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The map label for this gene is mdtA [H]

Identifier: 86751328

GI number: 86751328

Start: 4797019

End: 4798125

Strand: Reverse

Name: mdtA [H]

Synonym: RPB_4222

Alternate gene names: 86751328

Gene position: 4798125-4797019 (Counterclockwise)

Preceding gene: 86751329

Following gene: 86751327

Centisome position: 89.99

GC content: 69.02

Gene sequence:

>1107_bases
ATGTTTGCGCATCCGATGTTCGATGGATTGTTCCGGCTGTTCGCGGGCTTCATGCTCGCGCTTGTGGCGCTCGCTCTGGC
CGGATGTGATGAGCAGAAGGCCACCCGGGATCGTCCAGCGCGGCCTGTTCTGGTCGACACTGTCTACTATGCCGCCGCTT
CGCCGAAGCGCAGCTTTGTCGGAACGATTCGGCCGCGGATCGAAACCGATATCGGCTTTCGGGTCGCCGGCAAGGTCGCT
CAGCGCCTCGTCGAGGTCGGCCAGACGGTGGAGCCCGGCCAGACGCTGGCGTTGCTCGACCAGACCGATCTCAAATTGCA
AGCCGAGCAGGCGGACGCCGAGCACAGCGCGGCCAAGGGCGTGCTGGCGCAGGCGAGGGCCTCGGAAAATCGCGCCAAGG
AGCTCCGCGCCAAAGGCTGGGCGACCGAGGCTCAGATGGACCAGGCGCGCGCGGCCGCCGACGAGGCGCGCGCCCGCTTT
GCCCGCGCCGAGCGCTCGGTCGACCTGACCCGCAACGCGCTGTCCTACGCCAGCCTGGTGGCCGACACCCGTGGCGTCGT
CACCGCGGCGCTGATCGACTCCGGACAGGTGGTCTCGGCGGGGCAGGCGGCCTTCCGCATCGCGCGGTTCGGCGAGAAGG
AGGCGGTGGTGGCGATCCCGGAGACGCTGATCACCCGGGCGACCCAGGGCGTCGCCAGCGTTTCGCTGTGGTCGGAGCCG
GGTCGCAGCTATGCGGCGAAGCTGCGGGAGGTCGCGCCGATGGCCGATCCCGCGACCCGCACGTTTCTCGCCAAGTTCAC
CCTGCCCGATGCCGACGACCGCGTCGTGCTCGGGATGACCGCGACGCTGACGCTGGCCGATCCGGACACGCTCCGCGTCG
CCCGGGTGCCGCTGTCGGCGCTGTTCAATCAGGGTGGCACGCCGTCGGTCTATGTCGTGGACTCCGCCGGACAGGTGACG
CTGAAGCCGGTGACGGTGAAGGCCTATGAGACCGAGAAGGTCGTGATCGGCGGCGGCGTCGAGGACGGCGCCAAGGTGGT
CGTGCTCGGGGTGCAGAAGCTCGATCCGGCCGAGAAGGTTCGGGTCGTGTCGTCGCTGTCGTTCTAG

Upstream 100 bases:

>100_bases
AGTATAGCGCAGGACCCTCTGAAATCGTGATCACTGACGATTATTGACAATCGTCAGTGATCATTCGACAGTTCCGCCGT
CGCTTTTTGAGGGCCTGTCG

Downstream 100 bases:

>100_bases
ATCACGCGGGGGCCCGATGCGTTGGTTCAATCTGTCGGCGTGGGCGGTCGCGCATCCGGCGCTGATCTTGTTCCTCATCG
TGGCGTTGGGCGTCTCCGGG

Product: secretion protein HlyD

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MFAHPMFDGLFRLFAGFMLALVALALAGCDEQKATRDRPARPVLVDTVYYAAASPKRSFVGTIRPRIETDIGFRVAGKVA
QRLVEVGQTVEPGQTLALLDQTDLKLQAEQADAEHSAAKGVLAQARASENRAKELRAKGWATEAQMDQARAAADEARARF
ARAERSVDLTRNALSYASLVADTRGVVTAALIDSGQVVSAGQAAFRIARFGEKEAVVAIPETLITRATQGVASVSLWSEP
GRSYAAKLREVAPMADPATRTFLAKFTLPDADDRVVLGMTATLTLADPDTLRVARVPLSALFNQGGTPSVYVVDSAGQVT
LKPVTVKAYETEKVVIGGGVEDGAKVVVLGVQKLDPAEKVRVVSSLSF

Sequences:

>Translated_368_residues
MFAHPMFDGLFRLFAGFMLALVALALAGCDEQKATRDRPARPVLVDTVYYAAASPKRSFVGTIRPRIETDIGFRVAGKVA
QRLVEVGQTVEPGQTLALLDQTDLKLQAEQADAEHSAAKGVLAQARASENRAKELRAKGWATEAQMDQARAAADEARARF
ARAERSVDLTRNALSYASLVADTRGVVTAALIDSGQVVSAGQAAFRIARFGEKEAVVAIPETLITRATQGVASVSLWSEP
GRSYAAKLREVAPMADPATRTFLAKFTLPDADDRVVLGMTATLTLADPDTLRVARVPLSALFNQGGTPSVYVVDSAGQVT
LKPVTVKAYETEKVVIGGGVEDGAKVVVLGVQKLDPAEKVRVVSSLSF
>Mature_368_residues
MFAHPMFDGLFRLFAGFMLALVALALAGCDEQKATRDRPARPVLVDTVYYAAASPKRSFVGTIRPRIETDIGFRVAGKVA
QRLVEVGQTVEPGQTLALLDQTDLKLQAEQADAEHSAAKGVLAQARASENRAKELRAKGWATEAQMDQARAAADEARARF
ARAERSVDLTRNALSYASLVADTRGVVTAALIDSGQVVSAGQAAFRIARFGEKEAVVAIPETLITRATQGVASVSLWSEP
GRSYAAKLREVAPMADPATRTFLAKFTLPDADDRVVLGMTATLTLADPDTLRVARVPLSALFNQGGTPSVYVVDSAGQVT
LKPVTVKAYETEKVVIGGGVEDGAKVVVLGVQKLDPAEKVRVVSSLSF

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=378, Percent_Identity=24.6031746031746, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081796, Length=302, Percent_Identity=24.8344370860927, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789665, Length=371, Percent_Identity=23.989218328841, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39167; Mature: 39167

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAHPMFDGLFRLFAGFMLALVALALAGCDEQKATRDRPARPVLVDTVYYAAASPKRSFV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEHHHHCCCCCHHHH
GTIRPRIETDIGFRVAGKVAQRLVEVGQTVEPGQTLALLDQTDLKLQAEQADAEHSAAKG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEHHHCCCHHHHHHH
VLAQARASENRAKELRAKGWATEAQMDQARAAADEARARFARAERSVDLTRNALSYASLV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADTRGVVTAALIDSGQVVSAGQAAFRIARFGEKEAVVAIPETLITRATQGVASVSLWSEP
HHCCCCEEEEEECCCCEEECCHHHHHHHHCCCCCEEEECCHHHHHHHHCCHHEEEECCCC
GRSYAAKLREVAPMADPATRTFLAKFTLPDADDRVVLGMTATLTLADPDTLRVARVPLSA
CHHHHHHHHHHCCCCCCCHHHEEEEEECCCCCCCEEEEEEEEEEECCCCCEEEECCCHHH
LFNQGGTPSVYVVDSAGQVTLKPVTVKAYETEKVVIGGGVEDGAKVVVLGVQKLDPAEKV
HHCCCCCCEEEEEECCCEEEEEEEEEEEEECCEEEEECCCCCCCEEEEEEECCCCHHHHH
RVVSSLSF
HHHHHCCC
>Mature Secondary Structure
MFAHPMFDGLFRLFAGFMLALVALALAGCDEQKATRDRPARPVLVDTVYYAAASPKRSFV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEHHHHCCCCCHHHH
GTIRPRIETDIGFRVAGKVAQRLVEVGQTVEPGQTLALLDQTDLKLQAEQADAEHSAAKG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEHHHCCCHHHHHHH
VLAQARASENRAKELRAKGWATEAQMDQARAAADEARARFARAERSVDLTRNALSYASLV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADTRGVVTAALIDSGQVVSAGQAAFRIARFGEKEAVVAIPETLITRATQGVASVSLWSEP
HHCCCCEEEEEECCCCEEECCHHHHHHHHCCCCCEEEECCHHHHHHHHCCHHEEEECCCC
GRSYAAKLREVAPMADPATRTFLAKFTLPDADDRVVLGMTATLTLADPDTLRVARVPLSA
CHHHHHHHHHHCCCCCCCHHHEEEEEECCCCCCCEEEEEEEEEEECCCCCEEEECCCHHH
LFNQGGTPSVYVVDSAGQVTLKPVTVKAYETEKVVIGGGVEDGAKVVVLGVQKLDPAEKV
HHCCCCCCEEEEEECCCEEEEEEEEEEEEECCEEEEECCCCCCCEEEEEEECCCCHHHHH
RVVSSLSF
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]