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The map label for this gene is norM [H]

Identifier: 86751560

GI number: 86751560

Start: 5051822

End: 5053234

Strand: Direct

Name: norM [H]

Synonym: RPB_4462

Alternate gene names: 86751560

Gene position: 5051822-5053234 (Clockwise)

Preceding gene: 86751559

Following gene: 86751561

Centisome position: 94.75

GC content: 69.92

Gene sequence:

>1413_bases
ATGACCTCCTCGGATTTGCACCTCGCCGCCGGCGCCCGCGCGCCGGCGCAATCGTCTGCGTGGCGGACTGAAATCGTCGA
GACGCTGTGGCTCGCGGTGCCGATGGCACTGACGCAGCTCGGCCAGATCGCGATGATGACGACCGACCTCGCGCTGATCG
GCCGGCTCGGCGATTCCGCCGTGGCCGCGGCGGCGCTCGCCCATACGGTGCTGTTCATCGCCTTCATGCTCGGCATCGGC
CTCGTCTCCGCCGTGGCGCCGCTGGCGGCGCAGGCCTATGGCGCACGCGAGCCGCGCCAGGTCCGCGCATCGCTGCGCGT
CGGGATGTGGGCGGCGGTGATCGCCGGCATCCCGCTGACGCTGAGCCAGTTCTACGGCGAGCGGATGCTGCTGGCCGCTG
GCCAGGAGCCGCAGGTGGCTGAGCTCGCCGGGCGCTATCTGCATGGGCTCGCCTGGTCGCTGGTGCCGGGCTGGATCTTC
ATCGCGCTGCGCAGCTTCATGGGCGCGGTCAACCGCCCCGAGCCGGCGCTGTGGATCATGTTCGCCGCGGTGCCGCTGAA
CGGCGTGCTCGCCTACGCGCTGATCCACGGCGCGTTCGGGCTGCCGCAGCTCGGCATTTTCGGCGCCGGCCTCGCCACCA
GCATCATCTCGATCGCGATGGGCATCGCCGCGGCGGTGGCCTGCGTGACGCTGCAGCCTTTCCGCAAATATCAGGTGTTC
GGCGAACTGATGAAGTTCGATGCGCCGCTGATGCGACGGCTGCTGGCGCTCGGCCTGCCGATCTCCGGCGCCTCCGTGCT
GGAATACGGCGTGTTCGGCGCCGCCGCACTGTTGATGGGCCAGATCGGCACCGCGGCGCTCGCCGCGCATCAGATTGCGC
TGCAGATCGCCGCCATCATGTTCATGGTGCCGCTCGGCATCTCGCTCGCCGCCACCGTGCGCGTCGGCCATGCGATCGGC
CGTCACGATCCGGCCGGCGCACGCCGCGCCGGCTTCACCGCGATCGGGCTCGGATTCGTCTTCATGGCCTTGATGACGCT
GCTGGTGGCGCTGACGCGGCACGAGATTCCGCAACTGTTTCTCGGCAATTCCACGACGGCCGTGGAGACCGCGCAGCTCA
CCGCGTCGCTGCTGCTGGTCGGCGCCAGCTTCTTCATCGCCGACGGCCTGCAGGTGGTCGCCAACGGCGCGCTGCGCGGC
AAGAGCGATACCCGGATCCCGCTGCTGTTCGCGGTGCTGGGGTTCTGGGTGGTCGGCTTTCCGTTCAGCTATCTGCTCGG
CTTCCCCGGCGGCTTCGGCCCGTTCGGCGTTTGGATCGGGCTGGCGATCGGGCTCGCGGTCTATGCCGCGCTGCTGGTGG
CGCGATTCCATCTGCTGACGCGCGCGCCGCCGCCGGTTCCGGCGCAAAGCTGA

Upstream 100 bases:

>100_bases
CGAGTTCTTCCTCGGCGCACGCAGGGGTTGAGTTTCATATTCTTGCACGTCGTGATCCGATGGTCACGCTGCAGCCGCAA
GTTGGGCTATGGTGCGCGCC

Downstream 100 bases:

>100_bases
TCACTTCCGGCTTTACGCATCGCGGCGCGAAGCCTATCGGATCGCAATGAACGAACTCATCGCAATCGATCACGTCGGCC
ACCGCGGCGACGGCGTCAGC

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MTSSDLHLAAGARAPAQSSAWRTEIVETLWLAVPMALTQLGQIAMMTTDLALIGRLGDSAVAAAALAHTVLFIAFMLGIG
LVSAVAPLAAQAYGAREPRQVRASLRVGMWAAVIAGIPLTLSQFYGERMLLAAGQEPQVAELAGRYLHGLAWSLVPGWIF
IALRSFMGAVNRPEPALWIMFAAVPLNGVLAYALIHGAFGLPQLGIFGAGLATSIISIAMGIAAAVACVTLQPFRKYQVF
GELMKFDAPLMRRLLALGLPISGASVLEYGVFGAAALLMGQIGTAALAAHQIALQIAAIMFMVPLGISLAATVRVGHAIG
RHDPAGARRAGFTAIGLGFVFMALMTLLVALTRHEIPQLFLGNSTTAVETAQLTASLLLVGASFFIADGLQVVANGALRG
KSDTRIPLLFAVLGFWVVGFPFSYLLGFPGGFGPFGVWIGLAIGLAVYAALLVARFHLLTRAPPPVPAQS

Sequences:

>Translated_470_residues
MTSSDLHLAAGARAPAQSSAWRTEIVETLWLAVPMALTQLGQIAMMTTDLALIGRLGDSAVAAAALAHTVLFIAFMLGIG
LVSAVAPLAAQAYGAREPRQVRASLRVGMWAAVIAGIPLTLSQFYGERMLLAAGQEPQVAELAGRYLHGLAWSLVPGWIF
IALRSFMGAVNRPEPALWIMFAAVPLNGVLAYALIHGAFGLPQLGIFGAGLATSIISIAMGIAAAVACVTLQPFRKYQVF
GELMKFDAPLMRRLLALGLPISGASVLEYGVFGAAALLMGQIGTAALAAHQIALQIAAIMFMVPLGISLAATVRVGHAIG
RHDPAGARRAGFTAIGLGFVFMALMTLLVALTRHEIPQLFLGNSTTAVETAQLTASLLLVGASFFIADGLQVVANGALRG
KSDTRIPLLFAVLGFWVVGFPFSYLLGFPGGFGPFGVWIGLAIGLAVYAALLVARFHLLTRAPPPVPAQS
>Mature_469_residues
TSSDLHLAAGARAPAQSSAWRTEIVETLWLAVPMALTQLGQIAMMTTDLALIGRLGDSAVAAAALAHTVLFIAFMLGIGL
VSAVAPLAAQAYGAREPRQVRASLRVGMWAAVIAGIPLTLSQFYGERMLLAAGQEPQVAELAGRYLHGLAWSLVPGWIFI
ALRSFMGAVNRPEPALWIMFAAVPLNGVLAYALIHGAFGLPQLGIFGAGLATSIISIAMGIAAAVACVTLQPFRKYQVFG
ELMKFDAPLMRRLLALGLPISGASVLEYGVFGAAALLMGQIGTAALAAHQIALQIAAIMFMVPLGISLAATVRVGHAIGR
HDPAGARRAGFTAIGLGFVFMALMTLLVALTRHEIPQLFLGNSTTAVETAQLTASLLLVGASFFIADGLQVVANGALRGK
SDTRIPLLFAVLGFWVVGFPFSYLLGFPGGFGPFGVWIGLAIGLAVYAALLVARFHLLTRAPPPVPAQS

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=429, Percent_Identity=24.9417249417249, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI153792564, Length=428, Percent_Identity=22.6635514018692, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI38261960, Length=463, Percent_Identity=21.5982721382289, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI48994890, Length=445, Percent_Identity=30.3370786516854, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI226510954, Length=493, Percent_Identity=25.1521298174442, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320545, Length=430, Percent_Identity=24.1860465116279, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321821, Length=393, Percent_Identity=23.1552162849873, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49083; Mature: 48952

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSDLHLAAGARAPAQSSAWRTEIVETLWLAVPMALTQLGQIAMMTTDLALIGRLGDSA
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VAAAALAHTVLFIAFMLGIGLVSAVAPLAAQAYGAREPRQVRASLRVGMWAAVIAGIPLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHH
LSQFYGERMLLAAGQEPQVAELAGRYLHGLAWSLVPGWIFIALRSFMGAVNRPEPALWIM
HHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
FAAVPLNGVLAYALIHGAFGLPQLGIFGAGLATSIISIAMGIAAAVACVTLQPFRKYQVF
EHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GELMKFDAPLMRRLLALGLPISGASVLEYGVFGAAALLMGQIGTAALAAHQIALQIAAIM
HHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMVPLGISLAATVRVGHAIGRHDPAGARRAGFTAIGLGFVFMALMTLLVALTRHEIPQLF
HHHHHCHHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LGNSTTAVETAQLTASLLLVGASFFIADGLQVVANGALRGKSDTRIPLLFAVLGFWVVGF
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
PFSYLLGFPGGFGPFGVWIGLAIGLAVYAALLVARFHLLTRAPPPVPAQS
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TSSDLHLAAGARAPAQSSAWRTEIVETLWLAVPMALTQLGQIAMMTTDLALIGRLGDSA
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH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HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA