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The map label for this gene is gcvT [H]

Identifier: 86750847

GI number: 86750847

Start: 4276708

End: 4277856

Strand: Direct

Name: gcvT [H]

Synonym: RPB_3738

Alternate gene names: 86750847

Gene position: 4276708-4277856 (Clockwise)

Preceding gene: 86750843

Following gene: 86750848

Centisome position: 80.21

GC content: 69.89

Gene sequence:

>1149_bases
ATGCTGGCCCGTGATGATTCGCCTGCCCTGAAACGAACCCCGCTGCACGCGCTGCATCTGGCGCGCGGTGGAAAAATGGT
GCCGTTCGCGGGCTACGACATGCCGGTGCAATACGCGCCGGGCGTGCTGAAGGAACATCTCCACACCCGCGCGAGCGCCG
GCCTGTTCGACGTGTCGCATATGGGCCAGATCGAGTTGCGCGCCAGATCCGGCAGGCTCGACGACGCCGCGCAGGCGCTG
GAAACGCTCGTGCCGCAGGACATCGTCGCGCTGGCGCGAGGCCGCCAGCGCTACGCACAGTTCACCAACGACTCCGGCGG
CATCCTCGACGATCTGATGGTCACAAATCTCGGCGACCGGCTGTTCCTGGTGGTCAACGCCGCCTGCAAGACCGAGGACG
AGGCGCATCTGCGCGCGCATATGAGCGCGACCTGCGAGATCACGGCCCTGCCCGGGCGCGCGCTGCTGGCGCTGCAGGGA
CCGAAGGCCGAAGCCGCACTGGCGAAATTCTGTGCAGACGTCGTCGCACTGAAATTCATGGACGTCGCCGAACTGACGCT
GATGGACCTGCCCTGCGTCGTCTCGCGCTCCGGCTACACCGGCGAGGACGGCTTCGAGATTTCGGTGCCGGCCGACGGCG
CCGAGGCGTTCGCGCAGGCGCTGCTCGACCGCCCCGGCGTGCAGCCGATCGGGCTCGGCGCTCGCGACAGCCTGCGGCTG
GAGGCCGGGCTTTGCCTCTACGGCCACGACATCGACCCCACCACGACGCCGGTCGAGGCCGGATTGAGCTGGTCGATTCA
GAAGAGCCGCCGGTCCGGCGGCGCGCGGCCGGGCGGGTTCCTCGGCGCGGACGCGATCCTGGCGCAGCTCGACGCCGGCG
CCACGCGCAAGCGCGTCGGCTTGCGGCCGGAAGGCCGCGCCCCGGTGCGCGAGGGCGCGCCGCTTTATGCCGGTGCGGAC
ACAACCGATGCGATCGGCTCGGTGACGTCGGGCGGCTTCGGCCCGAGCCTGAATGCGCCGGTGGCGATGGGCTATCTGCC
CGCCTCCCAGGCCGCCATCGACAGCCTGGTTTTCGCCGAAGTGCGCGGCCAGCGGCTGCCGCTGCGCGTCGCGGCCATGC
CTTTCGTAACCAACACCTACAAGCGCTGA

Upstream 100 bases:

>100_bases
AATGCGGGGTCCGCCGACGGGATAATGCTCTCAGGCGCAGCGACAGATGGGGCTCGAATGGTGACGAGAAATAGGTCTCG
GGAACCGTGGGAGCCTGAAC

Downstream 100 bases:

>100_bases
GGGATGCTCATGACCACGCTCTACACCACCGATCACGAATGGCTGAAAATCGACGGCGACGTCGCCACGATCGGCATCAC
CAACTACGCGCAGGAACAGC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MLARDDSPALKRTPLHALHLARGGKMVPFAGYDMPVQYAPGVLKEHLHTRASAGLFDVSHMGQIELRARSGRLDDAAQAL
ETLVPQDIVALARGRQRYAQFTNDSGGILDDLMVTNLGDRLFLVVNAACKTEDEAHLRAHMSATCEITALPGRALLALQG
PKAEAALAKFCADVVALKFMDVAELTLMDLPCVVSRSGYTGEDGFEISVPADGAEAFAQALLDRPGVQPIGLGARDSLRL
EAGLCLYGHDIDPTTTPVEAGLSWSIQKSRRSGGARPGGFLGADAILAQLDAGATRKRVGLRPEGRAPVREGAPLYAGAD
TTDAIGSVTSGGFGPSLNAPVAMGYLPASQAAIDSLVFAEVRGQRLPLRVAAMPFVTNTYKR

Sequences:

>Translated_382_residues
MLARDDSPALKRTPLHALHLARGGKMVPFAGYDMPVQYAPGVLKEHLHTRASAGLFDVSHMGQIELRARSGRLDDAAQAL
ETLVPQDIVALARGRQRYAQFTNDSGGILDDLMVTNLGDRLFLVVNAACKTEDEAHLRAHMSATCEITALPGRALLALQG
PKAEAALAKFCADVVALKFMDVAELTLMDLPCVVSRSGYTGEDGFEISVPADGAEAFAQALLDRPGVQPIGLGARDSLRL
EAGLCLYGHDIDPTTTPVEAGLSWSIQKSRRSGGARPGGFLGADAILAQLDAGATRKRVGLRPEGRAPVREGAPLYAGAD
TTDAIGSVTSGGFGPSLNAPVAMGYLPASQAAIDSLVFAEVRGQRLPLRVAAMPFVTNTYKR
>Mature_382_residues
MLARDDSPALKRTPLHALHLARGGKMVPFAGYDMPVQYAPGVLKEHLHTRASAGLFDVSHMGQIELRARSGRLDDAAQAL
ETLVPQDIVALARGRQRYAQFTNDSGGILDDLMVTNLGDRLFLVVNAACKTEDEAHLRAHMSATCEITALPGRALLALQG
PKAEAALAKFCADVVALKFMDVAELTLMDLPCVVSRSGYTGEDGFEISVPADGAEAFAQALLDRPGVQPIGLGARDSLRL
EAGLCLYGHDIDPTTTPVEAGLSWSIQKSRRSGGARPGGFLGADAILAQLDAGATRKRVGLRPEGRAPVREGAPLYAGAD
TTDAIGSVTSGGFGPSLNAPVAMGYLPASQAAIDSLVFAEVRGQRLPLRVAAMPFVTNTYKR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=380, Percent_Identity=45.2631578947368, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI257796258, Length=361, Percent_Identity=45.4293628808864, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI257796254, Length=378, Percent_Identity=41.2698412698413, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI257796256, Length=314, Percent_Identity=44.2675159235669, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI24797151, Length=236, Percent_Identity=25.4237288135593, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI197927446, Length=343, Percent_Identity=25.6559766763848, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI21361378, Length=343, Percent_Identity=25.6559766763848, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1789272, Length=380, Percent_Identity=34.4736842105263, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17560118, Length=393, Percent_Identity=39.440203562341, Blast_Score=231, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6320222, Length=394, Percent_Identity=38.8324873096447, Blast_Score=248, Evalue=9e-67,
Organism=Drosophila melanogaster, GI20129441, Length=389, Percent_Identity=40.3598971722365, Blast_Score=253, Evalue=2e-67,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40321; Mature: 40321

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLARDDSPALKRTPLHALHLARGGKMVPFAGYDMPVQYAPGVLKEHLHTRASAGLFDVSH
CCCCCCCCCHHHCCHHHHHHHCCCCCCEECCCCCCHHHCCHHHHHHHHHHHCCCEEECCC
MGQIELRARSGRLDDAAQALETLVPQDIVALARGRQRYAQFTNDSGGILDDLMVTNLGDR
CCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCE
LFLVVNAACKTEDEAHLRAHMSATCEITALPGRALLALQGPKAEAALAKFCADVVALKFM
EEEEEEHHHCCCCHHHHHHHCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
DVAELTLMDLPCVVSRSGYTGEDGFEISVPADGAEAFAQALLDRPGVQPIGLGARDSLRL
HHHHHHHHCCCCEEECCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCEECCCCCCCEEE
EAGLCLYGHDIDPTTTPVEAGLSWSIQKSRRSGGARPGGFLGADAILAQLDAGATRKRVG
ECCEEEEECCCCCCCCCHHCCCEEEEEHHHHCCCCCCCCCCCHHHHHHHHCCCCCHHHCC
LRPEGRAPVREGAPLYAGADTTDAIGSVTSGGFGPSLNAPVAMGYLPASQAAIDSLVFAE
CCCCCCCCCCCCCCEEECCCCHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHH
VRGQRLPLRVAAMPFVTNTYKR
HCCCCCCEEEEECCHHHHCCCC
>Mature Secondary Structure
MLARDDSPALKRTPLHALHLARGGKMVPFAGYDMPVQYAPGVLKEHLHTRASAGLFDVSH
CCCCCCCCCHHHCCHHHHHHHCCCCCCEECCCCCCHHHCCHHHHHHHHHHHCCCEEECCC
MGQIELRARSGRLDDAAQALETLVPQDIVALARGRQRYAQFTNDSGGILDDLMVTNLGDR
CCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCE
LFLVVNAACKTEDEAHLRAHMSATCEITALPGRALLALQGPKAEAALAKFCADVVALKFM
EEEEEEHHHCCCCHHHHHHHCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
DVAELTLMDLPCVVSRSGYTGEDGFEISVPADGAEAFAQALLDRPGVQPIGLGARDSLRL
HHHHHHHHCCCCEEECCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCEECCCCCCCEEE
EAGLCLYGHDIDPTTTPVEAGLSWSIQKSRRSGGARPGGFLGADAILAQLDAGATRKRVG
ECCEEEEECCCCCCCCCHHCCCEEEEEHHHHCCCCCCCCCCCHHHHHHHHCCCCCHHHCC
LRPEGRAPVREGAPLYAGADTTDAIGSVTSGGFGPSLNAPVAMGYLPASQAAIDSLVFAE
CCCCCCCCCCCCCCEEECCCCHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHH
VRGQRLPLRVAAMPFVTNTYKR
HCCCCCCEEEEECCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA