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The map label for this gene is bioI [H]

Identifier: 86750762

GI number: 86750762

Start: 4192015

End: 4193235

Strand: Direct

Name: bioI [H]

Synonym: RPB_3652

Alternate gene names: 86750762

Gene position: 4192015-4193235 (Clockwise)

Preceding gene: 86750752

Following gene: 86750764

Centisome position: 78.63

GC content: 65.93

Gene sequence:

>1221_bases
ATGGAAATGCCCTCACGCGAACTGGCGGCGGAGTTCGAACTCGAACGGCTGACGCCGGAGTTCTATGACAATCCCTACCC
CACCTATCGCGCCCTGCAGACGCATCAGCCGGTCAAGCGGCTGCGCAATGGCGGGTACATCCTGACGCGCTATGACGATC
TGGTGACGGTCTACAAGAACACCACGCTGTTCAGCTCCGACAAGAAGCGCGAATTCGCGCCGAAATACGGCGACTCGCTG
CTGTTCGAGCATCACACTACCAGCCTGGTGTTCAACGACCCGCCGGCGCATACGCGAGTGCGGCGGCTGATCACGGGCGC
GCTGTCGCCGCGCGCGATCGCCGGCATGCAGCCGGATCTGATCGCGCTGGTCGACCGCCTGCTCGATGCGATGGCGGCCA
AAGCCGGCGTCGATCTGATCGAGGATTTCGCCGCCGCGATCCCGATCGAGGTGATCGGCAATCTGCTCGGCGTGCCGCAC
GACGAGCGCGGCCCGCTCCGCGACTGGTCGCTGGCGATTCTCGGCGCACTCGAGCCGGTGATCGGGCCGGAGACGTTTTC
GCGCGGCAATGAGGCTGTCCGCGACTTCCTCGCCTATCTCGAAATCCTGATCACGCGCCGTCGCGCCGAGCCCGGCGATC
CGGAGCACGATGTTCTGACCCGGCTGATCCAGGGCGACGACGGCACCGGCGAGAAGCTCTCCGCCAAGGAGCTGCTGCAC
AATTGCATCTTCCTGCTCAACGCCGGACATGAAACCACCACCAACCTGATCGGCAACGGGCTCGTGGCGCTCGCAGACAA
TCCTGCGGAAAAACAGCGGCTGATCGGCCAGCCCGGCCTCGCCCGCACCGCGGTCGAAGAGATCCTGCGCTATGAGAGCT
CGAACCAGCTCGGCAACCGCATCACCACCACCGAGGTCGAGATCGGAGGCGTAACGATGCAGGCCAACACCTCGCTGACG
CTGTGCATCGGCGCTGCCAACCGCGATCCGGCGCAGTTTCCCGATCCCGACCGGTTCGACGTCGGACGAACGCCGAACCG
GCACCTCGCTTTTGCCACGGGGCCACATCAATGCGCCGGCATGGCGCTGGCGCGGCTCGAAGGCGTGATCGCGCTGACGC
GATTCCTGGCGCGCTTCCCGAACTACACGCTCGACGGCACGCCGTCGCGCGGCGGGCGGGTGCGGTTTCGCGGCTATCTG
CGCGTGCCATGCCGCCTGTAG

Upstream 100 bases:

>100_bases
CCGCCCGGCGGTATCCCTCGAAGCCTCGTGCCTGCCGCCTCCGGCCAGCCGATATGCGTTTCGCGGGGAAACGCTCTATA
ACCAAGAAAACGGGAATGAC

Downstream 100 bases:

>100_bases
GCGACCTCAAAGTGGCCAACGCAGCAATCTGGTCGCGGACTTGCCGACCTCCTGGAGCAACTTCCGCTCTCCCAGAAACG
GAGTCGGAACCGGCCCCCAG

Product: cytochrome P450

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MEMPSRELAAEFELERLTPEFYDNPYPTYRALQTHQPVKRLRNGGYILTRYDDLVTVYKNTTLFSSDKKREFAPKYGDSL
LFEHHTTSLVFNDPPAHTRVRRLITGALSPRAIAGMQPDLIALVDRLLDAMAAKAGVDLIEDFAAAIPIEVIGNLLGVPH
DERGPLRDWSLAILGALEPVIGPETFSRGNEAVRDFLAYLEILITRRRAEPGDPEHDVLTRLIQGDDGTGEKLSAKELLH
NCIFLLNAGHETTTNLIGNGLVALADNPAEKQRLIGQPGLARTAVEEILRYESSNQLGNRITTTEVEIGGVTMQANTSLT
LCIGAANRDPAQFPDPDRFDVGRTPNRHLAFATGPHQCAGMALARLEGVIALTRFLARFPNYTLDGTPSRGGRVRFRGYL
RVPCRL

Sequences:

>Translated_406_residues
MEMPSRELAAEFELERLTPEFYDNPYPTYRALQTHQPVKRLRNGGYILTRYDDLVTVYKNTTLFSSDKKREFAPKYGDSL
LFEHHTTSLVFNDPPAHTRVRRLITGALSPRAIAGMQPDLIALVDRLLDAMAAKAGVDLIEDFAAAIPIEVIGNLLGVPH
DERGPLRDWSLAILGALEPVIGPETFSRGNEAVRDFLAYLEILITRRRAEPGDPEHDVLTRLIQGDDGTGEKLSAKELLH
NCIFLLNAGHETTTNLIGNGLVALADNPAEKQRLIGQPGLARTAVEEILRYESSNQLGNRITTTEVEIGGVTMQANTSLT
LCIGAANRDPAQFPDPDRFDVGRTPNRHLAFATGPHQCAGMALARLEGVIALTRFLARFPNYTLDGTPSRGGRVRFRGYL
RVPCRL
>Mature_406_residues
MEMPSRELAAEFELERLTPEFYDNPYPTYRALQTHQPVKRLRNGGYILTRYDDLVTVYKNTTLFSSDKKREFAPKYGDSL
LFEHHTTSLVFNDPPAHTRVRRLITGALSPRAIAGMQPDLIALVDRLLDAMAAKAGVDLIEDFAAAIPIEVIGNLLGVPH
DERGPLRDWSLAILGALEPVIGPETFSRGNEAVRDFLAYLEILITRRRAEPGDPEHDVLTRLIQGDDGTGEKLSAKELLH
NCIFLLNAGHETTTNLIGNGLVALADNPAEKQRLIGQPGLARTAVEEILRYESSNQLGNRITTTEVEIGGVTMQANTSLT
LCIGAANRDPAQFPDPDRFDVGRTPNRHLAFATGPHQCAGMALARLEGVIALTRFLARFPNYTLDGTPSRGGRVRFRGYL
RVPCRL

Specific function: Catalyzes the C-C bond cleavage of fatty acid linked to acyl carrier protein (ACP) to generate pimelic acid for biotin biosynthesis. It has high affinity for long-chain fatty acids with the greatest affinity for myristic acid [H]

COG id: COG2124

COG function: function code Q; Cytochrome P450

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family [H]

Homologues:

Organism=Homo sapiens, GI4503213, Length=218, Percent_Identity=28.8990825688073, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17540354, Length=213, Percent_Identity=26.7605633802817, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17552522, Length=342, Percent_Identity=24.2690058479532, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24642101, Length=169, Percent_Identity=27.810650887574, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972 [H]

Pfam domain/function: PF00067 p450 [H]

EC number: NA

Molecular weight: Translated: 44900; Mature: 44900

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMPSRELAAEFELERLTPEFYDNPYPTYRALQTHQPVKRLRNGGYILTRYDDLVTVYKN
CCCCCHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEC
TTLFSSDKKREFAPKYGDSLLFEHHTTSLVFNDPPAHTRVRRLITGALSPRAIAGMQPDL
CEEECCCCCHHCCCCCCCCEEEEECCCEEEECCCCHHHHHHHHHHHCCCCHHHCCCCCHH
IALVDRLLDAMAAKAGVDLIEDFAAAIPIEVIGNLLGVPHDERGPLRDWSLAILGALEPV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
IGPETFSRGNEAVRDFLAYLEILITRRRAEPGDPEHDVLTRLIQGDDGTGEKLSAKELLH
CCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHH
NCIFLLNAGHETTTNLIGNGLVALADNPAEKQRLIGQPGLARTAVEEILRYESSNQLGNR
HHHHHHCCCCHHHHHHHCCCEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHCCCCHHCCC
ITTTEVEIGGVTMQANTSLTLCIGAANRDPAQFPDPDRFDVGRTPNRHLAFATGPHQCAG
EEEEEEEECCEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHH
MALARLEGVIALTRFLARFPNYTLDGTPSRGGRVRFRGYLRVPCRL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCCC
>Mature Secondary Structure
MEMPSRELAAEFELERLTPEFYDNPYPTYRALQTHQPVKRLRNGGYILTRYDDLVTVYKN
CCCCCHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEC
TTLFSSDKKREFAPKYGDSLLFEHHTTSLVFNDPPAHTRVRRLITGALSPRAIAGMQPDL
CEEECCCCCHHCCCCCCCCEEEEECCCEEEECCCCHHHHHHHHHHHCCCCHHHCCCCCHH
IALVDRLLDAMAAKAGVDLIEDFAAAIPIEVIGNLLGVPHDERGPLRDWSLAILGALEPV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
IGPETFSRGNEAVRDFLAYLEILITRRRAEPGDPEHDVLTRLIQGDDGTGEKLSAKELLH
CCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHH
NCIFLLNAGHETTTNLIGNGLVALADNPAEKQRLIGQPGLARTAVEEILRYESSNQLGNR
HHHHHHCCCCHHHHHHHCCCEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHCCCCHHCCC
ITTTEVEIGGVTMQANTSLTLCIGAANRDPAQFPDPDRFDVGRTPNRHLAFATGPHQCAG
EEEEEEEECCEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHH
MALARLEGVIALTRFLARFPNYTLDGTPSRGGRVRFRGYLRVPCRL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763940; 9387221; 9384377 [H]