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The map label for this gene is cyaA [H]

Identifier: 86750775

GI number: 86750775

Start: 4206491

End: 4207810

Strand: Reverse

Name: cyaA [H]

Synonym: RPB_3665

Alternate gene names: 86750775

Gene position: 4207810-4206491 (Counterclockwise)

Preceding gene: 86750776

Following gene: 86750774

Centisome position: 78.92

GC content: 65.98

Gene sequence:

>1320_bases
ATGCAACTGCCGTGGCGACGGTCGTCGAGAATCTCCCAGCGCTCGACGCTGTCCGACGAAATCCGCAGCGCGTTGGCGCG
GGAAGTTCTGAAGACCGAACTGCTGCGCGCGAAGGTGCTGCTGTTCACCGTATCGGCGCTGATATCGACGCTGCTGGTGG
CGTACTGGATTTCCCCCGCGCAGATCGAGCGGATCTGGCGCGGCCAGTTCTCGCTGATGCCGCTGCTGTTGTCCTATGCG
CCGCTGCTGGCGATCGAAGTCAGCGTCATCATCATGCTGCGCCGGCGGTTGGCACGGGGGCACAATGTCCTGCATTGGGG
CCGCTATCTCGGCGTGCTGGTCGAGACCAGCCTGCCTTCGGTCGGCCTGTATCTGCAGATGACGACGATGGGCCCGGCCC
AGGCGCTCGCTTTCGCCGTCCCGTTCGCCTATTTCATCTTCATCATCCTGTCGACGCTGTGGCTCGATTTCTGGCTTTCG
GTCTTCACCGGATTCGTCGCCGCCGCCGAATTGCTGGCGCTCGCGATGCTCTACCAACCGCCGGGATTCGTGGGCGAGCC
TGCGCCGGATTTCGCCTTTCATCTGCTTCGCAGCCTGGTCATCCTGATCTGCGGCGTGCTCGCCGGCGGGGTCGGGATGC
AGTTGCGCCGACAATTCGAGGCTTCGATCGGCGCGGCCGACGCGCGGGATCGCATCACCAGCCTGTTCGGCCAGCACGTC
TCGCCGCAAGTGGTCGAGCAACTGCTCGCGGCGGGCACGGAGGTGACCGGCGAGACCCGGACGGTGGTGGTGATGTTCGT
CGATTTCCGCAATTTCACCGGCGCCGCTCGGACGCGGTCGCCGGAGGAGGTGGTCGCGCGGCTTGACGATGCTTTCGCCG
TGCTGGTCGACATCCTCGAGCGCCACGGCGGCATCGTGAACAAATTTCTCGGCGACGGATTTCTCGCGCTGTTCGGGGCG
CCGATCGATGATCCGCGCGCGGCGTCGTGCGCTGTGGCCGCGGCGCGCGAGATGCTGGCCGCGATGGATGACGACAACGC
CGGACGGGACTGGCCGTTGCGGATCGGCATCGGCATTCACACCGGCGATGCCGTGGTCGGCACTGTCGGCTCACCGCGGC
GCAAGGAGTACACGGTGATCGGCGACACCGTGAATTTCGCGTCGCGGCTGGAGTCCCTCAACAAACACTTCGGCACTCAG
CTTCTGATCTCGACGGCGATCCGCGACGAACTCGGCGATGCCGCGAGCGACGCCGTCCTGCTCGGCAACGTCGCGATGCG
CGGCTACGCCGAGCCGATGGCGGTCTGGCGGCTGGGCTGA

Upstream 100 bases:

>100_bases
TGGCGCTGGCGGCCCTGATGCTGATAGCGATGACGATCGCGGTGACCCGATTCCGCAGGACGCTGGACTGAGGCGGCCCC
GGGGCTGGAGGATTCGTCCA

Downstream 100 bases:

>100_bases
CGGGCCGTCGTCGCTGCATCGGCAGCCCCGGACCGCCGCGCGCGAACTCAGAAGTATTGATTAGTATATAAAATTCGAGA
TTGAGGACATTTTTACTGAA

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MQLPWRRSSRISQRSTLSDEIRSALAREVLKTELLRAKVLLFTVSALISTLLVAYWISPAQIERIWRGQFSLMPLLLSYA
PLLAIEVSVIIMLRRRLARGHNVLHWGRYLGVLVETSLPSVGLYLQMTTMGPAQALAFAVPFAYFIFIILSTLWLDFWLS
VFTGFVAAAELLALAMLYQPPGFVGEPAPDFAFHLLRSLVILICGVLAGGVGMQLRRQFEASIGAADARDRITSLFGQHV
SPQVVEQLLAAGTEVTGETRTVVVMFVDFRNFTGAARTRSPEEVVARLDDAFAVLVDILERHGGIVNKFLGDGFLALFGA
PIDDPRAASCAVAAAREMLAAMDDDNAGRDWPLRIGIGIHTGDAVVGTVGSPRRKEYTVIGDTVNFASRLESLNKHFGTQ
LLISTAIRDELGDAASDAVLLGNVAMRGYAEPMAVWRLG

Sequences:

>Translated_439_residues
MQLPWRRSSRISQRSTLSDEIRSALAREVLKTELLRAKVLLFTVSALISTLLVAYWISPAQIERIWRGQFSLMPLLLSYA
PLLAIEVSVIIMLRRRLARGHNVLHWGRYLGVLVETSLPSVGLYLQMTTMGPAQALAFAVPFAYFIFIILSTLWLDFWLS
VFTGFVAAAELLALAMLYQPPGFVGEPAPDFAFHLLRSLVILICGVLAGGVGMQLRRQFEASIGAADARDRITSLFGQHV
SPQVVEQLLAAGTEVTGETRTVVVMFVDFRNFTGAARTRSPEEVVARLDDAFAVLVDILERHGGIVNKFLGDGFLALFGA
PIDDPRAASCAVAAAREMLAAMDDDNAGRDWPLRIGIGIHTGDAVVGTVGSPRRKEYTVIGDTVNFASRLESLNKHFGTQ
LLISTAIRDELGDAASDAVLLGNVAMRGYAEPMAVWRLG
>Mature_439_residues
MQLPWRRSSRISQRSTLSDEIRSALAREVLKTELLRAKVLLFTVSALISTLLVAYWISPAQIERIWRGQFSLMPLLLSYA
PLLAIEVSVIIMLRRRLARGHNVLHWGRYLGVLVETSLPSVGLYLQMTTMGPAQALAFAVPFAYFIFIILSTLWLDFWLS
VFTGFVAAAELLALAMLYQPPGFVGEPAPDFAFHLLRSLVILICGVLAGGVGMQLRRQFEASIGAADARDRITSLFGQHV
SPQVVEQLLAAGTEVTGETRTVVVMFVDFRNFTGAARTRSPEEVVARLDDAFAVLVDILERHGGIVNKFLGDGFLALFGA
PIDDPRAASCAVAAAREMLAAMDDDNAGRDWPLRIGIGIHTGDAVVGTVGSPRRKEYTVIGDTVNFASRLESLNKHFGTQ
LLISTAIRDELGDAASDAVLLGNVAMRGYAEPMAVWRLG

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI167830411, Length=210, Percent_Identity=31.4285714285714, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4580422, Length=210, Percent_Identity=29.5238095238095, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI134152694, Length=216, Percent_Identity=26.8518518518519, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4504217, Length=217, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193206632, Length=221, Percent_Identity=31.2217194570136, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17534659, Length=179, Percent_Identity=32.4022346368715, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI193207841, Length=213, Percent_Identity=30.0469483568075, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17534657, Length=163, Percent_Identity=34.9693251533742, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994363, Length=141, Percent_Identity=31.9148936170213, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193210669, Length=141, Percent_Identity=31.9148936170213, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17561804, Length=171, Percent_Identity=32.1637426900585, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71982300, Length=212, Percent_Identity=30.188679245283, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI86564713, Length=183, Percent_Identity=28.9617486338798, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI62484477, Length=207, Percent_Identity=30.4347826086957, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI62484298, Length=207, Percent_Identity=30.4347826086957, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI116008008, Length=200, Percent_Identity=30.5, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI62473752, Length=157, Percent_Identity=32.484076433121, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17137448, Length=157, Percent_Identity=32.484076433121, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585694, Length=304, Percent_Identity=23.6842105263158, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24647268, Length=205, Percent_Identity=30.2439024390244, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI161078020, Length=216, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281366459, Length=157, Percent_Identity=33.1210191082803, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281366457, Length=157, Percent_Identity=33.1210191082803, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281366455, Length=157, Percent_Identity=33.1210191082803, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI56292422, Length=157, Percent_Identity=33.1210191082803, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI56292424, Length=157, Percent_Identity=33.1210191082803, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24666940, Length=157, Percent_Identity=33.1210191082803, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330468, Length=213, Percent_Identity=28.169014084507, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574512, Length=155, Percent_Identity=29.6774193548387, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221330470, Length=213, Percent_Identity=28.169014084507, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161076872, Length=155, Percent_Identity=29.6774193548387, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 47970; Mature: 47970

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLPWRRSSRISQRSTLSDEIRSALAREVLKTELLRAKVLLFTVSALISTLLVAYWISPA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
QIERIWRGQFSLMPLLLSYAPLLAIEVSVIIMLRRRLARGHNVLHWGRYLGVLVETSLPS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
VGLYLQMTTMGPAQALAFAVPFAYFIFIILSTLWLDFWLSVFTGFVAAAELLALAMLYQP
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGFVGEPAPDFAFHLLRSLVILICGVLAGGVGMQLRRQFEASIGAADARDRITSLFGQHV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
SPQVVEQLLAAGTEVTGETRTVVVMFVDFRNFTGAARTRSPEEVVARLDDAFAVLVDILE
CHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RHGGIVNKFLGDGFLALFGAPIDDPRAASCAVAAAREMLAAMDDDNAGRDWPLRIGIGIH
HCCCHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEE
TGDAVVGTVGSPRRKEYTVIGDTVNFASRLESLNKHFGTQLLISTAIRDELGDAASDAVL
CCCCEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHH
LGNVAMRGYAEPMAVWRLG
HHHHHHHCCCCCHHHEECC
>Mature Secondary Structure
MQLPWRRSSRISQRSTLSDEIRSALAREVLKTELLRAKVLLFTVSALISTLLVAYWISPA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
QIERIWRGQFSLMPLLLSYAPLLAIEVSVIIMLRRRLARGHNVLHWGRYLGVLVETSLPS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
VGLYLQMTTMGPAQALAFAVPFAYFIFIILSTLWLDFWLSVFTGFVAAAELLALAMLYQP
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGFVGEPAPDFAFHLLRSLVILICGVLAGGVGMQLRRQFEASIGAADARDRITSLFGQHV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
SPQVVEQLLAAGTEVTGETRTVVVMFVDFRNFTGAARTRSPEEVVARLDDAFAVLVDILE
CHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RHGGIVNKFLGDGFLALFGAPIDDPRAASCAVAAAREMLAAMDDDNAGRDWPLRIGIGIH
HCCCHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEE
TGDAVVGTVGSPRRKEYTVIGDTVNFASRLESLNKHFGTQLLISTAIRDELGDAASDAVL
CCCCEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHH
LGNVAMRGYAEPMAVWRLG
HHHHHHHCCCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]