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The map label for this gene is hisC

Identifier: 86751357

GI number: 86751357

Start: 4840376

End: 4841473

Strand: Direct

Name: hisC

Synonym: RPB_4254

Alternate gene names: 86751357

Gene position: 4840376-4841473 (Clockwise)

Preceding gene: 86751356

Following gene: 86751358

Centisome position: 90.79

GC content: 65.94

Gene sequence:

>1098_bases
ATGTCCCGTCCCGTGCCGAAGCCCGGCATTCTCGATATTGCGCCCTACACCCCCGGCAAGAGCCCCGTGCCCGAAGCCGG
CCGCAAGGTGTTCAAGCTCTCGGCCAACGAAACCCCGTTCGGCCCGTCGCCGCACGCGATCGCGGCCTATAAGAGCGCGG
CGGATCATCTCGAGGATTATCCGGAGGGCACCTCGCGGGTGCTGCGCGAGGCGATCGGCCGTGCCTACGGCCTCGACCCC
GACCGCATCATCTGCGGCGCCGGCTCCGACGAAATCCTGAACCTGTTGGCGCACACTTATCTCGGCCCCGGCGACGAGGC
GATCTCGTCGCAGCACGGCTTCCTGGTCTATCCGATCGCCACGCTGGCGAACGGCGCCACCAACGTGGTCGCGCCGGAAA
AGGACCTGACGACCGACGTCGACGCGATCCTCAGCAAGGTCACGCCGAACACCAAGCTGGTGTGGCTCGCCAACCCGAAC
AACCCGACCGGGACCTATATTCCGTTCGACGAGGTCAAGCGGCTGCGCGCCGGCCTGCCCTCGCACGTCGTGCTGGTCCT
CGACGCCGCCTATGCCGACTACGTCTCGAAGAACGACTACGAGATCGGCATCGAACTGGTCTCGACCACCGACAACACCG
TGCTGACCCACACCTTCTCCAAGGTGCACGGCCTCGCGAGCTTGCGGATCGGCTGGATGTTCGGCCCGGCGAATATTGTG
GACGCGGTCAACCGCATCCGCGGTCCGTTCAACACGTCGATCCCGGCGCAGCTCGCCGCGGTCGCGGCGATCCAGGACAC
CGCGCATGTCGACATGTCGCGCGTCCACACCGAGAAGTGGCGCGACCGACTGACCGAGGAGTTCACCAAACTCGGCCTGA
CAGTGACGCCGAGCGTCTGCAATTTCGTGCTGATGCATTTCCCGACCACGGCGGGCAAGACCGCGGCGGATGCCGACGCG
TTCCTGACCAAGCGCGGTCTCGTGCTGCGCGCGCTCGGCAATTACAAGCTGCCGCACGCGCTGCGCATGACCATCGGCAC
CGACGAGGCCAACGAGCTGGTAATCGCGGCGCTGACCGAGTTCATGGCGAAGCCATGA

Upstream 100 bases:

>100_bases
CCTCGTCGGCAGCCACGCGAGGCGCTATACGGTGCCCCCGAGCGGCAAGGCCCCGACCTGAAGGACCGGCCTGCAGCCGC
CTGACACTCCGGAGTTGACG

Downstream 100 bases:

>100_bases
CCGCGCCGCTGTTTCAACGGCTGGCGCTGATCGGCTTCGGCCTGATCGGCGGCTCGATCGCACGCGGCGCGCGGCTGCAG
GGTCTCGCGGGCGAGATCGT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MSRPVPKPGILDIAPYTPGKSPVPEAGRKVFKLSANETPFGPSPHAIAAYKSAADHLEDYPEGTSRVLREAIGRAYGLDP
DRIICGAGSDEILNLLAHTYLGPGDEAISSQHGFLVYPIATLANGATNVVAPEKDLTTDVDAILSKVTPNTKLVWLANPN
NPTGTYIPFDEVKRLRAGLPSHVVLVLDAAYADYVSKNDYEIGIELVSTTDNTVLTHTFSKVHGLASLRIGWMFGPANIV
DAVNRIRGPFNTSIPAQLAAVAAIQDTAHVDMSRVHTEKWRDRLTEEFTKLGLTVTPSVCNFVLMHFPTTAGKTAADADA
FLTKRGLVLRALGNYKLPHALRMTIGTDEANELVIAALTEFMAKP

Sequences:

>Translated_365_residues
MSRPVPKPGILDIAPYTPGKSPVPEAGRKVFKLSANETPFGPSPHAIAAYKSAADHLEDYPEGTSRVLREAIGRAYGLDP
DRIICGAGSDEILNLLAHTYLGPGDEAISSQHGFLVYPIATLANGATNVVAPEKDLTTDVDAILSKVTPNTKLVWLANPN
NPTGTYIPFDEVKRLRAGLPSHVVLVLDAAYADYVSKNDYEIGIELVSTTDNTVLTHTFSKVHGLASLRIGWMFGPANIV
DAVNRIRGPFNTSIPAQLAAVAAIQDTAHVDMSRVHTEKWRDRLTEEFTKLGLTVTPSVCNFVLMHFPTTAGKTAADADA
FLTKRGLVLRALGNYKLPHALRMTIGTDEANELVIAALTEFMAKP
>Mature_364_residues
SRPVPKPGILDIAPYTPGKSPVPEAGRKVFKLSANETPFGPSPHAIAAYKSAADHLEDYPEGTSRVLREAIGRAYGLDPD
RIICGAGSDEILNLLAHTYLGPGDEAISSQHGFLVYPIATLANGATNVVAPEKDLTTDVDAILSKVTPNTKLVWLANPNN
PTGTYIPFDEVKRLRAGLPSHVVLVLDAAYADYVSKNDYEIGIELVSTTDNTVLTHTFSKVHGLASLRIGWMFGPANIVD
AVNRIRGPFNTSIPAQLAAVAAIQDTAHVDMSRVHTEKWRDRLTEEFTKLGLTVTPSVCNFVLMHFPTTAGKTAADADAF
LTKRGLVLRALGNYKLPHALRMTIGTDEANELVIAALTEFMAKP

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=352, Percent_Identity=24.1477272727273, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788722, Length=284, Percent_Identity=27.4647887323944, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=391, Percent_Identity=26.0869565217391, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_RHOP2 (Q2IS68)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_487853.1
- ProteinModelPortal:   Q2IS68
- SMR:   Q2IS68
- STRING:   Q2IS68
- GeneID:   3912067
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_4254
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   YDIAARR
- ProtClustDB:   PRK02731
- BioCyc:   RPAL316058:RPB_4254-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39330; Mature: 39199

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPVPKPGILDIAPYTPGKSPVPEAGRKVFKLSANETPFGPSPHAIAAYKSAADHLEDY
CCCCCCCCCEEEECCCCCCCCCCCHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
PEGTSRVLREAIGRAYGLDPDRIICGAGSDEILNLLAHTYLGPGDEAISSQHGFLVYPIA
CCHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEHH
TLANGATNVVAPEKDLTTDVDAILSKVTPNTKLVWLANPNNPTGTYIPFDEVKRLRAGLP
HHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCC
SHVVLVLDAAYADYVSKNDYEIGIELVSTTDNTVLTHTFSKVHGLASLRIGWMFGPANIV
CEEEEEEEHHHHHHHCCCCCEEEEEEEECCCCEEEEHHHHHHHHHHHEEEEEEECCHHHH
DAVNRIRGPFNTSIPAQLAAVAAIQDTAHVDMSRVHTEKWRDRLTEEFTKLGLTVTPSVC
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHH
NFVLMHFPTTAGKTAADADAFLTKRGLVLRALGNYKLPHALRMTIGTDEANELVIAALTE
HHHHHHCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHH
FMAKP
HHCCC
>Mature Secondary Structure 
SRPVPKPGILDIAPYTPGKSPVPEAGRKVFKLSANETPFGPSPHAIAAYKSAADHLEDY
CCCCCCCCEEEECCCCCCCCCCCHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
PEGTSRVLREAIGRAYGLDPDRIICGAGSDEILNLLAHTYLGPGDEAISSQHGFLVYPIA
CCHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEHH
TLANGATNVVAPEKDLTTDVDAILSKVTPNTKLVWLANPNNPTGTYIPFDEVKRLRAGLP
HHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCC
SHVVLVLDAAYADYVSKNDYEIGIELVSTTDNTVLTHTFSKVHGLASLRIGWMFGPANIV
CEEEEEEEHHHHHHHCCCCCEEEEEEEECCCCEEEEHHHHHHHHHHHEEEEEEECCHHHH
DAVNRIRGPFNTSIPAQLAAVAAIQDTAHVDMSRVHTEKWRDRLTEEFTKLGLTVTPSVC
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHH
NFVLMHFPTTAGKTAADADAFLTKRGLVLRALGNYKLPHALRMTIGTDEANELVIAALTE
HHHHHHCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHH
FMAKP
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA