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The map label for this gene is trxB [H]

Identifier: 86751458

GI number: 86751458

Start: 4938758

End: 4940464

Strand: Reverse

Name: trxB [H]

Synonym: RPB_4356

Alternate gene names: 86751458

Gene position: 4940464-4938758 (Counterclockwise)

Preceding gene: 86751460

Following gene: 86751457

Centisome position: 92.66

GC content: 69.07

Gene sequence:

>1707_bases
ATGACCGGCTATGAGTTCGACGGAACCGACCTCGACGGCGGCGAGCGGGTCTATCCGCGCTATGACCAGACGTTTCCGGT
ACTGACGCCGGCCGAAATCGAACGGATGCGCCGTTTCGGCGAGATCCGGCGCTTCGCCGATGGCGAGATGCTGTTCGAAA
CCGGCAAGATCGGCCCCGGCATGTTCGTGGTGCTGTCGGGCCATGTGGCGGTCACTCAGCGCGACGGCCTCGGCCATGTC
ACCCCTGTGGTCGAGCAGGGCCCGGGGCAATTCCTCGCCGAAATCAGCCAGTTGGCCGGCCGGGTCGCGCTGGTCGACGG
CCGCGCCGACGGTGACGTCGAATGTCTGCTGATTCCGCCGGAGCGGCTGCGCGCGCTGCTGGTGGCCGAGGCCGATCTCG
GCGAGCGCATCATGCGGGCGCTGATCCTGCGCCGCGTCAATCTGATCCAGGGTGGCGTCGGCGGACCGGTGTTGATCGGC
TCGGCGACGTCGTCGGATGCGGTGCGGCTGATGGGCTTCCTGACCCGCAACGGCTGGCCGTTTCATCTGCTCGACCCTGC
GACCGACCGCGACGCTGCCGATCTGGTGACGCGTTTTTCGCCGGGGCCGCACGACCTGCCGCTGGTCGTCGCCTCCGATG
GTACGGTGCTGCGCAATCCGCGGGAAGCCGACCTCGCCCGTGCCATGGGCATGATCGGCAAGCTCGACCCCGCCAAGGTC
TACGACGTCGCGATCGTCGGCTCCGGTCCTGCGGGCTTGTCGACCGCGGTGTATGCGGCGTCGGAGGGCCTGTCGGTCGC
GGTCTGCGATCAGCGTGCGTTCGGTGGGCAGGCCGGTGCCAGCGCCCGGATCGAGAACTATCTCGGATTCCCGACCGGCA
TTTCCGGCCACGCGCTGACGGCCCGGGCCTTCAATCAGGCGCAGAAATTCGGCGCGGACATCATGATCCCGGTCGAGGTC
AAGTCGCTCGAATGCGGCAGCAACGACGGCACCTTCGCGCTGTCGCTGGACGACGGCGCAGCGCTGCGCGCCCGTGCGAT
CGTCGTCGCCAGCGGCGCGCGCTATCGCCGGCCCGAGATCGCCAACCTCGCCGCGTACGACGGTCGCGGGGTGTACTATT
GGGCGTCGCCGATCGAGGCGCGGCTGTGCAAGGATCAGGAGGTCATCCTCGTCGGTGGTGGCAACAGCGCCGGCCAGGCC
GCGGTGTATCTGTCGACGCATGCGGCGCGCGTCCACATGGTGATCCGCGGCGGCGGGCTCGCCGCCAGCATGTCGCGCTA
TCTGATCGAGCGGATCGAATCGACGGCGAATATCGAACTGGTGTTCAACACCGAGGTCGCCTCGGTGGACGGATCGCCCG
ATGGCGGCCTGGAGCGGGTGTCGTTGCGCAGCCGGCTGTCCGGTGATGATTGGACGATGGACGTGCGCAATCTGTTCCTG
TTCGTCGGCGCCGACCCGGCCACCGGCTGGCTCCATGGCTGTGGCGTCACGCTCGACCGGGCCGGTTTCGTGGTCACCGG
GGCGCCCGCCGAAGACGACCGCCAGCGGCCGGCGCAGGCGCTCGAAACCTCGGTGCCGGGCGTGTTCGCCGTCGGCGACG
TGCGCTCGGGCTCGGTCAAGCGCGTCGGTGGTGCGATCGGCGAGGGCGCGCAGGTGGTGGCCGCGCTGCACGGCTTTCTC
GCGGATTCGCTGCAGCCGGTGAAGTAG

Upstream 100 bases:

>100_bases
CGATCCCGGCGATGATGCCGGAATCGTTCAAGACAGCGATATCGGGAAAGCCGATGACGCCACCTGATACGACAGCATGG
CGGGCCGAAGGACACGATCG

Downstream 100 bases:

>100_bases
TCGGCATGCGTGCCTGCGCCGCGGGCATGATGCCGCCAATCGAAACGGCAGCGGCTTTGCTAACACGCTATGGAAAGATG
ATGGCGGTCATGTTATACGA

Product: cyclic nucleotide-regulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MTGYEFDGTDLDGGERVYPRYDQTFPVLTPAEIERMRRFGEIRRFADGEMLFETGKIGPGMFVVLSGHVAVTQRDGLGHV
TPVVEQGPGQFLAEISQLAGRVALVDGRADGDVECLLIPPERLRALLVAEADLGERIMRALILRRVNLIQGGVGGPVLIG
SATSSDAVRLMGFLTRNGWPFHLLDPATDRDAADLVTRFSPGPHDLPLVVASDGTVLRNPREADLARAMGMIGKLDPAKV
YDVAIVGSGPAGLSTAVYAASEGLSVAVCDQRAFGGQAGASARIENYLGFPTGISGHALTARAFNQAQKFGADIMIPVEV
KSLECGSNDGTFALSLDDGAALRARAIVVASGARYRRPEIANLAAYDGRGVYYWASPIEARLCKDQEVILVGGGNSAGQA
AVYLSTHAARVHMVIRGGGLAASMSRYLIERIESTANIELVFNTEVASVDGSPDGGLERVSLRSRLSGDDWTMDVRNLFL
FVGADPATGWLHGCGVTLDRAGFVVTGAPAEDDRQRPAQALETSVPGVFAVGDVRSGSVKRVGGAIGEGAQVVAALHGFL
ADSLQPVK

Sequences:

>Translated_568_residues
MTGYEFDGTDLDGGERVYPRYDQTFPVLTPAEIERMRRFGEIRRFADGEMLFETGKIGPGMFVVLSGHVAVTQRDGLGHV
TPVVEQGPGQFLAEISQLAGRVALVDGRADGDVECLLIPPERLRALLVAEADLGERIMRALILRRVNLIQGGVGGPVLIG
SATSSDAVRLMGFLTRNGWPFHLLDPATDRDAADLVTRFSPGPHDLPLVVASDGTVLRNPREADLARAMGMIGKLDPAKV
YDVAIVGSGPAGLSTAVYAASEGLSVAVCDQRAFGGQAGASARIENYLGFPTGISGHALTARAFNQAQKFGADIMIPVEV
KSLECGSNDGTFALSLDDGAALRARAIVVASGARYRRPEIANLAAYDGRGVYYWASPIEARLCKDQEVILVGGGNSAGQA
AVYLSTHAARVHMVIRGGGLAASMSRYLIERIESTANIELVFNTEVASVDGSPDGGLERVSLRSRLSGDDWTMDVRNLFL
FVGADPATGWLHGCGVTLDRAGFVVTGAPAEDDRQRPAQALETSVPGVFAVGDVRSGSVKRVGGAIGEGAQVVAALHGFL
ADSLQPVK
>Mature_567_residues
TGYEFDGTDLDGGERVYPRYDQTFPVLTPAEIERMRRFGEIRRFADGEMLFETGKIGPGMFVVLSGHVAVTQRDGLGHVT
PVVEQGPGQFLAEISQLAGRVALVDGRADGDVECLLIPPERLRALLVAEADLGERIMRALILRRVNLIQGGVGGPVLIGS
ATSSDAVRLMGFLTRNGWPFHLLDPATDRDAADLVTRFSPGPHDLPLVVASDGTVLRNPREADLARAMGMIGKLDPAKVY
DVAIVGSGPAGLSTAVYAASEGLSVAVCDQRAFGGQAGASARIENYLGFPTGISGHALTARAFNQAQKFGADIMIPVEVK
SLECGSNDGTFALSLDDGAALRARAIVVASGARYRRPEIANLAAYDGRGVYYWASPIEARLCKDQEVILVGGGNSAGQAA
VYLSTHAARVHMVIRGGGLAASMSRYLIERIESTANIELVFNTEVASVDGSPDGGLERVSLRSRLSGDDWTMDVRNLFLF
VGADPATGWLHGCGVTLDRAGFVVTGAPAEDDRQRPAQALETSVPGVFAVGDVRSGSVKRVGGAIGEGAQVVAALHGFLA
DSLQPVK

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081763, Length=329, Percent_Identity=31.6109422492401, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1787114, Length=299, Percent_Identity=31.438127090301, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6320560, Length=329, Percent_Identity=28.8753799392097, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6321898, Length=324, Percent_Identity=29.320987654321, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 59910; Mature: 59779

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50042 CNMP_BINDING_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGYEFDGTDLDGGERVYPRYDQTFPVLTPAEIERMRRFGEIRRFADGEMLFETGKIGPG
CCCCCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
MFVVLSGHVAVTQRDGLGHVTPVVEQGPGQFLAEISQLAGRVALVDGRADGDVECLLIPP
EEEEEECCEEEEECCCCCCCCCHHHCCCHHHHHHHHHHCCEEEEEECCCCCCEEEEEECH
ERLRALLVAEADLGERIMRALILRRVNLIQGGVGGPVLIGSATSSDAVRLMGFLTRNGWP
HHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCC
FHLLDPATDRDAADLVTRFSPGPHDLPLVVASDGTVLRNPREADLARAMGMIGKLDPAKV
EEEECCCCCCCHHHHHHHCCCCCCCCEEEEECCCCEECCCCHHHHHHHHHHHCCCCCCEE
YDVAIVGSGPAGLSTAVYAASEGLSVAVCDQRAFGGQAGASARIENYLGFPTGISGHALT
EEEEEECCCCCCCHHEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCEEE
ARAFNQAQKFGADIMIPVEVKSLECGSNDGTFALSLDDGAALRARAIVVASGARYRRPEI
HHHHHHHHHCCCCEEEEEEEEEEECCCCCCEEEEEECCCCCEEEEEEEEECCCCCCCCCC
ANLAAYDGRGVYYWASPIEARLCKDQEVILVGGGNSAGQAAVYLSTHAARVHMVIRGGGL
CEEEEECCCEEEEECCCHHHHHCCCCEEEEEECCCCCCCEEEEEEECCEEEEEEEECCCH
AASMSRYLIERIESTANIELVFNTEVASVDGSPDGGLERVSLRSRLSGDDWTMDVRNLFL
HHHHHHHHHHHHCCCCEEEEEEECEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEE
FVGADPATGWLHGCGVTLDRAGFVVTGAPAEDDRQRPAQALETSVPGVFAVGDVRSGSVK
EEECCCCCCCEECCCEEEECCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCHH
RVGGAIGEGAQVVAALHGFLADSLQPVK
HHCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TGYEFDGTDLDGGERVYPRYDQTFPVLTPAEIERMRRFGEIRRFADGEMLFETGKIGPG
CCCCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
MFVVLSGHVAVTQRDGLGHVTPVVEQGPGQFLAEISQLAGRVALVDGRADGDVECLLIPP
EEEEEECCEEEEECCCCCCCCCHHHCCCHHHHHHHHHHCCEEEEEECCCCCCEEEEEECH
ERLRALLVAEADLGERIMRALILRRVNLIQGGVGGPVLIGSATSSDAVRLMGFLTRNGWP
HHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCC
FHLLDPATDRDAADLVTRFSPGPHDLPLVVASDGTVLRNPREADLARAMGMIGKLDPAKV
EEEECCCCCCCHHHHHHHCCCCCCCCEEEEECCCCEECCCCHHHHHHHHHHHCCCCCCEE
YDVAIVGSGPAGLSTAVYAASEGLSVAVCDQRAFGGQAGASARIENYLGFPTGISGHALT
EEEEEECCCCCCCHHEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCEEE
ARAFNQAQKFGADIMIPVEVKSLECGSNDGTFALSLDDGAALRARAIVVASGARYRRPEI
HHHHHHHHHCCCCEEEEEEEEEEECCCCCCEEEEEECCCCCEEEEEEEEECCCCCCCCCC
ANLAAYDGRGVYYWASPIEARLCKDQEVILVGGGNSAGQAAVYLSTHAARVHMVIRGGGL
CEEEEECCCEEEEECCCHHHHHCCCCEEEEEECCCCCCCEEEEEEECCEEEEEEEECCCH
AASMSRYLIERIESTANIELVFNTEVASVDGSPDGGLERVSLRSRLSGDDWTMDVRNLFL
HHHHHHHHHHHHCCCCEEEEEEECEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEE
FVGADPATGWLHGCGVTLDRAGFVVTGAPAEDDRQRPAQALETSVPGVFAVGDVRSGSVK
EEECCCCCCCEECCCEEEECCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCHH
RVGGAIGEGAQVVAALHGFLADSLQPVK
HHCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11353084 [H]