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The map label for this gene is recQ [H]

Identifier: 86751799

GI number: 86751799

Start: 5321057

End: 5322913

Strand: Direct

Name: recQ [H]

Synonym: RPB_4701

Alternate gene names: 86751799

Gene position: 5321057-5322913 (Clockwise)

Preceding gene: 86751798

Following gene: 86751800

Centisome position: 99.8

GC content: 68.01

Gene sequence:

>1857_bases
ATGACCCTCTCCGCCTCGCGCCACGCCTCCGACGACCTCGATGCCCGCGCGCTGTCGACGCTGAATCACGTGTTCGGCCT
GCCCGGCTTTCGCGGCCATCAGGAAGCGATCATCCGCCATGTCGCGCATGGCGGCGATTGTCTGGTGCTGATGCCGACCG
GGGGCGGCAAGTCGCTGTGCTACCAGTTGCCCGCCCTGTTGAGAGACGGCTGCGGCATCGTGGTGTCGCCGCTGATCGCG
CTGATGCGCGACCAGGTGGCGGGGCTGCTGGAGGCCGGCGTGCGCGCCGCGGCGCTGAATTCCAGCCTAAGCTACGCCGA
GGCCGACGCGATCGAGCGGCAGCTGCTCGCCGGCGAACTCGACCTTTTATACGTCGCCCCCGAACGCCTGCTGACACCGC
GTTGCCTGGCGATGCTGGCGCGGGCGAAAATCGCGCTGTTCGCGATCGACGAGGCGCATTGCGTGTCGCAATGGGGCCAC
GACTTCCGGCCGGAATATGTCGGCCTCTCCGCCATCGCCGAGAAATTCCCCAACGTGCCGCGGATCGCCCTGACCGCGAC
CGCCGACGCACTGACGCGGCGCGAGATCAGCGAGCGGCTCGGCCTCACCGACGCGCCCTGCTTCGTGTCGAGCTTCGACC
GGCCGAACATCCGCTACGCCATCGTCGACAAGCAGAATGCGCCGGCGCAGCTCAAGGCGTTCATCGCCGACAAGCATATG
GGCCATTCCGGCGTGGTGTATTGCCTGTCGCGCGCCAAGGTCGAGGACATCGCCGACACGCTGTGCAAGGCCGGCATCGA
CGCGCTGCCCTATCACGCCGGTCTGCCGGCGGAGATCCGCGCGCGCAATCAGGACCGCTTCATCAACGAGGACGGCGTGG
TGATCGTCGCCACCATCGCGTTCGGCATGGGCATCGACAAGCCCGACGTGCGCTTCGTCGCGCATCTCGACCTGCCCAAG
AGCATCGAGGCCTATTATCAGGAGACCGGCCGCGCCGGCCGCGACGGCAAGCCGTCGGATGCCTGGATGGCCTACGGCCT
TTCCGACATCGTGCAGCAGCGGCGGATGATCGACGAATCCTCCGGCTCCGACGCCTTCAAGCGGGTGTCGATGGGCAAGC
TCGATGCGCTGGTCGGCCTGTGTGAATCCACCGCCTGCCGCCGCACCCGGCTGCTCGGCTATTTCGGCGAGACGGCGCTC
GAGCCGCAGTGCGGCAATTGCGATAATTGTCTGTCGCCGCCCAAGGTGATCGACGGCACCGTGGCGGCGCAGAAGCTGCT
GTCCTGCGCCTATCGCACCGGGCAGCGGTTCGGCGCCCAGCATCTGATCGACGTGCTGCTCGGCCGCCTGACCGAGCGCG
TCGGCCAGTTCGGCCACGACAAGCTCTCGGTGTTCGGCATCGGCGGCGAATTCAACGAGAAGCAATGGCGGGCGGTGATC
CGGCAATTGGTGTCGCTCGGGCACCTCGCGCCGGACAGCGAGGCGTTCGGCGCGCTGAAACTCACCGAGAGTTCGCGCGC
GGTGCTGAAGGGCGACGCGCAGGTGATGCTGCGCGAGCAGACCGGCGGCCGGCCGCCGCGGGCGAAATCCCGCCGCGGCG
ATCTGGTCGGCGGCGCGCCGCGCGAATCGACCGGCGATCCGGATCTGTTCGCGGCGCTGAAGGCGTGGCGCTCCGAGGTG
GCGAAGAGCCGCGGCGTGCCGGCCTATGTGGTGCTGCACGACGCCACCATGGACGGTATCGCCGCAGTGCGCCCACGCTC
GCTCGACGAACTGCGCGGCATTCCCGGGATCGGCGACAAGAAGCTGGAGCATTATGGCCAGGAATTGCTGGCCCTGGTAA
ATGCCTCAGGCAGCTGA

Upstream 100 bases:

>100_bases
CTGCGGCAAACATTCTGATGCAAGACCGAGAAGAATCGGCCGCGTTGGGCTATAGGCTTCACATGTCCGTACGCATGCTC
TTCTTCGCCCACCGATCCGC

Downstream 100 bases:

>100_bases
ACCGGCTGCCGCGCGGACGCTCGCCGCGATCACGGATTGTCAGAGAAAGGGTATCGGTGTCCAGCCCATCCCATCTTGCC
GCACTCGACAAGCTCAAGAC

Product: ATP-dependent DNA helicase, RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MTLSASRHASDDLDARALSTLNHVFGLPGFRGHQEAIIRHVAHGGDCLVLMPTGGGKSLCYQLPALLRDGCGIVVSPLIA
LMRDQVAGLLEAGVRAAALNSSLSYAEADAIERQLLAGELDLLYVAPERLLTPRCLAMLARAKIALFAIDEAHCVSQWGH
DFRPEYVGLSAIAEKFPNVPRIALTATADALTRREISERLGLTDAPCFVSSFDRPNIRYAIVDKQNAPAQLKAFIADKHM
GHSGVVYCLSRAKVEDIADTLCKAGIDALPYHAGLPAEIRARNQDRFINEDGVVIVATIAFGMGIDKPDVRFVAHLDLPK
SIEAYYQETGRAGRDGKPSDAWMAYGLSDIVQQRRMIDESSGSDAFKRVSMGKLDALVGLCESTACRRTRLLGYFGETAL
EPQCGNCDNCLSPPKVIDGTVAAQKLLSCAYRTGQRFGAQHLIDVLLGRLTERVGQFGHDKLSVFGIGGEFNEKQWRAVI
RQLVSLGHLAPDSEAFGALKLTESSRAVLKGDAQVMLREQTGGRPPRAKSRRGDLVGGAPRESTGDPDLFAALKAWRSEV
AKSRGVPAYVVLHDATMDGIAAVRPRSLDELRGIPGIGDKKLEHYGQELLALVNASGS

Sequences:

>Translated_618_residues
MTLSASRHASDDLDARALSTLNHVFGLPGFRGHQEAIIRHVAHGGDCLVLMPTGGGKSLCYQLPALLRDGCGIVVSPLIA
LMRDQVAGLLEAGVRAAALNSSLSYAEADAIERQLLAGELDLLYVAPERLLTPRCLAMLARAKIALFAIDEAHCVSQWGH
DFRPEYVGLSAIAEKFPNVPRIALTATADALTRREISERLGLTDAPCFVSSFDRPNIRYAIVDKQNAPAQLKAFIADKHM
GHSGVVYCLSRAKVEDIADTLCKAGIDALPYHAGLPAEIRARNQDRFINEDGVVIVATIAFGMGIDKPDVRFVAHLDLPK
SIEAYYQETGRAGRDGKPSDAWMAYGLSDIVQQRRMIDESSGSDAFKRVSMGKLDALVGLCESTACRRTRLLGYFGETAL
EPQCGNCDNCLSPPKVIDGTVAAQKLLSCAYRTGQRFGAQHLIDVLLGRLTERVGQFGHDKLSVFGIGGEFNEKQWRAVI
RQLVSLGHLAPDSEAFGALKLTESSRAVLKGDAQVMLREQTGGRPPRAKSRRGDLVGGAPRESTGDPDLFAALKAWRSEV
AKSRGVPAYVVLHDATMDGIAAVRPRSLDELRGIPGIGDKKLEHYGQELLALVNASGS
>Mature_617_residues
TLSASRHASDDLDARALSTLNHVFGLPGFRGHQEAIIRHVAHGGDCLVLMPTGGGKSLCYQLPALLRDGCGIVVSPLIAL
MRDQVAGLLEAGVRAAALNSSLSYAEADAIERQLLAGELDLLYVAPERLLTPRCLAMLARAKIALFAIDEAHCVSQWGHD
FRPEYVGLSAIAEKFPNVPRIALTATADALTRREISERLGLTDAPCFVSSFDRPNIRYAIVDKQNAPAQLKAFIADKHMG
HSGVVYCLSRAKVEDIADTLCKAGIDALPYHAGLPAEIRARNQDRFINEDGVVIVATIAFGMGIDKPDVRFVAHLDLPKS
IEAYYQETGRAGRDGKPSDAWMAYGLSDIVQQRRMIDESSGSDAFKRVSMGKLDALVGLCESTACRRTRLLGYFGETALE
PQCGNCDNCLSPPKVIDGTVAAQKLLSCAYRTGQRFGAQHLIDVLLGRLTERVGQFGHDKLSVFGIGGEFNEKQWRAVIR
QLVSLGHLAPDSEAFGALKLTESSRAVLKGDAQVMLREQTGGRPPRAKSRRGDLVGGAPRESTGDPDLFAALKAWRSEVA
KSRGVPAYVVLHDATMDGIAAVRPRSLDELRGIPGIGDKKLEHYGQELLALVNASGS

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=629, Percent_Identity=35.6120826709062, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI14591902, Length=450, Percent_Identity=36.6666666666667, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI14591904, Length=450, Percent_Identity=36.6666666666667, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI148612816, Length=442, Percent_Identity=40.7239819004525, Blast_Score=288, Evalue=1e-77,
Organism=Homo sapiens, GI51242943, Length=416, Percent_Identity=40.8653846153846, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI51242947, Length=407, Percent_Identity=41.2776412776413, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI110735439, Length=514, Percent_Identity=32.8793774319066, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI169218196, Length=514, Percent_Identity=32.8793774319066, Blast_Score=250, Evalue=4e-66,
Organism=Homo sapiens, GI284005309, Length=392, Percent_Identity=34.6938775510204, Blast_Score=187, Evalue=3e-47,
Organism=Escherichia coli, GI48994977, Length=607, Percent_Identity=45.7990115321252, Blast_Score=525, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI25145561, Length=653, Percent_Identity=36.1408882082695, Blast_Score=348, Evalue=5e-96,
Organism=Caenorhabditis elegans, GI71987997, Length=440, Percent_Identity=39.0909090909091, Blast_Score=295, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI71987993, Length=440, Percent_Identity=39.0909090909091, Blast_Score=295, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI32564293, Length=666, Percent_Identity=31.6816816816817, Blast_Score=292, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17552866, Length=531, Percent_Identity=33.7099811676083, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17555296, Length=339, Percent_Identity=25.3687315634218, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323844, Length=525, Percent_Identity=35.2380952380952, Blast_Score=323, Evalue=6e-89,
Organism=Drosophila melanogaster, GI24646066, Length=641, Percent_Identity=35.5694227769111, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24664226, Length=402, Percent_Identity=38.5572139303483, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI62472181, Length=404, Percent_Identity=38.1188118811881, Blast_Score=252, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24664230, Length=404, Percent_Identity=38.1188118811881, Blast_Score=252, Evalue=6e-67,
Organism=Drosophila melanogaster, GI21358123, Length=349, Percent_Identity=37.2492836676218, Blast_Score=202, Evalue=6e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 66694; Mature: 66563

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSASRHASDDLDARALSTLNHVFGLPGFRGHQEAIIRHVAHGGDCLVLMPTGGGKSLC
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHH
YQLPALLRDGCGIVVSPLIALMRDQVAGLLEAGVRAAALNSSLSYAEADAIERQLLAGEL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
DLLYVAPERLLTPRCLAMLARAKIALFAIDEAHCVSQWGHDFRPEYVGLSAIAEKFPNVP
EEEEECHHHHCCHHHHHHHHHHHEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
RIALTATADALTRREISERLGLTDAPCFVSSFDRPNIRYAIVDKQNAPAQLKAFIADKHM
EEEEEEHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCC
GHSGVVYCLSRAKVEDIADTLCKAGIDALPYHAGLPAEIRARNQDRFINEDGVVIVATIA
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCEECCCCEEEEEEEH
FGMGIDKPDVRFVAHLDLPKSIEAYYQETGRAGRDGKPSDAWMAYGLSDIVQQRRMIDES
HHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCHHHHHHHHHHHCCC
SGSDAFKRVSMGKLDALVGLCESTACRRTRLLGYFGETALEPQCGNCDNCLSPPKVIDGT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
VAAQKLLSCAYRTGQRFGAQHLIDVLLGRLTERVGQFGHDKLSVFGIGGEFNEKQWRAVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHH
RQLVSLGHLAPDSEAFGALKLTESSRAVLKGDAQVMLREQTGGRPPRAKSRRGDLVGGAP
HHHHHHCCCCCCCCCCCEEEECCCCCHHHCCCHHEEEECCCCCCCCCCCCCCCCCCCCCC
RESTGDPDLFAALKAWRSEVAKSRGVPAYVVLHDATMDGIAAVRPRSLDELRGIPGIGDK
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCCHHHHCCCCCCCHH
KLEHYGQELLALVNASGS
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TLSASRHASDDLDARALSTLNHVFGLPGFRGHQEAIIRHVAHGGDCLVLMPTGGGKSLC
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHH
YQLPALLRDGCGIVVSPLIALMRDQVAGLLEAGVRAAALNSSLSYAEADAIERQLLAGEL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
DLLYVAPERLLTPRCLAMLARAKIALFAIDEAHCVSQWGHDFRPEYVGLSAIAEKFPNVP
EEEEECHHHHCCHHHHHHHHHHHEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
RIALTATADALTRREISERLGLTDAPCFVSSFDRPNIRYAIVDKQNAPAQLKAFIADKHM
EEEEEEHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCC
GHSGVVYCLSRAKVEDIADTLCKAGIDALPYHAGLPAEIRARNQDRFINEDGVVIVATIA
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCEECCCCEEEEEEEH
FGMGIDKPDVRFVAHLDLPKSIEAYYQETGRAGRDGKPSDAWMAYGLSDIVQQRRMIDES
HHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCHHHHHHHHHHHCCC
SGSDAFKRVSMGKLDALVGLCESTACRRTRLLGYFGETALEPQCGNCDNCLSPPKVIDGT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
VAAQKLLSCAYRTGQRFGAQHLIDVLLGRLTERVGQFGHDKLSVFGIGGEFNEKQWRAVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHH
RQLVSLGHLAPDSEAFGALKLTESSRAVLKGDAQVMLREQTGGRPPRAKSRRGDLVGGAP
HHHHHHCCCCCCCCCCCEEEECCCCCHHHCCCHHEEEECCCCCCCCCCCCCCCCCCCCCC
RESTGDPDLFAALKAWRSEVAKSRGVPAYVVLHDATMDGIAAVRPRSLDELRGIPGIGDK
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCCHHHHCCCCCCCHH
KLEHYGQELLALVNASGS
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]