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The map label for this gene is yngI [H]

Identifier: 86751798

GI number: 86751798

Start: 5319225

End: 5320775

Strand: Direct

Name: yngI [H]

Synonym: RPB_4700

Alternate gene names: 86751798

Gene position: 5319225-5320775 (Clockwise)

Preceding gene: 86751797

Following gene: 86751799

Centisome position: 99.77

GC content: 64.73

Gene sequence:

>1551_bases
ATGTACACCGGACAGTTCGCGAACACCCATCCCGACCGCCCCGCTTTCATCATGGCCTCGACCGGCGCCGCCGTGAGCTA
TGCGGAGCTCGAGGCGCGCAGCAACCGCCTCGCGCATCTGCTGCGCCGGCACGGGCTGAAGCGGCTCGATCATTTCTCGA
TCTTCATGGAGAACAACGACCGCTACCTCGAAGCCTGCGGCGCCGGCGAGCGCACCGGCTCCTACTATACATGCGTCAAC
TCGTATCTTACCGCGCCTGAGCTGGTCTACATCCTGACCAACAGCGACTCCAAGGCGCTGATCACCTCGACCGCCAAGCT
CGACATCGCCCGCGAGGCGCTGAAACAGTGCCCCAACGTGACGCTGTGCGTAGTGGCCGACGGCGACGGCGAAAGCGAGC
GCATCGTCGGGCTCGCCGAGGCCACCAAAGGCCTGCCCGACACGCCGGTCGCCGACGAGAGCCTCGGCACCGCGATGCTC
TATTCGTCCGGCACCACCGGCCGACCGAAAGGCATCCTGCGGCCGCTGCCGGAGCAGCCGCCGTCGCAGCCGCTGCCGCT
GTTCCACTTCCTCAACATGCTGTGGAAGTATCGCAACGACATGATCTATCTGTCGCCGGCGCCGCTGTATCACTCCGCGC
CGCAGGCCGCGGTCGGCCTCGCCATCCGCGACGGCGGCACCGTGATCATCATGGAGCATTTCGATCCCGAGCACTATCTG
GCGCTGATCGAGAAGTACAAGGTGACGCACAGCCAGCTGGTGCCGACGATGTTCTCGCGGATGCTGAAGCTGCCCGAGGA
GGTGCGCAACAAATACGACCTCTCGACGCTGGAAGTCGCGATCCACGCCGCCGCGCCCTGCCCGCCGCAGGTCAAGGAAC
AGATGATCGCCTGGTGGGGGCCGATCATCCACGAATATTACGGCGCCACCGAAGGCCTCGGCTTCACCGCCTGCAACAGC
GAGGAATGGCTGGCGCATCGCGGCACCGTCGGCAAGGTGATGTTCGGCGACCTGCACATTCTCGACGACCGGATGCAGCC
CTGCCCCAAGGGCACGCCGGGGCAGATCTGGTTCAAGACCGCGACGCCGTTCGAATATTTCAACGATCCGGGCAAGACCA
ATGAGGCGCGCTCGGCCGACGGCAGCATGAGCACGGTCGGCGACGTCGGCTATGTCGACGACGACGGTTTTCTGCACCTC
ACCGACCGCGCCACCTTCATGATCATCTCCGGCGGCGTGAACATCTATCCGCAGGAATGCGAGAATCTGCTGATCACCCA
CCCCAAGGTCGCCGACGCCGCGGTGTTCGGCGTGCCGAACGAGGATCTGGGTGAAGAGGTCAAGGCGGTGATCCAGCCGA
TCCCCGGCGTCGACCCGGACGTCGACCTGGCGCAGGAACTGATCGCGTTCTGCGGGCAGTCGCTGTCCCGCCAGAAGGTG
CCGCGCTCGATCGACTTTCTCGAGGAACTGCCGCGGCTGCCGACCGGCAAACTCTACAAGCGGCTGCTGCGGGACAAATA
TTGGGGCAACAAGGAAACGCGGATCGTGTGA

Upstream 100 bases:

>100_bases
CGCGCCTCTGGATTGCTTCGCCTTCGGCTCGCAATGACGGTGGAGGACGGATCGACTTCGACAATCAGCAACTCAGGCAC
GCATCAGCACGAGGGACACG

Downstream 100 bases:

>100_bases
GCGGCGCAACGCGCACTGCGCAACCTCTCCCGCTTGCGGGAGAGGTCGGATCGCGCAGCGATCCGGGTGAGGGAACTCCC
CTCCGCGAACGCATCGTCAG

Product: acyl-CoA synthetase

Products: AMP; diphosphate; acyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MYTGQFANTHPDRPAFIMASTGAAVSYAELEARSNRLAHLLRRHGLKRLDHFSIFMENNDRYLEACGAGERTGSYYTCVN
SYLTAPELVYILTNSDSKALITSTAKLDIAREALKQCPNVTLCVVADGDGESERIVGLAEATKGLPDTPVADESLGTAML
YSSGTTGRPKGILRPLPEQPPSQPLPLFHFLNMLWKYRNDMIYLSPAPLYHSAPQAAVGLAIRDGGTVIIMEHFDPEHYL
ALIEKYKVTHSQLVPTMFSRMLKLPEEVRNKYDLSTLEVAIHAAAPCPPQVKEQMIAWWGPIIHEYYGATEGLGFTACNS
EEWLAHRGTVGKVMFGDLHILDDRMQPCPKGTPGQIWFKTATPFEYFNDPGKTNEARSADGSMSTVGDVGYVDDDGFLHL
TDRATFMIISGGVNIYPQECENLLITHPKVADAAVFGVPNEDLGEEVKAVIQPIPGVDPDVDLAQELIAFCGQSLSRQKV
PRSIDFLEELPRLPTGKLYKRLLRDKYWGNKETRIV

Sequences:

>Translated_516_residues
MYTGQFANTHPDRPAFIMASTGAAVSYAELEARSNRLAHLLRRHGLKRLDHFSIFMENNDRYLEACGAGERTGSYYTCVN
SYLTAPELVYILTNSDSKALITSTAKLDIAREALKQCPNVTLCVVADGDGESERIVGLAEATKGLPDTPVADESLGTAML
YSSGTTGRPKGILRPLPEQPPSQPLPLFHFLNMLWKYRNDMIYLSPAPLYHSAPQAAVGLAIRDGGTVIIMEHFDPEHYL
ALIEKYKVTHSQLVPTMFSRMLKLPEEVRNKYDLSTLEVAIHAAAPCPPQVKEQMIAWWGPIIHEYYGATEGLGFTACNS
EEWLAHRGTVGKVMFGDLHILDDRMQPCPKGTPGQIWFKTATPFEYFNDPGKTNEARSADGSMSTVGDVGYVDDDGFLHL
TDRATFMIISGGVNIYPQECENLLITHPKVADAAVFGVPNEDLGEEVKAVIQPIPGVDPDVDLAQELIAFCGQSLSRQKV
PRSIDFLEELPRLPTGKLYKRLLRDKYWGNKETRIV
>Mature_516_residues
MYTGQFANTHPDRPAFIMASTGAAVSYAELEARSNRLAHLLRRHGLKRLDHFSIFMENNDRYLEACGAGERTGSYYTCVN
SYLTAPELVYILTNSDSKALITSTAKLDIAREALKQCPNVTLCVVADGDGESERIVGLAEATKGLPDTPVADESLGTAML
YSSGTTGRPKGILRPLPEQPPSQPLPLFHFLNMLWKYRNDMIYLSPAPLYHSAPQAAVGLAIRDGGTVIIMEHFDPEHYL
ALIEKYKVTHSQLVPTMFSRMLKLPEEVRNKYDLSTLEVAIHAAAPCPPQVKEQMIAWWGPIIHEYYGATEGLGFTACNS
EEWLAHRGTVGKVMFGDLHILDDRMQPCPKGTPGQIWFKTATPFEYFNDPGKTNEARSADGSMSTVGDVGYVDDDGFLHL
TDRATFMIISGGVNIYPQECENLLITHPKVADAAVFGVPNEDLGEEVKAVIQPIPGVDPDVDLAQELIAFCGQSLSRQKV
PRSIDFLEELPRLPTGKLYKRLLRDKYWGNKETRIV

Specific function: Could Catalyze The Transfer Of CoA To Crotonobetaine Or Carnitine. [C]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=536, Percent_Identity=27.6119402985075, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI122937307, Length=503, Percent_Identity=27.4353876739563, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI42544132, Length=523, Percent_Identity=26.3862332695985, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI38505220, Length=537, Percent_Identity=26.2569832402235, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI115511026, Length=501, Percent_Identity=26.1477045908184, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI157311624, Length=504, Percent_Identity=25, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI157311622, Length=504, Percent_Identity=25, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI58082049, Length=504, Percent_Identity=25.1984126984127, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI28416953, Length=550, Percent_Identity=24.9090909090909, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI40807357, Length=544, Percent_Identity=24.4485294117647, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI38524616, Length=562, Percent_Identity=25.4448398576512, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI221142682, Length=528, Percent_Identity=26.7045454545455, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1788107, Length=550, Percent_Identity=27.0909090909091, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI145693145, Length=515, Percent_Identity=24.8543689320388, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790505, Length=538, Percent_Identity=23.2342007434944, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786810, Length=355, Percent_Identity=27.6056338028169, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=509, Percent_Identity=28.4872298624754, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17531443, Length=534, Percent_Identity=26.9662921348315, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI32563687, Length=486, Percent_Identity=27.5720164609054, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17559526, Length=511, Percent_Identity=27.3972602739726, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17538037, Length=528, Percent_Identity=29.9242424242424, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17557194, Length=537, Percent_Identity=28.4916201117318, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71994703, Length=537, Percent_Identity=25.6983240223464, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17560308, Length=376, Percent_Identity=30.0531914893617, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71994694, Length=537, Percent_Identity=25.6983240223464, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71994690, Length=537, Percent_Identity=25.6983240223464, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI115534440, Length=549, Percent_Identity=23.1329690346084, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560140, Length=385, Percent_Identity=24.9350649350649, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17551278, Length=558, Percent_Identity=23.8351254480287, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71996755, Length=487, Percent_Identity=23.6139630390144, Blast_Score=89, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6319699, Length=361, Percent_Identity=27.7008310249307, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21355181, Length=515, Percent_Identity=26.9902912621359, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24581924, Length=552, Percent_Identity=26.0869565217391, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24648260, Length=531, Percent_Identity=25.6120527306968, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18859661, Length=520, Percent_Identity=24.8076923076923, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI19922652, Length=512, Percent_Identity=23.4375, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21356441, Length=504, Percent_Identity=23.6111111111111, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24648253, Length=475, Percent_Identity=23.5789473684211, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28573631, Length=553, Percent_Identity=25.3164556962025, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45550496, Length=545, Percent_Identity=23.1192660550459, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI20130353, Length=553, Percent_Identity=25.3164556962025, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI45552801, Length=545, Percent_Identity=23.1192660550459, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24656500, Length=517, Percent_Identity=22.0502901353965, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24648255, Length=475, Percent_Identity=23.5789473684211, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21356947, Length=513, Percent_Identity=23.5867446393762, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281365686, Length=324, Percent_Identity=24.0740740740741, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281364798, Length=538, Percent_Identity=23.6059479553903, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583465, Length=538, Percent_Identity=23.6059479553903, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583463, Length=538, Percent_Identity=23.6059479553903, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648257, Length=356, Percent_Identity=25.561797752809, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24653035, Length=505, Percent_Identity=20.990099009901, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21358303, Length=328, Percent_Identity=23.4756097560976, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI161076582, Length=514, Percent_Identity=21.011673151751, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.3

Molecular weight: Translated: 57193; Mature: 57193

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTGQFANTHPDRPAFIMASTGAAVSYAELEARSNRLAHLLRRHGLKRLDHFSIFMENND
CCCCCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHHCHHHCCEEEEEEECCC
RYLEACGAGERTGSYYTCVNSYLTAPELVYILTNSDSKALITSTAKLDIAREALKQCPNV
CEEEECCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHHCCCC
TLCVVADGDGESERIVGLAEATKGLPDTPVADESLGTAMLYSSGTTGRPKGILRPLPEQP
EEEEEECCCCCCCCEEEEHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
PSQPLPLFHFLNMLWKYRNDMIYLSPAPLYHSAPQAAVGLAIRDGGTVIIMEHFDPEHYL
CCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHEEEEEECCCEEEEEECCCCHHHH
ALIEKYKVTHSQLVPTMFSRMLKLPEEVRNKYDLSTLEVAIHAAAPCPPQVKEQMIAWWG
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHEEEEEECCCCCCHHHHHHHHHHHH
PIIHEYYGATEGLGFTACNSEEWLAHRGTVGKVMFGDLHILDDRMQPCPKGTPGQIWFKT
HHHHHHHCCCCCCCEEECCCHHHHHHCCCCCEEEECCEEEECCCCCCCCCCCCCEEEEEE
ATPFEYFNDPGKTNEARSADGSMSTVGDVGYVDDDGFLHLTDRATFMIISGGVNIYPQEC
CCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEECCEEEEEEECCCEECCHHH
ENLLITHPKVADAAVFGVPNEDLGEEVKAVIQPIPGVDPDVDLAQELIAFCGQSLSRQKV
CCEEECCCCHHCEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHC
PRSIDFLEELPRLPTGKLYKRLLRDKYWGNKETRIV
CCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MYTGQFANTHPDRPAFIMASTGAAVSYAELEARSNRLAHLLRRHGLKRLDHFSIFMENND
CCCCCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHHCHHHCCEEEEEEECCC
RYLEACGAGERTGSYYTCVNSYLTAPELVYILTNSDSKALITSTAKLDIAREALKQCPNV
CEEEECCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHHCCCC
TLCVVADGDGESERIVGLAEATKGLPDTPVADESLGTAMLYSSGTTGRPKGILRPLPEQP
EEEEEECCCCCCCCEEEEHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
PSQPLPLFHFLNMLWKYRNDMIYLSPAPLYHSAPQAAVGLAIRDGGTVIIMEHFDPEHYL
CCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHEEEEEECCCEEEEEECCCCHHHH
ALIEKYKVTHSQLVPTMFSRMLKLPEEVRNKYDLSTLEVAIHAAAPCPPQVKEQMIAWWG
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHEEEEEECCCCCCHHHHHHHHHHHH
PIIHEYYGATEGLGFTACNSEEWLAHRGTVGKVMFGDLHILDDRMQPCPKGTPGQIWFKT
HHHHHHHCCCCCCCEEECCCHHHHHHCCCCCEEEECCEEEECCCCCCCCCCCCCEEEEEE
ATPFEYFNDPGKTNEARSADGSMSTVGDVGYVDDDGFLHLTDRATFMIISGGVNIYPQEC
CCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEECCEEEEEEECCCEECCHHH
ENLLITHPKVADAAVFGVPNEDLGEEVKAVIQPIPGVDPDVDLAQELIAFCGQSLSRQKV
CCEEECCCCHHCEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHC
PRSIDFLEELPRLPTGKLYKRLLRDKYWGNKETRIV
CCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; long-chain carboxylic acid; CoA

Specific reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]