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The map label for this gene is srrB [H]

Identifier: 86751764

GI number: 86751764

Start: 5278875

End: 5280611

Strand: Direct

Name: srrB [H]

Synonym: RPB_4666

Alternate gene names: 86751764

Gene position: 5278875-5280611 (Clockwise)

Preceding gene: 86751763

Following gene: 86751765

Centisome position: 99.01

GC content: 65.57

Gene sequence:

>1737_bases
ATGGCCGACCAGGACGATATCCTCCAGCTGATCGAAGATACCGAGCCCGGGCCCGAGCCGTCGAACACCAAGCGGTGGAA
GATCGCGGTGATCGACGACGATCCCGCCGTCCACGAGGGCACCCGCTTCGCGCTCAGCGACTACAATCTCAACGGCCAGA
CCCTGGAAATCCTCTCGGCCTATTCGGGCGCCGAGGGCCGCGAACTGATGCGGGCCAATCCCGACATTGCCGCGGTGCTG
CTCGACGTCATCATGGAGTCGGACGCGGCCGGGCTCGAACTGGTCGAGTTCATCCGCAACGAGATGCGCAACGAGACCGT
TCGCATCATCCTGCGCACCGGCCAGCCGGGCCAGGCGCCGGAACGCCGGGTGATCGTCGACTACGACATCAACGACTACA
AGGCCAAGACCGAGCTCACCGCCGACAAGCTGTTCACGTCGCTGACCGCCGCACTGCGCAGCTACCAGCAACTGGAGCGG
ATGGTGCAGACGCGGCGCGGGCTCGAGATCATCATCGACGCCGCCTCCACGTTGTACGATTTCAAATCGATGCAGCGGCT
GGCCGAAGGCGTGCTGACCCAGATCGCCTCGCTGCTCAATGTCGACTGCGCGGGAATCCTGGTGCTGCGCGACGCCGGCG
ACGATTTTTCGGTGCTGGCCGGCTCCGGCTGTTACAGCCGCTTCATCGGTTCGGCCGGTATCCGGCCGCTCGATCAGGAC
CTGCGGCAAATGGTCGAGGAGGCGTTCCGACGCCGCAAGCACGAATTCGCCGATCAACGCACCGTGCTGTATGTCCGGAC
CGGCAGCGGGCGCGAGGTCGTGGTGCTGCTGCAGGCCGAGCGTGAACTCACCGACACCGACCGCTCGCTGGTCGAGATTT
TCGGTAGCCGGCTGTCGATCGCATTCGACAATGTGATCCTCTACAAGCAGCTCCACGAGGCCAACACCCAGCTCGAGGAC
CGGGTCGCGCAGCGCACCCGCGCGCTGACCCAGGCCAATCGCCGGCTGTCGACGCAATGGATGCGGTTGCAGCGCGCCAA
CGCCTTCAAGAACGAGATTCTCGGCACCGTCGCCCACGACCTGAAGAATCCACTTGGCGTCATCCTCGGCCGCACCGAGA
TGCTGACCGAACTGATCGGCGCCGATTCGCCCAAGGAAAACGTCATCGCCCAGGTCGATCACATCCGCGAGGCGACGCGG
CGGCTGACCTCGATGGTGGACCACCTGATCTCAGATGCGATGGCCGACGCCTTCGACATTTCGATCCGGCGCGAGGCGGT
CGATCTCGCCGCATTGGTCGCCGAAGTGGCCGAGGCCAACCGGCCGATGGCGCAGAACAAGCAGCAGGCGATCTCGGTGT
CGATCCCCGACGCCCGGATGACGATGTGCGACGCCGATCGGGTGCGCGAGGCGATCGACAATCTGGTCAGCAACGCCATC
AAATACAGTCCGATCGGCGGCAAGATCGCGCTGCAGGTCGACGGCGACGACGCCAACACCGTCGTCCGCGTCACCGACGA
GGGCGCCGGCCTGTCGCCGGAGGATCTGAGCCGGCTTTTCGGCCGGTTCCAGCGCCTCTCCGCCAAGCCGACCGCCGGCG
AGAGCTCGACCGGGCTCGGCCTGTCGATCGTCAAGAAGATCATCGACATGCACGGCGGCAATGTCGGCGCCCACAGCCCC
GGCCCTGGCCAGGGCGCGACCTTCACCATCACCCTGCCCGCATCGCCCGCATCATGA

Upstream 100 bases:

>100_bases
AATCAAGGCTGGGACAAGGCACGACTTTTCGCATTATCATGCCCCGCACCGCCACCGGCGGGCCGACCGACGCCGACACG
CCCATCGACGGAAATGTGAA

Downstream 100 bases:

>100_bases
GCCACAGCCCGCACATCATCGTCGTCGACGACGAAGCCCCTGCCCGCGAAATGGTCGGCGACTATCTGCGCATGCACGGC
TTCGCCGTGACGCTGTGCGA

Product: response regulator receiver sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MADQDDILQLIEDTEPGPEPSNTKRWKIAVIDDDPAVHEGTRFALSDYNLNGQTLEILSAYSGAEGRELMRANPDIAAVL
LDVIMESDAAGLELVEFIRNEMRNETVRIILRTGQPGQAPERRVIVDYDINDYKAKTELTADKLFTSLTAALRSYQQLER
MVQTRRGLEIIIDAASTLYDFKSMQRLAEGVLTQIASLLNVDCAGILVLRDAGDDFSVLAGSGCYSRFIGSAGIRPLDQD
LRQMVEEAFRRRKHEFADQRTVLYVRTGSGREVVVLLQAERELTDTDRSLVEIFGSRLSIAFDNVILYKQLHEANTQLED
RVAQRTRALTQANRRLSTQWMRLQRANAFKNEILGTVAHDLKNPLGVILGRTEMLTELIGADSPKENVIAQVDHIREATR
RLTSMVDHLISDAMADAFDISIRREAVDLAALVAEVAEANRPMAQNKQQAISVSIPDARMTMCDADRVREAIDNLVSNAI
KYSPIGGKIALQVDGDDANTVVRVTDEGAGLSPEDLSRLFGRFQRLSAKPTAGESSTGLGLSIVKKIIDMHGGNVGAHSP
GPGQGATFTITLPASPAS

Sequences:

>Translated_578_residues
MADQDDILQLIEDTEPGPEPSNTKRWKIAVIDDDPAVHEGTRFALSDYNLNGQTLEILSAYSGAEGRELMRANPDIAAVL
LDVIMESDAAGLELVEFIRNEMRNETVRIILRTGQPGQAPERRVIVDYDINDYKAKTELTADKLFTSLTAALRSYQQLER
MVQTRRGLEIIIDAASTLYDFKSMQRLAEGVLTQIASLLNVDCAGILVLRDAGDDFSVLAGSGCYSRFIGSAGIRPLDQD
LRQMVEEAFRRRKHEFADQRTVLYVRTGSGREVVVLLQAERELTDTDRSLVEIFGSRLSIAFDNVILYKQLHEANTQLED
RVAQRTRALTQANRRLSTQWMRLQRANAFKNEILGTVAHDLKNPLGVILGRTEMLTELIGADSPKENVIAQVDHIREATR
RLTSMVDHLISDAMADAFDISIRREAVDLAALVAEVAEANRPMAQNKQQAISVSIPDARMTMCDADRVREAIDNLVSNAI
KYSPIGGKIALQVDGDDANTVVRVTDEGAGLSPEDLSRLFGRFQRLSAKPTAGESSTGLGLSIVKKIIDMHGGNVGAHSP
GPGQGATFTITLPASPAS
>Mature_577_residues
ADQDDILQLIEDTEPGPEPSNTKRWKIAVIDDDPAVHEGTRFALSDYNLNGQTLEILSAYSGAEGRELMRANPDIAAVLL
DVIMESDAAGLELVEFIRNEMRNETVRIILRTGQPGQAPERRVIVDYDINDYKAKTELTADKLFTSLTAALRSYQQLERM
VQTRRGLEIIIDAASTLYDFKSMQRLAEGVLTQIASLLNVDCAGILVLRDAGDDFSVLAGSGCYSRFIGSAGIRPLDQDL
RQMVEEAFRRRKHEFADQRTVLYVRTGSGREVVVLLQAERELTDTDRSLVEIFGSRLSIAFDNVILYKQLHEANTQLEDR
VAQRTRALTQANRRLSTQWMRLQRANAFKNEILGTVAHDLKNPLGVILGRTEMLTELIGADSPKENVIAQVDHIREATRR
LTSMVDHLISDAMADAFDISIRREAVDLAALVAEVAEANRPMAQNKQQAISVSIPDARMTMCDADRVREAIDNLVSNAIK
YSPIGGKIALQVDGDDANTVVRVTDEGAGLSPEDLSRLFGRFQRLSAKPTAGESSTGLGLSIVKKIIDMHGGNVGAHSPG
PGQGATFTITLPASPAS

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: COG3437

COG function: function code KT; Response regulator containing a CheY-like receiver domain and an HD-GYP domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=29.004329004329, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788713, Length=235, Percent_Identity=28.5106382978723, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI145693157, Length=236, Percent_Identity=29.2372881355932, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786783, Length=219, Percent_Identity=31.5068493150685, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI48994928, Length=354, Percent_Identity=23.4463276836158, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790861, Length=239, Percent_Identity=30.5439330543933, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081816, Length=241, Percent_Identity=30.7053941908714, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=257, Percent_Identity=28.4046692607004, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1789149, Length=241, Percent_Identity=28.2157676348548, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1790346, Length=232, Percent_Identity=26.2931034482759, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=27.7272727272727, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788549, Length=231, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1790300, Length=252, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789808, Length=201, Percent_Identity=28.3582089552239, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788279, Length=219, Percent_Identity=23.2876712328767, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787894, Length=226, Percent_Identity=25.6637168141593, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63555; Mature: 63424

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADQDDILQLIEDTEPGPEPSNTKRWKIAVIDDDPAVHEGTRFALSDYNLNGQTLEILSA
CCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHH
YSGAEGRELMRANPDIAAVLLDVIMESDAAGLELVEFIRNEMRNETVRIILRTGQPGQAP
HCCCCCHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
ERRVIVDYDINDYKAKTELTADKLFTSLTAALRSYQQLERMVQTRRGLEIIIDAASTLYD
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
FKSMQRLAEGVLTQIASLLNVDCAGILVLRDAGDDFSVLAGSGCYSRFIGSAGIRPLDQD
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCHHHHHHCCCCCCHHHHH
LRQMVEEAFRRRKHEFADQRTVLYVRTGSGREVVVLLQAERELTDTDRSLVEIFGSRLSI
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHH
AFDNVILYKQLHEANTQLEDRVAQRTRALTQANRRLSTQWMRLQRANAFKNEILGTVAHD
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKNPLGVILGRTEMLTELIGADSPKENVIAQVDHIREATRRLTSMVDHLISDAMADAFDI
HCCCHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIRREAVDLAALVAEVAEANRPMAQNKQQAISVSIPDARMTMCDADRVREAIDNLVSNAI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHE
KYSPIGGKIALQVDGDDANTVVRVTDEGAGLSPEDLSRLFGRFQRLSAKPTAGESSTGLG
EECCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCH
LSIVKKIIDMHGGNVGAHSPGPGQGATFTITLPASPAS
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
ADQDDILQLIEDTEPGPEPSNTKRWKIAVIDDDPAVHEGTRFALSDYNLNGQTLEILSA
CCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHH
YSGAEGRELMRANPDIAAVLLDVIMESDAAGLELVEFIRNEMRNETVRIILRTGQPGQAP
HCCCCCHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
ERRVIVDYDINDYKAKTELTADKLFTSLTAALRSYQQLERMVQTRRGLEIIIDAASTLYD
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
FKSMQRLAEGVLTQIASLLNVDCAGILVLRDAGDDFSVLAGSGCYSRFIGSAGIRPLDQD
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCHHHHHHCCCCCCHHHHH
LRQMVEEAFRRRKHEFADQRTVLYVRTGSGREVVVLLQAERELTDTDRSLVEIFGSRLSI
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHH
AFDNVILYKQLHEANTQLEDRVAQRTRALTQANRRLSTQWMRLQRANAFKNEILGTVAHD
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKNPLGVILGRTEMLTELIGADSPKENVIAQVDHIREATRRLTSMVDHLISDAMADAFDI
HCCCHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIRREAVDLAALVAEVAEANRPMAQNKQQAISVSIPDARMTMCDADRVREAIDNLVSNAI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHE
KYSPIGGKIALQVDGDDANTVVRVTDEGAGLSPEDLSRLFGRFQRLSAKPTAGESSTGLG
EECCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCH
LSIVKKIIDMHGGNVGAHSPGPGQGATFTITLPASPAS
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA