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The map label for this gene is proC [H]

Identifier: 86751278

GI number: 86751278

Start: 4742089

End: 4742934

Strand: Direct

Name: proC [H]

Synonym: RPB_4171

Alternate gene names: 86751278

Gene position: 4742089-4742934 (Clockwise)

Preceding gene: 86751277

Following gene: 86751282

Centisome position: 88.94

GC content: 73.76

Gene sequence:

>846_bases
ATGCTCGCCATGGCCAACACTCCGAAGTCACCCGCCCTGCAGCAGCTCGGCGGCAATCTCGTGCTCGCCGGCGCCGGCAA
GATGGGCGGCGCGCTGCTCACCGGCTGGCTTGCGCAAGGGCTCGACGGCGGCGAGGTGGTGGTGATCGACCCGCAGCCCT
CCGACGAGATCCGCGCGCTGACCGCGCGCGGCGTTCGCATCAACGCCGCGGCGTCCGATGTCGGCGCGGTGGCGACGATG
CTGGTCGCGGTGAAGCCGCAGACCTTCGCCGGCGCCGCTCCCGCGTTGCGCAGCTATGCCGGCCCCTCGACTCTGGTGGT
GTCGGTGATGGCCGGCACGCCGATCGCCGCCCTCGCCGCGCAGATCGGCGGTCACGTCGTCCGCGCGATGCCGAACACGC
CGGCGGCAATCGGCCGCGGCATCACGGTGGCGGTCGCCGCCGATGACGTCACGCCCCAACAGCGCGCCACTGCGGACGCG
CTGCTGCGCGCCACCGGCGCGGTCGAATGGGTCGAGGACGAGAGCTTGATCGACGCCGTCACCGCGGTGTCGGGCTCGGG
CCCGGCCTACGTCTTCCTGCTCGCCGAGGAACTGGCCCGCGCCGGCGTCGAGGCCGGCCTGCCGGAAGCGCTCGCGACGA
CGCTGGCGCGCGCCACCGTCGCGGGCTCCGGCGAACTGCTGCATCGCTCCGAGCTGGATTCCGCGACGCTGCGCCAAAAC
GTCACCTCCCCCGGCGGCACCACCGCCGCCGCACTCGCCGTGCTGATGGCCGACGACGGCTTCCGCCCGCTGCTGACCCG
CGCGGTGGCGGCGGCGGCGAAGCGATCGCGGGAATTGGCGAAGTAA

Upstream 100 bases:

>100_bases
GACGAACTGATCCGGGCGGCCTCAGCCCTGGCACTTGTGACGCCCTCGTTGTTCCCATAAAACGCCTGCGAGAACGCGCC
GCCGTCGCGGCGCGCGATGG

Downstream 100 bases:

>100_bases
TCGCGACGCTTCCACACACACCGACGTCATCGCCCGGCTCGACCGGGCGACCCAGTATTCCAGAGTGGTCGTTATAGACG
TGTGCGCTCTGGAATACTGG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MLAMANTPKSPALQQLGGNLVLAGAGKMGGALLTGWLAQGLDGGEVVVIDPQPSDEIRALTARGVRINAAASDVGAVATM
LVAVKPQTFAGAAPALRSYAGPSTLVVSVMAGTPIAALAAQIGGHVVRAMPNTPAAIGRGITVAVAADDVTPQQRATADA
LLRATGAVEWVEDESLIDAVTAVSGSGPAYVFLLAEELARAGVEAGLPEALATTLARATVAGSGELLHRSELDSATLRQN
VTSPGGTTAAALAVLMADDGFRPLLTRAVAAAAKRSRELAK

Sequences:

>Translated_281_residues
MLAMANTPKSPALQQLGGNLVLAGAGKMGGALLTGWLAQGLDGGEVVVIDPQPSDEIRALTARGVRINAAASDVGAVATM
LVAVKPQTFAGAAPALRSYAGPSTLVVSVMAGTPIAALAAQIGGHVVRAMPNTPAAIGRGITVAVAADDVTPQQRATADA
LLRATGAVEWVEDESLIDAVTAVSGSGPAYVFLLAEELARAGVEAGLPEALATTLARATVAGSGELLHRSELDSATLRQN
VTSPGGTTAAALAVLMADDGFRPLLTRAVAAAAKRSRELAK
>Mature_281_residues
MLAMANTPKSPALQQLGGNLVLAGAGKMGGALLTGWLAQGLDGGEVVVIDPQPSDEIRALTARGVRINAAASDVGAVATM
LVAVKPQTFAGAAPALRSYAGPSTLVVSVMAGTPIAALAAQIGGHVVRAMPNTPAAIGRGITVAVAADDVTPQQRATADA
LLRATGAVEWVEDESLIDAVTAVSGSGPAYVFLLAEELARAGVEAGLPEALATTLARATVAGSGELLHRSELDSATLRQN
VTSPGGTTAAALAVLMADDGFRPLLTRAVAAAAKRSRELAK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=264, Percent_Identity=34.8484848484849, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI24797095, Length=264, Percent_Identity=34.469696969697, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI24797097, Length=264, Percent_Identity=34.469696969697, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI198041662, Length=267, Percent_Identity=29.5880149812734, Blast_Score=95, Evalue=8e-20,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=35.0943396226415, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=31.2977099236641, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17540664, Length=282, Percent_Identity=29.7872340425532, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320861, Length=224, Percent_Identity=30.8035714285714, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21358587, Length=271, Percent_Identity=34.3173431734317, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24647700, Length=155, Percent_Identity=43.2258064516129, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24648116, Length=213, Percent_Identity=34.7417840375587, Blast_Score=104, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28066; Mature: 28066

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAMANTPKSPALQQLGGNLVLAGAGKMGGALLTGWLAQGLDGGEVVVIDPQPSDEIRAL
CCCCCCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHH
TARGVRINAAASDVGAVATMLVAVKPQTFAGAAPALRSYAGPSTLVVSVMAGTPIAALAA
HHCCEEEECCHHHHHHHHHHHHHCCCCHHCCCCHHHHHHCCCHHEEEEECCCCCHHHHHH
QIGGHVVRAMPNTPAAIGRGITVAVAADDVTPQQRATADALLRATGAVEWVEDESLIDAV
HHCCEEEEECCCCCHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEECCCHHHHHHH
TAVSGSGPAYVFLLAEELARAGVEAGLPEALATTLARATVAGSGELLHRSELDSATLRQN
HHCCCCCCEEEEEEHHHHHHCCHHCCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHC
VTSPGGTTAAALAVLMADDGFRPLLTRAVAAAAKRSRELAK
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLAMANTPKSPALQQLGGNLVLAGAGKMGGALLTGWLAQGLDGGEVVVIDPQPSDEIRAL
CCCCCCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHH
TARGVRINAAASDVGAVATMLVAVKPQTFAGAAPALRSYAGPSTLVVSVMAGTPIAALAA
HHCCEEEECCHHHHHHHHHHHHHCCCCHHCCCCHHHHHHCCCHHEEEEECCCCCHHHHHH
QIGGHVVRAMPNTPAAIGRGITVAVAADDVTPQQRATADALLRATGAVEWVEDESLIDAV
HHCCEEEEECCCCCHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEECCCHHHHHHH
TAVSGSGPAYVFLLAEELARAGVEAGLPEALATTLARATVAGSGELLHRSELDSATLRQN
HHCCCCCCEEEEEEHHHHHHCCHHCCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHC
VTSPGGTTAAALAVLMADDGFRPLLTRAVAAAAKRSRELAK
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]