36.9918699186992, Blast_Score=147, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17540406, Length=246, Percent_Identity=35.7723577235772, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI193203301, Length=150, Percent_Identity=30, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6321903, Length=256, Percent_Identity=33.59375, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6325323, Length=151, Percent_Identity=28.476821192053, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24582879, Length=261, Percent_Identity=39.463601532567, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24660640, Length=156, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28573937, Length=126, Percent_Identity=31.7460317460317, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 27559; Mature: 27428

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPALSPALTPDRLDRFARHIVLPEVGAIGQARLAASHVVLVGMGGIGSPALQYLAGAG
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCEEEEEECCCCCHHHHHHHHCCC
VGRLTLIDDDVVEASNLQRQTIYTEEDLGKPKAQAAAAWVARFDPALEVVHHVTRIGREN
CCEEEEECCCHHHHHCCHHHHCCCHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
AADLIAGADVVLDGSDNFATRLSVSDACVSVGVALSSVALGRFQGQVANFAGHRPGEACY
HHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RCFVGDAFDAEDCDTCADLGVLGAMVGMIGAFGAMAAMRVLLEGVSTLGDPQWGQLHVFD
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
GLKPSLRTMRIARDPECRGCTSGQ
CCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TTPALSPALTPDRLDRFARHIVLPEVGAIGQARLAASHVVLVGMGGIGSPALQYLAGAG
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCEEEEEECCCCCHHHHHHHHCCC
VGRLTLIDDDVVEASNLQRQTIYTEEDLGKPKAQAAAAWVARFDPALEVVHHVTRIGREN
CCEEEEECCCHHHHHCCHHHHCCCHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
AADLIAGADVVLDGSDNFATRLSVSDACVSVGVALSSVALGRFQGQVANFAGHRPGEACY
HHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RCFVGDAFDAEDCDTCADLGVLGAMVGMIGAFGAMAAMRVLLEGVSTLGDPQWGQLHVFD
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
GLKPSLRTMRIARDPECRGCTSGQ
CCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA