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The map label for this gene is mdtE [H]

Identifier: 86751403

GI number: 86751403

Start: 4888903

End: 4889910

Strand: Reverse

Name: mdtE [H]

Synonym: RPB_4301

Alternate gene names: 86751403

Gene position: 4889910-4888903 (Counterclockwise)

Preceding gene: 86751404

Following gene: 86751402

Centisome position: 91.71

GC content: 69.44

Gene sequence:

>1008_bases
ATGACGATGCGGATTCGCGACATGATCACGGCCGGTGCCTGCGCCGCCCTCCTGCTCGGCGCGGCGGCGACGCCCGCGGC
GGCGGCGACGCTCACGGTGGCGGAGCAGAAGGTCTCGGACGAGAAGGCGGTGTTCGCCACCGTCGAGAGCATCAGCGTCG
TGCCGGCGCGCAGCCGGATCGGCGGCACCGTGATCGCCCTGAAAGTGCGCGAGGGCGACAGCGTCGCCCGCGGCCAGGAA
ATCGCGACGATCGGCGACGACAAGCTGACGCTGCAGATGAATTCGCTCGACGCGCAGATGCAGGCGCTGCTGGCGCAGGC
GTCGCAGGCGCAGATCGATTTCGACCGCACCAGCGGCCTGGTCGAACGCGGCACGCTGGCGCGCACCAAGCTCGACGAGG
CGCGCACCACGCTCAACGTGGCCGAGAACAATCTGCGCGCCAAGACCGCGGAGCGCGCGGTGGTGCAGCAGCAGTTCAAG
GAGGGCCAGGTGCTGGCGCCCGACGACGGCCGCGTGCTGAAGAAGATGGTCGCGGTCGGCTCGGTGGTGCTGCAGGGCGA
TACCATCGTCACGGTGGCGCAGCAGCACTACAAGCTGCGGCTGCGGGTGCCGGAACGGCACGCGCGGTTCCTCAAACAGG
GTGATCGCGTTCGCGTCGACGGCGCCGAGTTCGGCGACCACACGGCGAAGTTCGGCACGATTGACCTCGTCTACCCGCTG
ATCGAGGACGGCCGCGTCGTCGCCGATGCCTCCGTCGAGGGGCTCGGCCAGTATTTCGTCGGCGACCGGCTGCGGGTGTG
GGTCTCCGGCGGCGAGCGCCCGGCCTTCGTCATTCCGTCGCGCTACATCAAGACCGAATTCGGCATCGACTACGTCCAGC
TCGGCGAGCCGGGCAAGACCGTCGCGGTGCCGGTGCAGCGCGGCCGCGATCATCCCACGCCGGACATGCCGGACGGCCTC
GAGATCCTCTCGGGCCTGCGTAATGGTGACAGGTTGGTGCAGCCGTGA

Upstream 100 bases:

>100_bases
CGATCGCGAGCGAGCCGGCTCGCGAACTCCTGACCACGCTGTACCGGCTGTACTGTCCGGCGCCGCCCGCGCGGAAGACG
GCAAGCAAACCTGAGAAGGC

Downstream 100 bases:

>100_bases
ACCTCGGAATCTCGGGCCGCCTGACCAAGGCCACCATCCTTTCCCCGCTGACGCCGCTGTTCCTGCTGGCCTCGCTCGTC
GTCGGGCTGTTCGCGCTGGT

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTMRIRDMITAGACAALLLGAAATPAAAATLTVAEQKVSDEKAVFATVESISVVPARSRIGGTVIALKVREGDSVARGQE
IATIGDDKLTLQMNSLDAQMQALLAQASQAQIDFDRTSGLVERGTLARTKLDEARTTLNVAENNLRAKTAERAVVQQQFK
EGQVLAPDDGRVLKKMVAVGSVVLQGDTIVTVAQQHYKLRLRVPERHARFLKQGDRVRVDGAEFGDHTAKFGTIDLVYPL
IEDGRVVADASVEGLGQYFVGDRLRVWVSGGERPAFVIPSRYIKTEFGIDYVQLGEPGKTVAVPVQRGRDHPTPDMPDGL
EILSGLRNGDRLVQP

Sequences:

>Translated_335_residues
MTMRIRDMITAGACAALLLGAAATPAAAATLTVAEQKVSDEKAVFATVESISVVPARSRIGGTVIALKVREGDSVARGQE
IATIGDDKLTLQMNSLDAQMQALLAQASQAQIDFDRTSGLVERGTLARTKLDEARTTLNVAENNLRAKTAERAVVQQQFK
EGQVLAPDDGRVLKKMVAVGSVVLQGDTIVTVAQQHYKLRLRVPERHARFLKQGDRVRVDGAEFGDHTAKFGTIDLVYPL
IEDGRVVADASVEGLGQYFVGDRLRVWVSGGERPAFVIPSRYIKTEFGIDYVQLGEPGKTVAVPVQRGRDHPTPDMPDGL
EILSGLRNGDRLVQP
>Mature_334_residues
TMRIRDMITAGACAALLLGAAATPAAAATLTVAEQKVSDEKAVFATVESISVVPARSRIGGTVIALKVREGDSVARGQEI
ATIGDDKLTLQMNSLDAQMQALLAQASQAQIDFDRTSGLVERGTLARTKLDEARTTLNVAENNLRAKTAERAVVQQQFKE
GQVLAPDDGRVLKKMVAVGSVVLQGDTIVTVAQQHYKLRLRVPERHARFLKQGDRVRVDGAEFGDHTAKFGTIDLVYPLI
EDGRVVADASVEGLGQYFVGDRLRVWVSGGERPAFVIPSRYIKTEFGIDYVQLGEPGKTVAVPVQRGRDHPTPDMPDGLE
ILSGLRNGDRLVQP

Specific function: Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=273, Percent_Identity=28.2051282051282, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082036, Length=184, Percent_Identity=30.9782608695652, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 36165; Mature: 36034

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMRIRDMITAGACAALLLGAAATPAAAATLTVAEQKVSDEKAVFATVESISVVPARSRI
CCEEHHHHHHHHHHHHHHHCCCCCCCHHEEEEHHHHHCCCCHHEEEEEHHEEEECCHHCC
GGTVIALKVREGDSVARGQEIATIGDDKLTLQMNSLDAQMQALLAQASQAQIDFDRTSGL
CCEEEEEEEECCCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHCEEEHHHHCCC
VERGTLARTKLDEARTTLNVAENNLRAKTAERAVVQQQFKEGQVLAPDDGRVLKKMVAVG
HHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHH
SVVLQGDTIVTVAQQHYKLRLRVPERHARFLKQGDRVRVDGAEFGDHTAKFGTIDLVYPL
HEEECCCEEEEEECCCEEEEEECCHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEEEEH
IEDGRVVADASVEGLGQYFVGDRLRVWVSGGERPAFVIPSRYIKTEFGIDYVQLGEPGKT
HCCCEEEEECCHHHHHHHHCCCEEEEEEECCCCCEEECCCHHHHHHCCCCEEEECCCCCE
VAVPVQRGRDHPTPDMPDGLEILSGLRNGDRLVQP
EEEEHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TMRIRDMITAGACAALLLGAAATPAAAATLTVAEQKVSDEKAVFATVESISVVPARSRI
CEEHHHHHHHHHHHHHHHCCCCCCCHHEEEEHHHHHCCCCHHEEEEEHHEEEECCHHCC
GGTVIALKVREGDSVARGQEIATIGDDKLTLQMNSLDAQMQALLAQASQAQIDFDRTSGL
CCEEEEEEEECCCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHCEEEHHHHCCC
VERGTLARTKLDEARTTLNVAENNLRAKTAERAVVQQQFKEGQVLAPDDGRVLKKMVAVG
HHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHH
SVVLQGDTIVTVAQQHYKLRLRVPERHARFLKQGDRVRVDGAEFGDHTAKFGTIDLVYPL
HEEECCCEEEEEECCCEEEEEECCHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEEEEH
IEDGRVVADASVEGLGQYFVGDRLRVWVSGGERPAFVIPSRYIKTEFGIDYVQLGEPGKT
HCCCEEEEECCHHHHHHHHCCCEEEEEEECCCCCEEECCCHHHHHHCCCCEEEECCCCCE
VAVPVQRGRDHPTPDMPDGLEILSGLRNGDRLVQP
EEEEHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]