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The map label for this gene is dapA2 [H]

Identifier: 86751623

GI number: 86751623

Start: 5113782

End: 5114693

Strand: Direct

Name: dapA2 [H]

Synonym: RPB_4525

Alternate gene names: 86751623

Gene position: 5113782-5114693 (Clockwise)

Preceding gene: 86751622

Following gene: 86751624

Centisome position: 95.91

GC content: 68.97

Gene sequence:

>912_bases
ATGGAGACCGAATCCGAGCCGCCCAGCGGGCTGTGGCTGCCGCTGATCACGCCGTTTTGCGACGGCGCGCTCGACGCAGC
CTCATTGCGCCGGCTGATCGCCCACTATGCGCGGCAGCCGATCGACCGGCTGATCCTCGCCGCCACCACCGGCGAAGGGC
TGACGCTCGACGACGACGAAATCGAGCAATTGGTGATGCTGACGGCCGAGGCGCTGGCCGAGGCCGGCCGCGCGCTGCCG
GTGTGGCTCGGCCTGTGCGGCAGCGATACGCGCAAACTGGTGCGGACGCTGGCGCGGGTCGCGAACTGGCCGGTCGACGG
CTATCTGATCGCCTGCCCGTCCTACTCGCGGCCGTCGCAACAAGGGCTGGTGCTGCATTTCGAGGCGCTGTCGGACGCCG
CGACGCGGCCGATCATGATCTACAACATTCCCTATCGGACCGGCGTCAATCTCGGCAACGCGGCGATGCTGCATCTCGCC
GCGCGCGACAACATCGTCGGCGTCAAGGATTGCTGCGCCGATACGCGGCAGACCGTCGAACTGCTGCACGACAGGCCGCG
CGGCTTCGCCGTGCTGAGCGGCGAGGACGCGCTGTATTTCGGCGCGCTGGTGCGCGGCTGCGACGGCGCGGTGCTGGCCT
CGGCGCATATCGAGACCGAGGCCTTCGCCACGGTGCGGCAGCGCATCCTGGCCGACGACCGGCTCGGCGCCTCGATCGCA
TGGCAGCGGCTCGCCGAAGTCCCGAAGCTGCTGTTCGCCGAGCCATCGCCTGCGGCGCTGAAATACGCGCTGTGGCGGCT
GGGGCTGATCGACAGCCCGGAATTGCGGCTGCCGCTGACCGGCATCAGCGACGACCTCGCCAAAGCCCTCGACGCCCGGC
TTTTGGCCGCTAAATCCGGTACTTACGCGTGA

Upstream 100 bases:

>100_bases
AGATCGATACGCAGTTCGCAATCACCCAAAAACCCCGCCGGTTTCGACGGGGTTTTTTGTTGCGCTCCGTCGGCCGGCTC
CTCGCGAAGGAGACACCACG

Downstream 100 bases:

>100_bases
TGCGACGGGCTTGCGCCGGCGCGCCGGCGCGGCCTCCGGAAGTTCGGCCGCGGCCCTTGACGGCGGCGGCTGGAGGCCCG
TCTATGCGTCGCGAAGGCTG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS 2 [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
METESEPPSGLWLPLITPFCDGALDAASLRRLIAHYARQPIDRLILAATTGEGLTLDDDEIEQLVMLTAEALAEAGRALP
VWLGLCGSDTRKLVRTLARVANWPVDGYLIACPSYSRPSQQGLVLHFEALSDAATRPIMIYNIPYRTGVNLGNAAMLHLA
ARDNIVGVKDCCADTRQTVELLHDRPRGFAVLSGEDALYFGALVRGCDGAVLASAHIETEAFATVRQRILADDRLGASIA
WQRLAEVPKLLFAEPSPAALKYALWRLGLIDSPELRLPLTGISDDLAKALDARLLAAKSGTYA

Sequences:

>Translated_303_residues
METESEPPSGLWLPLITPFCDGALDAASLRRLIAHYARQPIDRLILAATTGEGLTLDDDEIEQLVMLTAEALAEAGRALP
VWLGLCGSDTRKLVRTLARVANWPVDGYLIACPSYSRPSQQGLVLHFEALSDAATRPIMIYNIPYRTGVNLGNAAMLHLA
ARDNIVGVKDCCADTRQTVELLHDRPRGFAVLSGEDALYFGALVRGCDGAVLASAHIETEAFATVRQRILADDRLGASIA
WQRLAEVPKLLFAEPSPAALKYALWRLGLIDSPELRLPLTGISDDLAKALDARLLAAKSGTYA
>Mature_303_residues
METESEPPSGLWLPLITPFCDGALDAASLRRLIAHYARQPIDRLILAATTGEGLTLDDDEIEQLVMLTAEALAEAGRALP
VWLGLCGSDTRKLVRTLARVANWPVDGYLIACPSYSRPSQQGLVLHFEALSDAATRPIMIYNIPYRTGVNLGNAAMLHLA
ARDNIVGVKDCCADTRQTVELLHDRPRGFAVLSGEDALYFGALVRGCDGAVLASAHIETEAFATVRQRILADDRLGASIA
WQRLAEVPKLLFAEPSPAALKYALWRLGLIDSPELRLPLTGISDDLAKALDARLLAAKSGTYA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=213, Percent_Identity=26.7605633802817, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788823, Length=280, Percent_Identity=32.5, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786463, Length=253, Percent_Identity=28.0632411067194, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082415, Length=267, Percent_Identity=25.0936329588015, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789620, Length=286, Percent_Identity=25.1748251748252, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32753; Mature: 32753

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METESEPPSGLWLPLITPFCDGALDAASLRRLIAHYARQPIDRLILAATTGEGLTLDDDE
CCCCCCCCCCEEHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCHHH
IEQLVMLTAEALAEAGRALPVWLGLCGSDTRKLVRTLARVANWPVDGYLIACPSYSRPSQ
HHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCC
QGLVLHFEALSDAATRPIMIYNIPYRTGVNLGNAAMLHLAARDNIVGVKDCCADTRQTVE
CCEEEEEEHHHCCCCCCEEEEECCHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LLHDRPRGFAVLSGEDALYFGALVRGCDGAVLASAHIETEAFATVRQRILADDRLGASIA
HHHCCCCCEEEECCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHH
WQRLAEVPKLLFAEPSPAALKYALWRLGLIDSPELRLPLTGISDDLAKALDARLLAAKSG
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCC
TYA
CCC
>Mature Secondary Structure
METESEPPSGLWLPLITPFCDGALDAASLRRLIAHYARQPIDRLILAATTGEGLTLDDDE
CCCCCCCCCCEEHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCHHH
IEQLVMLTAEALAEAGRALPVWLGLCGSDTRKLVRTLARVANWPVDGYLIACPSYSRPSQ
HHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCC
QGLVLHFEALSDAATRPIMIYNIPYRTGVNLGNAAMLHLAARDNIVGVKDCCADTRQTVE
CCEEEEEEHHHCCCCCCEEEEECCHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LLHDRPRGFAVLSGEDALYFGALVRGCDGAVLASAHIETEAFATVRQRILADDRLGASIA
HHHCCCCCEEEECCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHH
WQRLAEVPKLLFAEPSPAALKYALWRLGLIDSPELRLPLTGISDDLAKALDARLLAAKSG
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCC
TYA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]