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The map label for this gene is apt

Identifier: 86751419

GI number: 86751419

Start: 4900786

End: 4901331

Strand: Reverse

Name: apt

Synonym: RPB_4317

Alternate gene names: 86751419

Gene position: 4901331-4900786 (Counterclockwise)

Preceding gene: 86751420

Following gene: 86751414

Centisome position: 91.93

GC content: 65.93

Gene sequence:

>546_bases
ATGACCCCCGAACTTGCCCATGATTTGAAGGCCAGTGTCCGGACCATTCCGGACTATCCCAAACCCGGCATCATGTTCCG
CGACATCACCACGCTGATGGGTGATCCGCGCTCGTTCCGCCGCGCCGTCGACGAACTGGTGCAGCCCTGGGCCGGCTCCA
AGATCGACAAGGTCGCCGGCATCGAGGCGCGGGGCTTCATCATCGGCGGCGCGATCGCCCATCAGGTGTCGTCGGGCTTC
GTGCCGATCCGCAAGAAGGGCAAGCTGCCGCACACCTGCGTGTCGATGGAATACACGCTGGAATACGGCACCGATCACAT
CGAGATTCACGTCGATGCGATCACGCCGGGCGAGCGCGTGATCCTGGTCGACGATCTGATCGCCACCGGCGGCACCGCCG
AGGGCGCCATCAAGCTGCTGCGCCAGATCGGCGCCGAAGTCGTCGCCGCCTGCTTCATCATCGACCTCCCGGATCTGGGC
GGCGCCGCCAAGGTCCGCAGCATGGGCGTCCCGGTCCGCACGCTGGTCGAGTTCGGCGGGCACTGA

Upstream 100 bases:

>100_bases
TGGGCTGCTAACACGCCCCGGCGGCAGTTATCCGAATTACCGGATTGCCTCCGACGCCCCGCAATGACGAATTGAGCCAC
CCGCAACAGAGATCGCGCCG

Downstream 100 bases:

>100_bases
GCTCTCCTGCTGCGCGTTCGCGCCAGGCGATCGCCGCTAGCGCTCCGTCATCCTGAGGTGCCGCCGCGCAGCGGCGGCCT
CGAAGGATGAGCCGCAAGCA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MTPELAHDLKASVRTIPDYPKPGIMFRDITTLMGDPRSFRRAVDELVQPWAGSKIDKVAGIEARGFIIGGAIAHQVSSGF
VPIRKKGKLPHTCVSMEYTLEYGTDHIEIHVDAITPGERVILVDDLIATGGTAEGAIKLLRQIGAEVVAACFIIDLPDLG
GAAKVRSMGVPVRTLVEFGGH

Sequences:

>Translated_181_residues
MTPELAHDLKASVRTIPDYPKPGIMFRDITTLMGDPRSFRRAVDELVQPWAGSKIDKVAGIEARGFIIGGAIAHQVSSGF
VPIRKKGKLPHTCVSMEYTLEYGTDHIEIHVDAITPGERVILVDDLIATGGTAEGAIKLLRQIGAEVVAACFIIDLPDLG
GAAKVRSMGVPVRTLVEFGGH
>Mature_180_residues
TPELAHDLKASVRTIPDYPKPGIMFRDITTLMGDPRSFRRAVDELVQPWAGSKIDKVAGIEARGFIIGGAIAHQVSSGFV
PIRKKGKLPHTCVSMEYTLEYGTDHIEIHVDAITPGERVILVDDLIATGGTAEGAIKLLRQIGAEVVAACFIIDLPDLGG
AAKVRSMGVPVRTLVEFGGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=169, Percent_Identity=42.0118343195266, Blast_Score=143, Evalue=9e-35,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=44.8, Blast_Score=120, Evalue=5e-28,
Organism=Escherichia coli, GI1786675, Length=173, Percent_Identity=52.6011560693642, Blast_Score=196, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17509087, Length=176, Percent_Identity=40.9090909090909, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6323619, Length=175, Percent_Identity=38.8571428571429, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=36.8421052631579, Blast_Score=103, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17136334, Length=172, Percent_Identity=37.2093023255814, Blast_Score=116, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_RHOP2 (Q2IS06)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_487915.1
- HSSP:   P07741
- ProteinModelPortal:   Q2IS06
- SMR:   Q2IS06
- STRING:   Q2IS06
- GeneID:   3912130
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_4317
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   RPAL316058:RPB_4317-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19424; Mature: 19293

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPELAHDLKASVRTIPDYPKPGIMFRDITTLMGDPRSFRRAVDELVQPWAGSKIDKVAG
CCCHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHCC
IEARGFIIGGAIAHQVSSGFVPIRKKGKLPHTCVSMEYTLEYGTDHIEIHVDAITPGERV
CCCCCEEEEHHHHHHHHCCCEEECCCCCCCCEEEEEEEEEECCCCEEEEEEEEECCCCEE
ILVDDLIATGGTAEGAIKLLRQIGAEVVAACFIIDLPDLGGAAKVRSMGVPVRTLVEFGG
EEEECHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCHHHHHHHCC
H
C
>Mature Secondary Structure 
TPELAHDLKASVRTIPDYPKPGIMFRDITTLMGDPRSFRRAVDELVQPWAGSKIDKVAG
CCHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHCC
IEARGFIIGGAIAHQVSSGFVPIRKKGKLPHTCVSMEYTLEYGTDHIEIHVDAITPGERV
CCCCCEEEEHHHHHHHHCCCEEECCCCCCCCEEEEEEEEEECCCCEEEEEEEEECCCCEE
ILVDDLIATGGTAEGAIKLLRQIGAEVVAACFIIDLPDLGGAAKVRSMGVPVRTLVEFGG
EEEECHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCHHHHHHHCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA